Publication for Shmt1 and Mthfd1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Shmt1	serine hydroxymethyltransferase 1 (soluble)	20425			[link]
mmu	Mthfd1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	108156

Pubmed ID	Priority	Text
22140583	0.98	SHMT1 has been designated as negatively affecting flux to purines because mice with decreased MTHFD1 activity show enhanced de novo thymidylate synthesis, suggesting that SHMT1 and MTHFD1 compete for a limiting pool of THF in the cytoplasm.
29955725	0.98	MTHFD1, SHMT1, SHMT2alpha, TYMS, and DHFR) are SUMO-ylated and translocate to the nucleus during the S-phase.
27411012	0.97	SHMT1, SHMT2, MTHFD1, MTHFD2), as well as in enzymes of pyrimidine biosynthesis (DHODH, UMPS), consistent with our proteomic dataset.
21406397	0.94	Mthfd1 gene product or from serine through SHMT1 to support methionine and thymidylate biosynthesis (Figure 1).
29979702	0.90	SHMT1, SHMT2, MTHFD1, MTHFD2, GART, ATIC, MTRR, and DHFR.
23651732	0.86	Mthfd1, Mthfd1l, Mthfd2, Mthfr, Mtr, Shmt1, Slc46a1, and Tyms mildly deregulated; only Tyms and Mthfd2 showed more than a 2-fold expression change.
22171071	0.71	Mthfd1, Mthfr and Shmt1), Mthfd2 null embryos die by E15.5 but neural tube closure is complete and null mutants for Mtr, Mtrr and Mthfs die before E9.5, prior to neural tube closure.
26853819	0.65	SHMT1 and SHMT2alpha from serine and tetrahydrofolate or by the activity of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) from formate and tetrahydrofolate.