Orthologous genes in OrthoFinder**

Species Gene Description
 mcc-u.3   PDE4A   phosphodiesterase 4A 
 mcc-r.3   PDE4A   phosphodiesterase 4A 
 mcc-m.4   PDE4A   phosphodiesterase 4A 
 mcc-u.3   PDE4D   phosphodiesterase 4D 
 mcc-u.3   PDE4B   phosphodiesterase 4B 
 hsa-u.4   PDE4A   phosphodiesterase 4A 
 mmu-u.4   Pde4c   phosphodiesterase 4C, cAMP specific 
 mmu-u.4   Pde4d   phosphodiesterase 4D, cAMP specific 
 mmu-u.4   Pde4a   phosphodiesterase 4A, cAMP specific 
 rno-u.3   Pde4d   phosphodiesterase 4D 
 rno-u.3   Pde4b   phosphodiesterase 4B 
 cfa-u.3   PDE4A   phosphodiesterase 4A 
 cfa-u.3   PDE4C   phosphodiesterase 4C 
 gga-u.3   PDE4C   phosphodiesterase 4C 
 gga-u.3   PDE4B   phosphodiesterase 4B 
 dre-u.3   pde4a   phosphodiesterase 4A, cAMP-specific 
 dre-u.3   pde4cb   phosphodiesterase 4C, cAMP-specific b 
 dre-u.3   pde4d   phosphodiesterase 4D, cAMP-specific 
 dme-u.3   dnc   dunce 
 sce-u.3   PDE2   3',5'-cyclic-nucleotide phosphodiesterase PDE2 
 spo-u.3   lkh1   dual-specificity 

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Top 50 coexpressed genes to PDE4A (mcc-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 mcc4144   Endocytosis  4 241 2.20
 mcc4330   Notch signaling pathway  2 60 -
 mcc4666   Fc gamma R-mediated phagocytosis  2 106 -
 mcc4360   Axon guidance  2 182 -
 mcc4810   Regulation of actin cytoskeleton  3 221 -

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mcc:PDE4A (phosphodiesterase 4A) External Links;


Show/Hide Columns:        
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

mcc-u.3
for
PDE4A
mcc-r.3
for
PDE4A
mcc-m.4
for
PDE4A
mcc-u.3
for
PDE4D
mcc-u.3
for
PDE4B
hsa-u.4
for
PDE4A
mmu-u.4
for
Pde4c
mmu-u.4
for
Pde4d
mmu-u.4
for
Pde4a
rno-u.3
for
Pde4d
rno-u.3
for
Pde4b
cfa-u.3
for
PDE4A
cfa-u.3
for
PDE4C
gga-u.3
for
PDE4C
gga-u.3
for
PDE4B
dre-u.3
for
pde4a
dre-u.3
for
pde4cb
dre-u.3
for
pde4d
dme-u.3
for
dnc
sce-u.3
for
PDE2
spo-u.3
for
lkh1
1 NCOR2 nuclear receptor corepressor 2 706261 5.0 3.1
 1.9
 0.8
-0.4
 -1.0
-1.8
 4.0
0.6
 -0.3
-0.8
 0.7
0.5
 3.4
-0.1
 1.8
-0.7
 0.1
-0.3
 3.7
2.0
 0.3
-0.3
 -0.3
-0.6
 1.0
0.8
 2.2
1.0
 0.6
0.4
 0.3
-0.4
 5.4
 0.5
 -1.4
2 LIMK1 LIM domain kinase 1 699494 5.0 2.5
 2.7
 -0.3
 0.0
 3.3
 0.3
 1.0
 3.3
 0.3
 0.3
 2.2
 1.5
 1.1
 0.9
 0.9
-0.1
 2.1
0.9
 0.1
-0.5
 1.0

3 GIT1 GIT ArfGAP 1 716944 4.9 2.6
0.5
-0.2
 1.7
-0.3
 2.1
0.7
 0.1
-0.7
 1.4
0.2
 3.0
0.0
 0.2
-2.1
 0.2
-0.1
 0.9
-1.8
 1.0
-0.1
 1.6
-0.5
 0.8
0.5
 0.9
0.6
 1.5
0.6
 1.5
0.4
 -1.5

4 MEF2D myocyte enhancer factor 2D 718449 4.9 2.1
 3.0
 3.1
2.7
 2.2
1.4
 3.8
1.2
 0.3
0.1
 1.9
0.7
 3.0
1.9
 2.7
2.4
 2.4
2.4
 1.5
0.8
 1.7
1.1
 0.8
0.5
 3.1
2.0
 0.8
0.6
 1.9
1.1
 1.6
1.5
 2.7
 0.6
-0.0
 1.7
5 ATXN2L ataxin 2 like 708359 4.5 2.1
 2.6
 -0.4
-1.1
 -0.3
-1.0
 2.1
1.1
 0.9
0.5
 1.4
-0.3
 3.2
2.3
 0.2
-0.4
 1.1
0.1
 2.6
1.3
 0.2
-0.3
 -0.4
-0.5
 -0.2
-0.8
 0.4
-0.3
 -0.1
-1.5
 -1.7
-2.9
 2.3
 -0.3
 -0.5
6 DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B 698848 4.4 2.1
 2.6
 0.7
 0.3
 0.0
 1.2
 0.6
 2.0
 0.2
 -0.2
 -0.1
 1.8







7 PRRC2A proline rich coiled-coil 2A 715715 4.2 1.7
 2.9
 -1.5
 0.8
 2.2
 -0.5
 -0.6
 2.9
 -1.2
 -0.4
 1.7
 -0.1




1.3

8 PCGF1 polycomb group ring finger 1 715341 EGK_05474 4.2 1.6
 3.0
 1.2
 -0.2
 1.2
 -1.1
 -0.9
 1.2
 -1.3
 -0.8
 -0.4
 -0.6
 -0.8
 -0.0
 0.2
 -1.8
 0.4


9 C16H17orf107 chromosome 16 C17orf107 homolog 710390 4.1 2.2
1.6
 1.7
 2.6














10 PACS1 phosphofurin acidic cluster sorting protein 1 714696 4.1 2.2
0.5
-0.2
 1.3
0.5
 1.3
1.1
 0.2
-1.2
 0.9
-0.5
 3.4
0.8
 1.7
0.7
 1.2
0.4
 2.1
1.4
 -0.5
-1.2
 1.3
0.1
 3.0
0.2
 3.0
1.4
 1.3
0.9
 5.0
4.4
 2.1

11 PLEKHM2 pleckstrin homology and RUN domain containing M2 701382 4.0 1.9
 2.3
 0.2
 0.9
 1.3
 1.3
 0.4
 2.2
 0.4
 0.9
 3.7
 0.8
 1.0
 1.5
 0.3
 0.3
 -0.3
 1.6

12 POM121C POM121 transmembrane nucleoporin C 716176 4.0 2.6
 1.5
 2.7
 -1.0
 2.0
0.6
 -0.1
 0.4
 1.0
 -0.7
 -0.3
 3.2
 -0.1
 -0.9
 -0.6
 -0.1
 -2.4
 -1.0


13 CIZ1 CDKN1A interacting zinc finger protein 1 717725 4.0 1.3
 3.1
 0.4
 0.1
 1.4
 0.3
 0.2
 2.2
 -0.6
 0.3
 0.9
 0.4
 -1.1
 0.8
 0.3
-1.5
 0.7
-0.3
 1.3
-1.8
 0.6

14 ZBTB7A zinc finger and BTB domain containing 7A 721817 4.0 1.3
 3.0
 0.3
 -1.9
 3.2
 0.0
 0.0
 1.8
 -0.6
 -1.0
 5.1
 -0.2
 -0.4
 -0.1
 0.4
 1.7
 3.0


15 WDR47 WD repeat domain 47 696942 4.0 2.1
3.0
 0.4
 0.9
 -0.6
 0.2
 0.4
 1.6
 -0.3
 -2.2
 -0.0
 -0.8
 0.3
 1.0
0.6
 -0.0
-0.9
 -0.1
-0.4

-1.5
16 AMZ2 archaelysin family metallopeptidase 2 718873 3.9 2.1
1.4
 1.0
 0.9
 -0.5
 0.2
 0.8
 0.9
 0.9
 0.1
 -0.7







17 MED15 mediator complex subunit 15 695807 EGK_02810 3.8 1.6
 2.5
 0.9
 0.6
 0.7
 0.1
 0.0
 1.0
 -2.0
 -0.8
 -1.4
 -0.4
 -0.0
 0.9
 -0.2
 -0.5
 -1.1
 -0.0
0.3
18 MAPRE3 microtubule associated protein RP/EB family member 3 106992881 EGK_05145 3.8 2.0
3.0
1.8
 2.2
0.2
 1.6
0.9
 0.2
-0.3
 1.2
1.1
 3.8
1.7
 1.3
0.4
 2.4
0.3
 0.9
-1.6
 -0.5
-1.5
 1.3
-0.4
 2.0
1.3
 1.6
1.5
 0.7
-0.0
 0.9
0.6
 -0.6
-0.7
 -0.7
 -0.5
19 SCN1B sodium voltage-gated channel beta subunit 1 707134 3.8 1.0
 3.3
 -0.4
 0.7
 3.4
 0.2
 1.0
 4.3
 1.0
 0.7
 0.7
 1.8
 1.7
 0.5
 2.2
1.1
 0.7
-0.7
 -0.4
-1.7


20 EPN1 epsin 1 702956 3.8 1.9
 2.2
 0.1
-0.5
 0.2
-0.6
 1.8
1.8
 -0.2
-0.2
 1.0
0.3
 2.5
1.2
 1.2
-0.8
 0.8
-0.5
 2.1
1.8
 1.3
0.7
 1.7
-0.3
 1.2
0.7
 3.5
1.7
 0.8
-0.0
 0.6
0.6
 -0.4
 -1.9
-2.1
21 MADD MAP kinase activating death domain 713613 EGK_06296 3.8 2.9
 0.8
 1.6
 0.4
 2.4
 -0.4
 0.9
 -0.2
 1.2
 0.2
 0.9
 -0.4
 -0.4
 1.6
 -0.6
 1.1
 -1.2
 0.6

22 EHBP1L1 EH domain binding protein 1 like 1 721918 3.8 1.1
 3.1
 -0.5
 -0.3
 0.7
 -0.2
 0.1
 1.6
 -0.3
 -1.0
 2.8
 0.1

1.6
 -0.2
 1.5


23 INF2 inverted formin 2 706242 3.8 0.5
 4.0
 0.4
 1.0
 1.0
 2.1
 -0.0
 1.1
 -2.6
 0.7
 0.9
 1.5
 -1.0
 -0.2
 0.4
 1.2
 1.6


24 PXN paxillin 696336 3.7 1.6
 2.4
 0.5
0.4
 2.6
0.6
 0.6
0.5
 2.5
1.3
 0.6
-0.1
 1.5
1.1
 2.0
0.5
 1.9
1.7
 1.4
1.4
 0.1
0.0
 1.1
0.6
 1.7
0.5
 0.4
0.2
 1.8
1.7
 2.7
-0.0
 1.3
0.3
 2.4
-0.1
25 BIN1 bridging integrator 1 713587 3.6 1.9
2.0
0.5
 3.3
-0.9
 0.9
0.9
 -0.0
-0.1
 1.1
0.1
 2.2
-0.4
 0.8
-0.7
 1.2
-0.2
 2.1
1.0
 0.7
-0.1
 0.9
-1.9
 0.4
-0.1
 1.9
1.0
 0.8
-0.2
 2.0
0.0
 1.9

26 STAT4 signal transducer and activator of transcription 4 693854 3.6 1.9
3.4
 1.0
 1.4
 -0.4
 0.8
 -0.3
 0.4
 1.0
 -0.1
 -0.7
 0.0
 0.0
 -0.1
 -0.2
 -0.0


27 PCDH1 protocadherin 1 106998973 3.6 1.9
1.2
 -0.4
 0.6
 1.0
 -0.5
 0.2
 -0.4
 0.3
 0.6
 -0.7
 1.2
 2.3
 3.0
0.5
 1.8
1.1
 1.4
0.2


28 SFXN3 sideroflexin 3 712607 3.5 1.9
1.7
0.9
 0.1
-0.1
 2.4
0.1
 0.6
-0.2
 1.1
0.1
 1.6
-0.1
 0.5
0.1
 1.4
 -0.1
-0.4
 -0.1
-0.7
 1.4
-0.5
 2.0
-0.2
 0.8
-0.5
 1.6
0.4
 2.6
2.3
 1.6
-0.2
 -0.3
29 FMNL1 formin like 1 716211 3.5 1.6
 2.2
 0.4
0.2
 1.3
0.8
 5.1
1.2
 2.7
0.5
 0.3
0.1
 3.5
0.5
 -0.6
-0.7
 1.8
0.6
 1.2
0.5
 -0.1
-0.2
 0.7
-0.6
 1.1
1.0
 0.8
0.5
 1.4
0.3
 1.5
1.5
 0.8
 0.2
30 MOSPD3 motile sperm domain containing 3 712566 3.5 0.7
 3.2
 -0.2
 -0.5
 1.0
 -0.6
 -0.6
 2.9
 -1.6
 -1.1
 1.2
 -0.2







31 ARRDC2 arrestin domain containing 2 719299 3.5 1.1
 2.8
 2.0
1.8
 3.0
2.6
 3.6
0.2
 2.4
0.4
 0.4
0.0
 0.9
0.0
 0.4
-0.1
 2.1
1.6
 1.7
0.3
 1.7
0.5
 2.2
0.3
 2.1
0.0
 0.8
0.1
 1.0
0.7
 0.4
 1.0
0.7

32 LRP1 LDL receptor related protein 1 710965 3.5 1.9
1.3
-2.1
 0.3
-0.2
 3.0
0.4
 -0.5
-1.1
 3.3
0.5
 1.0
-0.1
 0.1
-1.8
 -0.0
-0.6
 1.9
-0.5
 -0.3
-0.6
 -0.0
-0.4
 1.3
0.5
 1.2
0.5
 1.6
0.1
 4.1
1.4
 1.9

33 ACTN3 actinin alpha 3 713811 3.5 2.3
 1.2
 1.0
0.9
 1.2
0.9
 0.7
0.6
 0.4
0.3
 0.3
0.1
 0.8
0.4
 0.4
0.3
 0.5
0.2
 1.5
0.8
 2.4
1.2
 0.6
-0.5
 1.5
1.1
 0.6
-0.2
 1.7
-0.1
 0.8
-0.1
 3.9

34 PHC2 polyhomeotic homolog 2 710201 3.4 1.4
 2.3
 1.4
0.7
 1.5
0.3
 1.0
0.8
 -0.2
 1.2
 1.0
 -0.4
-1.2
 1.2
0.7
 0.9
-0.7
 -0.5
-1.1
 -0.3
-0.3
 0.1
-0.9
 1.6
0.9
 1.8
0.4
 0.5
-0.3
 0.8
-0.3

35 LOC718462 archaemetzincin-2-like 718462 3.4 2.0
 1.6

















36 CARM1 coactivator associated arginine methyltransferase 1 715977 3.4 1.5
 2.2
 -0.9
 -0.4
 3.3
 0.1
 -0.3
 2.9
 0.5
 0.7
 2.7
 1.2
 0.7
 -0.1
 0.8
 -0.5
 -1.3
 -1.5

37 FKBP8 FKBP prolyl isomerase 8 720232 EGK_10334 3.4 0.8
 3.1
 0.0
 -0.3
 1.9
 -0.1
 -0.3
 0.7
 -1.0
 0.1
 0.1
 -0.4
 -0.4
 0.6
 -0.2
-0.4
 1.1
-0.2
 -0.3
-1.0
 -0.7

38 TLE2 TLE family member 2, transcriptional corepressor 721644 3.4 1.9
 1.7
 1.0
0.7
 3.5
0.9
 1.7
1.3
 2.9
0.9
 0.6
0.5
 1.6
-0.6
 1.7
-0.1
 0.7
0.5
 0.9
0.8
 0.7
 2.0
-0.4
 1.3
0.6
 1.8
0.8
 1.5
-0.3
 1.7
0.4
 1.8

39 FAM219A family with sequence similarity 219 member A 700651 3.4 1.8
1.1
 0.2
 0.5
 0.1
 0.8
 1.6
 1.4
 1.0
 0.6
 2.0
 -0.6
 1.0
 1.5
-0.5
 0.9
-0.3
 1.9
0.3


40 PLBD2 phospholipase B domain containing 2 714669 3.4 1.8
-0.1
 -1.2
 3.2
 0.8
 -0.6
 1.5
 -1.6
 -1.2
 1.5
 -1.1
 -0.1
 -1.3
 -0.3
 -0.2
 -0.1


41 TAF6 TATA-box binding protein associated factor 6 710863 EGK_13513 3.4 1.9
 1.6
 -0.1
 -1.2
 1.9
 0.5
 -0.8
 1.1
 -0.5
 0.3
 1.5
 -0.6

-1.0
 0.5
 0.1
 -1.2
-1.6
 0.4
 -0.9
42 AP2A1 adaptor related protein complex 2 subunit alpha 1 719038 3.4 1.7
 1.8
 -0.8
-1.2
 -0.3
-1.1
 2.2
0.7
 -0.0
-0.4
 0.4
-0.2
 3.1
0.6
 0.9
0.3
 0.7
-0.6
 1.9
-0.8
 -0.5
-1.4
 0.1
 0.1
 0.3
 0.2
 -1.4
 -0.3
 0.1
43 EFHD2 EF-hand domain family member D2 694155 3.3 1.6
 2.0
 0.4
-1.1
 1.0
0.6
 1.7
0.0
 1.0
-0.4
 -0.2
-0.3
 0.6
0.5
 -0.6
-1.3
 0.9
0.6
 0.4
-0.4
 0.4
-0.8
 0.1
 1.1
 0.2
-0.6
 -0.7
-2.4
 0.8
0.6
 -0.6

44 PER1 period circadian regulator 1 721948 3.3 2.0
 1.5
 1.2
0.9
 2.1
0.5
 3.2
2.5
 1.3
1.1
 1.5
1.0
 1.7
1.2
 1.4
0.3
 -0.1
-0.4
 1.5
0.9
 1.7
0.2
 0.3
-0.4
 0.5
0.1
 -0.0
-0.4
 0.3
0.3
 2.8
0.9
 0.5
2.4
0.8
45 SH3BP2 SH3 domain binding protein 2 700932 3.3 1.2
 2.4
 -1.3
 0.6
 1.4
 -0.1
 -1.0
 -0.8
 -1.9
 0.7
 -1.7
 0.4
 -1.0
 1.5
 0.1
 -1.2
 -0.9


46 PKM pyruvate kinase M1/2 697742 3.3 2.1
 1.4
 0.2
0.1
 1.0
0.5
 0.2
-0.9
 0.6
-0.4
 0.4
-0.7
 1.3
-0.3
 -1.4
 -0.8
 0.8
-0.4
 1.2
-1.9
 0.3
 1.2
 0.9
0.1
 1.1
0.1
 -0.4
-1.3
 2.1
0.3
 0.6
-1.1
47 HEATR9 HEAT repeat containing 9 716382 3.3 2.5
 0.7
 0.4
 -0.2















48 DTD1 D-aminoacyl-tRNA deacylase 1 700895 3.3 1.8
0.9
 -1.1
 0.8
 -0.2
 0.3
 -0.2
 0.7
 0.3
 -2.1
 -0.8
 0.6
 1.0
 -0.7
 1.7
 0.5
 0.9
 -0.5
 -0.5
49 SIRPA signal regulatory protein alpha 717811 3.3 1.7
 1.8
 -0.3
-0.4
 2.1
1.0
 1.0
-0.9
 -0.9
-1.2
 0.3
-0.6
 0.9
-0.3
 -0.9
 0.3
 0.6
0.5
 1.6
1.4
 0.6
-0.4
 1.4
-0.7




-1.0
50 SEMA7A semaphorin 7A 702185 3.2 1.0
 2.6
 -0.5
 1.7
 1.0
 1.5
 0.8
 1.7
 2.1
 1.1
 0.3
 1.6
 0.4
 2.0
 1.5
 1.6
 2.2


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