[←][→] rno  Map2k5 Gene
functional annotation
Function   mitogen activated protein kinase kinase 5  
GO BP
GO:0070375 [list] [network] ERK5 cascade  (3 genes)  IMP  
GO:2000342 [list] [network] negative regulation of chemokine (C-X-C motif) ligand 2 production  (4 genes)  IMP  
GO:0034115 [list] [network] negative regulation of heterotypic cell-cell adhesion  (11 genes)  IMP  
GO:0090051 [list] [network] negative regulation of cell migration involved in sprouting angiogenesis  (16 genes)  IMP  
GO:0032717 [list] [network] negative regulation of interleukin-8 production  (17 genes)  IMP  
GO:2001240 [list] [network] negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (36 genes)  IMP  
GO:0060761 [list] [network] negative regulation of response to cytokine stimulus  (64 genes)  IMP  
GO:0032088 [list] [network] negative regulation of NF-kappaB transcription factor activity  (83 genes)  IMP  
GO:0043154 [list] [network] negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (89 genes)  IMP  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (149 genes)  IEA  
GO:0000165 [list] [network] MAPK cascade  (151 genes)  IC ISO  
GO:0030307 [list] [network] positive regulation of cell growth  (194 genes)  IMP  
GO:0050679 [list] [network] positive regulation of epithelial cell proliferation  (221 genes)  IDA  
GO:0071363 [list] [network] cellular response to growth factor stimulus  (567 genes)  IMP  
GO:0007507 [list] [network] heart development  (631 genes)  ISO  
GO:0006468 [list] [network] protein phosphorylation  (680 genes)  IDA  
GO:0000122 [list] [network] negative regulation of transcription by RNA polymerase II  (920 genes)  IMP  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1255 genes)  IMP  
GO:0051247 [list] [network] positive regulation of protein metabolic process  (1490 genes)  IMP  
GO CC
GO:0005819 [list] [network] spindle  (361 genes)  ISO  
GO:0005829 [list] [network] cytosol  (3690 genes)  IDA TAS  
GO:0005634 [list] [network] nucleus  (6599 genes)  IDA  
GO:0016020 [list] [network] membrane  (9382 genes)  IEA  
GO MF
GO:0004708 [list] [network] MAP kinase kinase activity  (14 genes)  IBA IC  
GO:0004714 [list] [network] transmembrane receptor protein tyrosine kinase activity  (110 genes)  IEA  
GO:0106310 [list] [network] protein serine kinase activity  (239 genes)  IEA  
GO:0106311 [list] [network] protein threonine kinase activity  (239 genes)  IEA  
GO:0004672 [list] [network] protein kinase activity  (557 genes)  IDA  
GO:0005524 [list] [network] ATP binding  (1380 genes)  IDA  
GO:0046872 [list] [network] metal ion binding  (3303 genes)  IEA  
KEGG rno04010 [list] [network] MAPK signaling pathway (293 genes)
rno04540 [list] [network] Gap junction (87 genes)
rno04722 [list] [network] Neurotrophin signaling pathway (120 genes)
rno04921 [list] [network] Oxytocin signaling pathway (155 genes)
rno05418 [list] [network] Fluid shear stress and atherosclerosis (151 genes)
Protein NP_001029159.1  NP_058942.1  XP_006243291.1  XP_017450990.1  XP_017450991.1  XP_038936881.1  XP_038936882.1  XP_038936883.1  XP_038936884.1  XP_038936885.1  XP_038936886.1  XP_038936887.1  XP_038936888.1  XP_038936889.1  XP_038936890.1 
BLAST NP_001029159.1  NP_058942.1  XP_006243291.1  XP_017450990.1  XP_017450991.1  XP_038936881.1  XP_038936882.1  XP_038936883.1  XP_038936884.1  XP_038936885.1  XP_038936886.1  XP_038936887.1  XP_038936888.1  XP_038936889.1  XP_038936890.1 
Orthologous [Ortholog page] MAP2K5 (hsa)  Map2k5 (mmu)  MAP2K5 (gga)  MAP2K5 (cfa)  MAP2K5 (mcc)  MKK1 (sce)  map2k5 (dre)  MAP2K5 (fca) 
Subcellular
localization
wolf
cyto 5,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 2  (predict for NP_001029159.1)
cyto 5,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 1,  extr 1,  E.R. 1,  pero 1  (predict for NP_058942.1)
cyto 4,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 2  (predict for XP_006243291.1)
cyto 5,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 1  (predict for XP_017450990.1)
cyto 5,  cysk 4,  lyso 1  (predict for XP_017450991.1)
cyto 4,  cyto_nucl 4,  nucl 3,  E.R._mito 2,  mito 1  (predict for XP_038936881.1)
cyto 4,  cyto_nucl 4,  nucl 3,  cyto_pero 3,  E.R._mito 2,  mito 1  (predict for XP_038936882.1)
cyto_nucl 4,  cyto 4,  nucl 3,  E.R._mito 2,  mito 1  (predict for XP_038936883.1)
cyto 4,  cyto_nucl 4,  nucl 3,  E.R._mito 2,  mito 1  (predict for XP_038936884.1)
cyto 5,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 1  (predict for XP_038936885.1)
cyto 5,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 1  (predict for XP_038936886.1)
cyto 4,  cyto_nucl 4,  nucl 2,  E.R._mito 2,  mito 1,  pero 1,  cysk 1  (predict for XP_038936887.1)
cyto 4,  cysk 3,  nucl 2,  cyto_plas 2,  cyto_golg 2  (predict for XP_038936888.1)
cyto 4,  cyto_nucl 4,  nucl 3,  E.R._mito 2,  mito 1  (predict for XP_038936889.1)
cyto 4,  cyto_nucl 4,  nucl 3,  E.R._mito 2,  mito 1  (predict for XP_038936890.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04722 Neurotrophin signaling pathway 2
rno00562 Inositol phosphate metabolism 2
rno04070 Phosphatidylinositol signaling system 2
rno04613 Neutrophil extracellular trap formation 2
rno05022 Pathways of neurodegeneration - multiple diseases 2
Genes directly connected with Map2k5 on the network
coex z* Locus Function* Coexpression
detail		 Entrez Gene ID*
7.1 Gtf2i general transcription factor II I [detail] 353256
5.7 Smyd3 SET and MYND domain containing 3 [detail] 498295
5.6 Bcas3 BCAS3, microtubule associated cell migration factor [detail] 363662
Coexpressed
gene list		 [Coexpressed gene list for Map2k5]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 29568      
Refseq ID (protein) NP_001029159.1 
NP_058942.1 
XP_006243291.1 
XP_017450990.1 
XP_017450991.1 
XP_038936881.1 
XP_038936882.1 
XP_038936883.1 
XP_038936884.1 
XP_038936885.1 
XP_038936886.1 
XP_038936887.1 
XP_038936888.1 
XP_038936889.1 
XP_038936890.1 


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