| Representative coexpressed gene network |

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| hsa00230 |
Purine metabolism |
30 |
 |
| hsa04022 |
cGMP-PKG signaling pathway |
7 |
 |
| hsa04270 |
Vascular smooth muscle contraction |
6 |
 |
| hsa04924 |
Renin secretion |
6 |
 |
| hsa05032 |
Morphine addiction |
6 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| mmu00230 |
Purine metabolism |
45 |
 |
| mmu00240 |
Pyrimidine metabolism |
13 |
 |
| mmu01240 |
Biosynthesis of cofactors |
11 |
 |
| mmu00983 |
Drug metabolism - other enzymes |
8 |
 |
| mmu04022 |
cGMP-PKG signaling pathway |
8 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| rno00230 |
Purine metabolism |
48 |
 |
| rno05032 |
Morphine addiction |
14 |
 |
| rno04024 |
cAMP signaling pathway |
11 |
 |
| rno00240 |
Pyrimidine metabolism |
9 |
 |
| rno04022 |
cGMP-PKG signaling pathway |
8 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| gga00230 |
Purine metabolism |
30 |
 |
| gga00240 |
Pyrimidine metabolism |
10 |
 |
| gga04540 |
Gap junction |
6 |
 |
| gga04270 |
Vascular smooth muscle contraction |
5 |
 |
| gga00983 |
Drug metabolism - other enzymes |
4 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| dre00230 |
Purine metabolism |
57 |
 |
| dre00240 |
Pyrimidine metabolism |
12 |
 |
| dre04744 |
Phototransduction |
10 |
 |
| dre00983 |
Drug metabolism - other enzymes |
9 |
 |
| dre04270 |
Vascular smooth muscle contraction |
8 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| dme00230 |
Purine metabolism |
43 |
 |
| dme00240 |
Pyrimidine metabolism |
10 |
 |
| dme00983 |
Drug metabolism - other enzymes |
8 |
 |
| dme04213 |
Longevity regulating pathway - multiple species |
7 |
 |
| dme01240 |
Biosynthesis of cofactors |
6 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| cel00230 |
Purine metabolism |
29 |
 |
| cel00240 |
Pyrimidine metabolism |
5 |
 |
| cel00983 |
Drug metabolism - other enzymes |
5 |
 |
| cel00670 |
One carbon pool by folate |
4 |
 |
| cel01240 |
Biosynthesis of cofactors |
4 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| mcc00230 |
Purine metabolism |
29 |
 |
| mcc01240 |
Biosynthesis of cofactors |
9 |
 |
| mcc04924 |
Renin secretion |
8 |
 |
| mcc00983 |
Drug metabolism - other enzymes |
8 |
 |
| mcc04022 |
cGMP-PKG signaling pathway |
8 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| cfa00230 |
Purine metabolism |
32 |
 |
| cfa00240 |
Pyrimidine metabolism |
10 |
 |
| cfa04022 |
cGMP-PKG signaling pathway |
9 |
 |
| cfa00983 |
Drug metabolism - other enzymes |
5 |
 |
| cfa04270 |
Vascular smooth muscle contraction |
5 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| sce00230 |
Purine metabolism |
31 |
 |
| sce01200 |
Carbon metabolism |
7 |
 |
| sce01230 |
Biosynthesis of amino acids |
6 |
 |
| sce01240 |
Biosynthesis of cofactors |
6 |
 |
| sce00240 |
Pyrimidine metabolism |
6 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| spo00230 |
Purine metabolism |
22 |
 |
| spo00240 |
Pyrimidine metabolism |
4 |
 |
| spo00030 |
Pentose phosphate pathway |
3 |
 |
| spo01200 |
Carbon metabolism |
3 |
 |
| spo01230 |
Biosynthesis of amino acids |
3 |
 |
|

| KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
| fca00230 |
Purine metabolism |
37 |
 |
| fca04022 |
cGMP-PKG signaling pathway |
11 |
 |
| fca05032 |
Morphine addiction |
10 |
 |
| fca00983 |
Drug metabolism - other enzymes |
8 |
 |
| fca00240 |
Pyrimidine metabolism |
8 |
 |
|
| Gene list in the network |
|
|
Symbol |
Function* |
| |
Ada |
adenosine deaminase |
| |
Adk |
adenosine kinase |
| |
Adsl |
adenylosuccinate lyase |
| |
Adssl1 |
adenylosuccinate synthetase like 1 |
| |
Ak1 |
adenylate kinase 1 |
| |
Ak4 |
adenylate kinase 4 |
| |
Bnip3 |
BCL2/adenovirus E1B interacting protein 3 |
| |
Dck |
deoxycytidine kinase |
| |
Gart |
phosphoribosylglycinamide formyltransferase |
| |
Gda |
guanine deaminase |
| |
Hprt |
hypoxanthine guanine phosphoribosyl transferase |
| |
Mcm4 |
minichromosome maintenance complex component 4 |
| |
Nme1 |
NME/NM23 nucleoside diphosphate kinase 1 |
| |
Nme2 |
NME/NM23 nucleoside diphosphate kinase 2 |
| |
Npr1 |
natriuretic peptide receptor 1 |
| |
Mybbp1a |
MYB binding protein (P160) 1a |
| |
Enpp1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| |
Pnp |
purine-nucleoside phosphorylase |
| |
Prps1 |
phosphoribosyl pyrophosphate synthetase 1 |
| |
Rrm1 |
ribonucleotide reductase M1 |
| |
Tcf21 |
transcription factor 21 |
| |
Xdh |
xanthine dehydrogenase |
| |
Nt5e |
5' nucleotidase, ecto |
| |
Pde10a |
phosphodiesterase 10A |
| |
Pde7b |
phosphodiesterase 7B |
| |
Nt5c |
5',3'-nucleotidase, cytosolic |
| |
Gucy1b1 |
guanylate cyclase 1, soluble, beta 1 |
| |
Nme6 |
NME/NM23 nucleoside diphosphate kinase 6 |
| |
Pde3a |
phosphodiesterase 3A, cGMP inhibited |
| |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
| |
Usp14 |
ubiquitin specific peptidase 14 |
| |
Gucy1a1 |
guanylate cyclase 1, soluble, alpha 1 |
| |
Pgm2 |
phosphoglucomutase 2 |
| |
Paics |
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase |
| |
Pgm1 |
phosphoglucomutase 1 |
| |
Ddit4l |
DNA-damage-inducible transcript 4-like |
| |
Iqca |
IQ motif containing with AAA domain |
| |
Agl |
amylo-1,6-glucosidase, 4-alpha-glucanotransferase |
| |
Ak7 |
adenylate kinase 7 |
| |
Nme3 |
NME/NM23 nucleoside diphosphate kinase 3 |
| |
Adcy4 |
adenylate cyclase 4 |
| |
Mmrn2 |
multimerin 2 |
| |
Atic |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase |
| |
Prps2 |
phosphoribosyl pyrophosphate synthetase 2 |
| |
Enpp3 |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| |
Adcy2 |
adenylate cyclase 2 |
| |
Antkmt |
adenine nucleotide translocase lysine methyltransferase |
| |
Pde8b |
phosphodiesterase 8B |
| |
Adcy5 |
adenylate cyclase 5 |
| |
Gmps |
guanine monophosphate synthetase |
| |
Ppat |
phosphoribosyl pyrophosphate amidotransferase |
| |
Aimp2 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 |
| |
Rerg |
RAS-like, estrogen-regulated, growth-inhibitor |
| |
Gnl3l |
guanine nucleotide binding protein-like 3 (nucleolar)-like |
| |
Pfas |
phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) |
| |
Pde5a |
phosphodiesterase 5A, cGMP-specific |
| |
Prps1l3 |
phosphoribosyl pyrophosphate synthetase 1-like 3 |
| |
Arhgef15 |
Rho guanine nucleotide exchange factor (GEF) 15 |
| |
Ak9 |
adenylate kinase 9 |
| |
Pnp2 |
purine-nucleoside phosphorylase 2 |
|
|
|
|
Symbol |
Function* |
| |
nme2b.2 |
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 |
| |
rrm2 |
ribonucleotide reductase M2 polypeptide |
| |
rrm1 |
ribonucleotide reductase M1 polypeptide |
| |
gart |
phosphoribosylglycinamide formyltransferase |
| |
gucy2f |
guanylate cyclase 2F, retinal |
| |
gucy2d |
guanylate cyclase 2D, retinal |
| |
gnat1 |
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 |
| |
gnat2 |
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 |
| |
prps1a |
phosphoribosyl pyrophosphate synthetase 1A |
| |
atic |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| |
impdh2 |
IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| |
paics |
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| |
krcp |
kelch repeat-containing protein |
| |
slc25a4 |
solute carrier family 25 member 4 |
| |
tk1 |
thymidine kinase 1, soluble |
| |
rpe |
ribulose-5-phosphate-3-epimerase |
| |
gngt1 |
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 |
| |
nme2a |
NME/NM23 nucleoside diphosphate kinase 2a |
| |
pdzk1 |
PDZ domain containing 1 |
| |
pde6a |
phosphodiesterase 6A, cGMP-specific, rod, alpha |
| |
tktb |
transketolase b |
| |
vil1 |
villin 1 |
| |
adprm |
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent |
| |
aprt |
adenine phosphoribosyltransferase |
| |
guk1b |
guanylate kinase 1b |
| |
pde6hb |
phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog b |
| |
pde6c |
phosphodiesterase 6C, cGMP-specific, cone, alpha prime |
| |
ampd1 |
adenosine monophosphate deaminase 1 (isoform M) |
| |
nt5e |
5'-nucleotidase, ecto (CD73) |
| |
slc37a4b |
solute carrier family 37 member 4b |
| |
pgm2 |
phosphoglucomutase 2 |
| |
emc8 |
ER membrane protein complex subunit 8 |
| |
rpia |
ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase) |
| |
hprt1l |
hypoxanthine phosphoribosyltransferase 1, like |
| |
nudt5 |
nudix (nucleoside diphosphate linked moiety X)-type motif 5 |
| |
impdh1a |
IMP (inosine 5'-monophosphate) dehydrogenase 1a |
| |
nudt2 |
nudix (nucleoside diphosphate linked moiety X)-type motif 2 |
| |
entpd8 |
ectonucleoside triphosphate diphosphohydrolase 8 |
| |
arr3a |
arrestin 3a, retinal (X-arrestin) |
| |
ada |
adenosine deaminase |
| |
allc |
allantoicase |
| |
ak1 |
adenylate kinase 1 |
| |
nt5c2l1 |
5'-nucleotidase, cytosolic II, like 1 |
| |
osbpl7 |
oxysterol binding protein-like 7 |
| |
zgc:103759 |
zgc:103759 |
| |
dck |
deoxycytidine kinase |
| |
efcab6 |
EF-hand calcium binding domain 6 |
| |
zgc:103559 |
zgc:103559 |
| |
hif1al2 |
hypoxia inducible factor 1 subunit alpha, like 2 |
| |
slc29a2 |
solute carrier family 29 member 2 |
| |
ak7b |
adenylate kinase 7b |
| |
zgc:110540 |
zgc:110540 |
| |
srd5a2a |
steroid-5-alpha-reductase, alpha polypeptide 2a |
| |
gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
| |
adss2 |
adenylosuccinate synthase 2 |
| |
ak8 |
adenylate kinase 8 |
| |
pde6ga |
phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a |
| |
inaa |
internexin neuronal intermediate filament protein, alpha a |
| |
npr1b |
natriuretic peptide receptor 1b |
| |
unc119.2 |
unc-119 lipid binding chaperone B homolog 2 |
| |
adcy2b |
adenylate cyclase 2b (brain) |
| |
cacnb2b |
calcium channel, voltage-dependent, beta 2b |
| |
slc4a5a |
solute carrier family 4 member 5a |
| |
pde6b |
phosphodiesterase 6B, cGMP-specific, rod, beta |
| |
si:ch211-132f19.7 |
si:ch211-132f19.7 |
| |
xdh |
xanthine dehydrogenase |
| |
npr1a |
natriuretic peptide receptor 1a |
| |
si:dkey-206f10.1 |
si:dkey-206f10.1 |
| |
nt5c1aa |
5'-nucleotidase, cytosolic IAa |
| |
pde9al |
phosphodiesterase 9A like |
| |
dmtn |
dematin actin binding protein |
| |
lrmp |
lymphoid-restricted membrane protein |
| |
tmem130 |
transmembrane protein 130 |
| |
LOC569340 |
interphotoreceptor matrix proteoglycan 1 |
| |
pfas |
phosphoribosylformylglycinamidine synthase |
| |
adcy6a |
adenylate cyclase 6a |
| |
abcb11b |
ATP-binding cassette, sub-family B (MDR/TAP), member 11b |
| |
ppat |
phosphoribosyl pyrophosphate amidotransferase |
| |
gucy2ca |
guanylate cyclase 2Ca |
| |
rcvrn3 |
recoverin 3 |
| |
gmpr2 |
guanosine monophosphate reductase 2 |
| |
uraha |
urate (5-hydroxyiso-) hydrolase a |
| |
rgs9a |
regulator of G protein signaling 9a |
| |
papss2a |
3'-phosphoadenosine 5'-phosphosulfate synthase 2a |
| |
ahcyl1 |
adenosylhomocysteinase-like 1 |
| |
gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
| |
glmnb |
glomulin, FKBP associated protein b |
| |
abcf3 |
ATP-binding cassette, sub-family F (GCN20), member 3 |
| |
gucy2g |
guanylate cyclase 2g |
| |
LOC100535624 |
uncharacterized LOC100535624 |
| |
pde1cb |
phosphodiesterase 1C, calmodulin-dependent b |
|
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|
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