| functional annotation |
| Function |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase |
|
| GO BP |
|
GO:0000105 [list] [network] histidine biosynthetic process
|
(2 genes)
|
IEA
|
 |
|
GO:0009257 [list] [network] 10-formyltetrahydrofolate biosynthetic process
|
(2 genes)
|
IMP
ISO
|
|
|
GO:0019346 [list] [network] transsulfuration
|
(5 genes)
|
IMP
|
|
|
GO:0009086 [list] [network] methionine biosynthetic process
|
(12 genes)
|
ISO
|
|
|
GO:0035999 [list] [network] tetrahydrofolate interconversion
|
(12 genes)
|
IBA
IMP
ISO
|
|
|
GO:0006555 [list] [network] methionine metabolic process
|
(14 genes)
|
IMP
|
|
|
GO:0009070 [list] [network] serine family amino acid biosynthetic process
|
(16 genes)
|
ISO
|
|
|
GO:0001780 [list] [network] neutrophil homeostasis
|
(18 genes)
|
IMP
|
|
|
GO:0009069 [list] [network] serine family amino acid metabolic process
|
(36 genes)
|
IMP
|
|
|
GO:0006730 [list] [network] one-carbon metabolic process
|
(40 genes)
|
ISO
|
|
|
GO:0008652 [list] [network] cellular amino acid biosynthetic process
|
(60 genes)
|
IEA
|
|
|
GO:0061053 [list] [network] somite development
|
(88 genes)
|
IMP
|
|
|
GO:0001843 [list] [network] neural tube closure
|
(113 genes)
|
IMP
|
|
|
GO:0006164 [list] [network] purine nucleotide biosynthetic process
|
(129 genes)
|
IMP
|
|
|
GO:0007507 [list] [network] heart development
|
(585 genes)
|
IMP
|
|
|
GO:0008152 [list] [network] metabolic process
|
(7626 genes)
|
IEA
|
|
|
| GO CC |
|
| GO MF |
|
GO:0004329 [list] [network] formate-tetrahydrofolate ligase activity
|
(2 genes)
|
IMP
ISO
|
|
|
GO:0004477 [list] [network] methenyltetrahydrofolate cyclohydrolase activity
|
(3 genes)
|
IBA
ISO
|
|
|
GO:0004487 [list] [network] methylenetetrahydrofolate dehydrogenase (NAD+) activity
|
(3 genes)
|
IDA
|
|
|
GO:0004486 [list] [network] methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
|
(4 genes)
|
ISO
|
|
|
GO:0004488 [list] [network] methylenetetrahydrofolate dehydrogenase (NADP+) activity
|
(4 genes)
|
IBA
|
|
|
GO:0016874 [list] [network] ligase activity
|
(164 genes)
|
IEA
|
|
|
GO:0016491 [list] [network] oxidoreductase activity
|
(801 genes)
|
IEA
|
|
|
GO:0005524 [list] [network] ATP binding
|
(1396 genes)
|
IEA
|
|
|
GO:0000166 [list] [network] nucleotide binding
|
(2052 genes)
|
IEA
|
|
|
GO:0016787 [list] [network] hydrolase activity
|
(2400 genes)
|
IEA
|
|
|
GO:0003824 [list] [network] catalytic activity
|
(5635 genes)
|
IEA
|
|
|
| KEGG |
mmu00670 [list] [network] One carbon pool by folate (19 genes) |
 |
| mmu01240 [list] [network] Biosynthesis of cofactors (152 genes) |
|
| Protein |
NP_620084.2
XP_030102369.1
|
| BLAST |
NP_620084.2
XP_030102369.1
|
| Orthologous |
[Ortholog page]
MTHFD1 (hsa)
MTHFD1L (hsa)
pug (dme)
Mthfd1 (rno)
K07E3.4 (cel)
mthfd1b (dre)
Mthfd1l (mmu)
Mthfd1l (rno)
MTHFD1L (gga)
MTHFD1 (gga)
MTHFD1L (cfa)
MTHFD1 (cfa)
MTHFD1L (mcc)
MTHFD1 (mcc)
MIS1 (sce)
ADE3 (sce)
mthfd1l (dre)
MTHFD1L (fca)
MTHFD1 (fca)
|
Subcellular
localization
wolf |
|
cyto 7,
cyto_nucl 3,
extr 2
|
(predict for NP_620084.2)
|
|
cyto 7,
cysk 1,
extr 1
|
(predict for XP_030102369.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| mmu05012 |
Parkinson disease |
4 |
 |
| mmu05022 |
Pathways of neurodegeneration - multiple diseases |
4 |
 |
| mmu01240 |
Biosynthesis of cofactors |
4 |
 |
| mmu00190 |
Oxidative phosphorylation |
3 |
 |
| mmu04714 |
Thermogenesis |
3 |
 |
Genes directly connected with Mthfd1 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 7.9 |
Gart |
phosphoribosylglycinamide formyltransferase |
[detail] |
2 |
14450 |
| 7.3 |
Trap1 |
TNF receptor-associated protein 1 |
[detail] |
0 |
68015 |
| 7.3 |
Gfm1 |
G elongation factor, mitochondrial 1 |
[detail] |
0 |
28030 |
| 6.3 |
Pitrm1 |
pitrilysin metallepetidase 1 |
[detail] |
0 |
69617 |
| 5.8 |
Shmt1 |
serine hydroxymethyltransferase 1 (soluble) |
[detail] |
8 |
20425 |
| 5.5 |
Prps2 |
phosphoribosyl pyrophosphate synthetase 2 |
[detail] |
0 |
110639 |
| 5.4 |
Sfxn2 |
sideroflexin 2 |
[detail] |
0 |
94279 |
|
Coexpressed
gene list |
[Coexpressed gene list for Mthfd1]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Mthfd1 Gene
