| functional annotation |
| Function |
GNAS complex locus |
|
| GO BP |
|
GO:0043950 [list] [network] positive regulation of cAMP-mediated signaling
|
(2 genes)
|
ISS
|
 |
|
GO:0071880 [list] [network] adenylate cyclase-activating adrenergic receptor signaling pathway
|
(4 genes)
|
ISS
|
|
|
GO:0043547 [list] [network] positive regulation of GTPase activity
|
(6 genes)
|
ISS
|
|
|
GO:0007189 [list] [network] adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
(14 genes)
|
ISS
|
|
|
| GO CC |
|
| GO MF |
|
GO:0010856 [list] [network] adenylate cyclase activator activity
|
(1 genes)
|
ISS
|
|
|
GO:0005525 [list] [network] GTP binding
|
(32 genes)
|
IEA
|
|
|
GO:0046872 [list] [network] metal ion binding
|
(167 genes)
|
IEA
|
|
|
| KEGG |
cfa01522 [list] [network] Endocrine resistance (94 genes) |
 |
| cfa04015 [list] [network] Rap1 signaling pathway (213 genes) |
|
| cfa04020 [list] [network] Calcium signaling pathway (239 genes) |
|
| cfa04024 [list] [network] cAMP signaling pathway (215 genes) |
|
| cfa04072 [list] [network] Phospholipase D signaling pathway (150 genes) |
|
| cfa04261 [list] [network] Adrenergic signaling in cardiomyocytes (148 genes) |
|
| cfa04270 [list] [network] Vascular smooth muscle contraction (135 genes) |
|
| cfa04540 [list] [network] Gap junction (88 genes) |
|
| cfa04611 [list] [network] Platelet activation (121 genes) |
|
| cfa04713 [list] [network] Circadian entrainment (99 genes) |
|
| cfa04714 [list] [network] Thermogenesis (263 genes) |
|
| cfa04724 [list] [network] Glutamatergic synapse (113 genes) |
|
| cfa04726 [list] [network] Serotonergic synapse (113 genes) |
|
| cfa04728 [list] [network] Dopaminergic synapse (133 genes) |
|
| cfa04730 [list] [network] Long-term depression (59 genes) |
|
| cfa04750 [list] [network] Inflammatory mediator regulation of TRP channels (100 genes) |
|
| cfa04911 [list] [network] Insulin secretion (83 genes) |
|
| cfa04912 [list] [network] GnRH signaling pathway (89 genes) |
|
| cfa04913 [list] [network] Ovarian steroidogenesis (45 genes) |
|
| cfa04915 [list] [network] Estrogen signaling pathway (138 genes) |
|
| cfa04916 [list] [network] Melanogenesis (100 genes) |
|
| cfa04918 [list] [network] Thyroid hormone synthesis (73 genes) |
|
| cfa04921 [list] [network] Oxytocin signaling pathway (150 genes) |
|
| cfa04922 [list] [network] Glucagon signaling pathway (107 genes) |
|
| cfa04923 [list] [network] Regulation of lipolysis in adipocytes (55 genes) |
|
| cfa04924 [list] [network] Renin secretion (70 genes) |
|
| cfa04925 [list] [network] Aldosterone synthesis and secretion (94 genes) |
|
| cfa04926 [list] [network] Relaxin signaling pathway (130 genes) |
|
| cfa04927 [list] [network] Cortisol synthesis and secretion (64 genes) |
|
| cfa04928 [list] [network] Parathyroid hormone synthesis, secretion and action (106 genes) |
|
| cfa04934 [list] [network] Cushing syndrome (154 genes) |
|
| cfa04935 [list] [network] Growth hormone synthesis, secretion and action (114 genes) |
|
| cfa04961 [list] [network] Endocrine and other factor-regulated calcium reabsorption (51 genes) |
|
| cfa04962 [list] [network] Vasopressin-regulated water reabsorption (44 genes) |
|
| cfa04970 [list] [network] Salivary secretion (78 genes) |
|
| cfa04971 [list] [network] Gastric acid secretion (73 genes) |
|
| cfa04972 [list] [network] Pancreatic secretion (92 genes) |
|
| cfa04976 [list] [network] Bile secretion (73 genes) |
|
| cfa05012 [list] [network] Parkinson disease (299 genes) |
|
| cfa05030 [list] [network] Cocaine addiction (48 genes) |
|
| cfa05031 [list] [network] Amphetamine addiction (68 genes) |
|
| cfa05032 [list] [network] Morphine addiction (92 genes) |
|
| cfa05034 [list] [network] Alcoholism (188 genes) |
|
| cfa05142 [list] [network] Chagas disease (102 genes) |
|
| cfa05146 [list] [network] Amoebiasis (102 genes) |
|
| cfa05163 [list] [network] Human cytomegalovirus infection (219 genes) |
|
| cfa05165 [list] [network] Human papillomavirus infection (329 genes) |
|
| cfa05200 [list] [network] Pathways in cancer (537 genes) |
|
| cfa05207 [list] [network] Chemical carcinogenesis - receptor activation (197 genes) |
|
| cfa05414 [list] [network] Dilated cardiomyopathy (94 genes) |
|
| Protein |
NP_001003263.1
XP_038288729.1
XP_038288730.1
XP_038288731.1
XP_038288732.1
XP_038288733.1
XP_038288734.1
XP_038288735.1
XP_038288736.1
|
| BLAST |
NP_001003263.1
XP_038288729.1
XP_038288730.1
XP_038288731.1
XP_038288732.1
XP_038288733.1
XP_038288734.1
XP_038288735.1
XP_038288736.1
|
| Orthologous |
[Ortholog page]
GNAL (hsa)
GNAS (hsa)
Gnal (mmu)
Gnas (mmu)
Gnal (rno)
Gnas (rno)
Galphas (dme)
gsa-1 (cel)
gnal2 (dre)
GNAS (gga)
GNAL (gga)
gnal (dre)
gnas (dre)
GNAL (cfa)
LOC694289 (mcc)
GNAL (fca)
LOC101098453 (fca)
GNAL (mcc)
|
Subcellular
localization
wolf |
|
cyto 4,
pero 2,
mito_pero 2,
plas 1,
extr_plas 1,
nucl 1,
extr 1
|
(predict for NP_001003263.1)
|
|
cyto 4,
cyto_nucl 3,
nucl 2,
cyto_mito 2,
pero 2,
mito_pero 1
|
(predict for XP_038288729.1)
|
|
cyto 4,
cyto_nucl 3,
nucl 3,
cyto_mito 2,
cyto_plas 2,
pero 2
|
(predict for XP_038288730.1)
|
|
cyto 4,
pero 2,
mito_pero 2,
plas 1,
extr_plas 1,
nucl 1,
extr 1
|
(predict for XP_038288731.1)
|
|
cyto 4,
pero 2,
mito_pero 2,
plas 1,
extr_plas 1,
nucl 1,
extr 1
|
(predict for XP_038288732.1)
|
|
cyto 4,
pero 2,
mito_pero 2,
plas 1,
extr_plas 1,
nucl 1,
extr 1
|
(predict for XP_038288733.1)
|
|
cyto 5,
mito 2,
E.R._mito 2,
nucl 1
|
(predict for XP_038288734.1)
|
|
cyto 4,
nucl 2,
mito 2,
mito_pero 1,
plas 1,
extr_plas 1,
pero 1,
golg 1
|
(predict for XP_038288735.1)
|
|
cyto 4,
nucl 2,
mito 2,
mito_pero 1,
plas 1,
extr_plas 1,
pero 1,
golg 1
|
(predict for XP_038288736.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| cfa01522 |
Endocrine resistance |
3 |
 |
| cfa04024 |
cAMP signaling pathway |
3 |
 |
| cfa04270 |
Vascular smooth muscle contraction |
3 |
 |
| cfa04540 |
Gap junction |
3 |
 |
| cfa04912 |
GnRH signaling pathway |
3 |
 |
Genes directly connected with GNAS on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
Entrez Gene ID* |
| 5.7 |
FKBP8 |
FKBP prolyl isomerase 8 |
[detail] |
484819 |
| 5.6 |
NELFCD |
negative elongation factor complex member C/D |
[detail] |
477276 |
| 4.9 |
NCSTN |
nicastrin |
[detail] |
488638 |
| 4.9 |
PTOV1 |
PTOV1 extended AT-hook containing adaptor protein |
[detail] |
612927 |
| 4.4 |
AHCYL1 |
adenosylhomocysteinase like 1 |
[detail] |
611790 |
|
Coexpressed
gene list |
[Coexpressed gene list for GNAS]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
GNAS Gene
