| functional annotation |
| Function |
epidermal growth factor |
|
| GO BP |
|
GO:0038029 [list] [network] epidermal growth factor receptor signaling pathway via MAPK cascade
|
(1 genes)
|
ISO
|
 |
|
GO:1900127 [list] [network] positive regulation of hyaluronan biosynthetic process
|
(5 genes)
|
ISO
|
|
|
GO:0090370 [list] [network] negative regulation of cholesterol efflux
|
(7 genes)
|
IDA
|
|
|
GO:1905278 [list] [network] positive regulation of epithelial tube formation
|
(8 genes)
|
ISO
|
|
|
GO:1902966 [list] [network] positive regulation of protein localization to early endosome
|
(9 genes)
|
ISO
|
|
|
GO:0021940 [list] [network] positive regulation of cerebellar granule cell precursor proliferation
|
(11 genes)
|
IDA
|
|
|
GO:0045741 [list] [network] positive regulation of epidermal growth factor-activated receptor activity
|
(12 genes)
|
ISO
|
|
|
GO:0060749 [list] [network] mammary gland alveolus development
|
(22 genes)
|
IGI
|
|
|
GO:0010800 [list] [network] positive regulation of peptidyl-threonine phosphorylation
|
(30 genes)
|
ISO
|
|
|
GO:0002092 [list] [network] positive regulation of receptor internalization
|
(34 genes)
|
ISO
|
|
|
GO:0070371 [list] [network] ERK1 and ERK2 cascade
|
(34 genes)
|
ISO
|
|
|
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway
|
(43 genes)
|
IDA
IGI
ISO
|
|
|
GO:2000008 [list] [network] regulation of protein localization to cell surface
|
(43 genes)
|
ISO
|
|
|
GO:0061098 [list] [network] positive regulation of protein tyrosine kinase activity
|
(44 genes)
|
IDA
|
|
|
GO:0045840 [list] [network] positive regulation of mitotic nuclear division
|
(45 genes)
|
ISO
|
|
|
GO:0045740 [list] [network] positive regulation of DNA replication
|
(47 genes)
|
ISO
|
|
|
GO:0090279 [list] [network] regulation of calcium ion import
|
(52 genes)
|
ISO
|
|
|
GO:0043388 [list] [network] positive regulation of DNA binding
|
(59 genes)
|
IDA
|
|
|
GO:0048146 [list] [network] positive regulation of fibroblast proliferation
|
(70 genes)
|
ISO
|
|
|
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling
|
(75 genes)
|
ISO
|
|
|
GO:2000573 [list] [network] positive regulation of DNA biosynthetic process
|
(76 genes)
|
ISO
|
|
|
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation
|
(89 genes)
|
IDA
|
|
|
GO:0046425 [list] [network] regulation of receptor signaling pathway via JAK-STAT
|
(89 genes)
|
IDA
|
|
|
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation
|
(98 genes)
|
ISO
|
|
|
GO:2000060 [list] [network] positive regulation of ubiquitin-dependent protein catabolic process
|
(103 genes)
|
IDA
|
|
|
GO:0090263 [list] [network] positive regulation of canonical Wnt signaling pathway
|
(107 genes)
|
ISO
|
|
|
GO:0010595 [list] [network] positive regulation of endothelial cell migration
|
(108 genes)
|
ISO
|
|
|
GO:0043406 [list] [network] positive regulation of MAP kinase activity
|
(109 genes)
|
ISO
|
|
|
GO:0051897 [list] [network] positive regulation of protein kinase B signaling
|
(116 genes)
|
ISO
|
|
|
GO:0048754 [list] [network] branching morphogenesis of an epithelial tube
|
(168 genes)
|
IDA
|
|
|
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation
|
(191 genes)
|
IDA
|
|
|
GO:0051048 [list] [network] negative regulation of secretion
|
(198 genes)
|
ISO
|
|
|
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade
|
(228 genes)
|
ISO
|
|
|
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation
|
(262 genes)
|
IDA
|
|
|
GO:0050708 [list] [network] regulation of protein secretion
|
(298 genes)
|
ISO
|
|
|
GO:0001525 [list] [network] angiogenesis
|
(326 genes)
|
ISO
|
|
|
GO:0043410 [list] [network] positive regulation of MAPK cascade
|
(482 genes)
|
IDA
ISO
|
|
|
GO:0051223 [list] [network] regulation of protein transport
|
(546 genes)
|
ISO
|
|
|
GO:0030335 [list] [network] positive regulation of cell migration
|
(567 genes)
|
ISO
|
|
|
GO:0042327 [list] [network] positive regulation of phosphorylation
|
(835 genes)
|
ISO
|
|
|
GO:0008284 [list] [network] positive regulation of cell population proliferation
|
(1011 genes)
|
IDA
IGI
ISO
|
|
|
GO:0010628 [list] [network] positive regulation of gene expression
|
(1244 genes)
|
ISO
|
|
|
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated
|
(1550 genes)
|
ISO
|
|
|
| GO CC |
|
GO:0070062 [list] [network] extracellular exosome
|
(104 genes)
|
ISO
|
|
|
GO:0005615 [list] [network] extracellular space
|
(2015 genes)
|
IDA
ISO
|
|
|
GO:0005576 [list] [network] extracellular region
|
(2754 genes)
|
TAS
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(5442 genes)
|
IBA
IDA
TAS
|
|
|
GO:0016021 [list] [network] integral component of membrane
|
(5954 genes)
|
IEA
|
|
|
GO:0016020 [list] [network] membrane
|
(9571 genes)
|
IEA
|
|
|
| GO MF |
|
GO:0005154 [list] [network] epidermal growth factor receptor binding
|
(38 genes)
|
IDA
ISO
|
|
|
GO:0008083 [list] [network] growth factor activity
|
(148 genes)
|
ISO
|
|
|
GO:0005085 [list] [network] guanyl-nucleotide exchange factor activity
|
(198 genes)
|
ISO
|
|
|
GO:0005509 [list] [network] calcium ion binding
|
(634 genes)
|
IEA
|
|
|
GO:0005515 [list] [network] protein binding
|
(9507 genes)
|
IPI
|
|
|
| KEGG |
mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes) |
 |
| mmu04010 [list] [network] MAPK signaling pathway (294 genes) |
|
| mmu04012 [list] [network] ErbB signaling pathway (84 genes) |
|
| mmu04014 [list] [network] Ras signaling pathway (232 genes) |
|
| mmu04015 [list] [network] Rap1 signaling pathway (214 genes) |
|
| mmu04020 [list] [network] Calcium signaling pathway (240 genes) |
|
| mmu04066 [list] [network] HIF-1 signaling pathway (114 genes) |
|
| mmu04068 [list] [network] FoxO signaling pathway (131 genes) |
|
| mmu04072 [list] [network] Phospholipase D signaling pathway (149 genes) |
|
| mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes) |
|
| mmu04510 [list] [network] Focal adhesion (201 genes) |
|
| mmu04540 [list] [network] Gap junction (86 genes) |
|
| mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes) |
|
| mmu04810 [list] [network] Regulation of actin cytoskeleton (220 genes) |
|
| mmu05160 [list] [network] Hepatitis C (165 genes) |
|
| mmu05165 [list] [network] Human papillomavirus infection (362 genes) |
|
| mmu05200 [list] [network] Pathways in cancer (543 genes) |
|
| mmu05207 [list] [network] Chemical carcinogenesis - receptor activation (225 genes) |
|
| mmu05208 [list] [network] Chemical carcinogenesis - reactive oxygen species (222 genes) |
|
| mmu05210 [list] [network] Colorectal cancer (88 genes) |
|
| mmu05212 [list] [network] Pancreatic cancer (76 genes) |
|
| mmu05213 [list] [network] Endometrial cancer (58 genes) |
|
| mmu05214 [list] [network] Glioma (74 genes) |
|
| mmu05215 [list] [network] Prostate cancer (99 genes) |
|
| mmu05218 [list] [network] Melanoma (72 genes) |
|
| mmu05219 [list] [network] Bladder cancer (41 genes) |
|
| mmu05223 [list] [network] Non-small cell lung cancer (72 genes) |
|
| mmu05224 [list] [network] Breast cancer (147 genes) |
|
| mmu05226 [list] [network] Gastric cancer (150 genes) |
|
| mmu05231 [list] [network] Choline metabolism in cancer (98 genes) |
|
| mmu05235 [list] [network] PD-L1 expression and PD-1 checkpoint pathway in cancer (88 genes) |
|
| Protein |
NP_001297666.1
NP_001316523.1
NP_034243.2
XP_006501053.1
XP_011238312.1
XP_011238313.1
|
| BLAST |
NP_001297666.1
NP_001316523.1
NP_034243.2
XP_006501053.1
XP_011238312.1
XP_011238313.1
|
| Orthologous |
[Ortholog page]
EGF (hsa)
Egf (rno)
egf (dre)
EGF (cfa)
EGF (gga)
EGF (fca)
EGF (mcc)
|
Subcellular
localization
wolf |
|
E.R. 3,
cyto 2,
nucl 2,
plas 1,
mito_pero 1,
mito 1,
extr_plas 1,
pero 1
|
(predict for NP_001297666.1)
|
|
E.R. 3,
cyto 2,
nucl 2,
plas 1,
mito_pero 1,
mito 1,
extr_plas 1,
pero 1
|
(predict for NP_001316523.1)
|
|
plas 4,
extr_plas 4,
extr 3,
E.R. 2,
E.R._golg 1
|
(predict for NP_034243.2)
|
|
plas 4,
extr_plas 4,
extr 3,
E.R. 2,
E.R._golg 1
|
(predict for XP_006501053.1)
|
|
plas 4,
extr_plas 4,
extr 3,
E.R. 2,
E.R._golg 1
|
(predict for XP_011238312.1)
|
|
plas 4,
extr_plas 4,
extr 3,
E.R. 2,
E.R._golg 1
|
(predict for XP_011238313.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| mmu04020 |
Calcium signaling pathway |
2 |
 |
| mmu04510 |
Focal adhesion |
2 |
 |
| mmu04810 |
Regulation of actin cytoskeleton |
2 |
 |
Genes directly connected with Egf on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 5.1 |
Cdnf |
cerebral dopamine neurotrophic factor |
[detail] |
0 |
227526 |
| 4.9 |
Zc3h6 |
zinc finger CCCH type containing 6 |
[detail] |
0 |
78751 |
| 4.7 |
Asb15 |
ankyrin repeat and SOCS box-containing 15 |
[detail] |
0 |
78910 |
|
Coexpressed
gene list |
[Coexpressed gene list for Egf]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Egf Gene
