| functional annotation |
| Function |
epidermal growth factor |
|
| GO BP |
|
GO:0038029 [list] [network] epidermal growth factor receptor signaling pathway via MAPK cascade
|
(1 genes)
|
ISO
ISS
|
 |
|
GO:1900127 [list] [network] positive regulation of hyaluronan biosynthetic process
|
(5 genes)
|
ISO
|
|
|
GO:0090370 [list] [network] negative regulation of cholesterol efflux
|
(7 genes)
|
ISO
|
|
|
GO:1905278 [list] [network] positive regulation of epithelial tube formation
|
(8 genes)
|
ISO
|
|
|
GO:1902966 [list] [network] positive regulation of protein localization to early endosome
|
(9 genes)
|
ISO
|
|
|
GO:0021940 [list] [network] positive regulation of cerebellar granule cell precursor proliferation
|
(11 genes)
|
ISO
|
|
|
GO:0045741 [list] [network] positive regulation of epidermal growth factor-activated receptor activity
|
(13 genes)
|
ISO
|
|
|
GO:0060749 [list] [network] mammary gland alveolus development
|
(22 genes)
|
ISO
|
|
|
GO:0010800 [list] [network] positive regulation of peptidyl-threonine phosphorylation
|
(29 genes)
|
ISO
|
|
|
GO:0002092 [list] [network] positive regulation of receptor internalization
|
(34 genes)
|
ISO
|
|
|
GO:0070371 [list] [network] ERK1 and ERK2 cascade
|
(37 genes)
|
ISO
|
|
|
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway
|
(42 genes)
|
IDA
ISO
|
|
|
GO:2000008 [list] [network] regulation of protein localization to cell surface
|
(43 genes)
|
ISO
|
|
|
GO:0045840 [list] [network] positive regulation of mitotic nuclear division
|
(48 genes)
|
ISO
|
|
|
GO:0045740 [list] [network] positive regulation of DNA replication
|
(51 genes)
|
ISO
ISS
|
|
|
GO:0090279 [list] [network] regulation of calcium ion import
|
(52 genes)
|
ISO
|
|
|
GO:0061098 [list] [network] positive regulation of protein tyrosine kinase activity
|
(57 genes)
|
ISO
|
|
|
GO:0043388 [list] [network] positive regulation of DNA binding
|
(60 genes)
|
ISO
ISS
|
|
|
GO:0048146 [list] [network] positive regulation of fibroblast proliferation
|
(75 genes)
|
IDA
|
|
|
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process
|
(77 genes)
|
IDA
|
|
|
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling
|
(81 genes)
|
ISO
|
|
|
GO:0046425 [list] [network] regulation of receptor signaling pathway via JAK-STAT
|
(90 genes)
|
ISO
ISS
|
|
|
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation
|
(97 genes)
|
ISO
|
|
|
GO:0043406 [list] [network] positive regulation of MAP kinase activity
|
(101 genes)
|
ISO
|
|
|
GO:2000060 [list] [network] positive regulation of ubiquitin-dependent protein catabolic process
|
(103 genes)
|
ISO
|
|
|
GO:0090263 [list] [network] positive regulation of canonical Wnt signaling pathway
|
(106 genes)
|
ISO
|
|
|
GO:0010595 [list] [network] positive regulation of endothelial cell migration
|
(111 genes)
|
ISO
|
|
|
GO:0051897 [list] [network] positive regulation of protein kinase B signaling
|
(122 genes)
|
ISO
|
|
|
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation
|
(149 genes)
|
ISO
|
|
|
GO:0048754 [list] [network] branching morphogenesis of an epithelial tube
|
(168 genes)
|
ISO
|
|
|
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation
|
(204 genes)
|
ISO
|
|
|
GO:0051048 [list] [network] negative regulation of secretion
|
(216 genes)
|
ISO
|
|
|
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade
|
(232 genes)
|
IDA
|
|
|
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation
|
(273 genes)
|
ISO
|
|
|
GO:0001525 [list] [network] angiogenesis
|
(287 genes)
|
ISO
|
|
|
GO:0050708 [list] [network] regulation of protein secretion
|
(310 genes)
|
IMP
|
|
|
GO:0001822 [list] [network] kidney development
|
(354 genes)
|
IEP
|
|
|
GO:0043410 [list] [network] positive regulation of MAPK cascade
|
(490 genes)
|
ISO
|
|
|
GO:0030335 [list] [network] positive regulation of cell migration
|
(586 genes)
|
ISO
|
|
|
GO:0042327 [list] [network] positive regulation of phosphorylation
|
(842 genes)
|
ISO
|
|
|
GO:0008284 [list] [network] positive regulation of cell population proliferation
|
(1044 genes)
|
ISO
|
|
|
GO:0010628 [list] [network] positive regulation of gene expression
|
(1232 genes)
|
ISO
|
|
|
GO:0035556 [list] [network] intracellular signal transduction
|
(1357 genes)
|
TAS
|
|
|
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated
|
(1618 genes)
|
ISO
|
|
|
GO:0007165 [list] [network] signal transduction
|
(5227 genes)
|
IEA
|
|
|
| GO CC |
|
GO:0070062 [list] [network] extracellular exosome
|
(105 genes)
|
ISO
|
|
|
GO:0005615 [list] [network] extracellular space
|
(1510 genes)
|
IDA
ISO
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(5814 genes)
|
IBA
ISO
|
|
|
GO:0016021 [list] [network] integral component of membrane
|
(6265 genes)
|
IEA
|
|
|
| GO MF |
|
GO:0005154 [list] [network] epidermal growth factor receptor binding
|
(35 genes)
|
IDA
ISO
TAS
|
|
|
GO:0008083 [list] [network] growth factor activity
|
(145 genes)
|
IEA
ISO
|
|
|
GO:0005085 [list] [network] guanyl-nucleotide exchange factor activity
|
(208 genes)
|
ISO
|
|
|
GO:0005509 [list] [network] calcium ion binding
|
(674 genes)
|
IEA
|
|
|
| KEGG |
rno01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (80 genes) |
 |
| rno04010 [list] [network] MAPK signaling pathway (293 genes) |
|
| rno04012 [list] [network] ErbB signaling pathway (85 genes) |
|
| rno04014 [list] [network] Ras signaling pathway (231 genes) |
|
| rno04015 [list] [network] Rap1 signaling pathway (213 genes) |
|
| rno04020 [list] [network] Calcium signaling pathway (238 genes) |
|
| rno04066 [list] [network] HIF-1 signaling pathway (114 genes) |
|
| rno04068 [list] [network] FoxO signaling pathway (134 genes) |
|
| rno04072 [list] [network] Phospholipase D signaling pathway (150 genes) |
|
| rno04151 [list] [network] PI3K-Akt signaling pathway (345 genes) |
|
| rno04510 [list] [network] Focal adhesion (200 genes) |
|
| rno04540 [list] [network] Gap junction (87 genes) |
|
| rno04630 [list] [network] JAK-STAT signaling pathway (158 genes) |
|
| rno04810 [list] [network] Regulation of actin cytoskeleton (223 genes) |
|
| rno05160 [list] [network] Hepatitis C (158 genes) |
|
| rno05165 [list] [network] Human papillomavirus infection (353 genes) |
|
| rno05200 [list] [network] Pathways in cancer (538 genes) |
|
| rno05207 [list] [network] Chemical carcinogenesis - receptor activation (228 genes) |
|
| rno05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (234 genes) |
|
| rno05210 [list] [network] Colorectal cancer (89 genes) |
|
| rno05212 [list] [network] Pancreatic cancer (75 genes) |
|
| rno05213 [list] [network] Endometrial cancer (59 genes) |
|
| rno05214 [list] [network] Glioma (74 genes) |
|
| rno05215 [list] [network] Prostate cancer (99 genes) |
|
| rno05218 [list] [network] Melanoma (73 genes) |
|
| rno05219 [list] [network] Bladder cancer (41 genes) |
|
| rno05223 [list] [network] Non-small cell lung cancer (73 genes) |
|
| rno05224 [list] [network] Breast cancer (148 genes) |
|
| rno05226 [list] [network] Gastric cancer (151 genes) |
|
| rno05231 [list] [network] Choline metabolism in cancer (98 genes) |
|
| rno05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (89 genes) |
|
| Protein |
NP_036974.2
XP_038957708.1
XP_038957709.1
|
| BLAST |
NP_036974.2
XP_038957708.1
XP_038957709.1
|
| Orthologous |
[Ortholog page]
EGF (hsa)
Egf (mmu)
egf (dre)
EGF (cfa)
EGF (gga)
EGF (fca)
EGF (mcc)
|
Subcellular
localization
wolf |
|
plas 8,
extr_plas 4,
extr 1,
E.R. 1
|
(predict for NP_036974.2)
|
|
extr_plas 3,
plas 3,
extr 3,
pero 2,
cyto 1
|
(predict for XP_038957708.1)
|
|
extr_plas 3,
extr 3,
plas 3,
pero 2,
cyto 1
|
(predict for XP_038957709.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| rno00280 |
Valine, leucine and isoleucine degradation |
6 |
 |
| rno00640 |
Propanoate metabolism |
4 |
 |
| rno01200 |
Carbon metabolism |
3 |
 |
| rno00310 |
Lysine degradation |
2 |
 |
| rno00380 |
Tryptophan metabolism |
2 |
 |
Genes directly connected with Egf on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
Entrez Gene ID* |
| 5.1 |
Mccc1 |
methylcrotonyl-CoA carboxylase subunit 1 |
[detail] |
294972 |
| 4.3 |
Nat8b |
N-acetyltransferase 8B |
[detail] |
171084 |
| 4.3 |
Sfxn2 |
sideroflexin 2 |
[detail] |
294011 |
|
Coexpressed
gene list |
[Coexpressed gene list for Egf]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Egf Gene
