Orthologous genes in OrthoFinder**

Species Gene Description
 rno-u.3   Mthfd2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 rno-r.3   Mthfd2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 rno-m.5   Mthfd2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 rno-u.3   Mthfd2l   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 
 mmu-u.4   Mthfd2l   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 
 mmu-u.4   Mthfd2   methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase 
 hsa-u.4   MTHFD2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 mcc-u.3   MTHFD2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 cfa-u.3   MTHFD2L   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like 
 cfa-u.3   MTHFD2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 gga-u.3   MTHFD2L   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like 
 gga-u.3   MTHFD2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 dre-u.3   mthfd2l   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like 
 dre-u.3   mthfd2   methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
 dme-u.3   Nmdmc   NAD-dependent methylenetetrahydrofolate dehydrogenase 

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Top 50 coexpressed genes to Mthfd2 (rno-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 rno970   Aminoacyl-tRNA biosynthesis  14 42 6.79
 rno1230   Biosynthesis of amino acids  7 67 7.31
 rno1240   Biosynthesis of cofactors  5 137 4.24
 rno260   Glycine, serine and threonine metabolism  4 39 5.25
 rno1200   Carbon metabolism  4 108 3.50

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rno:Mthfd2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) External Links;


Show/Hide Columns:        
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

rno-u.3
for
Mthfd2
rno-r.3
for
Mthfd2
rno-m.5
for
Mthfd2
rno-u.3
for
Mthfd2l
mmu-u.4
for
Mthfd2l
mmu-u.4
for
Mthfd2
hsa-u.4
for
MTHFD2
mcc-u.3
for
MTHFD2
cfa-u.3
for
MTHFD2L
cfa-u.3
for
MTHFD2
gga-u.3
for
MTHFD2L
gga-u.3
for
MTHFD2
dre-u.3
for
mthfd2l
dre-u.3
for
mthfd2
dme-u.3
for
Nmdmc
1 Slc7a1 solute carrier family 7 member 1 25648 12.2 6.1
 5.4
 2.6
2.1
 0.5
0.3
 12.5
6.1
 8.1
1.4
 3.6
0.8
 0.5
0.1
 6.1
0.9
 1.5
0.5
 8.0
5.2
 0.5
0.3
 3.9
1.0
 1.9
0.9
2 Asns asparagine synthetase (glutamine-hydrolyzing) 25612 12.0 5.8
 5.5
 -0.1
 0.3
 13.7
 12.4
 2.1
 -1.0
 4.9
 1.0
 8.1
 -0.6
 3.4
 4.7
3 Slc7a5 solute carrier family 7 member 5 50719 9.5 4.3
 4.7
 2.0
0.8
 1.8
1.2
 13.7
5.3
 8.2
7.6
 3.1
1.2
 1.1
0.8
 5.0
4.2
 1.5
0.4
 4.8
4.7
 0.8
0.2
 2.0
1.5
 2.6
2.0
4 Yars1 tyrosyl-tRNA synthetase 1 313047 8.6 4.0
 4.1
 0.7
 -0.9
 12.4
 11.2
 2.0
 0.4
 6.1
 -0.1
 8.2
 -0.1
 4.4
 2.1
5 Cars cysteinyl-tRNA synthetase 293638 8.5 3.9
 4.2
 -0.1
 -1.3
 12.8
 9.5
 1.8
 -1.3
 5.0
 1.0
 5.0
 -1.2
 3.4
 1.7
6 Trib3 tribbles pseudokinase 3 246273 8.1 3.7
 4.1
 1.3
1.0
 1.5
-0.4
 9.0
-0.1
 8.4
1.1
 1.5
1.3
 0.8
-0.1
 5.3
1.5
 1.4
0.1
 2.2
0.5
 0.8
0.3
 2.6
2.5
 0.7
7 Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 362196 7.9 3.4
 4.1
 1.6
0.9
 1.3
-0.7
 12.6
1.9
 10.4
1.7
 1.3
0.6
 1.0
0.7
 5.0
-0.5
 1.4
0.6
 7.5
0.6
 3.3
1.0
 4.3
0.8
 2.3
0.7
8 Nars1 asparaginyl-tRNA synthetase 1 291556 7.3 3.6
 3.4
 0.7
 -1.0
 12.5
 5.8
 1.7
 -0.2
 5.0
 1.2
 1.2
 -1.1
 2.4
 3.4
9 Aars1 alanyl-tRNA synthetase 1 292023 7.1 3.9
 2.9
 -0.3
-1.0
 -0.4
-2.1
 12.1
-0.5
 8.8
-1.3
 -0.1
-0.1
 1.3
-0.8
 5.1
1.5
 -0.3
-0.8
 5.2
0.5
 2.1
0.4
 2.9
-0.7
 2.7
10 Lars1 leucyl-tRNA synthetase 1 291624 7.0 3.4
 3.3
 -0.3
 -1.1
 8.4
 4.9
 1.1
 1.4
 2.7
 0.2
 1.8
 -0.7
 1.6
 2.1
11 Mars1 methionyl-tRNA synthetase 1 299851 6.7 3.7
 2.7
 -0.5
 -1.6
 9.0
 11.0
 0.4
 0.6
 2.8
 -2.3
 3.0
 -1.1
 2.2
 1.8
12 Atf4 activating transcription factor 4 79255 6.7 2.5
 3.8
 -0.2
 -0.6
 9.4
 5.7
 2.4
 -1.2
 5.2
 -0.4
 9.3
 -0.5
-0.7
 4.6
3.5
13 Psat1 phosphoserine aminotransferase 1 293820 6.6 3.5
 2.7
 0.0
 0.3
 10.8
 11.2
 2.2
 -0.2
 6.0
 0.5
 5.2
 -0.2
 3.7
 5.2
14 LOC120102233 uncharacterized LOC120102233 120102233 6.5 3.6












15 Iars1 isoleucyl-tRNA synthetase 1 306804 6.4 3.5
 2.6
 1.3
 -0.7
 9.9
 7.9
 0.7
 0.8
 3.3
 0.5
 7.3
 0.1
 1.5
 1.0
16 Eprs glutamyl-prolyl-tRNA synthetase 289352 6.3 3.6
 2.4
 -0.8
 -1.3
 7.1
 7.6
 0.6
 0.5
 2.5
 0.0
 4.6
 -0.7
 1.0
 2.0
17 Tars1 threonyl-tRNA synthetase 1 294810 6.2 2.9
 3.0
 1.7
0.4
 1.3
-0.4
 8.9
0.4
 10.7
-0.4
 2.7
-0.1
 0.9
-0.0
 4.4
-1.2
 2.6
0.2
 6.4
0.9
 -0.4
-0.4
 4.8
-0.8
 1.6
18 Phgdh phosphoglycerate dehydrogenase 58835 6.2 3.8
 2.2
 0.4
 1.3
 7.5
 8.2
 -0.8
 0.4
 1.9
 -1.1
 3.3
 -0.2
 4.2
 3.3
19 Psph phosphoserine phosphatase 304429 6.2 2.9
 3.0
 0.3
 0.2
 8.5
 6.8
 0.3
 0.6
 3.9
 -0.2
 6.7
 0.3
 1.6
 4.7
20 Sars1 seryl-tRNA synthetase 1 266975 6.0 3.0
 2.8
 1.2
 -0.3
 9.8
 7.1
 1.1
0.4
 0.8
 5.0
 -0.7
 5.4
 -0.1
 2.6
 2.7
21 Gars glycyl-tRNA synthetase 297113 5.9 2.8
 2.9
 0.1
 0.1
 13.3
 11.9
 1.5
 0.2
 4.2
 1.2
 8.2
 -0.4
 2.8
 1.0
22 Atf5 activating transcription factor 5 282840 5.8 2.8
 2.8
 -1.2
 -0.4
 8.3
 4.9
 0.7
 -1.1
 2.4

-0.2
-0.4
 2.8
2.7
23 Shmt2 serine hydroxymethyltransferase 2 299857 5.6 3.0
 2.4
 0.5
-0.1
 -0.3
-1.1
 8.3
-0.3
 9.9
-0.9
 2.1
-0.1
 -0.2
-0.5
 3.4
-2.0
 -0.3
 -1.2
 0.3
-0.4
 0.6
-0.1
 12.7
24 Slc3a2 solute carrier family 3 member 2 50567 5.6 2.8
 2.6
 -1.2
 -1.3
 8.1
 8.1
 -0.3
 -0.0
 1.6

0.5
-0.1
 2.3
0.6
 3.0
25 Adm2 adrenomedullin 2 399475 5.4 3.0
-0.8

8.3
-1.3
 -0.4
 -0.1
 2.7
 2.5
 1.8
26 Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 116636 5.3 2.4
 2.7
 0.6
-0.7
 0.6
-0.5
 6.9
-0.6
 7.6
0.1
 2.5
1.9
 0.9
0.3
 1.3
-0.1
 0.4
-0.2
 1.3
1.0
 0.2
-0.8
 1.1
-0.1
 1.8
27 Pycr1 pyrroline-5-carboxylate reductase 1 287877 5.2 2.4
 2.6
 1.5
0.3
 0.4
0.4
 8.6
2.8
 8.2
1.3
 0.7
-1.0
 0.5
-1.0
 4.2
-0.0
 0.5
0.4
 8.7
6.7
 1.8
0.4
 0.1
-0.5
 1.1
28 Wars1 tryptophanyl-tRNA synthetase 1 314442 5.1 3.0
 1.9
 1.3
 -0.7
 6.6
 8.8
 3.2
 0.4
 2.6
 1.5
 3.3
 -0.2
 2.0
 1.6
29 Xpot exportin for tRNA 314879 5.0 2.8
 1.9
 0.1
 0.3
 4.8
 10.6
 2.2
 1.3
 3.5
 0.1
 0.5
 0.7
 3.2
30 Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 361472 4.9 2.7
 2.0
 1.4
0.6
 0.4
-0.1
 6.0
0.0
 0.2
 1.1
1.1
 2.3
-0.6
 3.3
0.7
 0.0
 0.8
 -0.8
-1.3
 2.9
-0.7
 3.5
31 Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 361042 4.8 2.4
 2.1
 -0.8
-1.0
 0.5
-1.2
 9.1
-1.3
 9.5
-0.0
 2.3
-0.5
 1.0
0.1
 4.8
-1.4
 -1.0
 -1.8
 -0.0
-0.7
 0.6
-0.0
 2.5
32 Slc1a5 solute carrier family 1 member 5 292657 4.7 2.8
 1.7
 2.0
 -0.6
 4.7
 9.8
 2.8
 1.0
 3.4

-2.6
 2.7
33 Eif2b3 eukaryotic translation initiation factor 2B subunit gamma 171145 4.7 2.9
 1.6
 0.8
 0.9
 2.3
 0.5
 -1.2
 -0.2
 2.3
 -0.3
 1.0
 -0.5
 2.0
 1.9
34 LOC100909675 uncharacterized LOC100909675 100909675 4.6 2.5












35 Hspa9 heat shock protein family A (Hsp70) member 9 291671 4.5 3.0
 1.4
 1.1
-0.3
 0.7
0.3
 4.6
2.7
 5.3
2.7
 2.0
1.5
 0.9
0.7
 4.0
3.4
 2.2
1.1
 3.5
2.5
 1.5
1.2
 3.7
3.1
 2.9
1.1
36 LOC102547700 uncharacterized LOC102547700 102547700 4.5 2.5












37 Vars1 valyl-tRNA synthetase 1 25009 4.5 2.2
 2.1
 1.0
0.5
 0.3
0.2
 3.7
-0.8
 0.5
-0.1
 0.3
-0.7
 0.8
-0.3
 1.0
0.1
 -0.3
-1.2
 -0.4
-1.2
 2.3
-0.9
 2.5
-0.2
 2.2
-1.3
38 Slc6a9 solute carrier family 6 member 9 116509 4.4 2.2
 2.0
 0.3
 -0.5
 7.9
 5.4
 1.4
 -0.7
 2.8
 -0.2
 4.8
 -0.7
 1.4
 0.7
39 Eif2s2 eukaryotic translation initiation factor 2 subunit beta 296302 4.4 2.3
 1.9
 -0.3
 -0.2
 7.3
 9.2
 3.0
 1.7
 5.1
 0.3
 5.3
 -1.0
 0.4
 2.7
40 Ghitm growth hormone inducible transmembrane protein 290596 4.4 2.3
 1.9
 -0.1
 -1.2
 5.1
 4.2
 1.2
 0.6
 0.3
 -0.1
 -0.3
 -0.6
 0.6
 0.1
0.0
41 Slc7a11 solute carrier family 7 member 11 310392 4.4 1.9
 2.4
 2.0
0.8
 1.8
1.2
 13.7
5.3
 8.2
7.6
 3.1
1.2
 1.1
0.8
 5.0
4.2
 1.5
0.4
 4.8
4.7
 0.8
0.2
 2.0
1.5
 2.6
2.0
42 Cebpg CCAAT/enhancer binding protein gamma 25301 4.3 1.9
 2.3
 -0.3
 -0.3
 6.0
 10.4
 3.2
 1.2
 4.7
 0.9
 5.1
 -0.9
 3.9
43 Farsb phenylalanyl-tRNA synthetase subunit beta 301544 4.3 2.0
 2.2
 0.5
 0.4
 4.4
 1.6
 -0.7

-0.2
 1.7
 -0.0
 2.1
 2.2
44 Bcat1 branched chain amino acid transaminase 1 29592 4.3 2.7
 1.4
 2.6
-0.1
 -0.3
-1.1
 6.2
1.4
 5.3
1.0
 2.0
-0.3
 0.7
-0.7
 2.5
0.0
 0.0
 2.9
 0.3
-0.2
 1.9
1.4
 4.6
45 Ifrd1 interferon-related developmental regulator 1 29596 4.2 1.9
 2.2
 0.8
-0.3
 1.0
-0.2
 3.5
2.1
 4.6
1.1
 1.1
1.0
 1.6
0.8
 2.7
1.6
 0.4
 4.4
 -0.1
-0.5
 2.9
2.0
 2.9
46 Sesn2 sestrin 2 502988 4.2 1.9
 2.2
 -0.2
-0.6
 0.1
-0.7
 5.1
-0.8
 7.0
-0.5
 1.2
0.7
 0.5
-0.1
 3.3
-0.7
 1.3
0.7
 2.4
-0.4
 0.1
-0.0
 5.8
0.4
47 Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 85430 4.2 2.0
 2.0
 -0.1
-1.3
 0.5
-0.7
 5.1
0.2
 6.2
0.2
 1.2
-0.3
 -0.1
-0.6
 2.8
-2.3
 2.4
0.6
 5.9
0.3
 0.5
0.0
 2.0
1.4
 -1.1
48 Myc MYC proto-oncogene, bHLH transcription factor 24577 4.1 2.0
 1.9
 2.1
-0.2
 0.5
0.1
 1.6
-0.7
 3.9
 2.0
 0.9
 1.4
 1.0
 4.0
 0.4
0.4
 0.8
0.5
 0.8
49 Wdr43 WD repeat domain 43 362703 4.0 1.9
 2.0
 0.8
 0.7
 2.2
 3.3
 2.5
 1.5
 3.0
 -1.5
 1.1
 -0.4
 -0.0
 2.2
50 Casp4 caspase 4 114555 4.0 2.3
 1.6
 1.3
0.7
 1.1
0.6
 0.6
-0.5
 1.6
0.7
 1.8
0.9
 -0.3
-1.2
 0.9
0.2
 -0.3
 0.9
 1.3
0.1
 0.3
-0.4
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