Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-u.4  RYR2  ryanodine receptor 2 
 hsa-r.6  RYR2  ryanodine receptor 2 
 hsa-m.7  RYR2  ryanodine receptor 2 
 hsa-m2.4  RYR2  ryanodine receptor 2 
 hsa-u.4  RYR3  ryanodine receptor 3 
 hsa-u.4  RYR1  ryanodine receptor 1 
 mcc-u.3  RYR3  ryanodine receptor 3 
 mcc-u.3  RYR1  ryanodine receptor 1 
 mcc-u.3  RYR2  ryanodine receptor 2 
 mmu-u.4  Ryr3  ryanodine receptor 3 
 mmu-u.4  Ryr2  ryanodine receptor 2, cardiac 
 mmu-u.4  Ryr1  ryanodine receptor 1, skeletal muscle 
 rno-u.3  Ryr2  ryanodine receptor 2 
 rno-u.3  Ryr3  ryanodine receptor 3 
 rno-u.3  Ryr1  ryanodine receptor 1 
 cfa-u.3  RYR3  ryanodine receptor 3 
 cfa-u.3  RYR1  ryanodine receptor 1 
 cfa-u.3  RYR2  ryanodine receptor 2 
 gga-u.3  101748756  ryanodine receptor 1-like 
 gga-u.3  RYR2  ryanodine receptor 2 
 gga-u.3  RYR3  ryanodine receptor 3 
 dre-u.3  ryr2a  ryanodine receptor 2a (cardiac) 
 dre-u.3  ryr1a  ryanodine receptor 1a (skeletal) 
 dme-u.3  RyR  Ryanodine receptor 
 cel-u.3  unc-68  Uncharacterized protein 

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Top 50 coexpressed genes to RYR2 (hsa-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa4080   Neuroactive ligand-receptor interaction  5 189 3.60
 hsa4260   Cardiac muscle contraction  4 66 4.34
 hsa4261   Adrenergic signaling in cardiomyocytes  4 126 3.26
 hsa4024   cAMP signaling pathway  4 170 2.78
 hsa4020   Calcium signaling pathway  4 191 2.59

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hsa:RYR2 (ryanodine receptor 2) External Links;


Show/Hide Columns:          
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID
Other ID CoexPub LINK Target Reference

hsa-u.4
for
RYR2


hsa-r.6
for
RYR2


hsa-m.7
for
RYR2


hsa-m2.4
for
RYR2


hsa-u.4
for
RYR3


hsa-u.4
for
RYR1


mcc-u.3
for
RYR3


mcc-u.3
for
RYR1


mcc-u.3
for
RYR2


mmu-u.4
for
Ryr3


mmu-u.4
for
Ryr2


mmu-u.4
for
Ryr1


rno-u.3
for
Ryr2


rno-u.3
for
Ryr3


rno-u.3
for
Ryr1


cfa-u.3
for
RYR3


cfa-u.3
for
RYR1


cfa-u.3
for
RYR2


gga-u.3
for
101748756


gga-u.3
for
RYR2


gga-u.3
for
RYR3


dre-u.3
for
ryr2a


dre-u.3
for
ryr1a


dme-u.3
for
RyR


cel-u.3
for
unc-68

1 ACTN2 actinin alpha 2 88 0 4.9 5.0
2.7
3.5
3.2
0.7
7.0
4.7
1.0
0.0
4.1
1.3
2.1
0.4
3.1
0.3
2.4
-0.1
7.2
6.8
2.0
-0.5
2.8
1.9
7.8
4.3
0.5
0.1
2.3
2.2
2.1
1.0
1.6
1.3
2.4
0.1
4.1
-1.1
1.6
1.5
6.2
4.9
4.1
4.8
2 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2903 0 4.8 3.6
2.9
4.8
3.7
3.3
2.6
1.7
2.0
1.7
1.6
0.9
1.7
0.5
4.4
3.5
4.2
3.1
1.2
0.9
4.3
3.6
2.0
0.9
2.1
0.4
0.7
-0.6
1.5
0.5
1.1
-0.9
1.5
1.5
1.9
-0.5
1.1
-0.2
3.3
3.1
2.4
1.9
1.1
0.0
3 CACNA1C calcium voltage-gated channel subunit alpha1 C 775 0 4.8 3.3
2.0
5.1
2.7
2.6
8.6
4.4
2.6
2.3
4.0
2.5
2.0
1.5
4.3
3.7
4.6
4.5
9.5
1.7
4.5
3.4
2.8
2.5
7.0
1.3
2.6
0.9
2.9
1.9
1.1
0.8
2.7
1.7
4.5
2.1
3.3
1.3
3.2
2.9
6.4
4.5
9.7
2.2
7.2
6.7
4 RYR3 ryanodine receptor 3 6263 0 4.7 3.6
1.9
4.7
4.7
2.6
2.6
1.0
0.9
0.6
1.7
0.9
1.7
0.6
5.2
2.5
5.2
0.6
2.5
0.6
2.1
-0.4
2.2
2.1
2.2
-0.4
1.1
1.0
1.0
-0.2
1.1
-0.2
3.6
-1.5
2.2
-1.5
3.6
2.2
2.3
1.4
4.6
3.3


5 PPFIA2 PTPRF interacting protein alpha 2 8499 0 4.6 4.1
1.5
4.0
2.1
1.7
2.7
0.2
1.0
0.2
2.2
0.6
2.1
1.3
3.0
2.9
3.5
2.3
3.8
-0.1
2.1
1.1
2.4
1.0
2.5
1.1
0.8
0.1
1.8
-0.1
2.1
0.7
2.1
1.1
2.2
0.5
2.5
0.1
3.1
2.2
1.9
1.4
0.4
4.9
6 MYOCD myocardin 93649 0 4.5 3.8
1.7
4.0
2.4
-0.5



1.9
5.5
-2.1
2.2
-0.2
-1.1
0.6
1.1
0.6
0.9
1.4
0.8
0.5
-1.3
1.4
0.5
1.3

7 CADPS calcium dependent secretion activator 8618 0 4.4 3.4
1.7
4.4
3.1
0.4
0.2
-0.9
1.0
0.7
2.1
-0.2
1.6
1.6
2.3
-0.2
2.8
1.8
-1.3
-1.3
2.2
0.6
0.9
-0.2
0.2
-1.5
-0.2
-0.3
0.5
0.5
0.6
0.5
0.5
0.3
1.6
0.5
0.2
-1.2
3.4
2.0
2.9
1.2
1.1

8 CDH8 cadherin 8 1006 0 4.4 3.5
2.3
4.3
2.2
0.1
2.7
-0.3
0.8



1.2
0.6
-0.0






1.4
-0.4


9 SORCS1 sortilin related VPS10 domain containing receptor 1 114815 0 4.4 3.0
1.8
4.7
3.9
2.3
1.2
-0.6
2.2
3.6
1.2
-0.5
0.5
0.8
0.4
1.1
-0.4
0.9
0.3
-0.9
-0.6
3.1
2.4


10 HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 348980 0 4.4 4.1
2.7
3.5
2.0
3.2
1.0
0.9
1.2
1.2
4.3
-0.3
1.5
0.3
-1.0



0.4
0.3
-0.3
2.4
-0.0


11 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 345557 0 4.3 3.7
2.1
3.9
1.5
-0.1
1.3
1.3
-0.7
1.0
0.3
0.5
-0.0
1.2
0.8
2.8
-0.3
0.9
-0.5
1.4
0.5
-0.2
-1.5
0.3
-0.2
0.7
0.5
0.9
0.8
0.4
-1.6
0.7
-0.1
2.6
-0.2
1.4
-1.2
1.0
1.0
1.8
-0.1
-0.8
-0.9
12 LOC107984131 uncharacterized LOC107984131 107984131 0 4.3 4.4























13 CNTNAP4 contactin associated protein family member 4 85445 0 4.3 3.8
1.5
3.7
4.0
3.1
0.3
0.3
2.0
1.0
1.4
1.3
1.8
1.5
4.2
3.7
2.9
2.0
1.2
0.9
2.5
2.2
1.1
0.7
1.5
0.7
1.6
0.8
0.4
0.4
1.9
0.5
0.5
0.5
1.5
1.4
1.0
1.0
2.8
2.4
1.4
1.4
1.3
0.1
4.3
1.6
14 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 783 0 4.2 2.3
2.6
5.1
2.0
0.4
2.4
0.3
1.3
1.2
1.1
0.7
2.8
2.3
3.0
2.2
4.1
3.0
3.9
0.6
1.6
0.3
3.7
1.7
4.6
0.5
1.0
0.4
1.7
0.5
1.4
1.4
4.8
2.3
4.4
2.2
1.2
1.1
2.2
1.7
2.3
0.2
4.6
2.7
15 GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 64409 0 4.2 4.4
2.1
3.0
3.2
3.4
1.7
1.2
1.9
2.7
1.2
1.6
1.5
0.8
-0.0
0.6
0.9
-0.4
0.9
-0.4
-1.7
2.3
0.3


16 SPHKAP SPHK1 interactor, AKAP domain containing 80309 0 4.2 3.6
1.5
3.7
2.3
-0.1
0.3
0.1
0.7
3.4
6.5
-0.1
4.3
1.9
-1.2
1.8
-0.1
0.4
0.3
3.1
1.3
2.1
-0.2


17 CNTN4 contactin 4 152330 0 4.1 2.7
1.9
4.5
3.2
0.5
-0.7
-0.8
2.4
1.6
1.1
-0.2
0.9
0.6
3.0
2.5
4.0
2.9
0.1
-0.4
1.0
0.7
-0.3
-0.6
0.2
-0.2
0.5
-0.2
0.9
0.4
1.1
0.7
0.4
0.4
3.0
1.5
1.5
1.2
4.7
3.8
1.4
1.1
-0.2
4.6
18 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 55799 0 4.1 2.1
1.4
5.1
1.9
-0.4
1.5
0.9
1.2
0.2
0.7
-0.6
1.2
-1.5
5.4
-0.4
3.4
-0.4
0.5
0.1
1.0
4.7
0.9
2.2
0.5
1.6
0.3
0.3
1.5
-0.7
1.9
-1.3
2.9
0.3
1.3
0.6
6.1
2.9
4.4
19 XKR4 XK related 4 114786 0 4.1 4.2
1.4
3.0
3.2
-0.0
3.2
2.8
1.9
0.0
1.7
1.2
0.8
0.8



2.0
1.4
1.2
1.1
1.6
-0.4
-1.2
1.3
1.3
0.9
0.5
3.4
1.9
2.1
1.4
2.0
0.1
-0.2
-0.4
-1.5
0.7
20 RUNX1T1 RUNX1 partner transcriptional co-repressor 1 862 0 4.0 4.3
1.9
2.7
2.5
1.3
1.7
0.6
0.5
0.4
1.7
0.5
2.6
1.6
2.2
0.1
1.1
1.1
2.1
0.2
1.8
1.6
2.3
0.3
1.4
0.6
0.9
0.9
0.9
0.1
1.2
-0.3
1.7
1.3
0.4
-1.4
0.6
-0.9
1.2
1.2
0.6
0.3
0.0

21 GPR158 G protein-coupled receptor 158 57512 0 4.0 3.3
1.2
3.6
1.9
1.2
1.6
-0.7
1.7
1.1
1.0
0.7
0.9
-0.5
3.5
0.2
3.3
-0.1
0.2
-0.5
0.8
2.2
-0.4



0.7
0.4
1.2
-0.4
0.4
-1.0
2.0
0.8
0.5
-0.7
2.3
1.3
2.1
22 CSMD3 CUB and Sushi multiple domains 3 114788 0 3.9 2.7
1.6
4.2
3.6
3.0
2.2
0.8
2.1
1.1
1.6
0.8
1.3
1.0
6.8
5.5
4.7
2.9
0.9
0.5
1.9
1.3
1.9
1.4
1.0
0.9



1.0
0.7
3.2
2.3
2.4
2.2
2.8
2.7
1.7
1.1


23 PCDH11X protocadherin 11 X-linked 27328 0 3.9 4.4
0.8
2.5
3.0
0.7
1.7
-0.5
1.1
3.1
1.4
-0.2
1.2
-1.9
-1.6



0.4
1.4
1.8
2.1
0.6


24 ADGRL3 adhesion G protein-coupled receptor L3 23284 0 3.9 3.2
1.4
3.7
2.6
0.4
0.9
0.2
1.8
-1.0
0.2
-0.5
0.9
0.9
3.6
1.1
2.0
0.9
0.4
0.3
1.2
1.1
1.1
1.0
0.8
0.3
0.3
0.1
0.5
-0.1
2.6
1.1
3.3
-0.0
1.0
0.7
0.7
0.2
1.9
1.3
1.8
0.9
2.0
0.9
25 NELL1 neural EGFL like 1 4745 0 3.9 2.5
1.3
4.4
2.9
0.5
-0.2
-0.4
0.9
0.7
-0.7
-0.7
1.9
1.1
2.3
1.7
3.0
1.2
0.9
0.0
1.1
0.3
1.2
0.8
0.2
-0.8
0.8
-0.0
-0.2
-1.3
2.0
1.4
2.0
1.9
-0.2
-0.2
1.1
-0.6
2.5
2.0
0.4
-1.1
-0.6

26 ERC2 ELKS/RAB6-interacting/CAST family member 2 26059 0 3.8 3.0
2.1
3.7
1.9
0.6
0.5
-0.3
2.3
1.9
2.1
0.5
2.0
1.2
2.8
-0.2
3.3
1.1
0.5
1.7
0.5
0.9
0.5
0.8
-0.1
1.6
0.5
0.3
0.5
-0.8
1.3
0.5
1.3
0.6
1.8
0.3
1.5
-0.6
3.4
1.4
27 ATP8A2 ATPase phospholipid transporting 8A2 51761 0 3.8 3.2
1.5
3.5
2.3
1.6
1.7
0.4
1.3
1.2
1.8
1.3
1.9
1.0
3.0
1.6
2.0
0.6
0.3
0.3
1.5
1.0
1.8
1.1
2.2
1.4
1.7
1.3
0.4
0.3
1.0
0.9
2.3
1.1
2.0
1.5
1.4
1.1
2.2
1.2
1.0
1.0
1.5
1.0
2.7
2.2
28 PTCHD1 patched domain containing 1 139411 0 3.8 3.3
2.7
3.3
4.2
2.3
-0.2
1.4
2.2
1.4
1.8
1.2
1.8
-0.1
-0.0



-0.2
1.8
-0.0
0.9
-0.4


29 DGKB diacylglycerol kinase beta 1607 0 3.8 2.7
2.0
3.9
4.7
2.8
1.5
0.4
3.7
0.3
3.6
1.3
3.5
1.6
3.1
1.7
3.1
2.8
0.8
0.5
2.9
2.4
3.8
1.6
1.4
0.5
0.5
-0.4
0.2
0.0
1.3
-0.6
0.8
-0.0
2.9
-0.1
1.9
0.2
0.4
0.1
1.7
0.7
2.4
0.8
30 CDH12 cadherin 12 1010 0 3.7 2.4
1.7
4.2
1.9
-1.1
1.5
-0.7
1.1
2.6
3.1
0.4
2.2
-1.4
-0.0
0.1
-0.1
1.0



2.0
-0.4


31 GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 2566 0 3.7 2.9
2.7
3.6
2.9
1.9
1.8
1.2
1.0
1.0
1.2
0.8
1.5
1.0
3.3
1.7
3.2
2.0
0.2
0.1
1.7
0.3
0.2
-0.3
0.1
-0.7
-0.0
-0.6
-0.1
-0.3
0.9
0.6
1.2
0.1
2.7
1.6
1.6
1.6
1.8
0.6
0.1
0.1

0.4
32 GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 2565 0 3.7 3.3
2.1
3.2
2.9
1.9
1.8
1.2
1.0
1.0
1.2
0.8
1.5
1.0
3.3
1.7
3.2
2.0
0.2
0.1
1.7
0.3
0.2
-0.3
0.1
-0.7
-0.0
-0.6
-0.1
-0.3
0.9
0.6
1.2
0.1
2.7
1.6
1.6
1.6
1.8
0.6
0.1
0.1

0.4
33 ANK2 ankyrin 2 287 0 3.7 2.5
1.6
3.9
1.7
0.2
-0.4
0.9
3.7
0.7
2.7
0.5
3.5
2.3
1.3
2.3
-0.2
0.7
1.0
2.1
2.0
1.5
0.6


34 DYNC1I1 dynein cytoplasmic 1 intermediate chain 1 1780 0 3.6 2.3
2.3
4.1
2.2
0.2
-0.5
-0.6
0.3
0.3
1.2
-0.5
1.5
-0.8
1.7
0.6
1.8
-0.9
0.1
-0.9
0.6
-0.4
2.1
0.2
0.2
-0.6
0.6
-0.6
0.5
-0.9
0.8
0.2
0.7
-0.0
1.9
1.1
0.6
-0.1
3.4
0.4
0.2
-0.4
-0.6
-0.8
-0.3
35 UNC5D unc-5 netrin receptor D 137970 0 3.6 4.2
2.2
2.2
2.3
1.3
2.9
1.9
1.6
1.1
3.4
1.1
1.8
1.8
2.8
2.2
4.0
2.4
1.0
0.2
2.5
2.4
1.7
0.3
1.6
0.7
1.3
0.7
1.3
0.8
1.1
0.9
0.2
0.1
0.6
0.4
0.9
0.7
3.5
3.2
1.8
1.5
0.5
3.3
36 LOC112268151 uncharacterized LOC112268151 112268151 0 3.6 3.7























37 KCNH5 potassium voltage-gated channel subfamily H member 5 27133 0 3.6 3.3
1.5
3.0
2.4
1.5
1.0
-0.9
1.0
0.2
0.8
-0.2
0.4
0.2
2.1
0.9
2.7
2.1
0.5
0.0
0.7
0.5
-0.5
-0.9
0.7
-0.6
0.2
1.0
0.9
-0.7
-0.7
1.7
1.7
0.4
0.0
-0.2
0.0
2.4
0.2
38 SYT4 synaptotagmin 4 6860 0 3.6 2.6
1.8
3.7
2.9
1.7
3.9
2.3
1.0
0.9
2.2
2.1
3.6
3.1
2.8
2.3
2.7
2.3
2.2
0.9
2.8
2.3
1.7
1.3
2.0
1.1
1.6
0.8
1.9
1.2
2.1
1.6
1.5
1.0
2.1
1.5
2.5
1.5
3.7
3.1
1.2
1.2
1.6
1.2
2.3
1.6
39 PTPRT protein tyrosine phosphatase receptor type T 11122 0 3.5 3.4
0.7
2.8
3.6
0.5
1.7
1.3
0.9
0.6
1.6
1.0
1.2
1.2
2.8
-0.2
2.0
1.7
0.1
-0.2
2.6
1.2
1.3
0.2
0.6
-0.0
1.7
0.6
0.5
-0.5
1.9
0.8
2.3
0.5
2.7
0.9
1.2
0.9
2.8
2.0
1.6
0.2


40 LRRTM3 leucine rich repeat transmembrane neuronal 3 347731 0 3.5 2.7

3.4
2.5
1.8
0.5
0.2
-0.6
2.6
2.6
-0.1
2.1
0.9
-0.6



-1.4
1.6
1.2




41 RBFOX1 RNA binding fox-1 homolog 1 54715 0 3.5 3.5
2.4
2.6
4.7
2.3
4.6
2.7
2.1
0.8
1.2
1.1
3.9
1.9
2.5
0.9
3.0
2.2
5.1
1.3
4.3
2.9
1.9
0.5
3.6
1.1
2.0
-1.0
1.2
-0.5
2.1
0.5
2.9
2.0
1.2
1.0
0.6
0.0
2.4
1.8
1.7
-0.5
2.1
0.8
0.2
42 FHL5 four and a half LIM domains 5 9457 0 3.5 4.0
2.2
2.1
3.4
0.3
1.6
0.8
0.5
0.1
1.8
-1.6
2.4
-0.3
0.4
-0.7
2.1
-1.5
1.6
-1.3
1.0
-0.7
-0.1
-0.2
1.0
-0.3
1.0
0.3
1.0
0.6
1.8
0.6
1.1
-0.0
2.8
0.8
0.4
-0.3
0.0
-0.3
2.5
1.0

1.7
43 FABP6 fatty acid binding protein 6 2172 0 3.4 2.7
0.6
3.4
0.3
0.1
-0.3
-1.4
-0.8
-0.2
0.3
0.2
0.2
-0.6
0.5



0.6
0.8
0.0
-1.3
-0.0


44 ACTC1 actin alpha cardiac muscle 1 70 0 3.4 2.3
1.1
3.7
2.3
1.7
3.8
2.2
0.9
0.8
2.0
1.9
1.2
0.7
2.1
1.5
2.3
2.0
5.4
2.4
1.8
1.0
1.8
1.5
3.3
1.7
1.3
1.1
1.3
1.2
1.9
0.8
2.0
1.7
4.2
1.8
2.3
1.0
0.5
0.3
5.7
4.3
4.3
4.2
3.8
3.0
45 LGI2 leucine rich repeat LGI family member 2 55203 0 3.4 2.7
0.8
3.3
1.9
0.8
-0.2
-0.4
0.8
0.2
0.8
0.0
1.6
-1.2
1.1
0.5
0.4
-0.0
-0.7
2.6
-0.0
1.2
1.6


46 GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 2562 0 3.4 3.5
2.0
2.5
2.1
1.9
1.0
0.3
2.6
2.2
1.1
0.8
0.9
0.7
2.5
2.4
3.2
2.4
0.7
0.1
3.2
2.5
-0.2
-0.7
-0.1
-0.5
0.9
-0.6
1.6
0.6
0.4
1.3
0.9
1.5
0.5
1.4
1.1
0.8
-0.2
0.9
0.3
47 JPH1 junctophilin 1 56704 0 3.4 3.2
1.4
2.8
1.6
0.9
1.4
1.4
1.1
0.8
2.9
1.3
0.6
0.5
2.0
1.3
1.7
1.4
3.0
1.6
3.3
1.7
2.2
0.2
2.8
0.7
1.1
0.0
1.6
0.9
1.5
0.1
2.2
1.7
2.7
0.1
1.8
0.9
2.9
2.4
3.1
2.1

5.0
48 SORBS2 sorbin and SH3 domain containing 2 8470 0 3.4 2.2
2.0
3.7
1.4
-1.2
-1.6
-2.2
1.0
1.8
1.4
-0.3
0.9
1.4
-0.8
-0.3
-1.3
1.1
-1.8
2.5
-0.0
0.5
0.0
0.6
-1.1


49 CHRM2 cholinergic receptor muscarinic 2 1129 0 3.3 3.7
0.6
2.2
0.7
-1.0
1.7
-1.6
1.5
3.2
5.3
-1.9
1.7
-0.5
-2.1
1.6
0.6
1.2
-1.3
3.5
0.4
1.8
0.6


50 PDE10A phosphodiesterase 10A 10846 0 3.3 3.5
0.8
2.3
1.3
-1.2
1.6
-0.9
1.8
2.7
0.1
1.8
0.2
2.5
0.4
1.3
0.1
0.7
1.7
0.7
1.3
2.0
0.1

0.5
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