Publication for Cdkn1a and Phlda3

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	12575			[link]
mmu	Phlda3	pleckstrin homology like domain, family A, member 3	27280

Pubmed ID	Priority	Text
29351057	0.98	Cdkn1a (up 18-fold), Mdm2 (up 2.8-fold) and Phlda3 (up 6.5-fold).
	0.98	Cdkn1a, Aen, Phlda3, Bbc3 and Mdm2.
	0.97	Cdkn1a and Phlda3, were upregulated, although to a lesser degree, in SCID mice
	0.88	Cdkn1a and Phlda3 were upregulated 7.8-fold and 3.4-fold, respectively, in SCID) and involved fewer genes overall.
30605667	0.98	Phlda3, and Cdkn1a, were found among the upregulated transcripts in Bmi1-/- pro-B cells (Figure 4A; Table S1).
	0.98	Phlda3, and Cdkn1a, in Bmi1-/- pro-B cells from independent animals (Figure 4B).
20628553	0.98	p21CIP1 and Phlda3, were upregulated in Hdac3 CKO mice.
22579044	0.98	Cdkn1a/p21, Phlda3, and Trp53inp1, were all targets of the p53 transcriptional activator, a key transducer of ATM/ATR DNA damage signaling.
23085085	0.98	p21CIP1 and Phlda3, were also upregulated in Hdac3 CKOOSX mice, and BMSC exposed to the pan-Hdac inhibitor vorinostat during osteoblastic differentiation demonstrated DNA damage and cell cycle arrest.
31659152	0.98	Cdkn1a and two pro-apoptotic genes Trp53inp1 and PHLDA3 in Ppm1dT/+ confirming that truncated Ppm1d impairs the p53-dependent response of colon ISCs to genotoxic stress (Fig. 3c, Supplementary Fig. S2).
27482301	0.97	Cdkn1a, Gadd45b, Gadd45g, Phlda3, and Mdm2] of 18 genes, which showed statistically significant increases, were associated with cancer, cell cycle, cell death and survival, and cellular growth and proliferation.
	0.96	Cdkn1a, Mdmd2, Btg2, Ccng1, Ddit4, Gdf15, Hist1h1c, Hmox1, Hspb1, Phlda3, Plk2, and Pml] identified in this study have been reported to be directly associated with Trp53.
	0.93	Cdkn1a, Egfr, Gdf15, Hist1h1c, Jun, Lrp1, Mbd1, Mdm2, Phlda3, Plk2, Pml, Ppp1r3c, and Tubb4b (Tubb2c)] at 4 h, and 19 genes [Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Ddit4l, Ephx1, Gadd45b, Gdf15, Lrp1, Ly6a, Mdm2, Phlda3, Plk2, Pmm1, Ppp1r3c, St3gal5, and Tubb4b (Tubb2c)] at 48 h showed a statistical significance between the genotoxic and non-genotoxic hepatocarcinogens, as analyzed by the Welch's test.
	0.54	Cdkn1a, Cyp1a2, Ddit4, Ddit4l, Egfr, Ephx1, Gadd45b, Gdf15, HistH1, Hmox1, Hspb1, Igfbp1, Jun, Lrp1, Ly6a, Mbd1, Mdm2, Phlda3, Plk2, Pml, Pmm1, Ppp1r3c, Psma3, Rad52, Rcan1, St3gal5, Trp53, and Tubb4b (Tubb2c)] showed statistically significant changes in their gene expression, at least once at 4 h and/or 48 h, as computed by the Dunnett's test using the Gapdh gene to normalize the data.
30166543	0.97	Cdkn1a, Sesn2, Ddit4, Pmaip1, Zmat3 and Phlda3), antigen processing and presentation (H2-DMb2, CD74, H2-Aa, H2-Eb1, H2-Q1, H2-T3 and H2-Q6) and T-cell differentiation (Supplementary Data 1).
30770771	0.97	Cdkn1a, Hmox1, Phlda3, and Trp53inp1) are associated with apoptosis and/or stress response (Hspb1, Ephx1)
29746213	0.96	Cdkn1a and Phlda3) and mediators of inflammatory response (Il1b) in the Parp1-/- mice responding to radiation.
31492921	0.96	Cdkn1a (also known as p21) were not affected by Phlda3 inhibition (Fig. 8k,l).
29396430	0.94	p21, PHLDA3, FUCA1, IER5, PLK2, RPRM, PMAIP1 and PTP4A1, Fig. S1C-K).
31046668	0.92	Cdkn1a, Phlda3, Ifitm1 and Ifit3 (Additional file 6) suggests that the relative responses of the Trp53 regulated genes in the two strains are similar at low and high doses.
	0.53	Cdkn1a, Aen, Phlda3, Ccng1, Ifitm1, Ifit3) showing significant difference in expression in Il10-/- mice compared to WT after radiation exposure are presented here.
25162453	0.84	Cdkn1a and Phlda3 also showed the same time-dependent pattern of relative expression evident from the microarray data, with expression rising over the first few days after injection to 25-fold and 4.6-fold by day 3, then dropping to near control levels by day 30 despite continued accumulation of total dose.
28930658	0.83	Phlda3), vitamin-B1/Thiamin homeostasis (Slc19a2), pro-apoptotic/ tumor suppressor (Sesn2, Phlda3, Slc19a2), cell-cycle arrest (Cdkn1a), and negative regulation of p53 activity (Mdm2) (data not shown).
	0.68	Phlda3, and Sesn2) and the 2 p53-dependent ERGs induced by both IR and Lipid A (Mdm2 and Cdkn1a) (Figure 7B; see also Figure 6D).
22610609	0.78	Cdkn1a), growth differentiation factor 15 (Gdf15), carboxylesterase 5 (Ces5), pleckstrin homology-like domain, family A, member 3 (Phlda3), multimerin 2 (Mmrn2), cyclin G1 (Ccng1), serum amyloid A 3 (Saa3), and sestrin 2 (Sesn2) were the most upregulated genes in all the dose groups.
25987256	0.77	Cdkn1a, Ptp4a3, Zmat3, Bax, Ccng1 and Phlda3) in c-Kit-enriched hematopoietic progenitor cells.