Publication for SDHB and UQCRFS1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	SDHB	succinate dehydrogenase complex iron sulfur subunit B	6390			[link]
hsa	UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	7386

Pubmed ID	Priority	Text
24381713	0.98	SDHB), III ubiquinol-cytochrome-c reductase (CYC1, UQCRFS1, and UQCR), IV cytochrome c oxidase (COX5B, COX6A1, and COX8A), and surfeit locus protein 1 (SURF1) were found to be abundant in octo/nonagenarians.
26749241	0.97	SDHB protein levels were drastically reduced in cells lacking a functional SDHAF1 (immunoblot to SDHB), whereas UQCRFS1 (complex III Rieske protein), UQCRC2 (complex III core subunit), NDUFS1 (complex I Fe-S subunit), and ACO2 levels (mitochondrial aconitase) did not change.
29416685	0.97	SDHB, SDHC, and SDHD), eight genes for complex III coenzyme Q cytochrome c reductase (BCS1L, CYC1, UQCR11, UQCRC1, UQCRC2, UQCRFS1, UQCRH, and UQCRQ), 14 genes for complex IV cytochrome c oxidase (COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A2, COX7A2L, COX7B, COX8A, and COX8C), and 25 genes for complex V ATP synthase (ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6V0A2, ATP6V0D2, ATP6V1C2, ATP6V1E2, ATP6V1G3, LHPP, OXA1L, PPA1, and PPA2) (Figure 4A).
24606901	0.96	SDHB, NDUFS3 (a Fe-S subunit of Complex I) and UQCRFS1 (the Complex III Fe-S subunit also known as the Rieske Fe-S protein) protein levels were significantly reduced after seven or nine days of silencing (Figure S3A), consistent with the known instability of some Fe-S proteins when they fail to incorporate their clusters.
27143423	0.96	Sdhb (FC = -1.55, p = 0.0018); (4) 4 genes involved in electron transport chain and oxidative phosphorylation: Ndufs4 (FC = -1.88, p = 0.0011), Ndufs8 (FC = -1.75, p = 0.00073), Uqcrc2 (FC = -1.42, p = 0.0077), and Uqcrfs1 (FC = -1.74, p = 0.00087); (5) 7 genes involved in reduction and oxidation (Redox): Glrx (FC = -2.04, p = 0.0044), Glrx2 (FC = -2.07, p = 0.00053), Gpx1 (FC = -1.96, p = 0.0018), Gpx4 (FC = 1.47, p = 0.037), Prdx3 (FC = -1.47, p = 0.000023), Sod1 (FC = 2.09, p = 0.00077), and Sod2 (FC = -1.43, p = 0.000077); (6) 9 genes involved in transport: Hspd1 (FC = -2.30, p = 0.00013), Slc25a14 (FC = -1.60, p = 0.0017), Slc25a27 (FC = 1.68, p = 0.021), Slc25a4 (FC = -2.21, p = 0.0000003), Slc2a1 (FC = 1.78, p = 0.020), Slc2a3 (FC = 1.44, p = 0.022), Timm23 (FC = -1.99, p = 0.0015), Timm20 (FC = -1.83, p = 0.0037), Vdac2 (FC = -1.48, p = 0.030); (7) 1 gene involved in apoptosis: Bcl2 (FC = -1.58, p = 0.039); (8) 9 genes involved in lipid/ketone metabolism and cholesterol trafficking: Acaa1a (FC = -2.57, p = 0.000011), Acaa2 (FC = -1.70, p = 0.0031), Acadl (FC = -2.19, p = 0.0097), Acadm (FC = -1.49, p = 0.027), Acadvl (FC = 1.60, p = 0.045), Acat1 (FC = -1.58, p = 0.017), Cpt2 (FC = -1.59, p = 0.00090), Decr1 (FC = -1.76, p = 0.0045), and Rarb (FC = -1.69, p = 0.0022).
29623423	0.96	SDH, NDUFS3, NDUFA9, NDUFB4, NDUFA13, UQCRFS1) was found but no decrease of ferrochelatase.
23459395	0.95	SDHB, UQCRFS1) are also downregulated in VAT from T2D patients.
31881007	0.94	SDHB), CIII (UQCRFS1), complex IV (CIV) (COX6C and COX6B1), and CV (ATP5B, ATP5C1 and ATP5H).
21494430	0.93	SDHB, SDHC and SUCLA2), fatty acid metabolism (ACAA2, ACAT1, ACSL3, ACSL4, ACSL6, ADH1, ADH6, ALDH2, CPT1A, ECHS1, EHHADH, PECI and SLC25A29,), OXPHOS (ATP5D, ATP5E, ATP5I, ATP5O, ATP6V1E1, ATPAF2, COX15, COX17, COX18, COX6C, COX7A2, MIPEP, mt-ATP8, mt-ND1, NDUFA1, NDUFA10, NDUFA4, NDUFAB1, NDUFAF1, NDUFB10, NDUFB4L1, NDUFS1, NDUFS2, NDUFV1, PPA2, SDHA, SDHB, SDHC and UQCRFS1), REDOX (GPX1, GSTZ1 and PRDX1), and neurotransmitter production and transport (ABAT, AGXT, CAD, DDC, GAD1, GLS2, GLUD1, GPT, SLC25A18 and SLC25A22).
28878155	0.92	UQCRFS1, SDHB, and ATP5O were significantly associated with both neurodevelopmental toxicity and type-2 diabetes (p < 0.05).
	0.77	UQCRFS1, SDHB, and ATP5O) out of 30 were matched with BPA-mediated diseases, as shown in Table 5.
25477904	0.88	SDHB (subunit of complex II; Mitoscience, 1:200), alpha-UQCRFS1 (subunit of complex III; Mitoscience, 1:1000), alpha-MTCO2 (subunit of complex IV; Mitoscience, 1:1500), alpha-COX4 (subunit of complex IV; Mitoscience, 1:2000), alpha-Tubulin beta (Sigma, 1:2000).
25998209	0.75	Sdhb, Uqcrfs1, Cox5a, Atp5g1 and Ncor1 in NCoR1L2/L2 MEF cells infected with either an Ad-LacZ or Ad-Cre adenovirus grown in high glucose (25 mM) medium.
26550561	0.70	SDHB, NDUFB7, NDUFV2, NDUFB3, NDUFC1, NDUFB6, NDUFV1, UQCRFS1, NDUFA2, NDUFS4, COX7C, NDUFA8, NDUFB9, ATP5B, ATP5C1, ATP5F1, ETFA, SLC25A4, COX7A1, IDH3B, IDH3A, PDHB, MDH2, DLD, ATP5L, and PPA2.
27507061	0.67	SDHB), and UQCRFS1 (Table 1).
28738844	0.57	Sdh2 or Sdh2-His6Myc2 in sdh7 cells harboring human SDHAF3 alleles resulted in increased levels SDHAF3, regardless of the p.Phe53Leu variation; however, the expression of Myc-tagged Rip1, a target of another LYR motif protein, Mzm1, failed to do so (Fig. 1d).