[←][→] hsa  GNAI2 Gene
functional annotation
Function   G protein subunit alpha i2  
GO BP
GO:1903614 [list] [network] negative regulation of protein tyrosine phosphatase activity  (3 genes)  IEA  
GO:0140199 [list] [network] negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (4 genes)  IEA  
GO:0033864 [list] [network] positive regulation of NAD(P)H oxidase activity  (7 genes)  IEA  
GO:0045955 [list] [network] negative regulation of calcium ion-dependent exocytosis  (8 genes)  IEA  
GO:0001973 [list] [network] G protein-coupled adenosine receptor signaling pathway  (9 genes)  IBA  
GO:0035810 [list] [network] positive regulation of urine volume  (14 genes)  IEA  
GO:0035815 [list] [network] positive regulation of renal sodium excretion  (14 genes)  IEA  
GO:0007213 [list] [network] G protein-coupled acetylcholine receptor signaling pathway  (19 genes)  IEA  
GO:0007194 [list] [network] negative regulation of adenylate cyclase activity  (20 genes)  TAS  
GO:0032930 [list] [network] positive regulation of superoxide anion generation  (20 genes)  IEA  
GO:0046628 [list] [network] positive regulation of insulin receptor signaling pathway  (22 genes)  IEA  
GO:0007214 [list] [network] gamma-aminobutyric acid signaling pathway  (26 genes)  IBA  
GO:1904707 [list] [network] positive regulation of vascular associated smooth muscle cell proliferation  (49 genes)  IEA  
GO:2000179 [list] [network] positive regulation of neural precursor cell proliferation  (54 genes)  IEA  
GO:0050805 [list] [network] negative regulation of synaptic transmission  (60 genes)  IEA  
GO:0007193 [list] [network] adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (83 genes)  IBA TAS  
GO:0007189 [list] [network] adenylate cyclase-activating G protein-coupled receptor signaling pathway  (132 genes)  IEA  
GO:0030168 [list] [network] platelet activation  (141 genes)  TAS  
GO:0007584 [list] [network] response to nutrient  (166 genes)  TAS  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (217 genes)  IEA  
GO:0007188 [list] [network] adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (219 genes)  IBA  
GO:2001234 [list] [network] negative regulation of apoptotic signaling pathway  (233 genes)  IEA  
GO:0006457 [list] [network] protein folding  (234 genes)  TAS  
GO:0051924 [list] [network] regulation of calcium ion transport  (255 genes)  IEA  
GO:0008283 [list] [network] cell population proliferation  (478 genes)  IEA  
GO:0051301 [list] [network] cell division  (493 genes)  IMP  
GO:0030335 [list] [network] positive regulation of cell migration  (554 genes)  IEA  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (976 genes)  IMP  
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway  (1290 genes)  TAS  
GO:0007049 [list] [network] cell cycle  (1340 genes)  IEA  
GO:0007165 [list] [network] signal transduction  (5169 genes)  TAS  
GO CC
GO:0005834 [list] [network] heterotrimeric G-protein complex  (34 genes)  IBA  
GO:0030496 [list] [network] midbody  (195 genes)  IDA  
GO:0045121 [list] [network] membrane raft  (334 genes)  IEA  
GO:0044297 [list] [network] cell body  (577 genes)  IEA  
GO:0005813 [list] [network] centrosome  (613 genes)  IDA  
GO:0030425 [list] [network] dendrite  (635 genes)  IEA  
GO:0045202 [list] [network] synapse  (1341 genes)  IEA  
GO:0070062 [list] [network] extracellular exosome  (2212 genes)  HDA  
GO:1903561 [list] [network] extracellular vesicle  (2306 genes)  HDA  
GO:0005654 [list] [network] nucleoplasm  (4086 genes)  IDA  
GO:0005829 [list] [network] cytosol  (5345 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IDA TAS  
GO:0016020 [list] [network] membrane  (9592 genes)  HDA  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  IDA  
GO MF
GO:0031683 [list] [network] G-protein beta/gamma-subunit complex binding  (20 genes)  IBA  
GO:0003924 [list] [network] GTPase activity  (292 genes)  IBA  
GO:0001664 [list] [network] G protein-coupled receptor binding  (296 genes)  IBA  
GO:0005525 [list] [network] GTP binding  (378 genes)  IEA  
GO:0046872 [list] [network] metal ion binding  (4237 genes)  IEA  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04022 [list] [network] cGMP-PKG signaling pathway (167 genes)
hsa04024 [list] [network] cAMP signaling pathway (221 genes)
hsa04062 [list] [network] Chemokine signaling pathway (192 genes)
hsa04071 [list] [network] Sphingolipid signaling pathway (119 genes)
hsa04261 [list] [network] Adrenergic signaling in cardiomyocytes (150 genes)
hsa04360 [list] [network] Axon guidance (182 genes)
hsa04371 [list] [network] Apelin signaling pathway (139 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04611 [list] [network] Platelet activation (124 genes)
hsa04670 [list] [network] Leukocyte transendothelial migration (114 genes)
hsa04713 [list] [network] Circadian entrainment (97 genes)
hsa04723 [list] [network] Retrograde endocannabinoid signaling (148 genes)
hsa04724 [list] [network] Glutamatergic synapse (114 genes)
hsa04725 [list] [network] Cholinergic synapse (113 genes)
hsa04726 [list] [network] Serotonergic synapse (115 genes)
hsa04727 [list] [network] GABAergic synapse (89 genes)
hsa04728 [list] [network] Dopaminergic synapse (132 genes)
hsa04730 [list] [network] Long-term depression (60 genes)
hsa04914 [list] [network] Progesterone-mediated oocyte maturation (102 genes)
hsa04915 [list] [network] Estrogen signaling pathway (138 genes)
hsa04916 [list] [network] Melanogenesis (101 genes)
hsa04921 [list] [network] Oxytocin signaling pathway (154 genes)
hsa04923 [list] [network] Regulation of lipolysis in adipocytes (56 genes)
hsa04924 [list] [network] Renin secretion (69 genes)
hsa04926 [list] [network] Relaxin signaling pathway (129 genes)
hsa04928 [list] [network] Parathyroid hormone synthesis, secretion and action (106 genes)
hsa04934 [list] [network] Cushing syndrome (155 genes)
hsa04935 [list] [network] Growth hormone synthesis, secretion and action (119 genes)
hsa04971 [list] [network] Gastric acid secretion (76 genes)
hsa05012 [list] [network] Parkinson disease (266 genes)
hsa05030 [list] [network] Cocaine addiction (49 genes)
hsa05032 [list] [network] Morphine addiction (91 genes)
hsa05034 [list] [network] Alcoholism (187 genes)
hsa05133 [list] [network] Pertussis (76 genes)
hsa05142 [list] [network] Chagas disease (102 genes)
hsa05145 [list] [network] Toxoplasmosis (112 genes)
hsa05163 [list] [network] Human cytomegalovirus infection (225 genes)
hsa05170 [list] [network] Human immunodeficiency virus 1 infection (212 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes)
Protein NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1 
BLAST NP_001159897.1  NP_001269546.1  NP_001269547.1  NP_001269548.1  NP_001269549.1  NP_002061.1 
Orthologous [Ortholog page] GNA11 (hsa)  GNAI1 (hsa)  GNAI3 (hsa)  GNAO1 (hsa)  GNAQ (hsa)  GNAT1 (hsa)  GNAT2 (hsa)  GNAZ (hsa)  GNA14 (hsa)  Gna11 (mmu)  Gna14 (mmu)  Gnai1 (mmu)  Gnai2 (mmu)  Gnai3 (mmu)  Gnao1 (mmu)  Gnaq (mmu)  Gnat1 (mmu)  Gnat2 (mmu)  Gnaz (mmu)  Gnai3 (rno)  Gnai1 (rno)  Gnaz (rno)  Galphao (dme)  Galphaq (dme)  CG17760 (dme)  Galphai (dme)  Gnao1 (rno)  Gna11 (rno)  Gnai2 (rno)  Gnaq (rno)  gnat1 (dre)  gnat2 (dre)  gpa-16 (cel)  egl-30 (cel)  goa-1 (cel)  gpa-15 (cel)  gpa-4 (cel)  gpa-7 (cel)  gpa-2 (cel)  gpa-3 (cel)  gpa-1 (cel)  gpa-8 (cel)  odr-3 (cel)  Gnat3 (mmu)  CG30054 (dme)  Gnat3 (rno)  Gna14 (rno)  gnaia (dre)  gnai2b (dre)  gnai2a (dre)  GNAT3 (hsa)  Gnat1 (rno)  Gnat2 (rno)  GNA11 (gga)  GNAI3 (gga)  gnao1a (dre)  gnao1b (dre)  gnai1 (dre)  GNAT2 (gga)  GNAT1 (gga)  GNAI2 (gga)  GNAI1 (gga)  GNAT1 (cfa)  GNA11 (cfa)  GNAQ (cfa)  GNAO1 (gga)  GNAQ (gga)  GNAT3 (gga)  GNA14 (gga)  GNAI2 (cfa)  gna15.1 (dre)  gna14 (dre)  GNAI1 (cfa)  GNA14 (cfa)  GNAT2 (cfa)  GNAT3 (cfa)  gna11b (dre)  gna14a (dre)  gna11a (dre)  gnaz (dre)  gnaq (dre)  gnav1 (dre)  GNAO1 (mcc)  GNAZ (cfa)  GNAO1 (cfa)  GNAI3 (cfa)  GNAI3 (mcc)  GNAT2 (mcc)  GNAI2 (mcc)  GNAT1 (mcc)  GNA14 (mcc)  GNAQ (mcc)  GNAZ (mcc)  GNAT3 (mcc)  GNAI1 (mcc)  GNA11 (mcc)  GNAZ (gga)  GPA1 (sce)  GPA2 (sce)  gnai3 (dre)  gna15.2 (dre)  GNA11 (fca)  GNAI2 (fca)  GNAT1 (fca)  GNAI1 (fca)  GNAT3 (fca)  GNA14 (fca)  GNAQ (fca)  GNAI3 (fca)  GNAT2 (fca)  GNAZ (fca)  GNAO1 (fca) 
Subcellular
localization
wolf
cyto 7,  mito 1,  plas 1,  mito_pero 1  (predict for NP_001159897.1)
cyto 6,  plas 2,  mito 1,  pero 1,  E.R._mito 1  (predict for NP_001269546.1)
plas 3,  cyto 3,  cyto_mito 2,  extr 2,  mito 2,  E.R._mito 1,  lyso 1  (predict for NP_001269547.1)
plas 3,  cyto 3,  cyto_mito 3,  mito 2,  E.R._mito 1,  cyto_pero 1,  cyto_golg 1  (predict for NP_001269548.1)
plas 6,  cyto 2,  nucl 1,  mito 0,  E.R._mito 0  (predict for NP_001269549.1)
cyto 7,  mito_pero 1,  mito 1,  plas 1,  pero 1,  golg 1  (predict for NP_002061.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04810 Regulation of actin cytoskeleton 11
hsa05132 Salmonella infection 10
hsa04530 Tight junction 9
hsa05130 Pathogenic Escherichia coli infection 9
hsa05131 Shigellosis 8
Genes directly connected with GNAI2 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
9.0 RHOA ras homolog family member A [detail] 0 387
7.1 ACTB actin beta [detail] 0 60
6.8 MSN moesin [detail] 0 4478
6.5 TWF2 twinfilin actin binding protein 2 [detail] 0 11344
6.5 ARPC1B actin related protein 2/3 complex subunit 1B [detail] 0 10095
5.3 MAPKAPK3 MAPK activated protein kinase 3 [detail] 0 7867
Coexpressed
gene list		 [Coexpressed gene list for GNAI2]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 2771      
Refseq ID (protein) NP_001159897.1 
NP_001269546.1 
NP_001269547.1 
NP_001269548.1 
NP_001269549.1 
NP_002061.1 


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