| functional annotation |
| Function |
adenylate cyclase 8 |
|
| GO BP |
|
GO:0010255 [list] [network] glucose mediated signaling pathway
|
(3 genes)
|
ISS
|
 |
|
GO:0071315 [list] [network] cellular response to morphine
|
(5 genes)
|
ISS
|
|
|
GO:0150076 [list] [network] neuroinflammatory response
|
(6 genes)
|
ISS
|
|
|
GO:1900454 [list] [network] positive regulation of long-term synaptic depression
|
(6 genes)
|
ISS
|
|
|
GO:0038003 [list] [network] G protein-coupled opioid receptor signaling pathway
|
(8 genes)
|
ISS
|
|
|
GO:0006171 [list] [network] cAMP biosynthetic process
|
(10 genes)
|
IBA
|
|
|
GO:0031915 [list] [network] positive regulation of synaptic plasticity
|
(10 genes)
|
ISS
|
|
|
GO:1904322 [list] [network] cellular response to forskolin
|
(11 genes)
|
ISS
|
|
|
GO:0034199 [list] [network] activation of protein kinase A activity
|
(18 genes)
|
ISS
TAS
|
|
|
GO:0032793 [list] [network] positive regulation of CREB transcription factor activity
|
(20 genes)
|
ISS
|
|
|
GO:1900273 [list] [network] positive regulation of long-term synaptic potentiation
|
(23 genes)
|
ISS
|
|
|
GO:0071377 [list] [network] cellular response to glucagon stimulus
|
(27 genes)
|
ISS
TAS
|
|
|
GO:0007616 [list] [network] long-term memory
|
(34 genes)
|
IEA
|
|
|
GO:0003091 [list] [network] renal water homeostasis
|
(36 genes)
|
TAS
|
|
|
GO:0035774 [list] [network] positive regulation of insulin secretion involved in cellular response to glucose stimulus
|
(36 genes)
|
ISS
|
|
|
GO:0007190 [list] [network] activation of adenylate cyclase activity
|
(41 genes)
|
TAS
|
|
|
GO:0007193 [list] [network] adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
|
(83 genes)
|
TAS
|
|
|
GO:0071277 [list] [network] cellular response to calcium ion
|
(85 genes)
|
ISS
|
|
|
GO:0071333 [list] [network] cellular response to glucose stimulus
|
(86 genes)
|
ISS
|
|
|
GO:0007613 [list] [network] memory
|
(118 genes)
|
ISS
|
|
|
GO:0007189 [list] [network] adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
(132 genes)
|
IBA
TAS
|
|
|
GO:0007626 [list] [network] locomotory behavior
|
(174 genes)
|
ISS
|
|
|
GO:0051260 [list] [network] protein homooligomerization
|
(180 genes)
|
ISS
|
|
|
GO:0042593 [list] [network] glucose homeostasis
|
(202 genes)
|
ISS
|
|
|
GO:0002862 [list] [network] negative regulation of inflammatory response to antigenic stimulus
|
(208 genes)
|
TAS
|
|
|
GO:0051259 [list] [network] protein complex oligomerization
|
(235 genes)
|
ISS
|
|
|
GO:0007611 [list] [network] learning or memory
|
(254 genes)
|
TAS
|
|
|
GO:0007204 [list] [network] positive regulation of cytosolic calcium ion concentration
|
(280 genes)
|
ISS
|
|
|
GO:0051480 [list] [network] regulation of cytosolic calcium ion concentration
|
(319 genes)
|
ISS
|
|
|
GO:0080135 [list] [network] regulation of cellular response to stress
|
(716 genes)
|
ISS
|
|
|
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway
|
(1290 genes)
|
TAS
|
|
|
GO:0035556 [list] [network] intracellular signal transduction
|
(1640 genes)
|
IEA
|
|
|
GO:0007165 [list] [network] signal transduction
|
(5169 genes)
|
TAS
|
|
|
| GO CC |
|
GO:0032809 [list] [network] neuronal cell body membrane
|
(28 genes)
|
ISS
|
|
|
GO:0098686 [list] [network] hippocampal mossy fiber to CA3 synapse
|
(33 genes)
|
IEA
|
|
|
GO:0060076 [list] [network] excitatory synapse
|
(49 genes)
|
ISS
|
|
|
GO:0099056 [list] [network] integral component of presynaptic membrane
|
(66 genes)
|
IEA
|
|
|
GO:0005905 [list] [network] clathrin-coated pit
|
(70 genes)
|
ISS
|
|
|
GO:0048786 [list] [network] presynaptic active zone
|
(73 genes)
|
ISS
|
|
|
GO:0098685 [list] [network] Schaffer collateral - CA1 synapse
|
(78 genes)
|
IEA
|
|
|
GO:0005901 [list] [network] caveola
|
(83 genes)
|
ISS
|
|
|
GO:0044853 [list] [network] plasma membrane raft
|
(115 genes)
|
ISS
|
|
|
GO:0030665 [list] [network] clathrin-coated vesicle membrane
|
(116 genes)
|
IEA
|
|
|
GO:0016323 [list] [network] basolateral plasma membrane
|
(228 genes)
|
ISS
|
|
|
GO:0014069 [list] [network] postsynaptic density
|
(329 genes)
|
ISS
|
|
|
GO:0045121 [list] [network] membrane raft
|
(334 genes)
|
ISS
|
|
|
GO:0098978 [list] [network] glutamatergic synapse
|
(338 genes)
|
IEA
|
|
|
GO:0016324 [list] [network] apical plasma membrane
|
(364 genes)
|
ISS
|
|
|
GO:0015629 [list] [network] actin cytoskeleton
|
(508 genes)
|
ISS
|
|
|
GO:0030425 [list] [network] dendrite
|
(635 genes)
|
ISS
|
|
|
GO:0030424 [list] [network] axon
|
(644 genes)
|
ISS
|
|
|
GO:0005887 [list] [network] integral component of plasma membrane
|
(1649 genes)
|
IBA
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(5772 genes)
|
ISS
TAS
|
|
|
GO:0016020 [list] [network] membrane
|
(9592 genes)
|
ISS
|
|
|
| GO MF |
|
GO:0008294 [list] [network] calcium- and calmodulin-responsive adenylate cyclase activity
|
(2 genes)
|
ISS
|
|
|
GO:0004016 [list] [network] adenylate cyclase activity
|
(11 genes)
|
IBA
|
|
|
GO:0051721 [list] [network] protein phosphatase 2A binding
|
(32 genes)
|
ISS
|
|
|
GO:0005516 [list] [network] calmodulin binding
|
(200 genes)
|
ISS
|
|
|
GO:0046982 [list] [network] protein heterodimerization activity
|
(326 genes)
|
ISS
|
|
|
GO:0003779 [list] [network] actin binding
|
(442 genes)
|
ISS
|
|
|
GO:0042803 [list] [network] protein homodimerization activity
|
(680 genes)
|
ISS
|
|
|
GO:0046983 [list] [network] protein dimerization activity
|
(1049 genes)
|
ISS
|
|
|
GO:0005524 [list] [network] ATP binding
|
(1474 genes)
|
IEA
|
|
|
GO:0046872 [list] [network] metal ion binding
|
(4237 genes)
|
IEA
|
|
|
| KEGG |
hsa00230 [list] [network] Purine metabolism (126 genes) |
 |
| hsa01522 [list] [network] Endocrine resistance (98 genes) |
|
| hsa04015 [list] [network] Rap1 signaling pathway (210 genes) |
|
| hsa04020 [list] [network] Calcium signaling pathway (240 genes) |
|
| hsa04022 [list] [network] cGMP-PKG signaling pathway (167 genes) |
|
| hsa04024 [list] [network] cAMP signaling pathway (221 genes) |
|
| hsa04062 [list] [network] Chemokine signaling pathway (192 genes) |
|
| hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes) |
|
| hsa04114 [list] [network] Oocyte meiosis (131 genes) |
|
| hsa04211 [list] [network] Longevity regulating pathway (89 genes) |
|
| hsa04213 [list] [network] Longevity regulating pathway - multiple species (62 genes) |
|
| hsa04261 [list] [network] Adrenergic signaling in cardiomyocytes (150 genes) |
|
| hsa04270 [list] [network] Vascular smooth muscle contraction (134 genes) |
|
| hsa04371 [list] [network] Apelin signaling pathway (139 genes) |
|
| hsa04540 [list] [network] Gap junction (88 genes) |
|
| hsa04611 [list] [network] Platelet activation (124 genes) |
|
| hsa04713 [list] [network] Circadian entrainment (97 genes) |
|
| hsa04714 [list] [network] Thermogenesis (232 genes) |
|
| hsa04720 [list] [network] Long-term potentiation (67 genes) |
|
| hsa04723 [list] [network] Retrograde endocannabinoid signaling (148 genes) |
|
| hsa04724 [list] [network] Glutamatergic synapse (114 genes) |
|
| hsa04725 [list] [network] Cholinergic synapse (113 genes) |
|
| hsa04727 [list] [network] GABAergic synapse (89 genes) |
|
| hsa04742 [list] [network] Taste transduction (86 genes) |
|
| hsa04750 [list] [network] Inflammatory mediator regulation of TRP channels (98 genes) |
|
| hsa04911 [list] [network] Insulin secretion (86 genes) |
|
| hsa04912 [list] [network] GnRH signaling pathway (93 genes) |
|
| hsa04913 [list] [network] Ovarian steroidogenesis (51 genes) |
|
| hsa04914 [list] [network] Progesterone-mediated oocyte maturation (102 genes) |
|
| hsa04915 [list] [network] Estrogen signaling pathway (138 genes) |
|
| hsa04916 [list] [network] Melanogenesis (101 genes) |
|
| hsa04918 [list] [network] Thyroid hormone synthesis (75 genes) |
|
| hsa04921 [list] [network] Oxytocin signaling pathway (154 genes) |
|
| hsa04923 [list] [network] Regulation of lipolysis in adipocytes (56 genes) |
|
| hsa04925 [list] [network] Aldosterone synthesis and secretion (98 genes) |
|
| hsa04926 [list] [network] Relaxin signaling pathway (129 genes) |
|
| hsa04927 [list] [network] Cortisol synthesis and secretion (65 genes) |
|
| hsa04928 [list] [network] Parathyroid hormone synthesis, secretion and action (106 genes) |
|
| hsa04934 [list] [network] Cushing syndrome (155 genes) |
|
| hsa04935 [list] [network] Growth hormone synthesis, secretion and action (119 genes) |
|
| hsa04970 [list] [network] Salivary secretion (93 genes) |
|
| hsa04971 [list] [network] Gastric acid secretion (76 genes) |
|
| hsa04972 [list] [network] Pancreatic secretion (102 genes) |
|
| hsa04976 [list] [network] Bile secretion (89 genes) |
|
| hsa05032 [list] [network] Morphine addiction (91 genes) |
|
| hsa05163 [list] [network] Human cytomegalovirus infection (225 genes) |
|
| hsa05166 [list] [network] Human T-cell leukemia virus 1 infection (222 genes) |
|
| hsa05200 [list] [network] Pathways in cancer (531 genes) |
|
| hsa05207 [list] [network] Chemical carcinogenesis - receptor activation (212 genes) |
|
| hsa05414 [list] [network] Dilated cardiomyopathy (96 genes) |
|
| Protein |
NP_001106.1
XP_005250826.1
XP_006716564.1
XP_016868495.1
XP_016868496.1
|
| BLAST |
NP_001106.1
XP_005250826.1
XP_006716564.1
XP_016868495.1
XP_016868496.1
|
| Orthologous |
[Ortholog page]
Adcy8 (mmu)
Adcy8 (rno)
ADCY8 (gga)
ADCY8 (cfa)
ADCY8 (mcc)
adcy8 (dre)
ADCY8 (fca)
|
Subcellular
localization
wolf |
|
plas 10
|
(predict for NP_001106.1)
|
|
plas 10
|
(predict for XP_005250826.1)
|
|
plas 10
|
(predict for XP_006716564.1)
|
|
plas 10
|
(predict for XP_016868495.1)
|
|
plas 9
|
(predict for XP_016868496.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| hsa04724 |
Glutamatergic synapse |
5 |
 |
| hsa04020 |
Calcium signaling pathway |
4 |
 |
| hsa04723 |
Retrograde endocannabinoid signaling |
4 |
 |
| hsa05017 |
Spinocerebellar ataxia |
4 |
 |
| hsa04720 |
Long-term potentiation |
4 |
 |
Genes directly connected with ADCY8 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 5.4 |
CSMD2 |
CUB and Sushi multiple domains 2 |
[detail] |
0 |
114784 |
| 5.4 |
BRINP1 |
BMP/retinoic acid inducible neural specific 1 |
[detail] |
0 |
1620 |
| 5.1 |
GRIN2A |
glutamate ionotropic receptor NMDA type subunit 2A |
[detail] |
0 |
2903 |
| 4.8 |
GRM1 |
glutamate metabotropic receptor 1 |
[detail] |
0 |
2911 |
| 4.4 |
DGKK |
diacylglycerol kinase kappa |
[detail] |
0 |
139189 |
|
Coexpressed
gene list |
[Coexpressed gene list for ADCY8]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
ADCY8 Gene
