Orthologous genes in OrthoFinder**

Species Gene Description
 fca-r.1   IRS2   insulin receptor substrate 2 
 cfa-u.3   IRS1   insulin receptor substrate 1 
 cfa-u.3   IRS2   insulin receptor substrate 2 
 hsa-u.4   IRS1   insulin receptor substrate 1 
 hsa-u.4   IRS2   insulin receptor substrate 2 
 mmu-u.4   Irs2   insulin receptor substrate 2 
 mmu-u.4   Irs1   insulin receptor substrate 1 
 rno-u.3   Irs1   insulin receptor substrate 1 
 rno-u.3   Irs2   insulin receptor substrate 2 
 mcc-u.3   IRS1   insulin receptor substrate 1 
 mcc-u.3   IRS2   insulin receptor substrate 2 
 gga-u.3   IRS2   insulin receptor substrate 2 
 gga-u.3   IRS4   insulin receptor substrate 4 
 dre-u.3   irs4a   insulin receptor substrate 4a 
 dre-u.3   si:ch73-335l21.1   si:ch73-335l21.1 
 dre-u.3   794462   insulin receptor substrate 2-B-like 
 cel-u.3   ist-1   Insulin receptor SubsTrate homolog 
 spo-u.3   ssp1   serine/threonine protein kinase Ssp1 
 spo-u.3   ppk34   serine/threonine protein kinase Ppk34 

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Top 50 coexpressed genes to IRS2 (fca-r.1 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 fca4064   NF-kappa B signaling pathway  4 94 4.03
 fca4722   Neurotrophin signaling pathway  4 118 3.65
 fca5162   Measles  4 119 3.63
 fca5169   Epstein-Barr virus infection  4 194 2.83
 fca5132   Salmonella infection  4 242 2.49

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fca:IRS2 (insulin receptor substrate 2) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

fca-r.1
for
IRS2
cfa-u.3
for
IRS1
cfa-u.3
for
IRS2
hsa-u.4
for
IRS1
hsa-u.4
for
IRS2
mmu-u.4
for
Irs2
mmu-u.4
for
Irs1
rno-u.3
for
Irs1
rno-u.3
for
Irs2
mcc-u.3
for
IRS1
mcc-u.3
for
IRS2
gga-u.3
for
IRS2
gga-u.3
for
IRS4
dre-u.3
for
irs4a
dre-u.3
for
si:ch73-335l21.1
dre-u.3
for
794462
cel-u.3
for
ist-1
spo-u.3
for
ssp1
spo-u.3
for
ppk34
1 UBE2H ubiquitin conjugating enzyme E2 H 101086130 5.4 -0.8
 0.0
 0.8
 2.3
 2.0
 2.5
 1.2
 2.9
 -0.9
 0.5
 0.8
 2.5
 0.5
 0.4
 4.8
 1.5
 0.2
 0.3
2 IRF2BP2 interferon regulatory factor 2 binding protein 2 101086753 5.4 0.8
 1.3
 2.0
 5.0
 6.1
 1.8
 1.9
 5.7
 1.0
 5.3
 1.7
 2.3
 3.8
2.3
 -1.6
-3.2
 1.7
0.1
 1.6

3 NFKBIA NFKB inhibitor alpha 101090622 5.1 0.8
 0.9
 -0.3
 1.8
 2.8
 -0.6
 -1.0
 1.9
 -1.0
 0.9
 1.8
 1.4
 0.9
-0.1
 2.1
-0.2
 2.2
0.4


4 TSC22D3 TSC22 domain family member 3 101086705 5.1 -0.3
 2.1
 -0.3
 4.1
 2.2
 1.7
 0.1
 0.7
 -0.4
 3.1
 1.9
 2.9
 2.4
1.0
 2.0
-0.3
 1.7
0.1
 2.8
2.4

5 FOSL2 FOS like 2, AP-1 transcription factor subunit 101093515 5.0 0.9
 1.3
 1.3
 3.8
 5.9
 1.7
 1.2
 5.2
 0.1
 3.6
 3.3
 0.4
 0.7
 -0.4
 3.0


6 HIVEP1 HIVEP zinc finger 1 101092937 4.9 0.6
-0.2
 2.6
1.3
 3.0
1.1
 0.7
0.2
 2.0
0.7
 1.2
0.6
 0.7
0.5
 4.6
3.4
 2.0
1.5
 1.7
1.4
 1.5
0.5
 2.5
1.5
 2.1
1.1
 3.6
1.9
 3.2
2.6
 3.6

7 ULK1 unc-51 like autophagy activating kinase 1 101098658 4.9 1.4
0.7
 1.0
0.4
 1.1
-0.7
 3.3
0.9
 2.8
-0.1
 2.1
0.1
 0.8
0.3
 4.4
0.3
 0.8
-2.6
 3.6
0.5
 4.8
2.6
 3.6
3.3
 2.9
2.4
 4.5
1.5
 5.2
4.1
 1.4

8 KDM6B lysine demethylase 6B 101100010 4.5 0.4
-0.5
 1.5
0.9
 0.6
0.1
 1.6
0.2
 4.1
1.7
 0.2
0.2
 2.3
0.4
 3.5
1.4
 1.3
0.2
 2.0
1.3
 0.3
-0.3
 4.1
-0.9
 1.7
1.6
 0.1
-0.5
 4.3
0.8
 3.1
0.3
 0.6
 -0.4
9 KLF6 Kruppel like factor 6 101096489 4.5 2.0
1.2
 1.4
0.5
 1.2
 4.7
 4.3
3.4
 0.4
0.2
 1.9
0.6
 2.7
1.5
 1.0
-0.2
 3.3
2.9
 1.1
0.0
 1.7
0.1
 1.0
1.0
 -0.6
-0.7
 1.6
1.2
 1.0
 -0.6
 2.3
10 MED13L mediator complex subunit 13L 101099593 4.3 1.5
0.6
 1.5
1.0
 3.1
1.0
 3.3
1.5
 3.5
2.2
 0.8
-0.1
 1.3
0.7
 3.9
2.1
 1.1
0.1
 1.2
0.2
 0.1
-0.1
 3.7
3.7
 3.9
2.2
 -0.0
-0.4
 3.4
1.9
 3.9

11 NFIL3 nuclear factor, interleukin 3 regulated 101087431 4.3 0.3
 3.7
 1.0
 3.6
 4.1
 0.9
 2.7
 5.0
 0.3
 3.5
 3.6
 3.7
 2.3
 -0.2
 -1.1


12 ARL5B ADP ribosylation factor like GTPase 5B 101101479 4.3 1.9
-0.0
 0.9
0.4
 0.6
0.2
 0.7
-0.4
 3.9
0.7
 1.9
1.4
 4.1
2.3
 5.1
-0.4
 1.5
0.2
 1.4
-0.7
 2.3
-0.9
 1.4
0.9
 1.1
-0.2
 0.4
0.3
 1.2
1.0
 -0.1

13 TRIB1 tribbles pseudokinase 1 101087043 4.2 1.4
0.6
 2.0
0.3
 2.6
1.3
 2.5
0.8
 4.5
0.7
 2.9
0.3
 2.1
1.8
 4.7
2.0
 3.3
1.2
 1.9
0.5
 2.6
-0.7
 1.6
0.8
 0.8
-0.9
 1.0
0.5
 2.7
1.6


14 ETS2 ETS proto-oncogene 2, transcription factor 101080565 4.2 -0.1
-0.2
 1.5
-1.3
 1.2
0.4
 3.0
1.5
 2.4
-0.0
 1.0
-0.4
 1.2
0.3
 1.8
-0.1
 2.0
0.8
 2.5
0.0
 1.4
-1.0
 1.4
0.7
 -1.2
-1.6
 -0.4
-1.8
 1.0
0.4


15 KLF9 Kruppel like factor 9 101090808 4.1 0.1
 2.4
 1.1
 5.3
 4.6
 -0.4
 -1.5
 2.2
 0.9
 3.8
 2.0
 2.8
 0.0
 3.0
 3.7


16 CREBRF CREB3 regulatory factor 101091424 4.1 -0.9
 2.0
 -0.2
 3.3
 2.9
 -0.2
 -0.3
 1.2
 0.0
 3.8
 1.7
 4.4
 2.7
 0.3
 3.9


17 CSRNP1 cysteine and serine rich nuclear protein 1 101100149 4.1 -0.4
-0.4
 3.7
-0.5
 0.5
0.4
 2.6
-0.2
 4.4
-0.3
 1.1
0.7
 1.2
0.5
 4.8
1.2
 0.6
-0.8
 1.8
0.1
 1.1
0.7
 -0.1
-0.3
 0.7
0.5
 1.2
-0.2
 4.8
2.2
 0.1

18 ZFAND5 zinc finger AN1-type containing 5 101090146 4.1 0.0
-0.9
 1.8
-1.0
 0.4
-0.4
 4.5
0.1
 3.4
0.3
 0.9
0.4
 -0.3
-0.5
 3.6
1.0
 0.0
-0.3
 3.4
-0.5
 4.1
1.4
 3.4
1.0
 1.6
-0.2
 1.8
1.1
 4.5
3.7
 0.7
 0.3
 -0.2
19 KBTBD11 kelch repeat and BTB domain containing 11 109498675 4.0 -0.8
 0.5
 0.5
 5.1
 0.7
 -0.5
 -0.1
 1.0
 0.6
 1.8
 0.6
 2.0
 -0.3
 0.2
 -0.1


20 DDX3X DEAD-box helicase 3 X-linked 101090417 4.0 -0.0
-0.8
 -0.3
-0.4
 -0.1
-0.6
 0.6
0.0
 1.9
0.1
 0.5
-0.5
 2.0
0.7
 1.9
0.3
 1.1
0.4
 1.2
0.7
 1.5
0.5
 2.3
-0.8
 1.5
-0.1
 -0.6
-0.7
 2.9
1.9
 -0.4
-0.5
 1.2
 0.0
21 LOC105260984 uncharacterized LOC105260984 105260984 4.0

















22 MAFF MAF bZIP transcription factor F 105259911 4.0 1.9
1.6
 2.8
2.0
 1.4
0.2
 4.4
3.4
 5.7
4.8
 0.1
-0.8
 0.1
-0.6
 6.1
4.6
 0.9
0.7
 2.8
2.8
 3.6
1.6
 2.1
1.3
 1.9
1.4
 0.7
-0.1
 3.4
2.5
 1.8

23 IRF2BPL interferon regulatory factor 2 binding protein like 105259886 3.9 0.5
 3.3
 3.4
 2.7
 2.1
 -0.1
 -0.1
 4.1
 1.7
 4.2
 1.4
 2.3
 2.1
 -1.2
 2.1


24 LONRF1 LON peptidase N-terminal domain and ring finger 1 101091440 3.9 1.0
0.6
 1.6
1.3
 0.9
0.0
 2.1
1.8
 2.0
1.4
 0.8
0.3
 1.4
0.4
 3.0
1.0
 0.4
-0.9
 2.7
2.2
 3.1
2.2
 3.7
2.0
 1.5
0.8
 2.5
2.4
 3.0
2.1
3.3
 1.1
25 SUSD6 sushi domain containing 6 101101140 3.9 -0.2
 1.0
 -1.3
 0.6
 1.7
 -0.1
 0.5
 3.0
 0.3
 2.7
 1.1
 2.0
 2.0
0.1
 2.0
-1.2
 2.2
-0.4


26 ABCA1 ATP binding cassette subfamily A member 1 101083885 3.9 -0.1
-0.3
 0.2
-0.2
 1.8
-0.1
 1.1
0.9
 1.0
0.6
 0.4
-0.3
 2.1
-0.1
 0.8
0.6
 1.3
0.1
 1.2
0.3
 1.8
1.0
 2.0
1.3
 2.1
0.6
 1.6
-0.2
 4.1
1.7
 1.6

27 RHOB ras homolog family member B 101099371 3.8 0.7
0.4
 1.9
-0.1
 1.1
0.8
 3.4
0.6
 2.9
1.1
 1.3
-0.2
 -0.1
-0.3
 1.5
-0.0
 0.0
-0.1
 3.8
-0.5
 2.6
-0.1
 1.9
-0.2
 0.3
-0.6
 0.1
0.1
 0.8
0.7
 1.1
 3.0
0.7
 -0.3
-0.8
28 GADD45A growth arrest and DNA damage inducible alpha 493656 3.8 0.7
0.3
 3.0
2.0
 0.9
-0.4
 3.9
3.3
 4.1
3.7
 0.9
-0.5
 0.4
0.4
 4.4
4.2
 0.3
-0.1
 3.4
2.3
 3.6
1.8
 2.5
-0.0
 -0.1
-0.1
 0.3
-0.2
 0.7
0.5


29 LRCH1 leucine rich repeats and calponin homology domain containing 1 727691 3.8 0.0
-0.0
 0.4
0.4
 1.9
-0.5
 0.3
-0.5
 -0.4
-0.5
 1.5
-0.5
 1.1
0.7
 0.9
-0.4
 0.6
-0.7
 0.1
-0.3
 0.9
-0.3
 1.8
0.8
 1.9
1.8
 1.5
0.3
 1.0
-1.0
-0.5
 0.2
30 REM2 RRAD and GEM like GTPase 2 101090269 3.8 -1.6
 0.9
 0.1
 1.3
 0.7
 -0.0
 -0.7
 0.5
 0.6
 0.1







31 TNFAIP3 TNF alpha induced protein 3 101083682 3.8 -0.4
 1.7
 0.1
 2.0
 2.6
 -0.4
 1.3
 -0.1
 -0.0
 1.5
 1.5
 0.1
 -0.3
 0.4
 -0.1


32 RAI2 retinoic acid induced 2 101099182 3.7 0.3
 -0.3
 0.6
 0.7
 0.2
 2.4
 1.2
 0.1
 1.1
 -0.1
 1.9
 0.2
 2.3
 -0.3
 0.8


33 PDZD8 PDZ domain containing 8 101086755 3.7 0.7
 1.0
 0.6
 2.6
 0.8
 -0.6
 1.1
 1.9
 -1.0
 2.7
 0.1
 1.2
 0.9
 -1.3
 2.0
 2.9

34 IL6R interleukin 6 receptor 101085689 3.7 -0.1
 0.6
 0.7
 1.9
 2.3
 -0.8
 0.3
 1.0
 -0.2
 1.6
 -0.4
 0.6
 0.4
 0.9
 0.4


35 ATG2A autophagy related 2A 101080739 3.7 0.5
-0.2
 1.1
-0.3
 0.9
0.8
 3.2
1.3
 2.0
1.8
 0.5
-0.2
 1.0
 2.1
 0.0
-0.2
 2.7
1.3
 1.6
0.6
 4.0
-0.5
 3.1
1.3
 2.4
0.6
 4.1
1.1
 3.6

36 PPP1R15A protein phosphatase 1 regulatory subunit 15A 101084589 3.7 -0.0
 0.3
 0.3
 4.2
 3.9
 -0.2
 0.2
 5.5
 0.8
 2.6
 0.8
 -1.0
 0.9
0.7
 0.0
-0.4
 3.9
2.5


37 JMY junction mediating and regulatory protein, p53 cofactor 101089418 3.7 0.1
 1.1
 0.2
 3.2
 4.9
 0.8
 1.3
 4.3
 1.1
 4.4
 3.6
 4.1
 4.0
 1.9
 3.0


38 NCOA2 nuclear receptor coactivator 2 101094648 3.6 -1.0
 0.6
 0.7
 0.2
 1.8
 0.5
 1.5
 0.5
 -0.4
 -0.2
 -0.8
 3.9
 2.8
 0.6
 2.0


39 N4BP2L1 NEDD4 binding protein 2 like 1 101080502 3.6 0.7
0.1
 1.1
-0.5
 0.9
 0.5
 0.7
 0.4
 3.3
 0.1
 0.1
 -0.8
 -0.2
-0.9
 1.3
-0.4
 0.9
-0.9
 -0.5
-1.2
 2.5
-0.2


40 IRAK3 interleukin 1 receptor associated kinase 3 101093197 3.6 0.6
 0.4
 -1.1
 2.1
 -0.3
 -1.4

-0.6
 0.8

-2.0
 -1.9
 0.2


41 FOXO3 forkhead box O3 101081548 3.6 1.9
 1.4
 0.5
 5.2
 2.8
 0.1
 0.8
 3.6
 -0.4
 3.6
 3.3
 3.7
 1.6
0.4
 4.9
-0.4
 3.5
3.4
 1.5

42 ARID1B AT-rich interaction domain 1B 101091025 3.6 1.5
0.6
 2.4
1.1
 2.1
1.7
 1.9
0.7
 3.5
0.8
 1.8
1.5
 0.6
-0.5
 2.6
1.2
 2.0
1.8
 2.6
1.4
 0.0
-0.4
 2.8
2.1
 4.4
3.2
 -0.0
-0.3
 4.7
3.5
 2.1

43 NFKBIZ NFKB inhibitor zeta 101096093 3.6 -0.6
-1.6
 1.5
1.0
 0.6
-0.7
 1.0
-0.4
 2.4
1.0
 -0.7
-1.1
 1.3
-1.3
 1.2
0.1
 0.9
-0.9
 1.8
-1.0
 0.5
0.2
 1.5
0.0
 -0.1
-0.8
 0.3
-0.3
 -0.6
-1.3
 3.8

44 GADD45B growth arrest and DNA damage inducible beta 101087971 3.6 0.7
0.3
 3.0
2.0
 0.9
-0.4
 3.9
3.3
 4.1
3.7
 0.9
-0.5
 0.4
0.4
 4.4
4.2
 0.3
-0.1
 3.4
2.3
 3.6
1.8
 2.5
-0.0
 -0.1
-0.1
 0.3
-0.2
 0.7
0.5


45 CCNG2 cyclin G2 101097145 3.5 0.0
-0.6
 0.3
-0.3
 0.2
-0.1
 1.0
-0.2
 1.9
-0.8
 1.1
0.7
 0.0
-1.0
 2.2
-0.7
 1.1
0.4
 2.5
0.9
 0.6
-0.7
 2.2
0.5
 -0.2
-0.5
 0.8
0.1
 2.7
0.5


46 TRAF6 TNF receptor associated factor 6 101099750 3.5 -0.0
 -0.4
 0.5
 1.6
 2.2
 -0.1
 0.9
 1.1
 1.0
 -0.5
 -0.4
 2.4
 2.2
 1.4
 1.3


47 SGMS1 sphingomyelin synthase 1 101090897 3.5 -0.6
 0.6
 1.2
 0.5
 2.1
 -0.3
 -0.4
 1.4
 -2.0
 1.5
 -0.1
 2.8
 1.4
0.9
 1.7
0.5
 4.6
1.3
 1.0

48 RAB9A RAB9A, member RAS oncogene family 101089079 3.5 0.2
 -0.9
 -1.1
 1.4
 1.0
 0.9
 0.8
 0.3
 0.1
 0.1
 0.1
 3.1
 0.9
 -1.7
 0.6


49 PPP1R15B protein phosphatase 1 regulatory subunit 15B 101083996 3.5 -0.8
 1.8
 0.1
 2.4
 1.6
 0.4
 0.7
 1.6
 -0.3
 2.6
 0.3
 3.2
 0.5
 0.8
 1.4


50 ARRDC3 arrestin domain containing 3 101100696 3.5 0.2
0.2
 1.4
1.2
 0.2
0.0
 3.5
1.7
 1.7
1.6
 0.7
0.4
 0.4
0.0
 0.5
0.3
 -0.3
-0.5
 1.6
1.4
 2.1
1.2
 3.3
2.4
 2.4
1.8
 1.3
1.1
 3.0
2.3
 2.7
2.2

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