[←][→] hsa  GNAI3 Gene
functional annotation
Function   G protein subunit alpha i3  
GO BP
GO:0033864 [list] [network] positive regulation of NAD(P)H oxidase activity  (7 genes)  IEA  
GO:0007194 [list] [network] negative regulation of adenylate cyclase activity  (20 genes)  TAS  
GO:0032930 [list] [network] positive regulation of superoxide anion generation  (20 genes)  IEA  
GO:0046039 [list] [network] GTP metabolic process  (25 genes)  IDA  
GO:0007212 [list] [network] dopamine receptor signaling pathway  (33 genes)  IDA  
GO:1904707 [list] [network] positive regulation of vascular associated smooth muscle cell proliferation  (49 genes)  IEA  
GO:0016239 [list] [network] positive regulation of macroautophagy  (62 genes)  IMP  
GO:0007193 [list] [network] adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (83 genes)  IDA TAS  
GO:0006906 [list] [network] vesicle fusion  (90 genes)  IEA  
GO:0030168 [list] [network] platelet activation  (141 genes)  TAS  
GO:0007188 [list] [network] adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (219 genes)  IBA  
GO:2001234 [list] [network] negative regulation of apoptotic signaling pathway  (233 genes)  IEA  
GO:0006457 [list] [network] protein folding  (234 genes)  TAS  
GO:0051301 [list] [network] cell division  (493 genes)  IDA  
GO:0007420 [list] [network] brain development  (744 genes)  IEA  
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway  (1290 genes)  TAS  
GO:0007049 [list] [network] cell cycle  (1340 genes)  IEA  
GO CC
GO:0042588 [list] [network] zymogen granule  (15 genes)  IEA  
GO:0005834 [list] [network] heterotrimeric G-protein complex  (34 genes)  IBA  
GO:0030496 [list] [network] midbody  (195 genes)  IDA  
GO:0045121 [list] [network] membrane raft  (334 genes)  IEA  
GO:0005765 [list] [network] lysosomal membrane  (394 genes)  HDA  
GO:0005813 [list] [network] centrosome  (613 genes)  IDA  
GO:0000139 [list] [network] Golgi membrane  (626 genes)  IDA  
GO:0005789 [list] [network] endoplasmic reticulum membrane  (1133 genes)  IDA  
GO:0070062 [list] [network] extracellular exosome  (2212 genes)  HDA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IDA TAS  
GO:0016020 [list] [network] membrane  (9592 genes)  HDA  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  IDA  
GO MF
GO:0031821 [list] [network] G protein-coupled serotonin receptor binding  (5 genes)  IEA  
GO:0032794 [list] [network] GTPase activating protein binding  (15 genes)  IEA  
GO:0031683 [list] [network] G-protein beta/gamma-subunit complex binding  (20 genes)  IBA  
GO:0019003 [list] [network] GDP binding  (75 genes)  IDA  
GO:0003924 [list] [network] GTPase activity  (292 genes)  IBA IDA  
GO:0001664 [list] [network] G protein-coupled receptor binding  (296 genes)  IBA  
GO:0005525 [list] [network] GTP binding  (378 genes)  IEA  
GO:0019904 [list] [network] protein domain specific binding  (702 genes)  IEA  
GO:0046872 [list] [network] metal ion binding  (4237 genes)  IEA  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa04015 [list] [network] Rap1 signaling pathway (210 genes)
hsa04022 [list] [network] cGMP-PKG signaling pathway (167 genes)
hsa04024 [list] [network] cAMP signaling pathway (221 genes)
hsa04062 [list] [network] Chemokine signaling pathway (192 genes)
hsa04071 [list] [network] Sphingolipid signaling pathway (119 genes)
hsa04261 [list] [network] Adrenergic signaling in cardiomyocytes (150 genes)
hsa04360 [list] [network] Axon guidance (182 genes)
hsa04371 [list] [network] Apelin signaling pathway (139 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04611 [list] [network] Platelet activation (124 genes)
hsa04670 [list] [network] Leukocyte transendothelial migration (114 genes)
hsa04713 [list] [network] Circadian entrainment (97 genes)
hsa04723 [list] [network] Retrograde endocannabinoid signaling (148 genes)
hsa04724 [list] [network] Glutamatergic synapse (114 genes)
hsa04725 [list] [network] Cholinergic synapse (113 genes)
hsa04726 [list] [network] Serotonergic synapse (115 genes)
hsa04727 [list] [network] GABAergic synapse (89 genes)
hsa04728 [list] [network] Dopaminergic synapse (132 genes)
hsa04730 [list] [network] Long-term depression (60 genes)
hsa04914 [list] [network] Progesterone-mediated oocyte maturation (102 genes)
hsa04915 [list] [network] Estrogen signaling pathway (138 genes)
hsa04916 [list] [network] Melanogenesis (101 genes)
hsa04921 [list] [network] Oxytocin signaling pathway (154 genes)
hsa04923 [list] [network] Regulation of lipolysis in adipocytes (56 genes)
hsa04924 [list] [network] Renin secretion (69 genes)
hsa04926 [list] [network] Relaxin signaling pathway (129 genes)
hsa04928 [list] [network] Parathyroid hormone synthesis, secretion and action (106 genes)
hsa04934 [list] [network] Cushing syndrome (155 genes)
hsa04935 [list] [network] Growth hormone synthesis, secretion and action (119 genes)
hsa04971 [list] [network] Gastric acid secretion (76 genes)
hsa05012 [list] [network] Parkinson disease (266 genes)
hsa05030 [list] [network] Cocaine addiction (49 genes)
hsa05032 [list] [network] Morphine addiction (91 genes)
hsa05034 [list] [network] Alcoholism (187 genes)
hsa05133 [list] [network] Pertussis (76 genes)
hsa05142 [list] [network] Chagas disease (102 genes)
hsa05145 [list] [network] Toxoplasmosis (112 genes)
hsa05163 [list] [network] Human cytomegalovirus infection (225 genes)
hsa05170 [list] [network] Human immunodeficiency virus 1 infection (212 genes)
hsa05200 [list] [network] Pathways in cancer (531 genes)
hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes)
Protein NP_006487.1 
BLAST NP_006487.1 
Orthologous [Ortholog page] GNA11 (hsa)  GNAI1 (hsa)  GNAI2 (hsa)  GNAO1 (hsa)  GNAQ (hsa)  GNAT1 (hsa)  GNAT2 (hsa)  GNAZ (hsa)  GNA14 (hsa)  Gna11 (mmu)  Gna14 (mmu)  Gnai1 (mmu)  Gnai2 (mmu)  Gnai3 (mmu)  Gnao1 (mmu)  Gnaq (mmu)  Gnat1 (mmu)  Gnat2 (mmu)  Gnaz (mmu)  Gnai3 (rno)  Gnai1 (rno)  Gnaz (rno)  Galphao (dme)  Galphaq (dme)  CG17760 (dme)  Galphai (dme)  Gnao1 (rno)  Gna11 (rno)  Gnai2 (rno)  Gnaq (rno)  gnat1 (dre)  gnat2 (dre)  gpa-16 (cel)  egl-30 (cel)  goa-1 (cel)  gpa-15 (cel)  gpa-4 (cel)  gpa-7 (cel)  gpa-2 (cel)  gpa-3 (cel)  gpa-1 (cel)  gpa-8 (cel)  odr-3 (cel)  Gnat3 (mmu)  CG30054 (dme)  Gnat3 (rno)  Gna14 (rno)  gnaia (dre)  gnai2b (dre)  gnai2a (dre)  GNAT3 (hsa)  Gnat1 (rno)  Gnat2 (rno)  GNA11 (gga)  GNAI3 (gga)  gnao1a (dre)  gnao1b (dre)  gnai1 (dre)  GNAT2 (gga)  GNAT1 (gga)  GNAI2 (gga)  GNAI1 (gga)  GNAT1 (cfa)  GNA11 (cfa)  GNAQ (cfa)  GNAO1 (gga)  GNAQ (gga)  GNAT3 (gga)  GNA14 (gga)  GNAI2 (cfa)  gna15.1 (dre)  gna14 (dre)  GNAI1 (cfa)  GNA14 (cfa)  GNAT2 (cfa)  GNAT3 (cfa)  gna11b (dre)  gna14a (dre)  gna11a (dre)  gnaz (dre)  gnaq (dre)  gnav1 (dre)  GNAO1 (mcc)  GNAZ (cfa)  GNAO1 (cfa)  GNAI3 (cfa)  GNAI3 (mcc)  GNAT2 (mcc)  GNAI2 (mcc)  GNAT1 (mcc)  GNA14 (mcc)  GNAQ (mcc)  GNAZ (mcc)  GNAT3 (mcc)  GNAI1 (mcc)  GNA11 (mcc)  GNAZ (gga)  GPA1 (sce)  GPA2 (sce)  gnai3 (dre)  gna15.2 (dre)  GNA11 (fca)  GNAI2 (fca)  GNAT1 (fca)  GNAI1 (fca)  GNAT3 (fca)  GNA14 (fca)  GNAQ (fca)  GNAI3 (fca)  GNAT2 (fca)  GNAZ (fca)  GNAO1 (fca) 
Subcellular
localization
wolf
cyto 7,  mito_pero 1,  plas 1,  mito 1,  pero 1,  extr_plas 1  (predict for NP_006487.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04144 Endocytosis 6
hsa04530 Tight junction 5
hsa04810 Regulation of actin cytoskeleton 5
hsa04666 Fc gamma R-mediated phagocytosis 4
hsa05100 Bacterial invasion of epithelial cells 4
Genes directly connected with GNAI3 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
10.0 NRAS NRAS proto-oncogene, GTPase [detail] 0 4893
8.4 ACTR3 actin related protein 3 [detail] 0 10096
7.8 CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 [detail] 0 829
7.7 BZW1 basic leucine zipper and W2 domains 1 [detail] 0 9689
7.7 STXBP3 syntaxin binding protein 3 [detail] 0 6814
6.8 RAP1A RAP1A, member of RAS oncogene family [detail] 0 5906
6.7 TMEM167B transmembrane protein 167B [detail] 0 56900
5.8 PGM2 phosphoglucomutase 2 [detail] 0 55276
5.6 WDR47 WD repeat domain 47 [detail] 0 22911
Coexpressed
gene list		 [Coexpressed gene list for GNAI3]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 2773      
Refseq ID (protein) NP_006487.1 


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