[←][→] hsa  EGF Gene
functional annotation
Function   epidermal growth factor  
GO BP
GO:0038029 [list] [network] epidermal growth factor receptor signaling pathway via MAPK cascade  (1 genes)  IMP  
GO:1900127 [list] [network] positive regulation of hyaluronan biosynthetic process  (4 genes)  IDA  
GO:1905278 [list] [network] positive regulation of epithelial tube formation  (7 genes)  IDA  
GO:1902966 [list] [network] positive regulation of protein localization to early endosome  (8 genes)  IDA  
GO:0021940 [list] [network] positive regulation of cerebellar granule cell precursor proliferation  (10 genes)  IEA  
GO:0045741 [list] [network] positive regulation of epidermal growth factor-activated receptor activity  (13 genes)  IDA IMP TAS  
GO:0007171 [list] [network] activation of transmembrane receptor protein tyrosine kinase activity  (14 genes)  IEA  
GO:0060749 [list] [network] mammary gland alveolus development  (18 genes)  IEA  
GO:0090370 [list] [network] negative regulation of cholesterol efflux  (20 genes)  IEA  
GO:0002092 [list] [network] positive regulation of receptor internalization  (27 genes)  IDA  
GO:0010800 [list] [network] positive regulation of peptidyl-threonine phosphorylation  (30 genes)  IDA  
GO:0038128 [list] [network] ERBB2 signaling pathway  (32 genes)  TAS  
GO:0070371 [list] [network] ERK1 and ERK2 cascade  (33 genes)  IDA  
GO:0045746 [list] [network] negative regulation of Notch signaling pathway  (39 genes)  TAS  
GO:0045740 [list] [network] positive regulation of DNA replication  (40 genes)  IMP  
GO:2000008 [list] [network] regulation of protein localization to cell surface  (41 genes)  IDA  
GO:0045840 [list] [network] positive regulation of mitotic nuclear division  (43 genes)  IDA  
GO:0090279 [list] [network] regulation of calcium ion import  (47 genes)  IDA  
GO:0042059 [list] [network] negative regulation of epidermal growth factor receptor signaling pathway  (48 genes)  TAS  
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway  (51 genes)  IDA TAS  
GO:1901185 [list] [network] negative regulation of ERBB signaling pathway  (53 genes)  TAS  
GO:0043388 [list] [network] positive regulation of DNA binding  (56 genes)  ISS  
GO:0046425 [list] [network] regulation of receptor signaling pathway via JAK-STAT  (73 genes)  ISS  
GO:0043406 [list] [network] positive regulation of MAP kinase activity  (89 genes)  IDA  
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling  (91 genes)  IGI  
GO:2000060 [list] [network] positive regulation of ubiquitin-dependent protein catabolic process  (109 genes)  IEA  
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation  (111 genes)  IDA  
GO:0002576 [list] [network] platelet degranulation  (129 genes)  TAS  
GO:0048754 [list] [network] branching morphogenesis of an epithelial tube  (132 genes)  IEA  
GO:0010595 [list] [network] positive regulation of endothelial cell migration  (133 genes)  IDA  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IEA  
GO:0090263 [list] [network] positive regulation of canonical Wnt signaling pathway  (151 genes)  IDA  
GO:0051048 [list] [network] negative regulation of secretion  (171 genes)  IDA  
GO:0051897 [list] [network] positive regulation of protein kinase B signaling  (186 genes)  IDA TAS  
GO:0001525 [list] [network] angiogenesis  (316 genes)  IDA  
GO:0000165 [list] [network] MAPK cascade  (376 genes)  TAS  
GO:0043410 [list] [network] positive regulation of MAPK cascade  (431 genes)  IDA  
GO:0030335 [list] [network] positive regulation of cell migration  (554 genes)  IDA  
GO:0042327 [list] [network] positive regulation of phosphorylation  (812 genes)  IDA  
GO:0061024 [list] [network] membrane organization  (952 genes)  TAS  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (976 genes)  IDA  
GO:2000145 [list] [network] regulation of cell motility  (1046 genes)  TAS  
GO:0010628 [list] [network] positive regulation of gene expression  (1188 genes)  IDA  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1594 genes)  IDA  
GO:0007165 [list] [network] signal transduction  (5169 genes)  TAS  
GO CC
GO:0031093 [list] [network] platelet alpha granule lumen  (67 genes)  TAS  
GO:0030669 [list] [network] clathrin-coated endocytic vesicle membrane  (72 genes)  TAS  
GO:0005765 [list] [network] lysosomal membrane  (394 genes)  HDA  
GO:0070062 [list] [network] extracellular exosome  (2212 genes)  HDA IDA  
GO:0005615 [list] [network] extracellular space  (3622 genes)  HDA  
GO:0005576 [list] [network] extracellular region  (4632 genes)  TAS  
GO:0016021 [list] [network] integral component of membrane  (5388 genes)  IEA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IBA  
GO MF
GO:0030297 [list] [network] transmembrane receptor protein tyrosine kinase activator activity  (8 genes)  TAS  
GO:0005154 [list] [network] epidermal growth factor receptor binding  (33 genes)  TAS  
GO:0008083 [list] [network] growth factor activity  (162 genes)  IDA  
GO:0005085 [list] [network] guanyl-nucleotide exchange factor activity  (211 genes)  IDA  
GO:0005509 [list] [network] calcium ion binding  (713 genes)  IEA  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes)
hsa04010 [list] [network] MAPK signaling pathway (294 genes)
hsa04012 [list] [network] ErbB signaling pathway (85 genes)
hsa04014 [list] [network] Ras signaling pathway (232 genes)
hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04020 [list] [network] Calcium signaling pathway (240 genes)
hsa04066 [list] [network] HIF-1 signaling pathway (109 genes)
hsa04068 [list] [network] FoxO signaling pathway (131 genes)
hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes)
hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes)
hsa04510 [list] [network] Focal adhesion (201 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04630 [list] [network] JAK-STAT signaling pathway (162 genes)
hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes)
hsa05160 [list] [network] Hepatitis C (157 genes)
hsa05165 [list] [network] Human papillomavirus infection (331 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes)
hsa05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (223 genes)
hsa05210 [list] [network] Colorectal cancer (86 genes)
hsa05212 [list] [network] Pancreatic cancer (76 genes)
hsa05213 [list] [network] Endometrial cancer (58 genes)
hsa05214 [list] [network] Glioma (75 genes)
hsa05215 [list] [network] Prostate cancer (97 genes)
hsa05218 [list] [network] Melanoma (72 genes)
hsa05219 [list] [network] Bladder cancer (41 genes)
hsa05223 [list] [network] Non-small cell lung cancer (72 genes)
hsa05224 [list] [network] Breast cancer (147 genes)
hsa05226 [list] [network] Gastric cancer (149 genes)
hsa05231 [list] [network] Choline metabolism in cancer (98 genes)
hsa05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (89 genes)
Protein NP_001171601.1  NP_001171602.1  NP_001343950.1  NP_001954.2  XP_005262853.1  XP_011530009.1  XP_016863334.1  XP_016863335.1  XP_016863336.1  XP_016863337.1  XP_016863338.1  XP_016863339.1  XP_016863340.1  XP_016863342.1  XP_016863343.1  XP_016863344.1 
BLAST NP_001171601.1  NP_001171602.1  NP_001343950.1  NP_001954.2  XP_005262853.1  XP_011530009.1  XP_016863334.1  XP_016863335.1  XP_016863336.1  XP_016863337.1  XP_016863338.1  XP_016863339.1  XP_016863340.1  XP_016863342.1  XP_016863343.1  XP_016863344.1 
Orthologous [Ortholog page] Egf (mmu)  Egf (rno)  egf (dre)  EGF (cfa)  EGF (gga)  EGF (fca)  EGF (mcc) 
Subcellular
localization
wolf
E.R. 4,  plas 3,  extr_plas 3,  extr 2,  pero 1  (predict for NP_001171601.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 1,  pero 1  (predict for NP_001171602.1)
E.R. 4,  plas 3,  extr_plas 2,  extr 1,  pero 1  (predict for NP_001343950.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 2,  pero 1  (predict for NP_001954.2)
E.R. 4,  plas 3,  extr_plas 3,  extr 2,  pero 1  (predict for XP_005262853.1)
pero 5,  plas 2,  extr_plas 2,  extr 1,  nucl 1,  cyto 1,  mito 1,  cyto_nucl 1,  cyto_mito 1,  mito_nucl 1  (predict for XP_011530009.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 2  (predict for XP_016863334.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 2  (predict for XP_016863335.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 2,  pero 1  (predict for XP_016863336.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 1,  pero 1  (predict for XP_016863337.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 2,  pero 1  (predict for XP_016863338.1)
E.R. 4,  plas 3,  extr_plas 2,  extr 1,  pero 1  (predict for XP_016863339.1)
E.R. 4,  plas 3,  extr_plas 3,  extr 2,  pero 1  (predict for XP_016863340.1)
extr 5,  extr_plas 4,  plas 2,  E.R. 2,  lyso 1  (predict for XP_016863342.1)
extr 5,  extr_plas 4,  plas 2,  E.R. 2,  lyso 1  (predict for XP_016863343.1)
extr 5,  extr_plas 3,  plas 2,  E.R. 2,  lyso 1,  E.R._mito 1,  E.R._golg 1  (predict for XP_016863344.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04972 Pancreatic secretion 2
Genes directly connected with EGF on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
6.6 LIPH lipase H [detail] 0 200879
6.2 MFAP3L microfibril associated protein 3 like [detail] 0 9848
5.5 PKHD1L1 PKHD1 like 1 [detail] 0 93035
5.0 PLCH1 phospholipase C eta 1 [detail] 0 23007
4.5 VEPH1 ventricular zone expressed PH domain containing 1 [detail] 0 79674
4.1 SPX spexin hormone [detail] 0 80763
Coexpressed
gene list		 [Coexpressed gene list for EGF]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 1950      
Refseq ID (protein) NP_001171601.1 
NP_001171602.1 
NP_001343950.1 
NP_001954.2 
XP_005262853.1 
XP_011530009.1 
XP_016863334.1 
XP_016863335.1 
XP_016863336.1 
XP_016863337.1 
XP_016863338.1 
XP_016863339.1 
XP_016863340.1 
XP_016863342.1 
XP_016863343.1 
XP_016863344.1 


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