functional annotation |
Function |
cyclin-dependent kinase inhibitor 1A (P21) |
|
GO BP |
GO:1905179 [list] [network] negative regulation of cardiac muscle tissue regeneration
|
(2 genes)
|
IMP
|
|
GO:0071493 [list] [network] cellular response to UV-B
|
(8 genes)
|
IDA
|
|
GO:0006977 [list] [network] DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
|
(13 genes)
|
ISO
|
|
GO:0006978 [list] [network] DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
|
(14 genes)
|
IDA
|
|
GO:0045736 [list] [network] negative regulation of cyclin-dependent protein serine/threonine kinase activity
|
(25 genes)
|
IDA
|
|
GO:1904030 [list] [network] negative regulation of cyclin-dependent protein kinase activity
|
(27 genes)
|
ISO
|
|
GO:0071480 [list] [network] cellular response to gamma radiation
|
(28 genes)
|
IDA
|
|
GO:1904706 [list] [network] negative regulation of vascular associated smooth muscle cell proliferation
|
(28 genes)
|
ISO
|
|
GO:0090398 [list] [network] cellular senescence
|
(31 genes)
|
ISO
|
|
GO:0042771 [list] [network] intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
(32 genes)
|
IMP
|
|
GO:0007095 [list] [network] mitotic G2 DNA damage checkpoint signaling
|
(37 genes)
|
ISO
|
|
GO:2000279 [list] [network] negative regulation of DNA biosynthetic process
|
(41 genes)
|
ISO
|
|
GO:0034198 [list] [network] cellular response to amino acid starvation
|
(45 genes)
|
IMP
ISO
|
|
GO:0000086 [list] [network] G2/M transition of mitotic cell cycle
|
(46 genes)
|
ISO
|
|
GO:0030890 [list] [network] positive regulation of B cell proliferation
|
(46 genes)
|
IGI
|
|
GO:0042246 [list] [network] tissue regeneration
|
(56 genes)
|
IMP
|
|
GO:0071479 [list] [network] cellular response to ionizing radiation
|
(68 genes)
|
ISO
|
|
GO:0048146 [list] [network] positive regulation of fibroblast proliferation
|
(70 genes)
|
ISO
|
|
GO:2000134 [list] [network] negative regulation of G1/S transition of mitotic cell cycle
|
(70 genes)
|
ISO
|
|
GO:0000079 [list] [network] regulation of cyclin-dependent protein serine/threonine kinase activity
|
(73 genes)
|
IMP
|
|
GO:0000082 [list] [network] G1/S transition of mitotic cell cycle
|
(75 genes)
|
ISO
|
|
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process
|
(77 genes)
|
ISO
|
|
GO:0072331 [list] [network] signal transduction by p53 class mediator
|
(82 genes)
|
IEA
|
|
GO:0032091 [list] [network] negative regulation of protein binding
|
(98 genes)
|
ISO
|
|
GO:0006606 [list] [network] protein import into nucleus
|
(103 genes)
|
IMP
|
|
GO:2000278 [list] [network] regulation of DNA biosynthetic process
|
(118 genes)
|
IMP
|
|
GO:0009411 [list] [network] response to UV
|
(149 genes)
|
IMP
|
|
GO:1902806 [list] [network] regulation of cell cycle G1/S phase transition
|
(149 genes)
|
ISO
|
|
GO:0030308 [list] [network] negative regulation of cell growth
|
(204 genes)
|
ISO
|
|
GO:0031668 [list] [network] cellular response to extracellular stimulus
|
(220 genes)
|
ISO
|
|
GO:0042060 [list] [network] wound healing
|
(252 genes)
|
IMP
|
|
GO:0045860 [list] [network] positive regulation of protein kinase activity
|
(357 genes)
|
ISO
|
|
GO:0042326 [list] [network] negative regulation of phosphorylation
|
(394 genes)
|
ISO
|
|
GO:0007346 [list] [network] regulation of mitotic cell cycle
|
(460 genes)
|
IDA
IMP
|
|
GO:0007507 [list] [network] heart development
|
(585 genes)
|
IMP
|
|
GO:0043068 [list] [network] positive regulation of programmed cell death
|
(613 genes)
|
IMP
|
|
GO:0010942 [list] [network] positive regulation of cell death
|
(685 genes)
|
ISO
|
|
GO:0006974 [list] [network] cellular response to DNA damage stimulus
|
(691 genes)
|
IMP
ISO
|
|
GO:0008285 [list] [network] negative regulation of cell population proliferation
|
(764 genes)
|
IMP
ISO
|
|
GO:0043066 [list] [network] negative regulation of apoptotic process
|
(968 genes)
|
ISO
|
|
GO:0051726 [list] [network] regulation of cell cycle
|
(1007 genes)
|
IDA
IMP
ISO
|
|
GO:0010629 [list] [network] negative regulation of gene expression
|
(1078 genes)
|
IMP
|
|
GO:0007049 [list] [network] cell cycle
|
(1198 genes)
|
IEA
|
|
|
GO CC |
|
GO MF |
GO:0019912 [list] [network] cyclin-dependent protein kinase activating kinase activity
|
(1 genes)
|
ISO
|
|
GO:0140311 [list] [network] protein sequestering activity
|
(6 genes)
|
ISO
|
|
GO:0004861 [list] [network] cyclin-dependent protein serine/threonine kinase inhibitor activity
|
(12 genes)
|
IDA
|
|
GO:0030332 [list] [network] cyclin binding
|
(34 genes)
|
IDA
|
|
GO:0004860 [list] [network] protein kinase inhibitor activity
|
(62 genes)
|
ISO
|
|
GO:0031625 [list] [network] ubiquitin protein ligase binding
|
(316 genes)
|
ISO
|
|
GO:0019901 [list] [network] protein kinase binding
|
(774 genes)
|
ISO
|
|
GO:0044877 [list] [network] protein-containing complex binding
|
(1549 genes)
|
ISO
|
|
GO:0046872 [list] [network] metal ion binding
|
(3573 genes)
|
IEA
|
|
GO:0005515 [list] [network] protein binding
|
(9507 genes)
|
IPI
|
|
|
KEGG |
mmu01522 [list] [network] Endocrine resistance (93 genes) |
|
mmu01524 [list] [network] Platinum drug resistance (80 genes) |
|
mmu04012 [list] [network] ErbB signaling pathway (84 genes) |
|
mmu04066 [list] [network] HIF-1 signaling pathway (114 genes) |
|
mmu04068 [list] [network] FoxO signaling pathway (131 genes) |
|
mmu04110 [list] [network] Cell cycle (125 genes) |
|
mmu04115 [list] [network] p53 signaling pathway (72 genes) |
|
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes) |
|
mmu04218 [list] [network] Cellular senescence (184 genes) |
|
mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes) |
|
mmu04921 [list] [network] Oxytocin signaling pathway (153 genes) |
|
mmu04928 [list] [network] Parathyroid hormone synthesis, secretion and action (108 genes) |
|
mmu04934 [list] [network] Cushing syndrome (162 genes) |
|
mmu05160 [list] [network] Hepatitis C (165 genes) |
|
mmu05161 [list] [network] Hepatitis B (163 genes) |
|
mmu05163 [list] [network] Human cytomegalovirus infection (256 genes) |
|
mmu05165 [list] [network] Human papillomavirus infection (362 genes) |
|
mmu05166 [list] [network] Human T-cell leukemia virus 1 infection (250 genes) |
|
mmu05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (224 genes) |
|
mmu05169 [list] [network] Epstein-Barr virus infection (231 genes) |
|
mmu05200 [list] [network] Pathways in cancer (543 genes) |
|
mmu05202 [list] [network] Transcriptional misregulation in cancer (223 genes) |
|
mmu05203 [list] [network] Viral carcinogenesis (229 genes) |
|
mmu05205 [list] [network] Proteoglycans in cancer (205 genes) |
|
mmu05206 [list] [network] MicroRNAs in cancer (303 genes) |
|
mmu05210 [list] [network] Colorectal cancer (88 genes) |
|
mmu05211 [list] [network] Renal cell carcinoma (68 genes) |
|
mmu05212 [list] [network] Pancreatic cancer (76 genes) |
|
mmu05213 [list] [network] Endometrial cancer (58 genes) |
|
mmu05214 [list] [network] Glioma (74 genes) |
|
mmu05215 [list] [network] Prostate cancer (99 genes) |
|
mmu05216 [list] [network] Thyroid cancer (37 genes) |
|
mmu05217 [list] [network] Basal cell carcinoma (63 genes) |
|
mmu05218 [list] [network] Melanoma (72 genes) |
|
mmu05219 [list] [network] Bladder cancer (41 genes) |
|
mmu05220 [list] [network] Chronic myeloid leukemia (76 genes) |
|
mmu05222 [list] [network] Small cell lung cancer (93 genes) |
|
mmu05223 [list] [network] Non-small cell lung cancer (72 genes) |
|
mmu05224 [list] [network] Breast cancer (147 genes) |
|
mmu05225 [list] [network] Hepatocellular carcinoma (174 genes) |
|
mmu05226 [list] [network] Gastric cancer (150 genes) |
|
Protein |
NP_001104569.1
NP_031695.1
|
BLAST |
NP_001104569.1
NP_031695.1
|
Orthologous |
[Ortholog page]
CDKN1A (hsa)
Cdkn1a (rno)
CDKN1A (gga)
CDKN1A (cfa)
CDKN1A (fca)
CDKN1A (mcc)
cdkn1a (dre)
|
Subcellular localization wolf |
nucl 8,
cyto_nucl 5,
cyto 1
|
(predict for NP_001104569.1)
|
nucl 8,
cyto_nucl 5,
cyto 1
|
(predict for NP_031695.1)
|
|
Gene coexpression |
Network*for coexpressed genes |
KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
mmu04115 |
p53 signaling pathway |
7 |
|
mmu05166 |
Human T-cell leukemia virus 1 infection |
5 |
|
mmu05200 |
Pathways in cancer |
5 |
|
mmu05203 |
Viral carcinogenesis |
5 |
|
mmu01524 |
Platinum drug resistance |
4 |
|
Genes directly connected with Cdkn1a on the network
coex z* |
Locus |
Function* |
Coexpression detail |
CoexPub |
Entrez Gene ID* |
8.2 |
Phlda3 |
pleckstrin homology like domain, family A, member 3 |
[detail] |
17 |
27280 |
6.9 |
Eda2r |
ectodysplasin A2 receptor |
[detail] |
5 |
245527 |
6.5 |
Ddit4 |
DNA-damage-inducible transcript 4 |
[detail] |
0 |
74747 |
5.0 |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
[detail] |
0 |
58801 |
3.8 |
Cdkn2b |
cyclin dependent kinase inhibitor 2B |
[detail] |
0 |
12579 |
|
Coexpressed gene list |
[Coexpressed gene list for Cdkn1a]
|
Gene expression |
All samples |
[Expression pattern for all samples]
|
Tissue specificity* |
|