| functional annotation |
| Function |
mitogen-activated protein kinase kinase 5 |
|
| GO BP |
|
GO:0070375 [list] [network] ERK5 cascade
|
(2 genes)
|
IEA
|
 |
|
GO:2000342 [list] [network] negative regulation of chemokine (C-X-C motif) ligand 2 production
|
(6 genes)
|
ISS
|
|
|
GO:0071499 [list] [network] cellular response to laminar fluid shear stress
|
(8 genes)
|
TAS
|
|
|
GO:0034115 [list] [network] negative regulation of heterotypic cell-cell adhesion
|
(11 genes)
|
ISS
|
|
|
GO:2001240 [list] [network] negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
(33 genes)
|
ISS
|
|
|
GO:0032717 [list] [network] negative regulation of interleukin-8 production
|
(38 genes)
|
ISS
|
|
|
GO:0090051 [list] [network] negative regulation of cell migration involved in sprouting angiogenesis
|
(42 genes)
|
ISS
|
|
|
GO:0043154 [list] [network] negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
(82 genes)
|
ISS
|
|
|
GO:0060761 [list] [network] negative regulation of response to cytokine stimulus
|
(86 genes)
|
ISS
|
|
|
GO:0032088 [list] [network] negative regulation of NF-kappaB transcription factor activity
|
(92 genes)
|
ISS
|
|
|
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation
|
(149 genes)
|
IEA
|
|
|
GO:0030307 [list] [network] positive regulation of cell growth
|
(166 genes)
|
IEA
|
|
|
GO:0050679 [list] [network] positive regulation of epithelial cell proliferation
|
(209 genes)
|
IEA
|
|
|
GO:0071363 [list] [network] cellular response to growth factor stimulus
|
(508 genes)
|
ISS
|
|
|
GO:0007507 [list] [network] heart development
|
(537 genes)
|
IEA
|
|
|
GO:0000122 [list] [network] negative regulation of transcription by RNA polymerase II
|
(922 genes)
|
ISS
|
|
|
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II
|
(1184 genes)
|
ISS
|
|
|
GO:0051247 [list] [network] positive regulation of protein metabolic process
|
(1471 genes)
|
ISS
|
|
|
GO:0007165 [list] [network] signal transduction
|
(5169 genes)
|
TAS
|
|
|
| GO CC |
|
| GO MF |
|
GO:0004708 [list] [network] MAP kinase kinase activity
|
(18 genes)
|
IBA
|
|
|
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity
|
(127 genes)
|
IEA
|
|
|
GO:0106310 [list] [network] protein serine kinase activity
|
(360 genes)
|
IEA
|
|
|
GO:0106311 [list] [network] protein threonine kinase activity
|
(360 genes)
|
IEA
|
|
|
GO:0004672 [list] [network] protein kinase activity
|
(577 genes)
|
TAS
|
|
|
GO:0005524 [list] [network] ATP binding
|
(1474 genes)
|
IEA
|
|
|
GO:0046872 [list] [network] metal ion binding
|
(4237 genes)
|
IEA
|
|
|
GO:0005515 [list] [network] protein binding
|
(13898 genes)
|
IPI
|
|
|
| KEGG |
hsa04010 [list] [network] MAPK signaling pathway (294 genes) |
 |
| hsa04540 [list] [network] Gap junction (88 genes) |
|
| hsa04722 [list] [network] Neurotrophin signaling pathway (119 genes) |
|
| hsa04921 [list] [network] Oxytocin signaling pathway (154 genes) |
|
| hsa05418 [list] [network] Fluid shear stress and atherosclerosis (139 genes) |
|
| Protein |
NP_001193733.1
NP_002748.1
NP_660143.1
XP_011520089.1
XP_011520090.1
XP_016877903.1
XP_024305756.1
|
| BLAST |
NP_001193733.1
NP_002748.1
NP_660143.1
XP_011520089.1
XP_011520090.1
XP_016877903.1
XP_024305756.1
|
| Orthologous |
[Ortholog page]
Map2k5 (mmu)
Map2k5 (rno)
MAP2K5 (gga)
MAP2K5 (cfa)
MAP2K5 (mcc)
MKK1 (sce)
map2k5 (dre)
MAP2K5 (fca)
|
Subcellular
localization
wolf |
|
cysk 8,
cyto 1,
mito 1,
cyto_nucl 1
|
(predict for NP_001193733.1)
|
|
cyto 5,
cyto_pero 3,
mito 2,
nucl 2,
E.R._mito 2
|
(predict for NP_002748.1)
|
|
cyto 4,
mito 3,
cyto_pero 3,
E.R._mito 2,
nucl 2
|
(predict for NP_660143.1)
|
|
cyto 7,
E.R._mito 1,
mito 1,
golg 1
|
(predict for XP_011520089.1)
|
|
cyto 7,
E.R._mito 1,
golg 1,
mito 1
|
(predict for XP_011520090.1)
|
|
cyto 7,
E.R._mito 1,
mito 1,
golg 1
|
(predict for XP_016877903.1)
|
|
cysk 8,
cyto 1,
cyto_nucl 1
|
(predict for XP_024305756.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| hsa05205 |
Proteoglycans in cancer |
2 |
 |
Genes directly connected with MAP2K5 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 6.6 |
PARP16 |
poly(ADP-ribose) polymerase family member 16 |
[detail] |
0 |
54956 |
| 6.5 |
LETMD1 |
LETM1 domain containing 1 |
[detail] |
1 |
25875 |
| 6.2 |
DYM |
dymeclin |
[detail] |
0 |
54808 |
| 6.1 |
LRRC28 |
leucine rich repeat containing 28 |
[detail] |
0 |
123355 |
|
Coexpressed
gene list |
[Coexpressed gene list for MAP2K5]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
MAP2K5 Gene
