[←][→] hsa  GJA1 Gene
functional annotation
Function   gap junction protein alpha 1  
GO BP
GO:0010652 [list] [network] positive regulation of cell communication by chemical coupling  (2 genes)  IEA  
GO:0003104 [list] [network] positive regulation of glomerular filtration  (4 genes)  IEA  
GO:1905772 [list] [network] positive regulation of mesodermal cell differentiation  (4 genes)  IMP  
GO:1905867 [list] [network] epididymis development  (5 genes)  IEA  
GO:0014047 [list] [network] glutamate secretion  (6 genes)  ISS  
GO:0034775 [list] [network] glutathione transmembrane transport  (6 genes)  IEA  
GO:2000987 [list] [network] positive regulation of behavioral fear response  (7 genes)  IEA  
GO:0016264 [list] [network] gap junction assembly  (8 genes)  TAS  
GO:0032277 [list] [network] negative regulation of gonadotropin secretion  (8 genes)  IMP  
GO:1901164 [list] [network] negative regulation of trophoblast cell migration  (8 genes)  IMP  
GO:0071374 [list] [network] cellular response to parathyroid hormone stimulus  (9 genes)  IEA  
GO:0002544 [list] [network] chronic inflammatory response  (12 genes)  IEA  
GO:0035437 [list] [network] maintenance of protein localization in endoplasmic reticulum  (14 genes)  IEA  
GO:0086014 [list] [network] atrial cardiac muscle cell action potential  (14 genes)  TAS  
GO:0010649 [list] [network] regulation of cell communication by electrical coupling  (17 genes)  IEA  
GO:0015867 [list] [network] ATP transport  (17 genes)  IEA  
GO:0086064 [list] [network] cell communication by electrical coupling involved in cardiac conduction  (17 genes)  NAS  
GO:0060044 [list] [network] negative regulation of cardiac muscle cell proliferation  (20 genes)  IEA  
GO:0010644 [list] [network] cell communication by electrical coupling  (22 genes)  IDA  
GO:0046697 [list] [network] decidualization  (26 genes)  IEA  
GO:2000810 [list] [network] regulation of bicellular tight junction assembly  (26 genes)  IEA  
GO:0000132 [list] [network] establishment of mitotic spindle orientation  (30 genes)  IMP  
GO:2000648 [list] [network] positive regulation of stem cell proliferation  (30 genes)  IMP  
GO:0034405 [list] [network] response to fluid shear stress  (34 genes)  IEA  
GO:0045907 [list] [network] positive regulation of vasoconstriction  (34 genes)  IEA  
GO:0035633 [list] [network] maintenance of blood-brain barrier  (35 genes)  NAS  
GO:1905332 [list] [network] positive regulation of morphogenesis of an epithelium  (36 genes)  IMP  
GO:0003161 [list] [network] cardiac conduction system development  (37 genes)  NAS  
GO:2000279 [list] [network] negative regulation of DNA biosynthetic process  (39 genes)  IEA  
GO:0009268 [list] [network] response to pH  (43 genes)  IEA  
GO:0042908 [list] [network] xenobiotic transport  (43 genes)  ISS  
GO:0046849 [list] [network] bone remodeling  (43 genes)  ISS  
GO:1904646 [list] [network] cellular response to amyloid-beta  (47 genes)  ISS  
GO:1904707 [list] [network] positive regulation of vascular associated smooth muscle cell proliferation  (49 genes)  IMP  
GO:0140115 [list] [network] export across plasma membrane  (54 genes)  ISS  
GO:0002931 [list] [network] response to ischemia  (58 genes)  IEA  
GO:0001937 [list] [network] negative regulation of endothelial cell proliferation  (77 genes)  IEA  
GO:0032024 [list] [network] positive regulation of insulin secretion  (78 genes)  IEA  
GO:0071260 [list] [network] cellular response to mechanical stimulus  (79 genes)  IEA  
GO:0061045 [list] [network] negative regulation of wound healing  (81 genes)  IEA  
GO:0010232 [list] [network] vascular transport  (87 genes)  IEA  
GO:0003158 [list] [network] endothelium development  (96 genes)  IEA  
GO:0120162 [list] [network] positive regulation of cold-induced thermogenesis  (97 genes)  ISS  
GO:0032526 [list] [network] response to retinoic acid  (107 genes)  IEA  
GO:0032355 [list] [network] response to estradiol  (141 genes)  IEA  
GO:0009749 [list] [network] response to glucose  (153 genes)  IEA  
GO:0060348 [list] [network] bone development  (184 genes)  ISS  
GO:0043123 [list] [network] positive regulation of I-kappaB kinase/NF-kappaB signaling  (186 genes)  HMP  
GO:0030308 [list] [network] negative regulation of cell growth  (190 genes)  ISS  
GO:0045732 [list] [network] positive regulation of protein catabolic process  (232 genes)  IEA  
GO:0051924 [list] [network] regulation of calcium ion transport  (255 genes)  IEA  
GO:0007204 [list] [network] positive regulation of cytosolic calcium ion concentration  (280 genes)  IEA  
GO:0022898 [list] [network] regulation of transmembrane transporter activity  (291 genes)  IEA  
GO:0032496 [list] [network] response to lipopolysaccharide  (328 genes)  IEA  
GO:0043434 [list] [network] response to peptide hormone  (405 genes)  IEA  
GO:0048812 [list] [network] neuron projection morphogenesis  (491 genes)  IEA  
GO:0007283 [list] [network] spermatogenesis  (566 genes)  ISS  
GO:0034220 [list] [network] ion transmembrane transport  (865 genes)  IDA  
GO:0006915 [list] [network] apoptotic process  (912 genes)  IEA  
GO:0007267 [list] [network] cell-cell signaling  (1120 genes)  IBA IDA  
GO:0010628 [list] [network] positive regulation of gene expression  (1188 genes)  IMP  
GO:0034613 [list] [network] cellular protein localization  (1467 genes)  IMP  
GO:0042981 [list] [network] regulation of apoptotic process  (1534 genes)  IEA  
GO:0007165 [list] [network] signal transduction  (5169 genes)  IDA  
GO CC
GO:0005916 [list] [network] fascia adherens  (10 genes)  IEA  
GO:0005922 [list] [network] connexin complex  (21 genes)  IBA ISS  
GO:0005921 [list] [network] gap junction  (32 genes)  IDA ISS  
GO:0014704 [list] [network] intercalated disc  (50 genes)  IDA ISS  
GO:0030660 [list] [network] Golgi-associated vesicle membrane  (54 genes)  TAS  
GO:0005771 [list] [network] multivesicular body  (64 genes)  IEA  
GO:0044291 [list] [network] cell-cell contact zone  (72 genes)  IDA  
GO:0070160 [list] [network] tight junction  (129 genes)  IDA  
GO:0005741 [list] [network] mitochondrial outer membrane  (200 genes)  IEA  
GO:0045121 [list] [network] membrane raft  (334 genes)  ISS  
GO:0016324 [list] [network] apical plasma membrane  (364 genes)  ISS  
GO:0005769 [list] [network] early endosome  (398 genes)  IEA  
GO:0005925 [list] [network] focal adhesion  (421 genes)  HDA  
GO:0000139 [list] [network] Golgi membrane  (626 genes)  TAS  
GO:0005764 [list] [network] lysosome  (718 genes)  IEA  
GO:0005789 [list] [network] endoplasmic reticulum membrane  (1133 genes)  TAS  
GO:0005794 [list] [network] Golgi apparatus  (1594 genes)  ISS  
GO:0005739 [list] [network] mitochondrion  (1648 genes)  IDA  
GO:0005887 [list] [network] integral component of plasma membrane  (1649 genes)  TAS  
GO:0030054 [list] [network] cell junction  (2092 genes)  IDA  
GO:0005654 [list] [network] nucleoplasm  (4086 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (5772 genes)  IDA ISS TAS  
GO:0005737 [list] [network] cytoplasm  (11897 genes)  IDA  
GO:0043231 [list] [network] intracellular membrane-bounded organelle  (12534 genes)  IDA  
GO MF
GO:0034634 [list] [network] glutathione transmembrane transporter activity  (5 genes)  ISS  
GO:0086075 [list] [network] gap junction channel activity involved in cardiac conduction electrical coupling  (5 genes)  NAS  
GO:0055077 [list] [network] gap junction hemi-channel activity  (6 genes)  IMP  
GO:0071253 [list] [network] connexin binding  (6 genes)  IEA  
GO:1903763 [list] [network] gap junction channel activity involved in cell communication by electrical coupling  (8 genes)  IDA  
GO:0015562 [list] [network] efflux transmembrane transporter activity  (14 genes)  ISS  
GO:0005243 [list] [network] gap junction channel activity  (24 genes)  IBA IDA  
GO:0097718 [list] [network] disordered domain specific binding  (36 genes)  IEA  
GO:0030165 [list] [network] PDZ domain binding  (85 genes)  IEA  
GO:0008013 [list] [network] beta-catenin binding  (86 genes)  IPI  
GO:0017124 [list] [network] SH3 domain binding  (130 genes)  IEA  
GO:0015631 [list] [network] tubulin binding  (375 genes)  IDA  
GO:0015075 [list] [network] ion transmembrane transporter activity  (833 genes)  IDA  
GO:0005515 [list] [network] protein binding  (13898 genes)  IPI  
KEGG hsa04540 [list] [network] Gap junction (88 genes)
hsa05412 [list] [network] Arrhythmogenic right ventricular cardiomyopathy (77 genes)
Protein NP_000156.1 
BLAST NP_000156.1 
Orthologous [Ortholog page] Gja1 (mmu)  Gja1 (rno)  gja1b (dre)  GJA1 (gga)  GJA1 (cfa)  GJA1 (mcc)  GJA1 (fca) 
Subcellular
localization
wolf
plas 9  (predict for NP_000156.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04974 Protein digestion and absorption 6
hsa04392 Hippo signaling pathway - multiple species 4
hsa04510 Focal adhesion 4
hsa04611 Platelet activation 3
hsa04926 Relaxin signaling pathway 3
Genes directly connected with GJA1 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
4.3 YAP1 Yes1 associated transcriptional regulator [detail] 0 10413
4.2 PCDH18 protocadherin 18 [detail] 0 54510
4.1 COL5A2 collagen type V alpha 2 chain [detail] 0 1290
Coexpressed
gene list		 [Coexpressed gene list for GJA1]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 2697      
Refseq ID (protein) NP_000156.1 


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