| functional annotation |
| Function |
epidermal growth factor receptor |
|
| GO BP |
|
GO:0071364 [list] [network] cellular response to epidermal growth factor stimulus
|
(4 genes)
|
ISS
|
 |
|
GO:0007173 [list] [network] epidermal growth factor receptor signaling pathway
|
(8 genes)
|
ISS
|
|
|
GO:0007611 [list] [network] learning or memory
|
(18 genes)
|
ISS
|
|
|
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation
|
(39 genes)
|
IEA
|
|
|
| GO CC |
|
GO:0031965 [list] [network] nuclear membrane
|
(30 genes)
|
IEA
|
|
|
GO:0000139 [list] [network] Golgi membrane
|
(56 genes)
|
IEA
|
|
|
GO:0010008 [list] [network] endosome membrane
|
(59 genes)
|
IEA
|
|
|
GO:0005789 [list] [network] endoplasmic reticulum membrane
|
(109 genes)
|
IEA
|
|
|
GO:0016021 [list] [network] integral component of membrane
|
(476 genes)
|
IEA
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(477 genes)
|
IEA
|
|
|
GO:0005634 [list] [network] nucleus
|
(876 genes)
|
ISS
|
|
|
| GO MF |
|
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity
|
(37 genes)
|
IEA
|
|
|
GO:0004713 [list] [network] protein tyrosine kinase activity
|
(38 genes)
|
ISS
|
|
|
GO:0005524 [list] [network] ATP binding
|
(217 genes)
|
IEA
|
|
|
| KEGG |
gga04010 [list] [network] MAPK signaling pathway (260 genes) |
 |
| gga04012 [list] [network] ErbB signaling pathway (78 genes) |
|
| gga04020 [list] [network] Calcium signaling pathway (225 genes) |
|
| gga04068 [list] [network] FoxO signaling pathway (122 genes) |
|
| gga04144 [list] [network] Endocytosis (232 genes) |
|
| gga04510 [list] [network] Focal adhesion (191 genes) |
|
| gga04520 [list] [network] Adherens junction (71 genes) |
|
| gga04540 [list] [network] Gap junction (84 genes) |
|
| gga04810 [list] [network] Regulation of actin cytoskeleton (195 genes) |
|
| gga04912 [list] [network] GnRH signaling pathway (84 genes) |
|
| Protein |
NP_990828.2
XP_015136814.1
XP_025002843.1
XP_025002844.1
|
| BLAST |
NP_990828.2
XP_015136814.1
XP_025002843.1
XP_025002844.1
|
| Orthologous |
[Ortholog page]
EGFR (hsa)
ERBB2 (hsa)
ERBB4 (hsa)
Egfr (mmu)
Erbb2 (mmu)
Erbb4 (mmu)
Egfr (rno)
Erbb2 (rno)
Egfr (dme)
Erbb4 (rno)
let-23 (cel)
egfra (dre)
erbb2 (dre)
ERBB4 (gga)
ERBB2 (cfa)
EGFR (cfa)
ERBB2 (gga)
ERBB4 (cfa)
erbb4b (dre)
LOC571431 (dre)
EGFR (mcc)
ERBB4 (mcc)
ERBB2 (mcc)
ERBB2 (fca)
erbb4a (dre)
EGFR (fca)
ERBB4 (fca)
si:ch73-383l1.1 (dre)
|
Subcellular
localization
wolf |
|
plas 5,
extr_plas 3,
E.R. 2,
extr 1,
pero 1
|
(predict for NP_990828.2)
|
|
plas 5,
extr_plas 3,
E.R. 2,
extr 1,
pero 1
|
(predict for XP_015136814.1)
|
|
plas 5,
extr_plas 3,
E.R. 2,
extr 1,
pero 1
|
(predict for XP_025002843.1)
|
|
plas 5,
extr_plas 3,
E.R. 2,
extr 1,
pero 1
|
(predict for XP_025002844.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| gga04010 |
MAPK signaling pathway |
3 |
 |
| gga00020 |
Citrate cycle (TCA cycle) |
2 |
 |
| gga01200 |
Carbon metabolism |
2 |
 |
| gga01210 |
2-Oxocarboxylic acid metabolism |
2 |
 |
| gga01230 |
Biosynthesis of amino acids |
2 |
 |
Genes directly connected with EGFR on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
Entrez Gene ID* |
| 4.9 |
MYO10 |
myosin X |
[detail] |
101749223 |
| 4.8 |
IDH1 |
isocitrate dehydrogenase (NADP(+)) 1, cytosolic |
[detail] |
424112 |
| 4.7 |
RNF128 |
ring finger protein 128, E3 ubiquitin protein ligase |
[detail] |
422382 |
| 4.6 |
MET |
MET proto-oncogene, receptor tyrosine kinase |
[detail] |
396134 |
| 4.4 |
LGR4 |
leucine rich repeat containing G protein-coupled receptor 4 |
[detail] |
428605 |
| 4.2 |
RHOBTB1 |
Rho related BTB domain containing 1 |
[detail] |
423664 |
|
Coexpressed
gene list |
[Coexpressed gene list for EGFR]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
EGFR Gene
