[←][→] mmu  Shmt2 Gene
functional annotation
Function   serine hydroxymethyltransferase 2 (mitochondrial)  
GO BP
GO:0019264 [list] [network] glycine biosynthetic process from serine  (2 genes)  IBA ISO  
GO:0006565 [list] [network] L-serine catabolic process  (3 genes)  IBA  
GO:0006564 [list] [network] L-serine biosynthetic process  (4 genes)  ISO  
GO:0006545 [list] [network] glycine biosynthetic process  (6 genes)  ISO  
GO:0046655 [list] [network] folic acid metabolic process  (6 genes)  IBA  
GO:0006563 [list] [network] L-serine metabolic process  (8 genes)  ISO  
GO:0009113 [list] [network] purine nucleobase biosynthetic process  (8 genes)  IBA  
GO:0035999 [list] [network] tetrahydrofolate interconversion  (12 genes)  IBA  
GO:0006544 [list] [network] glycine metabolic process  (16 genes)  ISO  
GO:0046653 [list] [network] tetrahydrofolate metabolic process  (20 genes)  IBA ISO  
GO:0002082 [list] [network] regulation of oxidative phosphorylation  (25 genes)  IBA IMP ISO  
GO:0070129 [list] [network] regulation of mitochondrial translation  (26 genes)  IMP ISO  
GO:0070536 [list] [network] protein K63-linked deubiquitination  (30 genes)  ISO  
GO:0034340 [list] [network] response to type I interferon  (33 genes)  IBA ISO  
GO:1903715 [list] [network] regulation of aerobic respiration  (34 genes)  IMP ISO  
GO:0006730 [list] [network] one-carbon metabolic process  (40 genes)  IBA ISO  
GO:0051289 [list] [network] protein homotetramerization  (51 genes)  IBA ISO  
GO:0051262 [list] [network] protein tetramerization  (80 genes)  ISO  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (1011 genes)  ISO  
GO CC
GO:0070552 [list] [network] BRISC complex  (6 genes)  IBA ISO  
GO:0042645 [list] [network] mitochondrial nucleoid  (48 genes)  ISO  
GO:0005758 [list] [network] mitochondrial intermembrane space  (89 genes)  ISO  
GO:0005759 [list] [network] mitochondrial matrix  (276 genes)  IBA ISO  
GO:0005743 [list] [network] mitochondrial inner membrane  (454 genes)  HDA IBA ISO  
GO:0015630 [list] [network] microtubule cytoskeleton  (1262 genes)  ISO  
GO:0005739 [list] [network] mitochondrion  (1890 genes)  HDA ISO  
GO:0005829 [list] [network] cytosol  (3785 genes)  IBA  
GO:0005634 [list] [network] nucleus  (7226 genes)  IBA ISO  
GO:0016020 [list] [network] membrane  (9571 genes)  IEA  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IBA ISO  
GO MF
GO:0004372 [list] [network] glycine hydroxymethyltransferase activity  (2 genes)  IBA ISO  
GO:0008732 [list] [network] L-allo-threonine aldolase activity  (3 genes)  ISO  
GO:0070905 [list] [network] serine binding  (4 genes)  IBA  
GO:0050897 [list] [network] cobalt ion binding  (11 genes)  IBA  
GO:0000900 [list] [network] translation repressor activity, mRNA regulatory element binding  (13 genes)  IBA  
GO:0048027 [list] [network] mRNA 5'-UTR binding  (29 genes)  IBA  
GO:0030170 [list] [network] pyridoxal phosphate binding  (52 genes)  IBA ISO  
GO:0016597 [list] [network] amino acid binding  (64 genes)  ISO  
GO:0003682 [list] [network] chromatin binding  (648 genes)  ISO  
GO:0008270 [list] [network] zinc ion binding  (700 genes)  IBA  
GO:0042803 [list] [network] protein homodimerization activity  (780 genes)  IBA  
GO:0016740 [list] [network] transferase activity  (2235 genes)  IEA  
GO:0042802 [list] [network] identical protein binding  (2357 genes)  ISO  
GO:0003824 [list] [network] catalytic activity  (5635 genes)  IEA  
KEGG mmu00260 [list] [network] Glycine, serine and threonine metabolism (40 genes)
mmu00630 [list] [network] Glyoxylate and dicarboxylate metabolism (32 genes)
mmu00670 [list] [network] One carbon pool by folate (19 genes)
mmu01200 [list] [network] Carbon metabolism (121 genes)
mmu01230 [list] [network] Biosynthesis of amino acids (79 genes)
mmu01240 [list] [network] Biosynthesis of cofactors (152 genes)
mmu01523 [list] [network] Antifolate resistance (29 genes)
Protein NP_001239245.1  NP_082506.1 
BLAST NP_001239245.1  NP_082506.1 
Orthologous [Ortholog page] SHMT1 (hsa)  SHMT2 (hsa)  Shmt1 (mmu)  Shmt (dme)  mel-32 (cel)  Shmt1 (rno)  Shmt2 (rno)  shmt1 (dre)  SHMT1 (gga)  SHMT1 (cfa)  SHMT2 (cfa)  SHMT1 (mcc)  SHMT2 (mcc)  SHM2 (sce)  SHM1 (sce)  shmt2 (dre)  SHMT1 (fca)  SHMT2 (fca) 
Subcellular
localization
wolf
mito 9,  cyto_mito 5  (predict for NP_001239245.1)
mito 8,  cyto_mito 5  (predict for NP_082506.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu00970 Aminoacyl-tRNA biosynthesis 5
mmu01230 Biosynthesis of amino acids 4
mmu00670 One carbon pool by folate 4
mmu01240 Biosynthesis of cofactors 3
mmu00330 Arginine and proline metabolism 2
Genes directly connected with Shmt2 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
10.1 Aldh18a1 aldehyde dehydrogenase 18 family, member A1 [detail] 1 56454
9.5 Mars1 methionine-tRNA synthetase 1 [detail] 0 216443
8.9 Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 [detail] 0 20539
Coexpressed
gene list		 [Coexpressed gene list for Shmt2]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 108037      
Refseq ID (protein) NP_001239245.1 
NP_082506.1 


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