Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-u.4   KL   klotho 
 hsa-r.6   KL   klotho 
 hsa-m.7   KL   klotho 
 hsa-m2.4   KL   klotho 
 mcc-u.3   KL   klotho 
 mmu-u.4   Kl   klotho 
 rno-u.3   Kl   Klotho 
 cfa-u.3   KL   klotho 
 gga-u.3   KL   klotho 
 dre-u.3   kl   klotho 

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Top 50 coexpressed genes to KL (hsa-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa4020   Calcium signaling pathway  4 192 2.58
 hsa4514   Cell adhesion molecules  3 131 2.15
 hsa1522   Endocrine resistance  2 98 -
 hsa4014   Ras signaling pathway  2 232 -
 hsa4080   Neuroactive ligand-receptor interaction  3 353 -

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hsa:KL (klotho) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

hsa-u.4
for
KL
hsa-r.6
for
KL
hsa-m.7
for
KL
hsa-m2.4
for
KL
mcc-u.3
for
KL
mmu-u.4
for
Kl
rno-u.3
for
Kl
cfa-u.3
for
KL
gga-u.3
for
KL
dre-u.3
for
kl
1 BMX BMX non-receptor tyrosine kinase 660 0 4.5 4.3
 1.8
 3.6
 -0.9
 0.1
 0.9
 -1.2

2 ZNF366 zinc finger protein 366 167465 0 4.3 3.5
 -0.0
 4.0
0.8
 0.8
 1.3
 1.1
 0.8
3 STARD13 StAR related lipid transfer domain containing 13 90627 0 4.1 4.4
 1.6
 2.8
 0.7
-0.1
 1.8
-0.4
 1.7
-0.2
 0.2
0.0
 1.2
0.2
 1.4
1.1
4 EMCN endomucin 51705 0 4.1 3.7
 2.8
 3.4
 0.9
 0.6
 0.8
 0.3
 1.6
5 GIMAP8 GTPase, IMAP family member 8 155038 0 3.8 3.7
 2.2
 2.9
 0.1
 -0.1
 0.5
 -0.9

6 FHL5 four and a half LIM domains 5 9457 0 3.7 3.9
 2.6
 2.7
 -0.3
-0.3
 -0.0
-1.2
 0.5
-0.8
 0.2
0.1
 0.2
0.1
 -0.3
-0.7
7 GJA4 gap junction protein alpha 4 2701 0 3.7 2.1
 2.1
 4.4
 0.5
 -0.7
 0.4
0.6
 2.6
1.2
8 SHROOM4 shroom family member 4 57477 0 3.7 2.9
 1.9
 3.6
 -1.3
 1.1
 1.4
 -0.7
 0.9
 0.7
9 CLEC14A C-type lectin domain containing 14A 161198 0 3.7 3.2
 2.0
 3.2
 0.3
 -0.4
 0.1
 0.9
 -0.3
10 PDS5B PDS5 cohesin associated factor B 23047 0 3.7 2.8
 1.9
 3.6
 -0.3
-0.9
 1.7
-0.2
 0.3
0.3
 1.5
-0.4
 0.2
-0.2
 -0.4
-0.6
11 NSUN7 NOP2/Sun RNA methyltransferase family member 7 79730 0 3.6 3.4
 2.1
 2.8
 -1.3
1.0
 -0.7
 1.6
12 ADGRF5 adhesion G protein-coupled receptor F5 221395 0 3.5 3.1
 2.2
 3.0
 0.0
 -0.2
 0.9
 0.9
 1.5
13 PLA1A phospholipase A1 member A 51365 0 3.5 2.4
 1.3
 3.7
 -0.2
 -0.5
 0.3
 0.1
 0.2
 1.5
14 CA4 carbonic anhydrase 4 762 0 3.4 2.1
 1.4
 3.9
 0.3
 1.4
 1.5
 -0.2
 -0.1
 1.4
0.8
15 CLEC1A C-type lectin domain family 1 member A 51267 0 3.4 2.4
 2.4
 3.5
 0.1
 0.5
 1.4
 0.2

16 CNTN4 contactin 4 152330 0 3.4 1.6
 2.0
 4.4
 1.4
1.1
 2.4
1.9
 0.7
0.5
 1.3
0.7
 0.6
-0.0
 0.9
0.7
17 CDH5 cadherin 5 1003 0 3.4 2.9
 2.3
 3.0
 -0.2
 -0.9
 0.1
 1.0
 0.3
 0.6
18 PLVAP plasmalemma vesicle associated protein 83483 0 3.3 1.5
 1.6
 4.3
 0.1
 -0.4
 1.8
 -0.1
 -0.4
 0.9
0.2
19 SELP selectin P 6403 0 3.3 2.3
 1.4
 3.4
 0.7
-0.1
 0.2
-0.1
 1.3
0.5
 1.0
-0.0
 0.4
-0.1
 1.2
0.3
20 SV2B synaptic vesicle glycoprotein 2B 9899 0 3.2 1.9
 1.7
 3.8
 1.0
0.0
 1.7
1.5
 1.2
0.4
 2.8
1.7
 0.4
0.2
 0.4
0.3
21 CD93 CD93 molecule 22918 0 3.2 2.6
 2.0
 3.0
 -0.5
 -0.2
 0.0
 0.4
 -0.4
 0.2
22 ENPEP glutamyl aminopeptidase 2028 0 3.1 2.2
 2.5
 3.2
 2.7
0.6
 -0.1
-0.2
 0.3
-0.7
 0.7
-0.1
 2.1
0.8
 1.8
0.6
23 CYYR1 cysteine and tyrosine rich 1 116159 0 3.1 2.3
 2.6
 3.1
 1.1
 -0.1
 0.0
 0.3
 2.0
 -0.8
24 TDRD9 tudor domain containing 9 122402 0 3.0 2.7
 2.2
 2.6



-0.5
 2.7
25 ITGA9 integrin subunit alpha 9 3680 0 3.0 2.1
 1.8
 3.1
 0.2
 -1.6
 -0.8
 0.6
 0.0
 1.3
26 FGD5 FYVE, RhoGEF and PH domain containing 5 152273 0 3.0 1.9
 1.5
 3.3
 1.2
 -0.2
 0.1
 0.4
 -0.5
 1.2
27 AQP1 aquaporin 1 (Colton blood group) 358 0 3.0 2.1
 1.9
 3.1
 0.5
0.1
 2.9
2.6
 3.9
3.4
 1.1
0.7
 2.4
0.7
 1.4
0.5
28 ADPRH ADP-ribosylarginine hydrolase 141 0 3.0 2.6
 1.8
 2.7
 1.0
-0.9
 -0.2
-0.5
 -1.1
 0.1
-1.0
 0.0
-0.4
 0.5
-0.1
29 FLT1 fms related receptor tyrosine kinase 1 2321 0 3.0 2.1
 1.6
 3.1
 1.6
0.8
 0.5
0.4
 2.1
0.2
 0.7
0.1
 0.7
0.3
 1.9
0.8
30 GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 2561 0 3.0 1.5
 1.2
 3.7
 1.8
-0.7
 2.1
1.4
 1.4
0.8
 1.2
 0.7
0.2
 0.1
-0.5
31 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 345557 0 2.9 1.5
 1.7
 3.7
 0.2
-0.6
 1.0
0.3
 0.1
0.0
 0.7
-0.4
 1.4
0.7
 -0.0
-0.1
32 CYP7B1 cytochrome P450 family 7 subfamily B member 1 9420 0 2.9 2.7
 1.7
 2.5
 0.1
 1.0
 0.6
 0.0
 0.0
 -0.4
33 TSPAN2 tetraspanin 2 10100 0 2.9 2.4
 1.5
 2.7
 -0.0
-0.6
 0.5
-0.0
 1.5
0.6
 0.9
0.2
 0.1
0.1
 0.8
0.5
34 ADCY4 adenylate cyclase 4 196883 0 2.9 2.3
 2.0
 2.8
 0.6
 -1.4
 0.0
 -0.3

35 METTL24 methyltransferase like 24 728464 0 2.9 1.6
3.4


0.5
 0.1
36 ARHGEF15 Rho guanine nucleotide exchange factor 15 22899 0 2.9 2.3
 1.1
 2.7
 1.0
 -0.4
 1.3
 -1.0

37 PCDH12 protocadherin 12 51294 0 2.8 2.2
 1.2
 2.8
 0.9
 0.2
 0.4
 0.1
 0.8
 0.3
38 DLL4 delta like canonical Notch ligand 4 54567 0 2.8 2.3
 0.2
 2.6
 0.2
-0.5
 -0.8
-0.9
 0.1
-0.0
 0.7
-0.7
 1.1
-0.6
 0.5
0.2
39 PTPRB protein tyrosine phosphatase receptor type B 5787 0 2.8 1.7
 2.1
 3.2
 1.1
 -0.1
 1.0
 -0.2
 -0.1
 2.1
40 APLNR apelin receptor 187 0 2.8 1.6
 1.6
 3.3
 0.9
 0.2
 1.7
 0.4
 0.1
 -0.7
-0.8
41 LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 10894 0 2.8 2.2
 1.4
 2.7
 0.5
 -0.8
 -0.1
 0.6
 -0.7
 1.2
-0.9
42 PIWIL4 piwi like RNA-mediated gene silencing 4 143689 0 2.8 2.1
 1.2
 2.7


0.3

43 LPL lipoprotein lipase 4023 0 2.8 2.9
 1.7
 1.9
 0.3
 0.4
 0.3
 -0.9
 -0.5
 -0.1
44 JDP2-AS1 JDP2 antisense RNA 1 101928377 0 2.7 2.8







45 HAAO 3-hydroxyanthranilate 3,4-dioxygenase 23498 0 2.7 1.9
 -0.2
 2.9
 -0.2
 0.1
 -0.5
 0.8
 0.3
 1.4
46 AVPR1A arginine vasopressin receptor 1A 552 0 2.7 2.2
 0.2
 2.6
0.9
0.4
 2.1
1.5
 0.5
-0.8
 0.0
 0.9
-0.1
47 C1orf115 chromosome 1 open reading frame 115 79762 0 2.7 2.2
 1.3
 2.6
 0.9
 -0.9
 0.3
1.8
 0.6
48 CRHBP corticotropin releasing hormone binding protein 1393 0 2.7 1.7
 0.5
 3.0
 1.5
 0.3
 0.5
1.2
 0.7
49 GIMAP7 GTPase, IMAP family member 7 168537 0 2.7 2.4
 1.9
 2.4
 -0.5
 0.2
-0.4
 0.7
-0.3
 0.4
-0.7
50 GNA14 G protein subunit alpha 14 9630 0 2.7 1.9
 0.9
 2.8
 0.5
0.5
 1.4
0.4
 1.0
0.9
 0.7
0.6
 1.1
1.1
 1.7
0.8
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