[←][→] hsa  HTR2C Gene
functional annotation
Function   5-hydroxytryptamine receptor 2C  
GO BP
GO:0007208 [list] [network] phospholipase C-activating serotonin receptor signaling pathway  (3 genes)  IDA ISS  
GO:0010513 [list] [network] positive regulation of phosphatidylinositol biosynthetic process  (3 genes)  IDA  
GO:0043397 [list] [network] regulation of corticotropin-releasing hormone secretion  (3 genes)  ISS  
GO:0019934 [list] [network] cGMP-mediated signaling  (22 genes)  IDA  
GO:0032098 [list] [network] regulation of appetite  (22 genes)  ISS  
GO:0001662 [list] [network] behavioral fear response  (27 genes)  ISS  
GO:0051482 [list] [network] positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (34 genes)  ISS  
GO:0098664 [list] [network] G protein-coupled serotonin receptor signaling pathway  (34 genes)  IDA  
GO:0051209 [list] [network] release of sequestered calcium ion into cytosol  (44 genes)  IBA IMP  
GO:0045600 [list] [network] positive regulation of fat cell differentiation  (66 genes)  IEA  
GO:0007187 [list] [network] G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (67 genes)  IBA  
GO:0007631 [list] [network] feeding behavior  (81 genes)  ISS  
GO:0007200 [list] [network] phospholipase C-activating G protein-coupled receptor signaling pathway  (99 genes)  IBA  
GO:0031644 [list] [network] regulation of nervous system process  (144 genes)  ISS  
GO:0007626 [list] [network] locomotory behavior  (174 genes)  IEA  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (217 genes)  IDA  
GO:0042493 [list] [network] response to drug  (385 genes)  IBA  
GO:0007268 [list] [network] chemical synaptic transmission  (415 genes)  IBA  
GO:0006874 [list] [network] cellular calcium ion homeostasis  (420 genes)  IDA  
GO:0007186 [list] [network] G protein-coupled receptor signaling pathway  (1290 genes)  TAS  
GO CC
GO:0098666 [list] [network] G protein-coupled serotonin receptor complex  (4 genes)  IDA  
GO:0030425 [list] [network] dendrite  (635 genes)  IBA  
GO:0045202 [list] [network] synapse  (1341 genes)  IEA  
GO:0005887 [list] [network] integral component of plasma membrane  (1649 genes)  IBA IMP  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IDA TAS  
GO MF
GO:0071886 [list] [network] 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  (2 genes)  IDA  
GO:0001587 [list] [network] Gq/11-coupled serotonin receptor activity  (3 genes)  IDA  
GO:0051378 [list] [network] serotonin binding  (12 genes)  IDA  
GO:0004993 [list] [network] G protein-coupled serotonin receptor activity  (34 genes)  IBA IDA  
GO:0030594 [list] [network] neurotransmitter receptor activity  (111 genes)  IBA  
GO:0042802 [list] [network] identical protein binding  (1971 genes)  IPI  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa04020 [list] [network] Calcium signaling pathway (240 genes)
hsa04080 [list] [network] Neuroactive ligand-receptor interaction (353 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa04726 [list] [network] Serotonergic synapse (115 genes)
hsa04750 [list] [network] Inflammatory mediator regulation of TRP channels (98 genes)
Protein NP_000859.2  NP_001243689.2  NP_001243690.2 
BLAST NP_000859.2  NP_001243689.2  NP_001243690.2 
Orthologous [Ortholog page] HTR2A (hsa)  HTR2B (hsa)  Htr2a (mmu)  Htr2b (mmu)  Htr2c (mmu)  Htr2c (rno)  Htr2b (rno)  Htr2a (rno)  5-HT2A (dme)  5-HT2B (dme)  ser-1 (cel)  HTR2B (gga)  HTR2B (cfa)  HTR2A (cfa)  HTR2A (gga)  HTR2C (gga)  HTR2C (cfa)  htr2ab (dre)  htr2aa (dre)  HTR2A (mcc)  HTR2C (mcc)  HTR2B (mcc)  htr2b (dre)  htr2cl2 (dre)  dic1 (spo)  htr2cl1 (dre)  HTR2A (fca)  HTR2B (fca)  HTR2C (fca) 
Subcellular
localization
wolf
plas 10  (predict for NP_000859.2)
plas 10  (predict for NP_001243689.2)
plas 10  (predict for NP_001243690.2)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04080 Neuroactive ligand-receptor interaction 7
hsa04723 Retrograde endocannabinoid signaling 5
hsa04727 GABAergic synapse 5
hsa05032 Morphine addiction 5
hsa05033 Nicotine addiction 4
Genes directly connected with HTR2C on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
8.7 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 [detail] 0 2566
7.5 LOC102723546 uncharacterized LOC102723546 [detail] 0 102723546
7.2 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 [detail] 0 80070
5.5 IRS4 insulin receptor substrate 4 [detail] 0 8471
4.4 OPRK1 opioid receptor kappa 1 [detail] 0 4986
Coexpressed
gene list		 [Coexpressed gene list for HTR2C]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 3358      
Refseq ID (protein) NP_000859.2 
NP_001243689.2 
NP_001243690.2 


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