| functional annotation |
| Function |
hydroxysteroid (17-beta) dehydrogenase 8 |
|
| GO BP |
|
GO:0006703 [list] [network] estrogen biosynthetic process
|
(8 genes)
|
IBA
IEA
ISO
ISS
|
 |
|
GO:0051290 [list] [network] protein heterotetramerization
|
(15 genes)
|
ISO
ISS
|
|
|
GO:0008209 [list] [network] androgen metabolic process
|
(26 genes)
|
ISO
|
|
|
GO:0008210 [list] [network] estrogen metabolic process
|
(32 genes)
|
ISO
|
|
|
GO:0006633 [list] [network] fatty acid biosynthetic process
|
(112 genes)
|
IBA
IEA
ISO
ISS
|
|
|
| GO CC |
|
GO:1990204 [list] [network] oxidoreductase complex
|
(113 genes)
|
IEA
ISO
|
|
|
GO:0005759 [list] [network] mitochondrial matrix
|
(313 genes)
|
ISO
|
|
|
GO:0005740 [list] [network] mitochondrial envelope
|
(647 genes)
|
ISO
|
|
|
GO:0005886 [list] [network] plasma membrane
|
(5814 genes)
|
ISO
|
|
|
GO:0016020 [list] [network] membrane
|
(9382 genes)
|
ISO
|
|
|
| GO MF |
|
GO:0047025 [list] [network] 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
|
(1 genes)
|
ISO
ISS
|
|
|
GO:0070404 [list] [network] NADH binding
|
(5 genes)
|
ISO
ISS
|
|
|
GO:0003857 [list] [network] 3-hydroxyacyl-CoA dehydrogenase activity
|
(6 genes)
|
ISO
|
|
|
GO:0047035 [list] [network] testosterone dehydrogenase (NAD+) activity
|
(7 genes)
|
ISO
|
|
|
GO:0044594 [list] [network] 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
|
(8 genes)
|
IEA
|
|
|
GO:0072582 [list] [network] 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
|
(10 genes)
|
IEA
|
|
|
GO:0004303 [list] [network] estradiol 17-beta-dehydrogenase activity
|
(16 genes)
|
IBA
ISO
ISS
|
|
|
GO:0048038 [list] [network] quinone binding
|
(19 genes)
|
IBA
|
|
|
GO:0016616 [list] [network] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
(133 genes)
|
IBA
|
|
|
GO:0016491 [list] [network] oxidoreductase activity
|
(764 genes)
|
IEA
|
|
|
| KEGG |
rno00061 [list] [network] Fatty acid biosynthesis (18 genes) |
 |
| rno00140 [list] [network] Steroid hormone biosynthesis (83 genes) |
|
| rno01212 [list] [network] Fatty acid metabolism (61 genes) |
|
| Protein |
NP_997694.1
XP_006256026.1
XP_006256027.1
XP_006256028.1
XP_038954738.1
|
| BLAST |
NP_997694.1
XP_006256026.1
XP_006256027.1
XP_006256028.1
XP_038954738.1
|
| Orthologous |
[Ortholog page]
HSD17B8 (hsa)
H2-Ke6 (mmu)
CG3603 (dme)
hsd17b8 (dre)
CBR4 (hsa)
dhs-11 (cel)
dhs-25 (cel)
Cbr4 (mmu)
Cbr4 (rno)
cbr4 (dre)
CBR4 (gga)
CBR4 (cfa)
HSD17B8 (cfa)
CBR4 (mcc)
HSD17B8 (mcc)
OAR1 (sce)
LOC101086309 (fca)
CBR4 (fca)
LOC111556166 (fca)
LOC121106941 (gga)
LOC121106957 (gga)
|
Subcellular
localization
wolf |
|
mito 7,
mito_pero 3,
mito_nucl 3
|
(predict for NP_997694.1)
|
|
cyto_nucl 4,
cyto 3,
nucl 3,
cysk 3
|
(predict for XP_006256026.1)
|
|
mito 7,
cyto_mito 4,
extr 2,
cyto 1
|
(predict for XP_006256027.1)
|
|
cyto_nucl 4,
cyto 3,
nucl 3,
cysk 3
|
(predict for XP_006256028.1)
|
|
cyto 4,
cyto_nucl 3,
cysk 3,
nucl 2,
extr 1
|
(predict for XP_038954738.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| rno05012 |
Parkinson disease |
4 |
 |
| rno05014 |
Amyotrophic lateral sclerosis |
4 |
 |
| rno05022 |
Pathways of neurodegeneration - multiple diseases |
4 |
 |
| rno00190 |
Oxidative phosphorylation |
3 |
 |
| rno05010 |
Alzheimer disease |
3 |
 |
Genes directly connected with Hsd17b8 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
Entrez Gene ID* |
| 6.1 |
Fahd2a |
fumarylacetoacetate hydrolase domain containing 2A |
[detail] |
296131 |
| 6.1 |
Ring1 |
ring finger protein 1 |
[detail] |
309626 |
| 6.0 |
Bckdha |
branched chain keto acid dehydrogenase E1 subunit alpha |
[detail] |
25244 |
|
Coexpressed
gene list |
[Coexpressed gene list for Hsd17b8]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Hsd17b8 Gene
