[][] mmu  Cdkn1a Gene
functional annotation
Function   cyclin-dependent kinase inhibitor 1A (P21)
GO BP
GO:1905179 [list] [network] negative regulation of cardiac muscle tissue regeneration  (2 genes)  IMP  
GO:0071493 [list] [network] cellular response to UV-B  (8 genes)  IDA  
GO:0006977 [list] [network] DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (13 genes)  ISO  
GO:0006978 [list] [network] DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  (14 genes)  IDA  
GO:0045736 [list] [network] negative regulation of cyclin-dependent protein serine/threonine kinase activity  (25 genes)  IDA  
GO:1904030 [list] [network] negative regulation of cyclin-dependent protein kinase activity  (27 genes)  ISO  
GO:0071480 [list] [network] cellular response to gamma radiation  (28 genes)  IDA  
GO:1904706 [list] [network] negative regulation of vascular associated smooth muscle cell proliferation  (28 genes)  ISO  
GO:0090398 [list] [network] cellular senescence  (31 genes)  ISO  
GO:0042771 [list] [network] intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (32 genes)  IMP  
GO:0007095 [list] [network] mitotic G2 DNA damage checkpoint signaling  (37 genes)  ISO  
GO:2000279 [list] [network] negative regulation of DNA biosynthetic process  (41 genes)  ISO  
GO:0034198 [list] [network] cellular response to amino acid starvation  (45 genes)  IMP ISO  
GO:0000086 [list] [network] G2/M transition of mitotic cell cycle  (46 genes)  ISO  
GO:0030890 [list] [network] positive regulation of B cell proliferation  (46 genes)  IGI  
GO:0042246 [list] [network] tissue regeneration  (56 genes)  IMP  
GO:0071479 [list] [network] cellular response to ionizing radiation  (68 genes)  ISO  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (70 genes)  ISO  
GO:2000134 [list] [network] negative regulation of G1/S transition of mitotic cell cycle  (70 genes)  ISO  
GO:0000079 [list] [network] regulation of cyclin-dependent protein serine/threonine kinase activity  (73 genes)  IMP  
GO:0000082 [list] [network] G1/S transition of mitotic cell cycle  (75 genes)  ISO  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (77 genes)  ISO  
GO:0072331 [list] [network] signal transduction by p53 class mediator  (82 genes)  IEA  
GO:0032091 [list] [network] negative regulation of protein binding  (98 genes)  ISO  
GO:0006606 [list] [network] protein import into nucleus  (103 genes)  IMP  
GO:2000278 [list] [network] regulation of DNA biosynthetic process  (118 genes)  IMP  
GO:0009411 [list] [network] response to UV  (149 genes)  IMP  
GO:1902806 [list] [network] regulation of cell cycle G1/S phase transition  (149 genes)  ISO  
GO:0030308 [list] [network] negative regulation of cell growth  (204 genes)  ISO  
GO:0031668 [list] [network] cellular response to extracellular stimulus  (220 genes)  ISO  
GO:0042060 [list] [network] wound healing  (252 genes)  IMP  
GO:0045860 [list] [network] positive regulation of protein kinase activity  (357 genes)  ISO  
GO:0042326 [list] [network] negative regulation of phosphorylation  (394 genes)  ISO  
GO:0007346 [list] [network] regulation of mitotic cell cycle  (460 genes)  IDA IMP  
GO:0007507 [list] [network] heart development  (585 genes)  IMP  
GO:0043068 [list] [network] positive regulation of programmed cell death  (613 genes)  IMP  
GO:0010942 [list] [network] positive regulation of cell death  (685 genes)  ISO  
GO:0006974 [list] [network] cellular response to DNA damage stimulus  (691 genes)  IMP ISO  
GO:0008285 [list] [network] negative regulation of cell population proliferation  (764 genes)  IMP ISO  
GO:0043066 [list] [network] negative regulation of apoptotic process  (968 genes)  ISO  
GO:0051726 [list] [network] regulation of cell cycle  (1007 genes)  IDA IMP ISO  
GO:0010629 [list] [network] negative regulation of gene expression  (1078 genes)  IMP  
GO:0007049 [list] [network] cell cycle  (1198 genes)  IEA  
GO CC
GO:0070557 [list] [network] PCNA-p21 complex  (2 genes)  ISO  
GO:0000307 [list] [network] cyclin-dependent protein kinase holoenzyme complex  (43 genes)  IPI ISO  
GO:0048471 [list] [network] perinuclear region of cytoplasm  (687 genes)  ISO  
GO:0016604 [list] [network] nuclear body  (732 genes)  ISO  
GO:0005730 [list] [network] nucleolus  (895 genes)  ISO  
GO:0005654 [list] [network] nucleoplasm  (3580 genes)  ISO  
GO:0005829 [list] [network] cytosol  (3785 genes)  IDA  
GO:0032991 [list] [network] protein-containing complex  (5540 genes)  ISO  
GO:0005634 [list] [network] nucleus  (7226 genes)  IDA ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IDA ISO  
GO MF
GO:0019912 [list] [network] cyclin-dependent protein kinase activating kinase activity  (1 genes)  ISO  
GO:0140311 [list] [network] protein sequestering activity  (6 genes)  ISO  
GO:0004861 [list] [network] cyclin-dependent protein serine/threonine kinase inhibitor activity  (12 genes)  IDA  
GO:0030332 [list] [network] cyclin binding  (34 genes)  IDA  
GO:0004860 [list] [network] protein kinase inhibitor activity  (62 genes)  ISO  
GO:0031625 [list] [network] ubiquitin protein ligase binding  (316 genes)  ISO  
GO:0019901 [list] [network] protein kinase binding  (774 genes)  ISO  
GO:0044877 [list] [network] protein-containing complex binding  (1549 genes)  ISO  
GO:0046872 [list] [network] metal ion binding  (3573 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu01522 [list] [network] Endocrine resistance (93 genes)
mmu01524 [list] [network] Platinum drug resistance (80 genes)
mmu04012 [list] [network] ErbB signaling pathway (84 genes)
mmu04066 [list] [network] HIF-1 signaling pathway (114 genes)
mmu04068 [list] [network] FoxO signaling pathway (131 genes)
mmu04110 [list] [network] Cell cycle (125 genes)
mmu04115 [list] [network] p53 signaling pathway (72 genes)
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes)
mmu04218 [list] [network] Cellular senescence (184 genes)
mmu04630 [list] [network] JAK-STAT signaling pathway (168 genes)
mmu04921 [list] [network] Oxytocin signaling pathway (153 genes)
mmu04928 [list] [network] Parathyroid hormone synthesis, secretion and action (108 genes)
mmu04934 [list] [network] Cushing syndrome (162 genes)
mmu05160 [list] [network] Hepatitis C (165 genes)
mmu05161 [list] [network] Hepatitis B (163 genes)
mmu05163 [list] [network] Human cytomegalovirus infection (256 genes)
mmu05165 [list] [network] Human papillomavirus infection (362 genes)
mmu05166 [list] [network] Human T-cell leukemia virus 1 infection (250 genes)
mmu05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (224 genes)
mmu05169 [list] [network] Epstein-Barr virus infection (231 genes)
mmu05200 [list] [network] Pathways in cancer (543 genes)
mmu05202 [list] [network] Transcriptional misregulation in cancer (223 genes)
mmu05203 [list] [network] Viral carcinogenesis (229 genes)
mmu05205 [list] [network] Proteoglycans in cancer (205 genes)
mmu05206 [list] [network] MicroRNAs in cancer (303 genes)
mmu05210 [list] [network] Colorectal cancer (88 genes)
mmu05211 [list] [network] Renal cell carcinoma (68 genes)
mmu05212 [list] [network] Pancreatic cancer (76 genes)
mmu05213 [list] [network] Endometrial cancer (58 genes)
mmu05214 [list] [network] Glioma (74 genes)
mmu05215 [list] [network] Prostate cancer (99 genes)
mmu05216 [list] [network] Thyroid cancer (37 genes)
mmu05217 [list] [network] Basal cell carcinoma (63 genes)
mmu05218 [list] [network] Melanoma (72 genes)
mmu05219 [list] [network] Bladder cancer (41 genes)
mmu05220 [list] [network] Chronic myeloid leukemia (76 genes)
mmu05222 [list] [network] Small cell lung cancer (93 genes)
mmu05223 [list] [network] Non-small cell lung cancer (72 genes)
mmu05224 [list] [network] Breast cancer (147 genes)
mmu05225 [list] [network] Hepatocellular carcinoma (174 genes)
mmu05226 [list] [network] Gastric cancer (150 genes)
Protein NP_001104569.1  NP_031695.1 
BLAST NP_001104569.1  NP_031695.1 
Orthologous [Ortholog page] CDKN1A (hsa)Cdkn1a (rno)CDKN1A (gga)CDKN1A (cfa)CDKN1A (fca)CDKN1A (mcc)cdkn1a (dre)
Subcellular
localization
wolf
nucl 8,  cyto_nucl 5,  cyto 1  (predict for NP_001104569.1)
nucl 8,  cyto_nucl 5,  cyto 1  (predict for NP_031695.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04115 p53 signaling pathway 7
mmu05166 Human T-cell leukemia virus 1 infection 5
mmu05200 Pathways in cancer 5
mmu05203 Viral carcinogenesis 5
mmu01524 Platinum drug resistance 4
Genes directly connected with Cdkn1a on the network
coex z* Locus Function* Coexpression
detail
CoexPub Entrez Gene ID*
8.2 Phlda3 pleckstrin homology like domain, family A, member 3 [detail] 17 27280
6.9 Eda2r ectodysplasin A2 receptor [detail] 5 245527
6.5 Ddit4 DNA-damage-inducible transcript 4 [detail] 0 74747
5.0 Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 [detail] 0 58801
3.8 Cdkn2b cyclin dependent kinase inhibitor 2B [detail] 0 12579
Coexpressed
gene list
[Coexpressed gene list for Cdkn1a]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 12575    
Refseq ID (protein) NP_001104569.1 
NP_031695.1 


The preparation time of this page was 0.7 [sec].