| functional annotation |
| Function |
platelet derived growth factor C |
|
| GO BP |
|
GO:0007171 [list] [network] activation of transmembrane receptor protein tyrosine kinase activity
|
(14 genes)
|
IEA
|
 |
|
GO:0031954 [list] [network] positive regulation of protein autophosphorylation
|
(27 genes)
|
IBA
|
|
|
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway
|
(35 genes)
|
IBA
IDA
|
|
|
GO:0048146 [list] [network] positive regulation of fibroblast proliferation
|
(48 genes)
|
IDA
|
|
|
GO:0071230 [list] [network] cellular response to amino acid stimulus
|
(71 genes)
|
IEA
|
|
|
GO:0051781 [list] [network] positive regulation of cell division
|
(88 genes)
|
IEA
|
|
|
GO:0043406 [list] [network] positive regulation of MAP kinase activity
|
(89 genes)
|
IBA
|
|
|
GO:0014068 [list] [network] positive regulation of phosphatidylinositol 3-kinase signaling
|
(91 genes)
|
IBA
|
|
|
GO:0120162 [list] [network] positive regulation of cold-induced thermogenesis
|
(97 genes)
|
ISS
|
|
|
GO:0048565 [list] [network] digestive tract development
|
(124 genes)
|
IEA
|
|
|
GO:0060348 [list] [network] bone development
|
(184 genes)
|
IEA
|
|
|
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade
|
(217 genes)
|
IBA
|
|
|
GO:0050730 [list] [network] regulation of peptidyl-tyrosine phosphorylation
|
(267 genes)
|
IEA
|
|
|
GO:0048568 [list] [network] embryonic organ development
|
(429 genes)
|
IEA
|
|
|
GO:0030335 [list] [network] positive regulation of cell migration
|
(554 genes)
|
IBA
|
|
|
GO:0009887 [list] [network] animal organ morphogenesis
|
(947 genes)
|
IEA
|
|
|
GO:0008284 [list] [network] positive regulation of cell population proliferation
|
(976 genes)
|
IBA
IDA
|
|
|
GO:0007417 [list] [network] central nervous system development
|
(983 genes)
|
TAS
|
|
|
| GO CC |
|
GO:0005788 [list] [network] endoplasmic reticulum lumen
|
(313 genes)
|
TAS
|
|
|
GO:0000139 [list] [network] Golgi membrane
|
(626 genes)
|
TAS
|
|
|
GO:0009986 [list] [network] cell surface
|
(898 genes)
|
IDA
|
|
|
GO:0070062 [list] [network] extracellular exosome
|
(2212 genes)
|
HDA
|
|
|
GO:0005615 [list] [network] extracellular space
|
(3622 genes)
|
IBA
IDA
|
|
|
GO:0005576 [list] [network] extracellular region
|
(4632 genes)
|
TAS
|
|
|
GO:0005829 [list] [network] cytosol
|
(5345 genes)
|
IDA
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(5772 genes)
|
IDA
|
|
|
GO:0005634 [list] [network] nucleus
|
(8115 genes)
|
IEA
|
|
|
| GO MF |
|
GO:0005161 [list] [network] platelet-derived growth factor receptor binding
|
(15 genes)
|
IBA
IPI
|
|
|
GO:0070851 [list] [network] growth factor receptor binding
|
(141 genes)
|
IBA
|
|
|
GO:0008083 [list] [network] growth factor activity
|
(162 genes)
|
IEA
|
|
|
GO:0042803 [list] [network] protein homodimerization activity
|
(680 genes)
|
IPI
|
|
|
GO:0005515 [list] [network] protein binding
|
(13898 genes)
|
IPI
|
|
|
| KEGG |
hsa01521 [list] [network] EGFR tyrosine kinase inhibitor resistance (79 genes) |
 |
| hsa04010 [list] [network] MAPK signaling pathway (294 genes) |
|
| hsa04014 [list] [network] Ras signaling pathway (232 genes) |
|
| hsa04015 [list] [network] Rap1 signaling pathway (210 genes) |
|
| hsa04020 [list] [network] Calcium signaling pathway (240 genes) |
|
| hsa04072 [list] [network] Phospholipase D signaling pathway (148 genes) |
|
| hsa04151 [list] [network] PI3K-Akt signaling pathway (354 genes) |
|
| hsa04510 [list] [network] Focal adhesion (201 genes) |
|
| hsa04540 [list] [network] Gap junction (88 genes) |
|
| hsa04810 [list] [network] Regulation of actin cytoskeleton (218 genes) |
|
| hsa05215 [list] [network] Prostate cancer (97 genes) |
|
| hsa05218 [list] [network] Melanoma (72 genes) |
|
| hsa05231 [list] [network] Choline metabolism in cancer (98 genes) |
|
| Protein |
NP_057289.1
XP_011530426.1
XP_016863944.1
XP_016863945.1
|
| BLAST |
NP_057289.1
XP_011530426.1
XP_016863944.1
XP_016863945.1
|
| Orthologous |
[Ortholog page]
Pdgfc (mmu)
Pdgfc (rno)
PDGFC (gga)
PDGFC (cfa)
pdgfc (dre)
PDGFC (mcc)
PDGFC (fca)
|
Subcellular
localization
wolf |
|
extr 9,
lyso 1
|
(predict for NP_057289.1)
|
|
extr 5,
cyto 2,
mito 2,
cyto_nucl 1,
cyto_pero 1
|
(predict for XP_011530426.1)
|
|
extr 5,
cyto 3,
cyto_nucl 2,
nucl 1
|
(predict for XP_016863944.1)
|
|
extr 8,
lyso 1,
cyto 0,
cyto_nucl 0
|
(predict for XP_016863945.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| hsa04151 |
PI3K-Akt signaling pathway |
3 |
 |
| hsa04360 |
Axon guidance |
2 |
 |
| hsa04080 |
Neuroactive ligand-receptor interaction |
2 |
 |
| hsa05410 |
Hypertrophic cardiomyopathy |
2 |
 |
| hsa05418 |
Fluid shear stress and atherosclerosis |
2 |
 |
Genes directly connected with PDGFC on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 10.0 |
GLRB |
glycine receptor beta |
[detail] |
1 |
2743 |
| 5.0 |
SEMA3C |
semaphorin 3C |
[detail] |
0 |
10512 |
| 4.8 |
DCBLD2 |
discoidin, CUB and LCCL domain containing 2 |
[detail] |
0 |
131566 |
|
Coexpressed
gene list |
[Coexpressed gene list for PDGFC]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
PDGFC Gene
