functional annotation |
Function |
serine hydroxymethyltransferase 2 (mitochondrial) |
|
GO BP |
GO:0019264 [list] [network] glycine biosynthetic process from serine
|
(2 genes)
|
IBA
ISO
|
|
GO:0006565 [list] [network] L-serine catabolic process
|
(3 genes)
|
IBA
|
|
GO:0006564 [list] [network] L-serine biosynthetic process
|
(4 genes)
|
ISO
|
|
GO:0006545 [list] [network] glycine biosynthetic process
|
(6 genes)
|
ISO
|
|
GO:0046655 [list] [network] folic acid metabolic process
|
(6 genes)
|
IBA
|
|
GO:0006563 [list] [network] L-serine metabolic process
|
(8 genes)
|
ISO
|
|
GO:0009113 [list] [network] purine nucleobase biosynthetic process
|
(8 genes)
|
IBA
|
|
GO:0035999 [list] [network] tetrahydrofolate interconversion
|
(12 genes)
|
IBA
|
|
GO:0006544 [list] [network] glycine metabolic process
|
(16 genes)
|
ISO
|
|
GO:0046653 [list] [network] tetrahydrofolate metabolic process
|
(20 genes)
|
IBA
ISO
|
|
GO:0002082 [list] [network] regulation of oxidative phosphorylation
|
(25 genes)
|
IBA
IMP
ISO
|
|
GO:0070129 [list] [network] regulation of mitochondrial translation
|
(26 genes)
|
IMP
ISO
|
|
GO:0070536 [list] [network] protein K63-linked deubiquitination
|
(30 genes)
|
ISO
|
|
GO:0034340 [list] [network] response to type I interferon
|
(33 genes)
|
IBA
ISO
|
|
GO:1903715 [list] [network] regulation of aerobic respiration
|
(34 genes)
|
IMP
ISO
|
|
GO:0006730 [list] [network] one-carbon metabolic process
|
(40 genes)
|
IBA
ISO
|
|
GO:0051289 [list] [network] protein homotetramerization
|
(51 genes)
|
IBA
ISO
|
|
GO:0051262 [list] [network] protein tetramerization
|
(80 genes)
|
ISO
|
|
GO:0008284 [list] [network] positive regulation of cell population proliferation
|
(1011 genes)
|
ISO
|
|
|
GO CC |
|
GO MF |
GO:0004372 [list] [network] glycine hydroxymethyltransferase activity
|
(2 genes)
|
IBA
ISO
|
|
GO:0008732 [list] [network] L-allo-threonine aldolase activity
|
(3 genes)
|
ISO
|
|
GO:0070905 [list] [network] serine binding
|
(4 genes)
|
IBA
|
|
GO:0050897 [list] [network] cobalt ion binding
|
(11 genes)
|
IBA
|
|
GO:0000900 [list] [network] translation repressor activity, mRNA regulatory element binding
|
(13 genes)
|
IBA
|
|
GO:0048027 [list] [network] mRNA 5'-UTR binding
|
(29 genes)
|
IBA
|
|
GO:0030170 [list] [network] pyridoxal phosphate binding
|
(52 genes)
|
IBA
ISO
|
|
GO:0016597 [list] [network] amino acid binding
|
(64 genes)
|
ISO
|
|
GO:0003682 [list] [network] chromatin binding
|
(648 genes)
|
ISO
|
|
GO:0008270 [list] [network] zinc ion binding
|
(700 genes)
|
IBA
|
|
GO:0042803 [list] [network] protein homodimerization activity
|
(780 genes)
|
IBA
|
|
GO:0016740 [list] [network] transferase activity
|
(2235 genes)
|
IEA
|
|
GO:0042802 [list] [network] identical protein binding
|
(2357 genes)
|
ISO
|
|
GO:0003824 [list] [network] catalytic activity
|
(5635 genes)
|
IEA
|
|
|
KEGG |
mmu00260 [list] [network] Glycine, serine and threonine metabolism (40 genes) |
|
mmu00630 [list] [network] Glyoxylate and dicarboxylate metabolism (32 genes) |
|
mmu00670 [list] [network] One carbon pool by folate (19 genes) |
|
mmu01200 [list] [network] Carbon metabolism (121 genes) |
|
mmu01230 [list] [network] Biosynthesis of amino acids (79 genes) |
|
mmu01240 [list] [network] Biosynthesis of cofactors (152 genes) |
|
mmu01523 [list] [network] Antifolate resistance (29 genes) |
|
Protein |
NP_001239245.1
NP_082506.1
|
BLAST |
NP_001239245.1
NP_082506.1
|
Orthologous |
[Ortholog page]
SHMT1 (hsa)
SHMT2 (hsa)
Shmt1 (mmu)
Shmt (dme)
mel-32 (cel)
Shmt1 (rno)
Shmt2 (rno)
shmt1 (dre)
SHMT1 (gga)
SHMT1 (cfa)
SHMT2 (cfa)
SHMT1 (mcc)
SHMT2 (mcc)
SHM2 (sce)
SHM1 (sce)
shmt2 (dre)
SHMT1 (fca)
SHMT2 (fca)
|
Subcellular localization wolf |
mito 9,
cyto_mito 5
|
(predict for NP_001239245.1)
|
mito 8,
cyto_mito 5
|
(predict for NP_082506.1)
|
|
Gene coexpression |
Network*for coexpressed genes |
KEGG* ID |
Title |
#genes |
Link to the KEGG* map (Multiple genes) |
mmu00970 |
Aminoacyl-tRNA biosynthesis |
5 |
|
mmu01230 |
Biosynthesis of amino acids |
4 |
|
mmu00670 |
One carbon pool by folate |
4 |
|
mmu01240 |
Biosynthesis of cofactors |
3 |
|
mmu00330 |
Arginine and proline metabolism |
2 |
|
Genes directly connected with Shmt2 on the network
coex z* |
Locus |
Function* |
Coexpression detail |
CoexPub |
Entrez Gene ID* |
10.1 |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
[detail] |
1 |
56454 |
9.5 |
Mars1 |
methionine-tRNA synthetase 1 |
[detail] |
0 |
216443 |
8.9 |
Slc7a5 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 |
[detail] |
0 |
20539 |
|
Coexpressed gene list |
[Coexpressed gene list for Shmt2]
|
Gene expression |
All samples |
[Expression pattern for all samples]
|
Tissue specificity* |
|