KEGG 04115 p53 signaling pathway
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) gga(Chicken) dre(Zebrafish) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04115 p53 signaling pathway 30
hsa04110 Cell cycle 15
hsa05200 Pathways in cancer 13
hsa04218 Cellular senescence 13
hsa05169 Epstein-Barr virus infection 11
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04115 p53 signaling pathway 32
mmu04110 Cell cycle 20
mmu05200 Pathways in cancer 18
mmu04218 Cellular senescence 17
mmu05169 Epstein-Barr virus infection 14
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04115 p53 signaling pathway 26
rno04218 Cellular senescence 16
rno04110 Cell cycle 15
rno05166 Human T-cell leukemia virus 1 infection 10
rno05165 Human papillomavirus infection 9
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
gga04115 p53 signaling pathway 30
gga04110 Cell cycle 17
gga04218 Cellular senescence 13
gga04210 Apoptosis 10
gga04068 FoxO signaling pathway 8
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
dre04115 p53 signaling pathway 32
dre04110 Cell cycle 17
dre04218 Cellular senescence 17
dre04068 FoxO signaling pathway 13
dre04210 Apoptosis 12
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc04115 p53 signaling pathway 38
mcc04110 Cell cycle 21
mcc04218 Cellular senescence 19
mcc05200 Pathways in cancer 18
mcc05166 Human T-cell leukemia virus 1 infection 15
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa04115 p53 signaling pathway 26
cfa05200 Pathways in cancer 14
cfa04218 Cellular senescence 13
cfa04110 Cell cycle 12
cfa05169 Epstein-Barr virus infection 11
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04115 p53 signaling pathway 19
fca05170 Human immunodeficiency virus 1 infection 9
fca01524 Platinum drug resistance 8
fca04210 Apoptosis 8
fca05162 Measles 7
Gene list in the network
Symbol Function*
FAS Fas cell surface death receptor
BAX BCL2 associated X, apoptosis regulator
CCNB1 cyclin B1
CCND2 cyclin D2
CCNE1 cyclin E1
CDK1 cyclin dependent kinase 1
CDC6 cell division cycle 6
CDK6 cyclin dependent kinase 6
CHEK1 checkpoint kinase 1
CCN2 cellular communication network factor 2
DDB2 damage specific DNA binding protein 2
GADD45A growth arrest and DNA damage inducible alpha
FDXR ferredoxin reductase
SFN stratifin
CCN1 cellular communication network factor 1
KRT6A keratin 6A
MDM2 MDM2 proto-oncogene
GADD45B growth arrest and DNA damage inducible beta
SERPINE1 serpin family E member 1
SERPINB5 serpin family B member 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLH DNA polymerase eta
RRM2 ribonucleotide reductase regulatory subunit M2
SLC12A4 solute carrier family 12 member 4
THBS1 thrombospondin 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D
TNFRSF10D TNF receptor superfamily member 10d
TNFRSF10B TNF receptor superfamily member 10b
TNFRSF10A TNF receptor superfamily member 10a
CCNB2 cyclin B2
CCNE2 cyclin E2
PTTG1 PTTG1 regulator of sister chromatid separation, securin
TRIP13 thyroid hormone receptor interactor 13
FGFBP1 fibroblast growth factor binding protein 1
KIF20A kinesin family member 20A
GADD45G growth arrest and DNA damage inducible gamma
BBC3 BCL2 binding component 3
SESN1 sestrin 1
RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B
RPS27L ribosomal protein S27 like
TRIAP1 TP53 regulated inhibitor of apoptosis 1
DTL denticleless E3 ubiquitin protein ligase homolog
PIDD1 p53-induced death domain protein 1
TIGAR TP53 induced glycolysis regulatory phosphatase
SPC25 SPC25 component of NDC80 kinetochore complex
ZMAT3 zinc finger matrin-type 3
AEN apoptosis enhancing nuclease
CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1
SESN2 sestrin 2
TP53INP1 tumor protein p53 inducible nuclear protein 1
Symbol Function*
Apaf1 apoptotic peptidase activating factor 1
Birc5 baculoviral IAP repeat-containing 5
Atm ataxia telangiectasia mutated
Bax BCL2-associated X protein
Ccna2 cyclin A2
Ccnb2 cyclin B2
Ccne1 cyclin E1
Ccne2 cyclin E2
Ccng1 cyclin G1
Cdk1 cyclin-dependent kinase 1
Cdk2 cyclin-dependent kinase 2
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21)
Cdkn2a cyclin dependent kinase inhibitor 2A
Cdkn2b cyclin dependent kinase inhibitor 2B
Chek1 checkpoint kinase 1
Ei24 etoposide induced 2.4 mRNA
Fas Fas (TNF receptor superfamily member 6)
Ccn2 cellular communication network factor 2
Hells helicase, lymphoid specific
Ccn1 cellular communication network factor 1
Krt14 keratin 14
Mdm2 transformed mouse 3T3 cell double minute 2
Gadd45b growth arrest and DNA-damage-inducible 45 beta
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1
Prkdc protein kinase, DNA activated, catalytic polypeptide
Rrm2 ribonucleotide reductase M2
Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5
Aurkb aurora kinase B
Thbs1 thrombospondin 1
Tnfaip3 tumor necrosis factor, alpha-induced protein 3
Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b
Zmat3 zinc finger matrin type 3
Cdc6 cell division cycle 6
Gadd45g growth arrest and DNA-damage-inducible 45 gamma
Polk polymerase (DNA directed), kappa
Plek2 pleckstrin 2
Phlda3 pleckstrin homology like domain, family A, member 3
Gtse1 G two S phase expressed protein 1
Pbk PDZ binding kinase
Sfn stratifin
Pidd1 p53 induced death domain protein 1
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1
Perp PERP, TP53 apoptosis effector
S100a14 S100 calcium binding protein A14
Aen apoptosis enhancing nuclease
Ddias DNA damage-induced apoptosis suppressor
Ckap2 cytoskeleton associated protein 2
Cdc20 cell division cycle 20
Slc19a2 solute carrier family 19 (thiamine transporter), member 2
Bbc3 BCL2 binding component 3
Sesn2 sestrin 2
Atr ataxia telangiectasia and Rad3 related
Eda2r ectodysplasin A2 receptor
Ccnb1 cyclin B1
Symbol Function*
Igfbp3 insulin-like growth factor binding protein 3
Serpine1 serpin family E member 1
Tp53 tumor protein p53
Adm adrenomedullin
Gadd45a growth arrest and DNA-damage-inducible, alpha
Ccnb1 cyclin B1
Casp3 caspase 3
Ccng1 cyclin G1
Ccng2 cyclin G2
Cdk1 cyclin-dependent kinase 1
Ccn2 cellular communication network factor 2
Cdc20 cell division cycle 20
Apaf1 apoptotic peptidase activating factor 1
Cdk4 cyclin-dependent kinase 4
Chek2 checkpoint kinase 2
Ccna2 cyclin A2
Cdkn1a cyclin-dependent kinase inhibitor 1A
Chek1 checkpoint kinase 1
Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D
Cdkn3 cyclin-dependent kinase inhibitor 3
Gadd45g growth arrest and DNA-damage-inducible, gamma
Pidd1 p53-induced death domain protein 1
Sesn1 sestrin 1
Eda2r ectodysplasin A2 receptor
Gtse1 G-2 and S-phase expressed 1
Atm ATM serine/threonine kinase
Mdm4 MDM4 regulator of p53
Ckap2 cytoskeleton associated protein 2
Knstrn kinetochore-localized astrin/SPAG5 binding protein
Mms22l MMS22-like, DNA repair protein
Fancm FA complementation group M
Mdm2 MDM2 proto-oncogene
Racgap1 Rac GTPase-activating protein 1
Dcakd dephospho-CoA kinase domain containing
Kif20a kinesin family member 20A
Aen apoptosis enhancing nuclease
Rrm2 ribonucleotide reductase regulatory subunit M2
Ccnb2 cyclin B2
Thbs1 thrombospondin 1
Atr ATR serine/threonine kinase
Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Symbol Function*
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
CCND2 cyclin D2
SIAH1 siah E3 ubiquitin protein ligase 1
BIRC5 baculoviral IAP repeat containing 5
CHEK1 checkpoint kinase 1
CDKN1A cyclin dependent kinase inhibitor 1A
BID BH3 interacting domain death agonist
ATM ATM serine/threonine kinase
CASP3 caspase 3
MDM2 MDM2 proto-oncogene
STMN1 stathmin 1
CDK1 cyclin dependent kinase 1
BCL2 BCL2, apoptosis regulator
KRT5 keratin 5
CCNB1 cyclin B1
PTTG2 pituitary tumor-transforming 2
CCNG1 cyclin G1
KPNA2 karyopherin subunit alpha 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D
APAF1 apoptotic peptidase activating factor 1
MCM5 minichromosome maintenance complex component 5
EI24 EI24, autophagy associated transmembrane protein
ELL elongation factor for RNA polymerase II
CCNE2 cyclin E2
IGFBP3 insulin like growth factor binding protein 3
SERPINB5 serpin family B member 5
PERPA p53 apoptosis effector related to PMP22 A
RRM2 ribonucleotide reductase regulatory subunit M2
PBK PDZ binding kinase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
PSMD13 proteasome 26S subunit, non-ATPase 13
CD82 CD82 molecule
LOC423240 uncharacterized LOC423240
MCM6 minichromosome maintenance complex component 6
ATR ATR serine/threonine kinase
GTSE1 G2 and S-phase expressed 1
CDCA7 cell division cycle associated 7
CASP9 caspase 9
AURKB aurora kinase B
MTF1 metal regulatory transcription factor 1
GADD45A growth arrest and DNA damage inducible alpha
TMEM170A transmembrane protein 170A
SON SON DNA binding protein
DCK2 deoxycytidine kinase 2
RCHY1 ring finger and CHY zinc finger domain containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CDK2 cyclin dependent kinase 2
CDC6 cell division cycle 6
SESN2 sestrin 2
GADD45B growth arrest and DNA damage inducible beta
GDF15 growth differentiation factor 15
Symbol Function*
ccne1 cyclin E1
tp53 tumor protein p53
mdm2 MDM2 proto-oncogene
rrm2 ribonucleotide reductase M2 polypeptide
casp8 caspase 8, apoptosis-related cysteine peptidase
ccnb1 cyclin B1
baxa BCL2 associated X, apoptosis regulator a
siah1 siah E3 ubiquitin protein ligase 1
cebpd CCAAT enhancer binding protein delta
ccng1 cyclin G1
ccng2 cyclin G2
arrdc2 arrestin domain containing 2
socs3a suppressor of cytokine signaling 3a
taf1c TATA-box binding protein associated factor, RNA polymerase I subunit C
chek2 checkpoint kinase 2
ccnb2 cyclin B2
phlda3 pleckstrin homology-like domain, family A, member 3
asf1ba anti-silencing function 1Ba histone chaperone
rasl11b RAS-like, family 11, member B
gadd45aa growth arrest and DNA-damage-inducible, alpha, a
gadd45ga growth arrest and DNA-damage-inducible, gamma a
atm ATM serine/threonine kinase
gadd45ba growth arrest and DNA-damage-inducible, beta a
cdc20 cell division cycle 20 homolog
cdk2 cyclin-dependent kinase 2
sesn3 sestrin 3
ccne2 cyclin E2
gadd45ab growth arrest and DNA-damage-inducible, alpha, b
ip6k2b inositol hexakisphosphate kinase 2b
sesn1 sestrin 1
aurka aurora kinase A
ppm1db protein phosphatase, Mg2+/Mn2+ dependent, 1Db
casp9 caspase 9, apoptosis-related cysteine peptidase
gadd45bb growth arrest and DNA-damage-inducible, beta b
zgc:110540 zgc:110540
cdca7a cell division cycle associated 7a
gtse1 G-2 and S-phase expressed 1
bada BCL2 associated agonist of cell death a
atr ATR serine/threonine kinase
siva1 SIVA1, apoptosis-inducing factor
exo5 exonuclease 5
rps27l ribosomal protein S27 like
mat2al methionine adenosyltransferase II, alpha-like
bbc3 BCL2 binding component 3
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1
nasp nuclear autoantigenic sperm protein (histone-binding)
zgc:92606 zgc:92606
si:dkey-204l11.1 si:dkey-204l11.1
serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
sesn4 sestrin 4
cdkn1a cyclin-dependent kinase inhibitor 1A
ier2b immediate early response 2b
thbs1a thrombospondin 1a
LOC100535166 thrombospondin-1-like
LOC100537178 E3 ubiquitin-protein ligase RNF14-like
nfe2l2b nuclear factor, erythroid 2-like 2b
tpx2 TPX2 microtubule nucleation factor
Symbol Function*
GINS2 GINS complex subunit 2
APAF1 apoptotic peptidase activating factor 1
CSRNP1 cysteine and serine rich nuclear protein 1
CCND3 cyclin D3
MCM10 minichromosome maintenance 10 replication initiation factor
PTTG1 PTTG1 regulator of sister chromatid separation, securin
TBC1D24 TBC1 domain family member 24
TYMS thymidylate synthetase
CDK1 cyclin dependent kinase 1
SESN3 sestrin 3
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
CCNB1 cyclin B1
MDM4 MDM4 regulator of p53
CCNG2 cyclin G2
FANCI FA complementation group I
CDC6 cell division cycle 6
PIDD1 p53-induced death domain protein 1
CCNE1 cyclin E1
TOP2A DNA topoisomerase II alpha
LAGE3 L antigen family member 3
GADD45A growth arrest and DNA damage inducible alpha
SERTAD1 SERTA domain containing 1
CDK6 cyclin dependent kinase 6
CCNB2 cyclin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RRM2 ribonucleotide reductase regulatory subunit M2
PTEN phosphatase and tensin homolog
THBS1 thrombospondin 1
SIVA1 SIVA1 apoptosis inducing factor
RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B
BCL2 BCL2 apoptosis regulator
DCUN1D1 defective in cullin neddylation 1 domain containing 1
SPATA5 spermatogenesis associated 5
TRIP13 thyroid hormone receptor interactor 13
BIRC5 baculoviral IAP repeat containing 5
SHISA5 shisa family member 5
LOC709988 cyclin-dependent kinase inhibitor 2A
ZMAT3 zinc finger matrin-type 3
CCND2 cyclin D2
CDK2 cyclin dependent kinase 2
GADD45B growth arrest and DNA damage inducible beta
CDT1 chromatin licensing and DNA replication factor 1
BCL2L1 BCL2 like 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
DDB2 damage specific DNA binding protein 2
SERPINE1 serpin family E member 1
GTSE1 G2 and S-phase expressed 1
ATR ATR serine/threonine kinase
MCM4 minichromosome maintenance complex component 4
TNFRSF10B TNF receptor superfamily member 10b
MDM2 MDM2 proto-oncogene
BAX BCL2 associated X, apoptosis regulator
CDKN1A cyclin dependent kinase inhibitor 1A
CDCA3 cell division cycle associated 3
MAP3K2 mitogen-activated protein kinase kinase kinase 2
ZBED6 zinc finger BED-type containing 6
STEAP3 STEAP3 metalloreductase
ATM ATM serine/threonine kinase
LOC107000925 probable ribosome biogenesis protein RLP24 pseudogene
Symbol Function*
SERPINE1 serpin family E member 1
BAX BCL2 associated X, apoptosis regulator
MDM2 MDM2 proto-oncogene
KIF20A kinesin family member 20A
CYCS cytochrome c, somatic
LTBP1 latent transforming growth factor beta binding protein 1
HBP1 HMG-box transcription factor 1
CCN2 cellular communication network factor 2
ZFAND5 zinc finger AN1-type containing 5
E2F8 E2F transcription factor 8
KIF11 kinesin family member 11
PDCD4 programmed cell death 4
CCNB2 cyclin B2
KIF23 kinesin family member 23
CCNG2 cyclin G2
CCNG1 cyclin G1
SPAG5 sperm associated antigen 5
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
SESN1 sestrin 1
RRM2 ribonucleotide reductase regulatory subunit M2
DDB2 damage specific DNA binding protein 2
GADD45G growth arrest and DNA damage inducible gamma
ZFP36 ZFP36 ring finger protein
CCNE1 cyclin E1
GADD45B growth arrest and DNA damage inducible beta
SESN3 sestrin 3
CHEK2 checkpoint kinase 2
TIGAR TP53 induced glycolysis regulatory phosphatase
CCNE2 cyclin E2
THBS1 thrombospondin 1
DUSP1 dual specificity phosphatase 1
RFC2 replication factor C subunit 2
CCNB1 cyclin B1
GTSE1 G2 and S-phase expressed 1
DEPDC1B DEP domain containing 1B
CDK6 cyclin dependent kinase 6
CCND2 cyclin D2
BBC3 BCL2 binding component 3
PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
GADD45A growth arrest and DNA damage inducible alpha
CDK1 cyclin dependent kinase 1
Symbol Function*
BAX BCL2 associated X, apoptosis regulator
TP53 tumor protein p53
FAS Fas cell surface death receptor
CASP9 caspase 9
BID BH3 interacting domain death agonist
CHMP4A charged multivesicular body protein 4A
RCHY1 ring finger and CHY zinc finger domain containing 1
CCNB2 cyclin B2
MDM4 MDM4 regulator of p53
CHEK1 checkpoint kinase 1
TOP2A DNA topoisomerase II alpha
CCNB1 cyclin B1
CCNG1 cyclin G1
RSRC2 arginine and serine rich coiled-coil 2
GORAB golgin, RAB6 interacting
ATM ATM serine/threonine kinase
ICAM1 intercellular adhesion molecule 1
PTBP1 polypyrimidine tract binding protein 1
POLE2 DNA polymerase epsilon 2, accessory subunit
USF1 upstream transcription factor 1
RAB5C RAB5C, member RAS oncogene family
VPS13B vacuolar protein sorting 13 homolog B
CDK4 cyclin dependent kinase 4
SHISA5 shisa family member 5
RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B
CDK1 cyclin dependent kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
LOC105261012 tumor necrosis factor receptor superfamily member 1A-like


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