Orthologous genes in OrthoFinder**

Species Gene Description
 rno-u.3   Kl   Klotho 
 rno-r.3   Kl   Klotho 
 rno-m.5   Kl   Klotho 
 mmu-u.4   Kl   klotho 
 hsa-u.4   KL   klotho 
 mcc-u.3   KL   klotho 
 cfa-u.3   KL   klotho 
 gga-u.3   KL   klotho 
 dre-u.3   kl   klotho 

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Top 50 coexpressed genes to Kl (rno-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 rno4976   Bile secretion  4 85 3.90
 rno4080   Neuroactive ligand-receptor interaction  4 238 2.24
 rno4514   Cell adhesion molecules  3 128 2.17
 rno4670   Leukocyte transendothelial migration  2 117 -
 rno4024   cAMP signaling pathway  2 217 -

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rno:Kl (Klotho) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

rno-u.3
for
Kl
rno-r.3
for
Kl
rno-m.5
for
Kl
mmu-u.4
for
Kl
hsa-u.4
for
KL
mcc-u.3
for
KL
cfa-u.3
for
KL
gga-u.3
for
KL
dre-u.3
for
kl
1 Cltrn collectrin, amino acid transport regulator 57395 6.9 2.3
 4.3
 8.0
 0.7
 2.4
 0.9
 2.6
 2.1
2 Sostdc1 sclerostin domain containing 1 266803 6.1 3.0
 2.9
 6.5
 1.5
 2.5
0.3
 0.2
3 Tmem72 transmembrane protein 72 362424 6.0 2.8
 3.0
 12.0
2.6
2.3
 1.8
4 Mfrp membrane frizzled-related protein 315597 5.5 2.9
 2.3





5 Slc4a5 solute carrier family 4 member 5 297386 4.9 2.7
5.6
3.1
 0.7
0.3
 2.4
1.2
 1.3
0.5
 1.6
1.1
 1.6
1.4
6 Slco1a5 solute carrier organic anion transporter family, member 1A5 80900 4.6 2.1
 2.2
 5.0
2.7
0.4
0.8
7 Folr1 folate receptor alpha 171049 4.5 1.9
 2.5
 7.7
0.0
 1.4
1.0
 1.9
0.6
 0.4
-0.1
 2.6
0.2
 -0.4
8 Otx2 orthodenticle homeobox 2 305858 4.5 2.0
 2.3
 6.4
0.5
 0.2
0.2
 1.6
0.6
1.6
0.0
 0.2
0.1
9 Bhmt2 betaine-homocysteine S-methyltransferase 2 365972 4.3 1.5
 2.6
 2.9
2.5
 2.1
1.5
 3.0
1.8
 1.4
0.2
 -0.3
 0.2
10 Cldn2 claudin 2 300920 4.3 1.9
 2.2
 7.4
 0.2
0.2
 0.9
11 Htr2c 5-hydroxytryptamine receptor 2C 25187 4.2 1.5
 2.6
 6.4
0.3
 1.2
0.2

0.6
0.1
12 Glycam1 glycosylation dependent cell adhesion molecule 1 25258 4.2 2.5
 1.6
 0.7




13 Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 171138 4.1 2.0
 1.9
 7.2


0.4
14 Aqp6 aquaporin 6 29170 3.9 0.8
 3.0
 2.9
2.6
 3.0
1.3
 0.5
0.1
 1.1
0.7
 2.4
0.7
 1.4
0.5
15 Clic6 chloride intracellular channel 6 304081 3.9 2.1
5.1
2.0
 2.3
1.4
 2.8
0.5
 0.9
0.6
 3.0
1.2
 1.8
1.2
16 F5 coagulation factor V 304929 3.8 2.1
 1.5
 4.7
 2.5
 0.9
 1.6
 -0.9
 0.7
17 Mab21l4 mab-21 like 4 501185 3.7 2.2
 1.5
 1.9
 -0.2
 0.6
-0.2
18 Ttr transthyretin 24856 3.7 2.2
 1.4
 6.2
 1.0
 1.6
 -0.3
 0.2
0.0
 2.0
19 RGD1566368 similar to Solute carrier family 6 (neurotransmitter transporter), member 20 301083 3.7 0.7
 2.9
 4.8
3.9
1.6
 -0.6
 1.8
20 Lmx1a LIM homeobox transcription factor 1 alpha 289201 3.6 2.0
1.8
 -0.3
0.2
 1.2
0.6
 0.8
0.1
21 Cfap300 cilia and flagella associated protein 300 654482 3.6 1.5
 2.0
 0.5
 0.0
0.9
 -0.5
 0.6
22 Slc16a9 solute carrier family 16, member 9 687808 3.5 1.9
3.4
 0.9
 2.4
 0.2
 2.5
 0.1
-1.5
23 Ace angiotensin I converting enzyme 24310 3.5 2.1
 1.3
 3.7
2.3
 2.5
2.3
 0.0
-0.5
 -0.3
-1.4
 2.3
1.4
 2.4
-0.8
24 Glp1r glucagon-like peptide 1 receptor 25051 3.5 1.2
 2.2
 3.4
 1.1
 1.8


25 Prr32 proline rich 32 683753 3.4 1.9






26 Aqp1 aquaporin 1 25240 3.4 2.2
 1.2
 2.9
2.6
 3.0
1.3
 0.5
0.1
 1.1
0.7
 2.4
0.7
 1.4
0.5
27 C1qtnf3 C1q and TNF related 3 294806 3.4 1.2
 2.2
 1.2
 0.2
 1.1
 0.6
 0.2
28 Mdk midkine 81517 3.4 1.8
 1.5
 0.5
 -0.7
 -0.2
 0.3
 -0.8
 -0.8
-1.3
29 Trpv4 transient receptor potential cation channel, subfamily V, member 4 66026 3.4 1.9
 1.4
 5.3
1.3
 0.3
-0.0
 2.0
0.3
 0.4
-0.1
 0.4
0.1
 0.8
-0.3
30 Igfbpl1 insulin-like growth factor binding protein-like 1 366366 3.4 1.2
 2.1
 0.1
-0.2
 -0.0

31 Abca4 ATP binding cassette subfamily A member 4 310836 3.4 2.1
 1.2
 0.0
-1.3
 0.7
0.0
 0.5
0.1
 1.0
-1.2
 0.5
0.1
 0.6
0.4
32 Adipoq adiponectin, C1Q and collagen domain containing 246253 3.3 1.5
 1.7
 -1.0
 1.9
 -0.7
 1.2
 -0.6
33 Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 140726 3.3 0.9
 2.3
 1.9
1.1
 1.0
-0.2
 0.6
-0.8
 0.0
-0.7
 0.6
0.6
 1.3
1.3
34 Calcr calcitonin receptor 116506 3.3 0.5
 2.6
 1.8
0.1
 2.2
 1.4
 0.4
 0.3
-0.5
 1.2
0.5
35 Col4a4 collagen type IV alpha 4 chain 301562 3.2 1.4
 1.8
 5.9
5.0
 1.0
0.9
 1.9
0.8
 1.6
1.4
 1.5
1.4
 2.0
0.3
36 Scgb1c1 secretoglobin, family 1C, member 1 309100 3.2 1.6
 1.5
 0.5
0.9
 -0.8

37 Itpripl1 ITPRIP like 1 499885 3.1 1.8
-0.4
 -0.3
 -1.0
 1.1

38 Ca12 carbonic anhydrase 12 363085 3.1 1.7
 1.3
 5.0
 0.2
 1.1
 0.1
 -1.0
39 Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 170847 3.1 0.5
 2.5
 0.7
 2.0
 1.2
 -0.6
 1.1
 1.0
40 Slc5a12 solute carrier family 5 member 12 362188 3.1 0.8
 2.2
 4.8
1.8
 -0.3
 1.9
0.6
 1.4
1.2
 2.5
1.1
 3.1
2.5
41 Sema3g semaphorin 3G 290562 3.1 1.5
 1.4
 3.3
1.5
 1.6
1.3
 1.4
0.3
 1.7
1.5
 3.1
1.7
 0.9
0.7
42 Vav3 vav guanine nucleotide exchange factor 3 295378 3.0 1.0
 2.0
 0.7
0.3
 0.8
0.2
 -0.4
-0.4
 0.6
0.3
 0.9
-0.3
 0.2
-0.2
43 Slc12a8 solute carrier family 12, member 8 266733 3.0 1.7
 1.3
 0.3
 -0.3
1.5
 0.9
 1.6
44 Oacyl O-acyltransferase like 291549 3.0 0.6
 2.4




0.3
45 Slc6a18 solute carrier family 6 member 18 29323 3.0 1.3
 1.6
 3.8
1.8
 1.0
 1.8
 0.9
-0.8
 2.2
0.7
 2.4
1.6
46 Dgkg diacylglycerol kinase, gamma 25666 3.0 0.9
 2.1
 2.8
2.5
 2.1
2.0
 1.4
0.4
 -0.6
-1.5
 0.6
-0.5
 1.7
-0.2
47 Stra6 signaling receptor and transporter of retinol STRA6 363071 3.0 1.0
 1.9
 2.9
 0.3
 2.0
 0.6
 0.3
 -0.2
48 Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 29708 3.0 0.6
 2.3
 3.3
2.1
 1.6
1.2
 1.8
1.1
 1.3
1.1
 1.2
1.0
 0.3
0.1
49 Cdh3 cadherin 3 116777 3.0 1.7
 1.2
 2.0
0.3
 0.2
-0.6
 0.9
0.8
 1.3
0.3
 0.5
0.1
 2.4
0.6
50 Slc9a3 solute carrier family 9 member A3 24784 2.9 1.1
 1.7
 3.9
-0.2
 0.4
 1.1
0.9
 0.5
 3.1
0.8
 1.8
1.5
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