Orthologous genes in OrthoFinder**

Species Gene Description
 dme-u.3   Lrrk   Leucine-rich repeat kinase 
 dme-r.4   Lrrk   Leucine-rich repeat kinase 
 dme-m.5   Lrrk   Leucine-rich repeat kinase 
 cel-u.3   lrk-1   Leucine-rich repeat serine/threonine-protein kinase 1 
 hsa-u.4   LRRK1   leucine rich repeat kinase 1 
 mmu-u.4   Lrrk1   leucine-rich repeat kinase 1 
 rno-u.3   Lrrk1   leucine-rich repeat kinase 1 
 gga-u.3   LRRK1   leucine rich repeat kinase 1 
 dre-u.3   lrrk1   leucine-rich repeat kinase 1 
 mcc-u.3   LRRK1   leucine rich repeat kinase 1 
 cfa-u.3   LRRK1   leucine rich repeat kinase 1 

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Top 50 coexpressed genes to Lrrk (dme-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 dme310   Lysine degradation  2 35 2.05
 dme4214   Apoptosis - fly  2 63 -
 dme4140   Autophagy - animal  2 100 -
 dme4120   Ubiquitin mediated proteolysis  2 107 -
 dme4144   Endocytosis  2 125 -

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dme:Lrrk (Leucine-rich repeat kinase) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

dme-u.3
for
Lrrk
dme-r.4
for
Lrrk
dme-m.5
for
Lrrk
cel-u.3
for
lrk-1
hsa-u.4
for
LRRK1
mmu-u.4
for
Lrrk1
rno-u.3
for
Lrrk1
gga-u.3
for
LRRK1
dre-u.3
for
lrrk1
mcc-u.3
for
LRRK1
cfa-u.3
for
LRRK1
1 CG2747 uncharacterized protein 40950 Dmel_CG2747 9.1 4.7
 4.4
 7.6
 1.1
0.5
 2.8
1.7
 2.7
2.4
 1.6
0.4
 1.8
0.5
 0.5
0.4
 0.7
-0.3
2 CG14562 uncharacterized protein 40439 Dmel_CG14562 7.7 4.3
 3.3







3 Rbcn-3A Rabconnectin-3A 31557 Dmel_CG3585 7.5 3.1
 4.3
 6.6
 1.1
0.8
 -0.9
-1.4
 -0.5
-1.7
 0.9
0.6
 2.1
1.4
 0.5
0.2
 1.8
-0.6
4 Wnk Wnk kinase 40391 Dmel_CG7177 6.7 3.6
 3.1
 2.3
 -0.2
-2.0
 0.7
-1.8
 1.4
-0.7
 -0.5
 2.0
1.7
 -0.9
-1.7
 0.4
-0.8
5 Usp32 Ubiquitin specific protease 32 40169 Dmel_CG8334 6.6 3.7
 2.9
 2.1
 0.1
 -0.9
 -0.9
 -0.6
 -0.6
 -1.3
 0.9
6 Bruce BIR repeat containing ubiquitin-conjugating enzyme 41260 Dmel_CG6303 6.6 3.5
 3.1
 1.6
 0.2
 1.3
 -0.4
 -0.9
 4.8
 0.4
 1.4
7 Dab Disabled 39866 Dmel_CG9695 6.6 3.7
 2.9
 0.6
-1.7
 -0.8
 -0.3
 1.2
1.1
 -1.3
 -1.1
8 Camta Calmodulin-binding transcription activator 35974 Dmel_CG42332 6.6 3.9
2.8
 3.3
 1.4
 0.9
 -2.1
 2.0
-0.5
 1.6
 0.2
-1.8
9 ash1 absent, small, or homeotic discs 1 40133 Dmel_CG8887 6.5 2.8
 3.7
 3.9
1.4
 0.2
 -0.2
 0.9
 -0.5
 1.8
10 Wdr81 WD repeat domain 81 34616 Dmel_CG6734 6.5 4.7
 1.9
 5.7
 1.5
 2.6
 1.4
 0.9
 0.5
 1.9
 1.1
11 Ire1 Inositol-requiring enzyme-1 42358 Dmel_CG4583 6.4 3.9
 2.5
 1.8
 1.0
0.6
 2.6
 1.2
 0.0
-0.4
 3.1
0.2
 0.2
-0.3
 2.5
0.2
12 DIP2 DISCO Interacting Protein 2 252479 Dmel_CG7020 6.3 4.3
 2.1
 3.0
 0.6
0.4
 2.9
1.3
 0.9
0.6
 2.0
0.7
 1.2
1.1
 0.1
-0.0
 2.1
1.3
13 CG31998 uncharacterized protein 43774 Dmel_CG31998 6.3 3.2
 3.0







14 syd sunday driver 43905 Dmel_CG8110 6.2 2.9
 3.3
-0.3
 -0.1
 0.0
 0.7
 1.6
-0.5
 -0.3
 -0.0
15 Nak Numb-associated kinase 35154 Dmel_CG10637 6.1 4.7
 1.6
 1.1
 1.8
-0.8
 1.5
1.5
 0.6
0.2
 0.6
0.3
 4.2
3.1
 0.7
0.1
 0.8
0.7
16 cno canoe 40620 Dmel_CG42312 6.1 3.6
3.1
 0.0
 1.3
 1.1
 0.8
 2.1
-0.3
 -0.7
 1.4
17 CG6791 uncharacterized protein 41391 Dmel_CG6791 5.9 3.3
 2.6







18 hyd hyperplastic discs 41181 Dmel_CG9484 5.8 3.6
 2.2
 5.9
 0.8
 0.4
 -0.1
 1.0
 1.6
 -0.1
 0.9
19 Itpr Inositol 1,4,5,-trisphosphate receptor 40664 Dmel_CG1063 5.7 2.5
 3.2
 3.7
 3.2
2.3
 4.5
2.1
 3.2
2.5
 3.3
1.2
 2.1
2.0
 1.0
0.7
 1.7
1.5
20 Megf8 Multiple EGF like domains 8 34099 Dmel_CG7466 5.7 4.5
 1.3
0.8
 2.8
 1.6
0.6
 0.8
 1.0
21 Pkn Protein kinase N 35950 Dmel_CG2049 5.6 3.4
 2.2
 4.8
 0.5
0.1
 1.9
1.5
 1.6
0.3
 0.6
-0.2
 1.9
0.1
 1.8
0.8
 2.5
0.1
22 CG4049 uncharacterized protein 37860 Dmel_CG4049 5.6 2.9
 2.7
 1.6
 0.1
 0.9
 0.1
 2.1
 0.5
 -0.1
 -0.0
23 trr trithorax-related 31149 Dmel_CG3848 5.6 3.1
 2.5
 5.7
 0.4
 0.5
 0.0
 0.1
 2.2
2.0
 -0.3
 2.2
24 pps protein partner of snf 41524 Dmel_CG6525 5.4 3.0
 2.4
1.5
 -1.0
 -1.2
 -1.0
 0.1
 -0.9
 0.1
25 CG5521 uncharacterized protein 43242 Dmel_CG5521 5.4 3.0
 2.4
 2.8
 0.7
0.1
 0.8
-0.0
 1.0
0.4
 1.7
-0.1
 1.4
1.4
 1.2
0.3
 0.5
-0.7
26 Sec16 Secretory 16 32209 Dmel_CG32654 5.4 3.3
 2.1
 6.0
1.7
 2.2
 0.9
0.9
 2.7
1.0
 1.0
1.0
 1.9
-1.3
 0.7
-0.2
 2.1
0.2
27 CG34126 uncharacterized protein 318872 Dmel_CG34126 5.3 3.3
 2.1
 3.8
 1.4
0.8
 1.6
-0.0
 3.7
0.9
 2.4
-0.7
 3.2
0.4
 1.1
-2.6
 1.1
0.3
28 Dark Death-associated APAF1-related killer 36914 Dmel_CG6829 5.3 3.8
 1.5







29 Nf1 Neurofibromin 1 43149 Dmel_CG8318 5.3 4.5
 0.9
0.4
 0.8
 -0.2
 0.1
 4.5
0.8
 1.0
 0.5
30 Lztr1 Leucine zipper like transcription regulator 1 31037 Dmel_CG3711 5.3 3.3
 2.0
1.1
 0.9
 0.5
 1.6
 -0.5
 1.0
 0.3
31 PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 37461 Dmel_CG9856 5.3 3.5
 1.8







32 Ubr3 Ubr3 ubiquitin ligase 31713 Dmel_CG42593 5.2 1.7
 3.4
 8.7
 -0.1
 0.0
 0.3
 -1.2
 -0.1
 -0.4
 -0.1
33 Afti Aftiphilin 41744 Dmel_CG8538 5.2 3.6
 1.7
 0.0
 0.3
 -0.6
 -1.5
 -0.8
 0.0
-1.3
 0.0
 1.0
34 Sara Smad anchor for receptor activation 44263 Dmel_CG15667 5.1 2.9
 2.3
 1.5
 0.6
 1.3
0.1
 0.2
 1.6
0.3
 1.2
1.2
 1.3
1.0
 1.9
-0.3
35 ca claret 43518 Dmel_CG31037 5.1 3.6
 1.5
 2.9
 -0.0
 1.7
 1.3
 -0.3
 0.6
 -0.4
 -0.7
36 PlexB Plexin B 43766 Dmel_CG17245 5.1 2.2
 2.8
0.3
 -1.0
 0.2
5.7
 -0.2
 0.3
37 milt milton 45683 Dmel_CG43227 5.0 3.0
 2.1
 0.6
 3.4
-0.5
 0.9
-0.8
 1.5
0.1
 -0.2
-0.5
 2.0
0.6
 2.0
-0.7
 1.2
-0.8
38 GAPcenA GTPase activating protein and centrosome-associated 38945 Dmel_CG7112 5.0 3.2
 1.9
 4.0
1.5
1.2
 -0.1
 -0.8
 1.3
-0.5
 -0.8
 -0.1
39 sov small ovary 31615 Dmel_CG14438 5.0 2.1
 2.9







40 mv mauve 38259 Dmel_CG42863 5.0 3.0
 2.0

1.0
 -0.3
 -0.3
 2.6
 0.3
 0.2
41 Klp64D Kinesin-like protein at 64D 38611 Dmel_CG10642 4.9 2.1
 2.8
 3.5
 -1.2
 -0.7
 -0.3
 -0.5
 -2.8
 0.4
 -1.4
42 Vps13D Vacuolar protein sorting 13D 39448 Dmel_CG32113 4.9 3.4
 1.5
 4.9
 2.2
 0.7
 1.3
 0.3
 2.7
 1.5
 1.7
43 Rich RIC1 homolog 40456 Dmel_CG9063 4.9 2.9
 2.0
 4.0
 1.3
 0.8
 0.1
 -0.3
 4.5
 -0.4
 2.1
44 Adar Adenosine deaminase acting on RNA 31130 Dmel_CG12598 4.9 2.9
 2.0
 1.8
0.0
 0.5
0.1
 0.1
-1.0
 0.3
-0.9
 -0.0
-0.1
 3.6
1.8
 2.4
-1.3
 -0.8
45 dop drop out 39686 Dmel_CG6498 4.9 2.2
 2.6
 3.5
 2.0
-0.4
 1.8
-1.0
 0.9
-0.7
 1.8
0.4
 1.8
0.6
 1.5
-0.0
 2.0
1.1
46 Patronin patronin 36978 Dmel_CG33130 4.8 3.4
 1.5
 4.3
 0.0
-0.5
 1.3
0.2
 -0.4
-0.4
 0.7
-0.3
 1.4
0.7
 0.8
0.2
 1.2
0.4
47 CG9727 uncharacterized protein 40794 Dmel_CG9727 4.8 3.2
 1.7
1.4
 1.9
 1.5
 0.3
 0.7
 2.8
 0.6
48 Rfx Rfx 41266 Dmel_CG6312 4.8 2.4
 2.4
 4.6
 1.4
1.3
 0.8
0.2
 1.3
0.4
 1.6
1.2
 -0.1
-0.9
 0.2
-0.2
 0.7
0.5
49 CG8671 uncharacterized protein 35400 Dmel_CG8671 4.8 2.0
 2.8
 1.1
 1.2
-0.2
 1.3
-0.1
 1.8
0.3
 2.3
0.5
 2.7
0.4
 2.6
-0.4
 1.5
1.4
50 Ubr1 Ubr1 ubiquitin ligase 32687 Dmel_CG9086 4.8 3.2
 1.6
 4.6
 -0.4
 3.2
1.3
 1.7
0.2
 0.7
-0.2
 1.1
-0.1
 -0.3
-0.8
 0.4
0.4
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