Orthologous genes in OrthoFinder**

Species Gene Description
 mmu-m.5   Hmgcs2   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 
 mmu-u.4   Hmgcs2   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 
 mmu-r.6   Hmgcs2   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 
 mmu-u.4   Hmgcs1   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 
 rno-u.3   Hmgcs2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 rno-u.3   Hmgcs1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 hsa-u.4   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 hsa-u.4   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 mcc-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 mcc-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 cfa-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 cfa-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 gga-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 gga-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 dre-u.3   hmgcs1   3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 
 dme-u.3   Hmgs   HMG Coenzyme A synthase 
 cel-u.3   hmgs-1   Hydroxymethylglutaryl-CoA synthase 
 sce-u.3   ERG13   hydroxymethylglutaryl-CoA synthase 

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Top 50 coexpressed genes to Hmgcs2 (mmu-m.5 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 mmu3320   PPAR signaling pathway  8 78 6.98
 mmu71   Fatty acid degradation  7 47 6.60
 mmu1212   Fatty acid metabolism  4 58 6.14
 mmu4146   Peroxisome  4 86 6.73
 mmu4936   Alcoholic liver disease  5 124 3.32

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mmu:Hmgcs2 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2) External Links;


Show/Hide Columns:          
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

mmu-m.5
for
Hmgcs2
mmu-u.4
for
Hmgcs2
mmu-r.6
for
Hmgcs2
mmu-u.4
for
Hmgcs1
rno-u.3
for
Hmgcs2
rno-u.3
for
Hmgcs1
hsa-u.4
for
HMGCS2
hsa-u.4
for
HMGCS1
mcc-u.3
for
HMGCS1
mcc-u.3
for
HMGCS2
cfa-u.3
for
HMGCS2
cfa-u.3
for
HMGCS1
gga-u.3
for
HMGCS2
gga-u.3
for
HMGCS1
dre-u.3
for
hmgcs1
dme-u.3
for
Hmgs
cel-u.3
for
hmgs-1
sce-u.3
for
ERG13
1 4833417J20Rik RIKEN cDNA 4833417J20 gene 74604 0 3.8
















2 Acot1 acyl-CoA thioesterase 1 26897 6 3.6 7.2
 6.4
 0.8
0.6
 6.2
5.3
 1.7
1.0
 2.4
2.0
 2.3
0.9
 1.9
1.1
 2.2
1.9
 1.7
1.7
 1.5
1.3
 3.5
0.7
 1.5
0.1
 3.3
1.8
0.3
0.1
3 Angptl4 angiopoietin-like 4 57875 4 3.5 7.3
 6.9
 -0.7
 7.0
 -0.3
 1.1
 -1.0
 -1.0
 1.1
 0.6
 -2.4
 1.1
 0.3
 1.6


4 Cpt1a carnitine palmitoyltransferase 1a, liver 12894 43 3.0 6.2
 5.6
 -0.1
-0.5
 8.5
1.5
 -0.0
-1.1
 3.1
-1.3
 -1.3
-2.4
 0.3
-0.5
 2.6
-1.5
 0.9
-0.1
 -0.0
-1.5
 0.9
 1.5
 1.6
1.6
 0.4
 -2.1
5 Ppara peroxisome proliferator activated receptor alpha 19013 47 2.9 5.3
 4.3
 0.7
 0.8
 -0.2
 0.4
 0.4
 0.6
 0.3
 1.8
 2.0
 1.4
 2.0
 -0.5
-1.0


6 Cyp4f15 cytochrome P450, family 4, subfamily f, polypeptide 15 106648 0 2.9 5.5
 4.7
 0.6
0.5
 4.0
3.1
 1.6
1.0
 4.5
2.2
 1.5
1.1
 0.7
0.5
 3.4
1.8
 3.9
3.4
 0.8
0.5
 2.1
1.9
 2.0
1.0
 0.4
-0.4
 1.9
1.8
 1.5
1.3
 -0.1
7 Eci2 enoyl-Coenzyme A delta isomerase 2 23986 0 2.9 6.0
 5.5
 0.6
-0.1
 5.7
2.0
 1.2
0.8
 1.7
 -0.1
 0.4
 -0.4
 0.6
 1.2
 0.8
 2.4
 1.9
 -0.6
 -0.1
-0.6
 1.1
-0.4
8 Pbld1 phenazine biosynthesis-like protein domain containing 1 68371 0 2.7

-0.2
 2.0
0.1
 -0.7
-1.3
 1.5
 -0.1
 0.9
 0.6
 2.1
 0.4
 0.8
 1.4
 0.5
0.2
-1.0
 -0.2
9 Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 20887 1 2.7 5.7
 5.3
 1.4
1.0
 7.0
2.2
 1.1
1.1
 4.6
3.1
 1.1
0.7
 1.2
0.4
 2.4
1.8
 2.6
2.4
 0.7
0.6
 3.4
1.1
 1.0
0.8
 2.0
1.1
 1.8
1.1
 0.1
10 Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 57279 0 2.7 5.3
 4.8
 -0.3
 4.4
 0.1
 3.6
 -1.2
 0.9
 2.4
 1.2
 -0.6
 1.3
 1.0
 2.5
 3.7
1.3
 1.5
0.3
 1.8
-1.4
11 Slco2b1 solute carrier organic anion transporter family, member 2b1 101488 0 2.6 4.3
 3.1
 0.0
-1.0
 3.2
1.9
 -0.0
-0.6
 2.3
0.8
 0.3
-0.5
 0.5
0.2
 0.5
-0.9
 0.9
-0.3
 0.3
0.1
 1.1
0.6
 0.9
0.5
 0.1
1.7
12 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 52538 5 2.6 6.3
 6.6
 0.6
 6.7
 0.8
 2.3
 0.8
 0.4
 2.7
 2.8
 0.7
 1.5
 2.7
 1.1
 1.1
 0.5
13 Agtr1a angiotensin II receptor, type 1a 11607 0 2.5 5.0
 4.5
 0.3
 2.9
 0.6
 1.3
 0.0
 -0.5
 1.0
 1.7
 0.2
 -2.1
 -1.4
 0.6


14 Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 243168 0 2.5 4.1
 2.8
 0.3
-0.5
 3.6
1.7
 0.9
0.4
 1.4
0.5
 0.4
0.2
 0.6
0.1
 2.2
2.2
 2.2
1.8
 1.3
0.8
 1.9
1.2
 1.2
0.7
 0.8
0.5
 1.5
1.2
 1.4
0.8
 0.1
-0.6
15 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 56752 0 2.5 4.4
 3.5
 3.3
 1.5
 0.8
 1.3
 1.3
 -0.1
 0.4
 0.7
 2.1
 0.1
 -1.2
 1.6
0.7
0.1
16 Plin5 perilipin 5 66968 0 2.5 4.4
 3.4
 0.7
0.3
 3.2
2.9
 1.4
1.2
 1.7
0.8
 0.3
0.1
 2.1
-0.3
 1.4
0.4
 1.2
0.8
 0.7
-0.5
 1.4
1.4
 0.7
-0.0
 2.4
1.6
 1.7

17 B230114P17Rik RIKEN cDNA B230114P17 gene 402735 0 2.5
















18 Creb3l3 cAMP responsive element binding protein 3-like 3 208677 0 2.5 4.1
 2.9
 -0.5
 3.5
 0.7
 5.1
 -0.0
 1.0
 1.5
 2.3
 0.3
 2.7
 0.0
 -0.3
-0.6
-0.1
19 Lgals4 lectin, galactose binding, soluble 4 16855 0 2.4 4.7
 4.0
 0.4
0.2
 0.8
0.6
 1.4
0.5
 5.1
0.6
 -0.0
-0.2
 0.8
0.1
 1.5
0.6
 0.7
0.5
 2.0
1.1
 -0.9
 1.1
 1.0
0.7
 1.3
1.3
 1.1
0.6
20 Slc25a34 solute carrier family 25, member 34 384071 0 2.4 5.4
 5.3
 0.6
-0.6
 3.2
-1.1
 1.2
-2.2

-0.2
 1.6
 0.4
-0.7
 -0.2
-1.6
 1.6
 -0.0
 1.1
-0.2
 3.2
-0.3
0.5
21 Chrna2 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) 110902 0 2.4 3.5
 2.0
 3.4
0.0
 0.8
0.3
 0.8
0.7
 1.2
0.8
 1.2
0.4
 -0.2
-1.0
 0.1
0.1

0.2
0.2
 0.9
0.4
 -0.1
-0.4
 -0.1
-0.3
 1.3
0.5
22 Ech1 enoyl coenzyme A hydratase 1, peroxisomal 51798 0 2.4 4.9
 4.6
 0.7
 7.3
 -0.9
 3.4
 1.4
 0.2
 0.6

1.6
 1.4
 0.3
 0.9
 0.8
0.1
23 Pxmp4 peroxisomal membrane protein 4 59038 0 2.4 4.2
 3.3
 1.8
 2.0
 1.2
 -0.0
 0.6
 2.9
 0.1
 0.2
 2.4
 -1.0
 0.2
 0.9
1.9
24 Acot12 acyl-CoA thioesterase 12 74156 0 2.4 3.8
 2.6
 0.2
 2.1
 0.1



2.8
 0.0

-1.2


25 Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) 170442 0 2.4 4.5
 3.8
 -0.1
 2.0
 0.2
 0.8
 0.6
 0.5
 0.5
 1.7
 0.9
 1.9
 0.6
 1.9
 1.1
1.0
 2.0
 0.0
26 Hsdl2 hydroxysteroid dehydrogenase like 2 72479 0 2.4 4.9
 4.5
 1.3
 4.5
 0.1
 2.7
 -0.3
 1.2
 1.2
 1.5
 2.5
 0.4
 0.4
 -0.3
 1.7
 2.0
-0.5
27 Ephx2 epoxide hydrolase 2, cytoplasmic 13850 0 2.4 5.0
 4.7
 0.1
 4.5
 0.5
 1.9
 0.0
 0.2
 0.7
 1.6
 0.2
 1.9
 1.0
 1.4


28 Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 56448 0 2.3 4.4
 3.7
 0.2
-0.1
 2.8
1.6
 0.5
0.1
 1.3
 0.5
 -0.2
-0.4
 1.1
0.1
 1.6
 0.6
 0.0
 -0.4

0.2
29 Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta 231086 0 2.3 4.3
 3.5
 0.6
 3.4
 -0.0
 2.6
 -0.0
 0.5
 2.2
 1.2
 1.2
 2.3
 2.0
 2.1
 2.9
 2.2
30 Slc22a1 solute carrier family 22 (organic cation transporter), member 1 20517 0 2.2 3.8
 2.9
 1.0
1.0
 1.3
1.2
 1.1
0.6
 3.2
2.5
 0.8
0.5
 0.4
0.1
 2.2
1.7
 3.4
3.1
 1.5
0.9
 1.4
0.9
 1.2
1.0
 1.9
1.0
 2.2
1.9
 4.1
3.0
31 Fmo1 flavin containing monooxygenase 1 14261 0 2.2 5.0
 4.9
 0.5
-0.4
 2.5
2.0
 -0.1
-0.5
 2.4
1.7
 0.8
0.5
 1.6
0.9
 2.0
0.3
 3.8
1.8
 1.6
1.5
 1.4
-0.2
 0.5
-0.5
 0.3
-0.6
 1.6
-0.6
 2.4
2.1
 -0.3
32 Fabp1 fatty acid binding protein 1, liver 14080 0 2.2 4.4
 4.0
 0.5
 2.1
 1.4
 7.7
 0.8
 1.4
 3.8
 3.5
 0.8
 3.3
 0.3



33 Retsat retinol saturase (all trans retinol 13,14 reductase) 67442 0 2.2 4.6
 4.4
 -0.6
 4.4
 -0.1
 1.4
 1.0
 1.1
 0.3
 1.0
 2.1
 2.5
 0.4
 3.3
-0.1


34 Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 13119 0 2.2 4.6
 4.3
 0.6
0.5
 4.0
3.1
 1.6
1.0
 4.5
2.2
 1.5
1.1
 0.7
0.5
 3.4
1.8
 3.9
3.4
 0.8
0.5
 2.1
1.9
 2.0
1.0
 0.4
-0.4
 1.9
1.8
 1.5
1.3
 -0.1
35 Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 114664 0 2.2 3.7
 2.7
 0.3
-0.5
 3.6
1.7
 0.9
0.4
 1.4
0.5
 0.4
0.2
 0.6
0.1
 2.2
2.2
 2.2
1.8
 1.3
0.8
 1.9
1.2
 1.2
0.7
 0.8
0.5
 1.5
1.2
 1.4
0.8
 0.1
-0.6
36 Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 13106 0 2.2 3.4
 2.2
 1.8
1.2
 3.3
2.6
 2.0
1.4
 4.4
4.0
 0.9
0.6
 1.7
1.2
 3.0
2.7
 4.5
3.9
 1.2
0.8
 2.1
2.0
 1.3
0.9
 1.0
0.7
0.4
37 Fcgrt Fc fragment of IgG receptor and transporter 14132 0 2.2 4.0
 3.3
 -0.2
 3.2
 -0.6
 1.3
 -1.2
 -1.7
 0.4
 0.4
 -1.2





38 Vwa8 von Willebrand factor A domain containing 8 219189 0 2.2 3.4
 2.3
 0.2
 4.5
 0.2
 0.5
 0.4
 0.3
 -0.5
 0.9
 2.0
 0.5
 1.5
 1.0
 2.5
 0.5
39 Etfdh electron transferring flavoprotein, dehydrogenase 66841 0 2.2 4.3
 3.8
 1.2
 3.5
 1.2
 2.7
 0.2
 2.0
 1.4
 1.3
 0.7
 0.1
 1.1
 0.1
 1.4
 1.1
 3.0
40 Slc22a5 solute carrier family 22 (organic cation transporter), member 5 20520 0 2.1 3.6
 2.7
 1.0
1.0
 1.3
1.2
 1.1
0.6
 3.2
2.5
 0.8
0.5
 0.4
0.1
 2.2
1.7
 3.4
3.1
 1.5
0.9
 1.4
0.9
 1.2
1.0
 1.9
1.0
 2.2
1.9
 4.1
3.0
41 Vnn1 vanin 1 22361 0 2.1 4.5
 4.2
 2.9
0.9
 4.0
1.6
 2.0
0.1
 0.5
0.1
 -0.0
-0.3
 0.5
0.4
 0.7
0.2
 1.5
1.0
 0.3
-0.4
 0.3
-0.1
 1.0
0.7
 -0.5
 0.2
0.0

42 1110064A23Rik RIKEN cDNA 1110064A23 gene 68893 0 2.1
















43 Acadl acyl-Coenzyme A dehydrogenase, long-chain 11363 0 2.1 4.2
 3.9
 1.4
 4.5
 -0.5
 1.2
 0.2
 1.3
 0.4
 2.0
 0.8
 1.2
 1.4
 1.8


44 Htra3 HtrA serine peptidase 3 78558 0 2.1 3.4
 2.5
 -0.5
-0.9
 1.9
1.4
 -0.1
-0.5
 -0.2
-0.4
 0.0
-0.8
 -0.0
-0.2
 0.1
-0.1
 -0.2
-0.5
 0.2
-0.4
 1.1
0.4
 0.8
-0.7
 1.2
0.3
 1.2

45 Plin2 perilipin 2 11520 0 2.0 3.9
 3.3
 0.7
0.3
 3.2
2.9
 1.4
1.2
 1.7
0.8
 0.3
0.1
 2.1
-0.3
 1.4
0.4
 1.2
0.8
 0.7
-0.5
 1.4
1.4
 0.7
-0.0
 2.4
1.6
 1.7

46 Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 18670 0 2.0 3.3
 2.4
 0.5
-0.2
 0.9
0.6
 1.3
1.2
 1.4
0.1
 0.1
-0.6
 1.1
0.9
 1.2
0.6
 0.8
0.3
 0.1
-0.4
 1.7
-0.9
 1.0
0.9
 1.6
0.5
 0.3
0.2
 1.9
1.8
 -0.9
47 Klf11 Kruppel-like factor 11 194655 0 2.0 4.1
 3.7
 -0.2
 3.2
 -0.9
 0.5
 0.5
 -0.6
 0.7
 1.7
 -0.8
 -0.4
 -0.5
 2.8
2.5


48 Apoc4 apolipoprotein C-IV 11425 0 2.0 2.9
 1.6














49 Vtn vitronectin 22370 0 2.0 4.5
 4.5
 0.2
 2.4
 1.3
 3.0
 0.2
 0.5
 -0.5
 1.4
 0.5
 3.0
 0.7
 0.5
-0.6


50 Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 27273 0 2.0 4.7
 4.8
 2.1
0.2
 4.8
2.0
 1.5
-0.5
 2.6
0.8
 1.2
0.4
 0.1
-0.5
 1.0
0.7
 0.8
-0.1
 1.6
-0.3
 0.2
-0.5
 0.4
-0.9
 0.6
-0.2
 -0.2
 0.1
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