KEGG 00670 One carbon pool by folate
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) gga(Chicken) dre(Zebrafish) dme(Fly) cel(Nematoda) mcc(Monkey) cfa(Dog) sce(Budding yeast) spo(Fission yeast)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa00670 One carbon pool by folate 7
hsa01523 Antifolate resistance 4
hsa01240 Biosynthesis of cofactors 4
hsa01230 Biosynthesis of amino acids 2
hsa00230 Purine metabolism 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu00670 One carbon pool by folate 10
mmu01240 Biosynthesis of cofactors 7
mmu01523 Antifolate resistance 6
mmu01230 Biosynthesis of amino acids 4
mmu00230 Purine metabolism 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno00670 One carbon pool by folate 8
rno01240 Biosynthesis of cofactors 5
rno01523 Antifolate resistance 3
rno00260 Glycine, serine and threonine metabolism 2
rno00630 Glyoxylate and dicarboxylate metabolism 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
gga00230 Purine metabolism 3
gga00670 One carbon pool by folate 3
gga01240 Biosynthesis of cofactors 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
dre00670 One carbon pool by folate 11
dre00230 Purine metabolism 4
dre01240 Biosynthesis of cofactors 4
dre01230 Biosynthesis of amino acids 4
dre01200 Carbon metabolism 4
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
dme00670 One carbon pool by folate 9
dme00230 Purine metabolism 7
dme00260 Glycine, serine and threonine metabolism 5
dme01200 Carbon metabolism 5
dme01240 Biosynthesis of cofactors 4
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cel00670 One carbon pool by folate 8
cel00230 Purine metabolism 5
cel01240 Biosynthesis of cofactors 3
cel01230 Biosynthesis of amino acids 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc00670 One carbon pool by folate 6
mcc01523 Antifolate resistance 5
mcc01240 Biosynthesis of cofactors 3
mcc00230 Purine metabolism 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa00670 One carbon pool by folate 2
cfa00790 Folate biosynthesis 2
cfa01240 Biosynthesis of cofactors 2
cfa01523 Antifolate resistance 2
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
sce00670 One carbon pool by folate 6
sce00230 Purine metabolism 6
sce00260 Glycine, serine and threonine metabolism 4
sce00630 Glyoxylate and dicarboxylate metabolism 4
sce01200 Carbon metabolism 4
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
spo00670 One carbon pool by folate 7
spo01240 Biosynthesis of cofactors 3
spo00260 Glycine, serine and threonine metabolism 3
spo00630 Glyoxylate and dicarboxylate metabolism 3
spo01200 Carbon metabolism 3
Gene list in the network
Symbol Function*
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
DHFR dihydrofolate reductase
GARS1 glycyl-tRNA synthetase 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
MCM4 minichromosome maintenance complex component 4
MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
SHMT2 serine hydroxymethyltransferase 2
YARS1 tyrosyl-tRNA synthetase 1
RUVBL1 RuvB like AAA ATPase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
ALDH1L2 aldehyde dehydrogenase 1 family member L2
Symbol Function*
Dhfr dihydrofolate reductase
Gart phosphoribosylglycinamide formyltransferase
Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
Mybbp1a MYB binding protein (P160) 1a
Shmt1 serine hydroxymethyltransferase 1 (soluble)
Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Tyms thymidylate synthase
Umps uridine monophosphate synthetase
Aldh18a1 aldehyde dehydrogenase 18 family, member A1
Shmt2 serine hydroxymethyltransferase 2 (mitochondrial)
Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Pycr1 pyrroline-5-carboxylate reductase 1
Aldh1l2 aldehyde dehydrogenase 1 family, member L2
Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Gars glycyl-tRNA synthetase
Symbol Function*
Slc7a1 solute carrier family 7 member 1
Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Aldh1l1 aldehyde dehydrogenase 1 family, member L1
Shmt1 serine hydroxymethyltransferase 1
Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Tars1 threonyl-tRNA synthetase 1
Aldh1l2 aldehyde dehydrogenase 1 family, member L2
Shmt2 serine hydroxymethyltransferase 2
Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Aldh4a1 aldehyde dehydrogenase 4 family, member A1
Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Symbol Function*
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
PAICS phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
SHMT1 serine hydroxymethyltransferase 1
PPAT phosphoribosyl pyrophosphate amidotransferase
MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Symbol Function*
gart phosphoribosylglycinamide formyltransferase
atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
mthfd1b methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
slc1a4 solute carrier family 1 member 4
mtr 5-methyltetrahydrofolate-homocysteine methyltransferase
shmt1 serine hydroxymethyltransferase 1 (soluble)
rpia ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase)
amt aminomethyltransferase
mthfr methylenetetrahydrofolate reductase (NAD(P)H)
lars1b leucyl-tRNA synthetase 1b
pfas phosphoribosylformylglycinamidine synthase
abcb10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
shmt2 serine hydroxymethyltransferase 2 (mitochondrial)
aldh1l2 aldehyde dehydrogenase 1 family, member L2
aldh1l1 aldehyde dehydrogenase 1 family, member L1
Symbol Function*
Shmt Serine hydroxymethyl transferase
Paics PAICS bifunctional enzyme
CG31664 uncharacterized protein
Pfas Phosphoribosylformylglycinamidine synthase
Gart GART trifunctional enzyme
CG6415 uncharacterized protein
CG6287 uncharacterized protein
Mal-B2 Maltase B2
CG8665 uncharacterized protein
Sardh Sarcosine dehydrogenase
Mthfs Methenyltetrahydrofolate synthetase
Prps Phosphoribosyl pyrophosphate synthetase
CG7560 uncharacterized protein
AdenoK Adenosine Kinase
CG3999 uncharacterized protein
pug pugilist
AdSL Adenylosuccinate Lyase
CG11089 uncharacterized protein
Nmdmc NAD-dependent methylenetetrahydrofolate dehydrogenase
Symbol Function*
paic-1 Phosphoribosylaminoimidazole-succinocarboxamide synthase
mthf-1 putative methylenetetrahydrofolate reductase
mtrr-1 Methionine synthase reductase
metr-1 putative methionine synthase
pfas-1 putative phosphoribosylformylglycinamidine synthase
ppat-1 Amidophosphoribosyltransferase
mel-32 Serine hydroxymethyltransferase
atic-1 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase;MGS domain-containing protein
alh-3 10-formyltetrahydrofolate dehydrogenase
F38B6.4 Phosphoribosylglycinamide formyltransferase
K07E3.4 Formyltetrahydrofolate synthetase
dao-3 Methenyltetrahydrofolate cyclohydrolase
C52D10.3 DUF4140 domain-containing protein
Symbol Function*
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
TYMS thymidylate synthetase
SHMT1 serine hydroxymethyltransferase 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
LOC707951 serine hydroxymethyltransferase, cytosolic pseudogene
DHFR dihydrofolate reductase
NOLC1 nucleolar and coiled-body phosphoprotein 1
Symbol Function*
DHFR dihydrofolate reductase
LOC609048 dihydrofolate reductase
Symbol Function*
SHM2 glycine hydroxymethyltransferase SHM2
ADE13 adenylosuccinase ADE13
GCV3 glycine decarboxylase subunit H
ADE1 phosphoribosylaminoimidazolesuccinocarboxamide synthase
GCV1 glycine decarboxylase subunit T
VTC5 Vtc5p
ADE8 phosphoribosylglycinamide formyltransferase
ADE3 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3
MTD1 methylenetetrahydrofolate dehydrogenase (NAD(+))
ADE2 phosphoribosylaminoimidazole carboxylase ADE2
ADE17 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17
GCV2 glycine decarboxylase subunit P
ADE4 amidophosphoribosyltransferase
Symbol Function*
ade10 IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamideformyltransferase
SPBC1711.04 putative methylenetetrahydrofolate reductase
SPBC16H5.08c ATP-binding cassette sub-family F protein
ade9 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase
cho2 phosphatidylethanolamine N-methyltransferase Cho2
SPBC839.16 C1-5,6,7,8-tetrahydrofolate (THF) synthase
SPAC24C9.12c putative glycine hydroxymethyltransferase
gcv2 putative glycine cleavage complex subunit P
met9 methylenetetrahydrofolate reductase Met9
gcv1 putative glycine decarboxylase T subunit gcv1
met26 homocysteine methyltransferase Met26


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