[←][→] hsa  TJP1 Gene
functional annotation
Function   tight junction protein 1  
GO BP
GO:2000250 [list] [network] negative regulation of actin cytoskeleton reorganization  (1 genes)  IMP  
GO:0071896 [list] [network] protein localization to adherens junction  (5 genes)  IMP  
GO:1902396 [list] [network] protein localization to bicellular tight junction  (5 genes)  IMP  
GO:1905605 [list] [network] positive regulation of blood-brain barrier permeability  (5 genes)  IBA IMP  
GO:0034334 [list] [network] adherens junction maintenance  (6 genes)  IMP  
GO:2000049 [list] [network] positive regulation of cell-cell adhesion mediated by cadherin  (11 genes)  IMP  
GO:0090557 [list] [network] establishment of endothelial intestinal barrier  (16 genes)  IBA IMP  
GO:0150105 [list] [network] protein localization to cell-cell junction  (18 genes)  IBA IMP  
GO:2000810 [list] [network] regulation of bicellular tight junction assembly  (26 genes)  IMP TAS  
GO:0035329 [list] [network] hippo signaling  (27 genes)  TAS  
GO:1903672 [list] [network] positive regulation of sprouting angiogenesis  (28 genes)  IMP  
GO:0051497 [list] [network] negative regulation of stress fiber assembly  (32 genes)  ISS  
GO:0035633 [list] [network] maintenance of blood-brain barrier  (35 genes)  NAS  
GO:0031032 [list] [network] actomyosin structure organization  (108 genes)  IMP  
GO:0007043 [list] [network] cell-cell junction assembly  (126 genes)  TAS  
GO:0045216 [list] [network] cell-cell junction organization  (186 genes)  IBA IMP  
GO:1901888 [list] [network] regulation of cell junction assembly  (206 genes)  IMP  
GO:0098609 [list] [network] cell-cell adhesion  (513 genes)  IBA  
GO:0051493 [list] [network] regulation of cytoskeleton organization  (525 genes)  IMP  
GO:0030335 [list] [network] positive regulation of cell migration  (554 genes)  IMP  
GO:0043066 [list] [network] negative regulation of apoptotic process  (905 genes)  IMP  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (976 genes)  IMP  
GO CC
GO:0002102 [list] [network] podosome  (29 genes)  IEA  
GO:0005921 [list] [network] gap junction  (32 genes)  ISS  
GO:0005923 [list] [network] bicellular tight junction  (122 genes)  IBA IDA  
GO:0070160 [list] [network] tight junction  (129 genes)  IDA IMP  
GO:0043296 [list] [network] apical junction complex  (143 genes)  IDA  
GO:0005912 [list] [network] adherens junction  (170 genes)  TAS  
GO:0016323 [list] [network] basolateral plasma membrane  (228 genes)  IDA  
GO:0045177 [list] [network] apical part of cell  (432 genes)  IDA  
GO:0030054 [list] [network] cell junction  (2092 genes)  IDA TAS  
GO:0042995 [list] [network] cell projection  (2330 genes)  IEA  
GO:0005829 [list] [network] cytosol  (5345 genes)  IDA TAS  
GO:0032991 [list] [network] protein-containing complex  (5444 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IBA IDA ISS TAS  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  IDA  
GO MF
GO:0005516 [list] [network] calmodulin binding  (200 genes)  IEA  
GO:0045296 [list] [network] cadherin binding  (333 genes)  HDA  
GO:0050839 [list] [network] cell adhesion molecule binding  (544 genes)  IBA  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa04520 [list] [network] Adherens junction (71 genes)
hsa04530 [list] [network] Tight junction (169 genes)
hsa04540 [list] [network] Gap junction (88 genes)
hsa05110 [list] [network] Vibrio cholerae infection (50 genes)
hsa05120 [list] [network] Epithelial cell signaling in Helicobacter pylori infection (70 genes)
hsa05130 [list] [network] Pathogenic Escherichia coli infection (197 genes)
Protein NP_001287954.2  NP_001287955.1  NP_001317168.1  NP_001341941.1  NP_001341942.1  NP_001341943.1  NP_001341944.1  NP_003248.3  NP_783297.2  XP_005254676.2  XP_005254677.2  XP_011520274.2  XP_016878010.1  XP_016878011.1  XP_016878012.1  XP_016878013.1  XP_016878014.1  XP_016878015.1  XP_016878016.1  XP_016878020.1 
BLAST NP_001287954.2  NP_001287955.1  NP_001317168.1  NP_001341941.1  NP_001341942.1  NP_001341943.1  NP_001341944.1  NP_003248.3  NP_783297.2  XP_005254676.2  XP_005254677.2  XP_011520274.2  XP_016878010.1  XP_016878011.1  XP_016878012.1  XP_016878013.1  XP_016878014.1  XP_016878015.1  XP_016878016.1  XP_016878020.1 
Orthologous [Ortholog page] Tjp1 (mmu)  pyd (dme)  Tjp1 (rno)  tjp1a (dre)  TJP1 (cfa)  TJP1 (gga)  tjp2a (dre)  tjp1b (dre)  TJP1 (mcc)  TJP1 (fca) 
Subcellular
localization
wolf
nucl 5,  cyto_nucl 5,  cyto 3  (predict for NP_001287954.2)
nucl 6,  cyto_nucl 5,  cyto 3  (predict for NP_001287955.1)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for NP_001317168.1)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for NP_001341941.1)
nucl 6,  cyto_nucl 5,  cyto 3  (predict for NP_001341942.1)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for NP_001341943.1)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for NP_001341944.1)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for NP_003248.3)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for NP_783297.2)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_005254676.2)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_005254677.2)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_011520274.2)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_016878010.1)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_016878011.1)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_016878012.1)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_016878013.1)
nucl 6,  cyto_nucl 5,  cyto 3  (predict for XP_016878014.1)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for XP_016878015.1)
nucl 5,  cyto_nucl 5,  cyto 3  (predict for XP_016878016.1)
nucl 6,  cyto_nucl 4,  cyto 2,  extr 1  (predict for XP_016878020.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa05130 Pathogenic Escherichia coli infection 6
hsa04530 Tight junction 4
hsa04810 Regulation of actin cytoskeleton 3
hsa04520 Adherens junction 3
hsa04010 MAPK signaling pathway 2
Genes directly connected with TJP1 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
8.1 TEAD1 TEA domain transcription factor 1 [detail] 0 7003
6.8 PTPN21 protein tyrosine phosphatase non-receptor type 21 [detail] 0 11099
6.3 NCKAP1 NCK associated protein 1 [detail] 0 10787
6.2 GNG12 G protein subunit gamma 12 [detail] 0 55970
6.1 SH3D19 SH3 domain containing 19 [detail] 0 152503
6.0 CDC42BPA CDC42 binding protein kinase alpha [detail] 0 8476
5.7 MPDZ multiple PDZ domain crumbs cell polarity complex component [detail] 0 8777
5.6 MYO6 myosin VI [detail] 1 4646
5.4 FAT1 FAT atypical cadherin 1 [detail] 0 2195
5.2 MYO10 myosin X [detail] 0 4651
4.4 GULP1 GULP PTB domain containing engulfment adaptor 1 [detail] 0 51454
Coexpressed
gene list		 [Coexpressed gene list for TJP1]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 7082      
Refseq ID (protein) NP_001287954.2 
NP_001287955.1 
NP_001317168.1 
NP_001341941.1 
NP_001341942.1 
NP_001341943.1 
NP_001341944.1 
NP_003248.3 
NP_783297.2 
XP_005254676.2 
XP_005254677.2 
XP_011520274.2 
XP_016878010.1 
XP_016878011.1 
XP_016878012.1 
XP_016878013.1 
XP_016878014.1 
XP_016878015.1 
XP_016878016.1 
XP_016878020.1 


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