| functional annotation |
| Function |
adenylate cyclase 4 |
|
| GO BP |
|
GO:0006171 [list] [network] cAMP biosynthetic process
|
(10 genes)
|
ISS
|
 |
|
GO:0034199 [list] [network] activation of protein kinase A activity
|
(18 genes)
|
TAS
|
|
|
GO:0071377 [list] [network] cellular response to glucagon stimulus
|
(27 genes)
|
TAS
|
|
|
GO:0003091 [list] [network] renal water homeostasis
|
(36 genes)
|
TAS
|
|
|
GO:0007190 [list] [network] activation of adenylate cyclase activity
|
(41 genes)
|
TAS
|
|
|
GO:0007193 [list] [network] adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
|
(83 genes)
|
TAS
|
|
|
GO:0007189 [list] [network] adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
(132 genes)
|
IBA
TAS
|
|
|
GO:0002862 [list] [network] negative regulation of inflammatory response to antigenic stimulus
|
(208 genes)
|
TAS
|
|
|
GO:0007188 [list] [network] adenylate cyclase-modulating G protein-coupled receptor signaling pathway
|
(219 genes)
|
ISS
|
|
|
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway
|
(1290 genes)
|
TAS
|
|
|
GO:0035556 [list] [network] intracellular signal transduction
|
(1640 genes)
|
IEA
|
|
|
| GO CC |
|
GO:0030425 [list] [network] dendrite
|
(635 genes)
|
IEA
|
|
|
GO:0005887 [list] [network] integral component of plasma membrane
|
(1649 genes)
|
IBA
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(5772 genes)
|
TAS
|
|
|
GO:0016020 [list] [network] membrane
|
(9592 genes)
|
ISS
|
|
|
GO:0005737 [list] [network] cytoplasm
|
(11897 genes)
|
IDA
|
|
|
| GO MF |
|
GO:0004016 [list] [network] adenylate cyclase activity
|
(11 genes)
|
IBA
ISS
|
|
|
GO:0005080 [list] [network] protein kinase C binding
|
(55 genes)
|
IDA
|
|
|
GO:0005524 [list] [network] ATP binding
|
(1474 genes)
|
IEA
|
|
|
GO:0046872 [list] [network] metal ion binding
|
(4237 genes)
|
IEA
|
|
|
GO:0005515 [list] [network] protein binding
|
(13898 genes)
|
IPI
|
|
|
| KEGG |
hsa00230 [list] [network] Purine metabolism (126 genes) |
 |
| hsa01522 [list] [network] Endocrine resistance (98 genes) |
|
| hsa04015 [list] [network] Rap1 signaling pathway (210 genes) |
|
| hsa04020 [list] [network] Calcium signaling pathway (240 genes) |
|
| hsa04022 [list] [network] cGMP-PKG signaling pathway (167 genes) |
|
| hsa04024 [list] [network] cAMP signaling pathway (221 genes) |
|
| hsa04062 [list] [network] Chemokine signaling pathway (192 genes) |
|
| hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes) |
|
| hsa04114 [list] [network] Oocyte meiosis (131 genes) |
|
| hsa04211 [list] [network] Longevity regulating pathway (89 genes) |
|
| hsa04213 [list] [network] Longevity regulating pathway - multiple species (62 genes) |
|
| hsa04261 [list] [network] Adrenergic signaling in cardiomyocytes (150 genes) |
|
| hsa04270 [list] [network] Vascular smooth muscle contraction (134 genes) |
|
| hsa04371 [list] [network] Apelin signaling pathway (139 genes) |
|
| hsa04540 [list] [network] Gap junction (88 genes) |
|
| hsa04611 [list] [network] Platelet activation (124 genes) |
|
| hsa04713 [list] [network] Circadian entrainment (97 genes) |
|
| hsa04714 [list] [network] Thermogenesis (232 genes) |
|
| hsa04723 [list] [network] Retrograde endocannabinoid signaling (148 genes) |
|
| hsa04724 [list] [network] Glutamatergic synapse (114 genes) |
|
| hsa04725 [list] [network] Cholinergic synapse (113 genes) |
|
| hsa04727 [list] [network] GABAergic synapse (89 genes) |
|
| hsa04742 [list] [network] Taste transduction (86 genes) |
|
| hsa04750 [list] [network] Inflammatory mediator regulation of TRP channels (98 genes) |
|
| hsa04911 [list] [network] Insulin secretion (86 genes) |
|
| hsa04912 [list] [network] GnRH signaling pathway (93 genes) |
|
| hsa04913 [list] [network] Ovarian steroidogenesis (51 genes) |
|
| hsa04914 [list] [network] Progesterone-mediated oocyte maturation (102 genes) |
|
| hsa04915 [list] [network] Estrogen signaling pathway (138 genes) |
|
| hsa04916 [list] [network] Melanogenesis (101 genes) |
|
| hsa04918 [list] [network] Thyroid hormone synthesis (75 genes) |
|
| hsa04921 [list] [network] Oxytocin signaling pathway (154 genes) |
|
| hsa04923 [list] [network] Regulation of lipolysis in adipocytes (56 genes) |
|
| hsa04925 [list] [network] Aldosterone synthesis and secretion (98 genes) |
|
| hsa04926 [list] [network] Relaxin signaling pathway (129 genes) |
|
| hsa04927 [list] [network] Cortisol synthesis and secretion (65 genes) |
|
| hsa04928 [list] [network] Parathyroid hormone synthesis, secretion and action (106 genes) |
|
| hsa04934 [list] [network] Cushing syndrome (155 genes) |
|
| hsa04935 [list] [network] Growth hormone synthesis, secretion and action (119 genes) |
|
| hsa04970 [list] [network] Salivary secretion (93 genes) |
|
| hsa04971 [list] [network] Gastric acid secretion (76 genes) |
|
| hsa04972 [list] [network] Pancreatic secretion (102 genes) |
|
| hsa04976 [list] [network] Bile secretion (89 genes) |
|
| hsa05032 [list] [network] Morphine addiction (91 genes) |
|
| hsa05163 [list] [network] Human cytomegalovirus infection (225 genes) |
|
| hsa05166 [list] [network] Human T-cell leukemia virus 1 infection (222 genes) |
|
| hsa05200 [list] [network] Pathways in cancer (531 genes) |
|
| hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes) |
|
| hsa05414 [list] [network] Dilated cardiomyopathy (96 genes) |
|
| Protein |
NP_001185497.1
NP_001185521.1
NP_640340.2
|
| BLAST |
NP_001185497.1
NP_001185521.1
NP_640340.2
|
| Orthologous |
[Ortholog page]
Adcy4 (rno)
Adcy4 (mmu)
ADCY4 (cfa)
ADCY4 (mcc)
ADCY4 (fca)
|
Subcellular
localization
wolf |
|
plas 10
|
(predict for NP_001185497.1)
|
|
plas 10
|
(predict for NP_001185521.1)
|
|
plas 10
|
(predict for NP_640340.2)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| hsa01522 |
Endocrine resistance |
2 |
 |
| hsa05200 |
Pathways in cancer |
2 |
 |
Genes directly connected with ADCY4 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 11.6 |
RIPK3 |
receptor interacting serine/threonine kinase 3 |
[detail] |
0 |
11035 |
| 8.6 |
ARHGEF15 |
Rho guanine nucleotide exchange factor 15 |
[detail] |
0 |
22899 |
| 7.4 |
CLEC1A |
C-type lectin domain family 1 member A |
[detail] |
0 |
51267 |
| 6.8 |
ACVRL1 |
activin A receptor like type 1 |
[detail] |
0 |
94 |
| 5.8 |
LRRC32 |
leucine rich repeat containing 32 |
[detail] |
0 |
2615 |
| 5.4 |
LOC105371058 |
uncharacterized LOC105371058 |
[detail] |
0 |
105371058 |
|
Coexpressed
gene list |
[Coexpressed gene list for ADCY4]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
ADCY4 Gene
