[←][→] mmu  Map2k5 Gene
functional annotation
Function   mitogen-activated protein kinase kinase 5  
GO BP
GO:0070375 [list] [network] ERK5 cascade  (3 genes)  ISO  
GO:2000342 [list] [network] negative regulation of chemokine (C-X-C motif) ligand 2 production  (10 genes)  ISO  
GO:0034115 [list] [network] negative regulation of heterotypic cell-cell adhesion  (11 genes)  ISO  
GO:0032717 [list] [network] negative regulation of interleukin-8 production  (16 genes)  ISO  
GO:0090051 [list] [network] negative regulation of cell migration involved in sprouting angiogenesis  (16 genes)  ISO  
GO:2001240 [list] [network] negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (33 genes)  ISO  
GO:0060761 [list] [network] negative regulation of response to cytokine stimulus  (66 genes)  ISO  
GO:0032088 [list] [network] negative regulation of NF-kappaB transcription factor activity  (79 genes)  ISO  
GO:0043154 [list] [network] negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (82 genes)  ISO  
GO:0000165 [list] [network] MAPK cascade  (136 genes)  IMP  
GO:0030307 [list] [network] positive regulation of cell growth  (206 genes)  ISO  
GO:0050679 [list] [network] positive regulation of epithelial cell proliferation  (214 genes)  ISO  
GO:0071363 [list] [network] cellular response to growth factor stimulus  (426 genes)  ISO  
GO:0007507 [list] [network] heart development  (585 genes)  IMP  
GO:0006468 [list] [network] protein phosphorylation  (665 genes)  ISO  
GO:0016310 [list] [network] phosphorylation  (836 genes)  IEA  
GO:0000122 [list] [network] negative regulation of transcription by RNA polymerase II  (948 genes)  ISO  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1250 genes)  ISO  
GO:0051247 [list] [network] positive regulation of protein metabolic process  (1454 genes)  ISO  
GO CC
GO:0005819 [list] [network] spindle  (330 genes)  IDA  
GO:0005829 [list] [network] cytosol  (3785 genes)  ISO  
GO:0005634 [list] [network] nucleus  (7226 genes)  ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IEA  
GO MF
GO:0004708 [list] [network] MAP kinase kinase activity  (15 genes)  IBA  
GO:0004713 [list] [network] protein tyrosine kinase activity  (134 genes)  IEA  
GO:0004674 [list] [network] protein serine/threonine kinase activity  (442 genes)  IEA  
GO:0004672 [list] [network] protein kinase activity  (583 genes)  ISO  
GO:0016301 [list] [network] kinase activity  (740 genes)  IEA  
GO:0005524 [list] [network] ATP binding  (1396 genes)  ISO  
GO:0000166 [list] [network] nucleotide binding  (2052 genes)  IEA  
GO:0016740 [list] [network] transferase activity  (2235 genes)  IEA  
GO:0046872 [list] [network] metal ion binding  (3573 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu04010 [list] [network] MAPK signaling pathway (294 genes)
mmu04540 [list] [network] Gap junction (86 genes)
mmu04722 [list] [network] Neurotrophin signaling pathway (121 genes)
mmu04921 [list] [network] Oxytocin signaling pathway (153 genes)
mmu05418 [list] [network] Fluid shear stress and atherosclerosis (148 genes)
Protein NP_001351421.1  NP_001351422.1  NP_001351423.1  NP_035970.1  XP_006511209.1  XP_011241042.1  XP_030100214.1  XP_036010824.1  XP_036010825.1  XP_036010826.1 
BLAST NP_001351421.1  NP_001351422.1  NP_001351423.1  NP_035970.1  XP_006511209.1  XP_011241042.1  XP_030100214.1  XP_036010824.1  XP_036010825.1  XP_036010826.1 
Orthologous [Ortholog page] MAP2K5 (hsa)  Map2k5 (rno)  MAP2K5 (gga)  MAP2K5 (cfa)  MAP2K5 (mcc)  MKK1 (sce)  map2k5 (dre)  MAP2K5 (fca) 
Subcellular
localization
wolf
mito 3,  cyto 3,  cyto_nucl 2,  cyto_pero 2,  E.R._mito 2,  extr 1,  nucl 1  (predict for NP_001351421.1)
mito 3,  cyto 3,  E.R._mito 3,  cyto_pero 2,  nucl 2  (predict for NP_001351422.1)
cyto 5,  cysk 4,  lyso 1  (predict for NP_001351423.1)
cyto 3,  mito 3,  cyto_pero 3,  E.R._mito 2,  nucl 2  (predict for NP_035970.1)
cyto 4,  cyto_pero 3,  mito 2,  E.R._mito 2,  nucl 2  (predict for XP_006511209.1)
cyto 5,  cyto_pero 3,  mito 2,  E.R._mito 2,  nucl 2  (predict for XP_011241042.1)
cyto 8,  extr 1,  E.R. 1  (predict for XP_030100214.1)
cyto 4,  cyto_pero 3,  mito 2,  E.R._mito 2,  nucl 2  (predict for XP_036010824.1)
cyto 4,  mito 3,  cyto_pero 3,  E.R._mito 2,  nucl 1  (predict for XP_036010825.1)
cyto 8,  extr 1,  E.R. 1  (predict for XP_036010826.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04010 MAPK signaling pathway 2
mmu04540 Gap junction 2
mmu04722 Neurotrophin signaling pathway 2
mmu04921 Oxytocin signaling pathway 2
mmu04350 TGF-beta signaling pathway 2
Genes directly connected with Map2k5 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
6.1 Fbxl17 F-box and leucine-rich repeat protein 17 [detail] 0 50758
6.0 Ccny cyclin Y [detail] 0 67974
5.8 Dym dymeclin [detail] 0 69190
Coexpressed
gene list		 [Coexpressed gene list for Map2k5]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 23938      
Refseq ID (protein) NP_001351421.1 
NP_001351422.1 
NP_001351423.1 
NP_035970.1 
XP_006511209.1 
XP_011241042.1 
XP_030100214.1 
XP_036010824.1 
XP_036010825.1 
XP_036010826.1 


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