| functional annotation |
| Function |
SHC (Src homology 2 domain containing) transforming protein 2 |
|
| GO BP |
|
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway
|
(365 genes)
|
IBA
|
 |
|
GO:0035556 [list] [network] intracellular signal transduction
|
(1356 genes)
|
IEA
|
|
|
| GO CC |
|
| GO MF |
|
GO:0030971 [list] [network] receptor tyrosine kinase binding
|
(80 genes)
|
IBA
|
|
|
GO:0019901 [list] [network] protein kinase binding
|
(774 genes)
|
IBA
|
|
|
| KEGG |
mmu01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes) |
 |
| mmu01522 [list] [network] Endocrine resistance (93 genes) |
|
| mmu04012 [list] [network] ErbB signaling pathway (84 genes) |
|
| mmu04014 [list] [network] Ras signaling pathway (232 genes) |
|
| mmu04062 [list] [network] Chemokine signaling pathway (192 genes) |
|
| mmu04072 [list] [network] Phospholipase D signaling pathway (149 genes) |
|
| mmu04370 [list] [network] VEGF signaling pathway (58 genes) |
|
| mmu04510 [list] [network] Focal adhesion (201 genes) |
|
| mmu04650 [list] [network] Natural killer cell mediated cytotoxicity (121 genes) |
|
| mmu04722 [list] [network] Neurotrophin signaling pathway (121 genes) |
|
| mmu04910 [list] [network] Insulin signaling pathway (139 genes) |
|
| mmu04915 [list] [network] Estrogen signaling pathway (134 genes) |
|
| mmu04917 [list] [network] Prolactin signaling pathway (74 genes) |
|
| mmu04926 [list] [network] Relaxin signaling pathway (129 genes) |
|
| mmu04935 [list] [network] Growth hormone synthesis, secretion and action (116 genes) |
|
| mmu05034 [list] [network] Alcoholism (205 genes) |
|
| mmu05100 [list] [network] Bacterial invasion of epithelial cells (76 genes) |
|
| mmu05214 [list] [network] Glioma (74 genes) |
|
| mmu05220 [list] [network] Chronic myeloid leukemia (76 genes) |
|
| mmu05224 [list] [network] Breast cancer (147 genes) |
|
| mmu05225 [list] [network] Hepatocellular carcinoma (174 genes) |
|
| mmu05226 [list] [network] Gastric cancer (150 genes) |
|
| Protein |
NP_001019710.1
|
| BLAST |
NP_001019710.1
|
| Orthologous |
[Ortholog page]
SHC1 (hsa)
Shc1 (mmu)
Shc3 (mmu)
SHC2 (hsa)
Shc (dme)
SHC3 (hsa)
Shc1 (rno)
Shc3 (rno)
Shc4 (mmu)
Shc2 (rno)
shc1 (dre)
SHC1 (gga)
SHC4 (hsa)
SHC4 (gga)
SHC3 (gga)
SHC3 (cfa)
SHC4 (cfa)
SHC1 (cfa)
shc2 (dre)
SHC3 (mcc)
SHC2 (cfa)
Shc4 (rno)
SHC4 (mcc)
SHC1 (mcc)
SHC2 (mcc)
SHC2 (gga)
shc-1 (cel)
shc3 (dre)
SHC2 (fca)
SHC1 (fca)
SHC3 (fca)
SHC4 (fca)
|
Subcellular
localization
wolf |
|
cyto_nucl 5,
cyto 4,
nucl 3,
mito 2
|
(predict for NP_001019710.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| mmu04060 |
Cytokine-cytokine receptor interaction |
2 |
 |
| mmu04360 |
Axon guidance |
2 |
 |
| mmu04390 |
Hippo signaling pathway |
2 |
 |
| mmu05224 |
Breast cancer |
2 |
 |
| mmu05225 |
Hepatocellular carcinoma |
2 |
 |
Genes directly connected with Shc2 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 8.9 |
C2cd4c |
C2 calcium-dependent domain containing 4C |
[detail] |
0 |
237397 |
| 7.0 |
Gprin1 |
G protein-regulated inducer of neurite outgrowth 1 |
[detail] |
0 |
26913 |
| 7.0 |
Lrp3 |
low density lipoprotein receptor-related protein 3 |
[detail] |
0 |
435965 |
| 5.8 |
Insyn1 |
inhibitory synaptic factor 1 |
[detail] |
0 |
319477 |
| 4.9 |
Smpd3 |
sphingomyelin phosphodiesterase 3, neutral |
[detail] |
0 |
58994 |
|
Coexpressed
gene list |
[Coexpressed gene list for Shc2]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Shc2 Gene
