Orthologous genes in OrthoFinder**

Species Gene Description
 sce-u.3   FUM1   fumarase FUM1 
 sce-r.3   FUM1   fumarase FUM1 
 sce-m.4   FUM1   fumarase FUM1 
 hsa-u.4   FH   fumarate hydratase 
 mmu-u.4   Fh1   fumarate hydratase 1 
 rno-u.3   Fh   fumarate hydratase 
 gga-u.3   FH   fumarate hydratase 
 dre-u.3   100535417   fumarate hydratase, mitochondrial-like 
 dre-u.3   fh   fumarate hydratase 
 dme-u.3   Fum3   Fumarase 3 
 dme-u.3   Fum4   Fumarase 4 
 dme-u.3   Fum2   Fumarase 2 
 cel-u.3   fum-1   putative fumarate hydratase, mitochondrial 
 mcc-u.3   FH   fumarate hydratase 
 cfa-u.3   FH   fumarate hydratase 

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Top 50 coexpressed genes to FUM1 (sce-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 sce1200   Carbon metabolism  21 109 6.51
 sce190   Oxidative phosphorylation  20 66 7.13
 sce20   Citrate cycle (TCA cycle)  18 30 6.78
 sce620   Pyruvate metabolism  7 50 6.72
 sce1230   Biosynthesis of amino acids  7 123 4.08

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sce:FUM1 (fumarase FUM1) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

sce-u.3
for
FUM1
sce-r.3
for
FUM1
sce-m.4
for
FUM1
hsa-u.4
for
FH
mmu-u.4
for
Fh1
rno-u.3
for
Fh
gga-u.3
for
FH
dre-u.3
for
100535417
dre-u.3
for
fh
dme-u.3
for
Fum3
dme-u.3
for
Fum4
dme-u.3
for
Fum2
cel-u.3
for
fum-1
mcc-u.3
for
FH
cfa-u.3
for
FH
1 LPD1 dihydrolipoyl dehydrogenase 850527 YFL018C 8.4 3.6
 4.4
 6.7
 7.1
 6.0
 5.2
 5.5
 9.2
 -0.2
 -0.3
 2.2
 9.5
 3.7
 5.6
2 KGD2 alpha-ketoglutarate dehydrogenase KGD2 851726 YDR148C 8.1 4.9
 2.8
 3.5
 6.4
 8.4
 5.0
 6.1
 7.3
 -0.5
 -0.4
 1.7
 12.6
 3.8
 5.8
3 IDH2 isocitrate dehydrogenase (NAD(+)) IDH2 854303 YOR136W 7.5 3.8
 3.4
 4.3
 7.4
 5.7
 2.7
 2.0
 3.6
 -0.8
 -0.6
 1.2
 9.8
 3.7
 5.8
4 IDH1 isocitrate dehydrogenase (NAD(+)) IDH1 855691 YNL037C 7.1 3.8
 3.0
 5.5
2.5
 8.8
7.9
 10.5
7.6
 4.1
 4.2
1.4
 4.8
1.5
 0.0
-0.9
 0.5
-0.1
 1.2
0.2
 5.8
4.5
 3.6
2.9
 4.2
3.9
5 ACO1 aconitate hydratase ACO1 851013 YLR304C 7.0 3.4
 3.3
 5.7
 7.7
 6.6
 4.9
 2.9
 5.6
 1.8
-0.5
 2.8
-0.3
 1.2
0.6
 8.3
 2.9
 4.5
6 CIT1 citrate (Si)-synthase CIT1 855732 YNR001C 6.6 3.8
 2.6
 5.5
 5.3
 5.0
 4.5
 3.6
 5.2
 2.8
0.3
 1.3
-0.5
 0.6
-0.1
 10.8
 3.0
 3.7
7 MDH1 malate dehydrogenase MDH1 853777 YKL085W 6.5 4.1
 2.2
 3.7
 7.2
 12.4
 6.6
 5.5
 8.2
 -0.5
 -0.4
 0.9
 10.6
 5.1
 0.9
8 QCR2 ubiquinol--cytochrome-c reductase subunit 2 856321 YPR191W 6.4 3.5
 2.7











9 KGD1 alpha-ketoglutarate dehydrogenase KGD1 854681 YIL125W 6.4 3.6
 2.6
 3.4
2.5
 5.3
1.6
 3.7
0.4
 2.8
0.7
 2.9
0.9
 6.8
0.7
 -0.3
 0.4
 1.9
 7.1
 3.6
0.9
 3.3
0.6
10 ATP3 F1F0 ATP synthase subunit gamma 852327 YBR039W 6.3 3.4
 2.7
 6.8
 7.9
 9.8
 6.0
 3.7
 6.7
 -0.3
 -0.0
 1.7
 9.1
 3.9
 5.9
11 POR1 porin POR1 855669 YNL055C 6.3 3.2
 2.9
 6.2
4.8
 5.0
4.9
 7.0
6.3
 5.9
1.8
 5.8
4.3
 7.0
6.4
 1.7
-0.2
 1.2
-0.2
 4.6
1.2
 10.5
 5.9
3.2
 5.9
4.4
12 ACH1 acetyl-CoA hydrolase 852266 YBL015W 6.0 3.3
 2.5











13 ATP2 F1F0 ATP synthase subunit beta 853585 YJR121W 5.8 2.9
 2.7
 8.9
 8.4
 11.6
 5.8
 6.9
 8.6
 1.1
-0.2
 0.7
-0.0
 2.0
0.8
 10.1
 4.3
 7.2
14 COR1 ubiquinol--cytochrome-c reductase subunit COR1 852235 YBL045C 5.4 3.0
 2.3











15 ATP16 F1F0 ATP synthase subunit delta 851560 YDL004W 5.3 2.8
 2.3
 3.2
 4.8
 5.7
 3.8
 5.9
 6.6
 0.0
 0.1
 1.2
 7.0
 2.2
 3.6
16 PDA1 pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha 856925 YER178W 5.2 1.5
 3.4
 9.1
 5.7
 4.3
 6.2
 4.5
-0.6
 5.6
-0.8
 0.7
-0.5
 1.0
0.3
 1.9
1.2
 7.8
 4.9
 8.1
17 ATP7 F1F0 ATP synthase subunit d 853853 YKL016C 5.0 2.7
 2.2
 4.8
 6.1
 7.9
 3.9
 4.3
 6.7
 -0.0
 -0.8
 0.5
 6.5
 4.2
 1.8
18 PET9 ADP/ATP carrier protein PET9 852250 YBL030C 5.0 2.2
 2.7
 6.0
4.4
 5.7
5.5
 5.7
5.0
 4.6
3.3
 4.3
1.7
 4.1
2.1
 0.3
-0.1
 0.9
-0.1
 2.5
1.8
 7.3
1.8
 3.4
2.3
 2.7
2.0
19 ATP5 F1F0 ATP synthase subunit 5 851892 YDR298C 5.0 2.9
 1.9
 4.9
 6.8
 7.5
 4.4
 4.0
 6.9
 -0.3
 -0.3
 1.8
 8.3
 2.8
 2.7
20 AAT2 aspartate transaminase AAT2 850714 YLR027C 4.9 2.2
 2.6
 6.5
 5.7
 8.2
 4.3
 2.1
 4.5
 -0.8
 0.9
 0.3
 4.2
 4.1
 6.3
21 CAM1 translation elongation factor EF1B gamma 856059 YPL048W 4.9 1.9
 2.9
 -0.1
 1.3
 0.0
 1.5
0.6
 1.4
 2.4
 -0.2
 -0.5
 -0.3
 4.5
 2.1
 1.1
22 ATP4 F1F0 ATP synthase subunit 4 856027 YPL078C 4.9 3.0
 1.8











23 ATP1 F1F0 ATP synthase subunit alpha 852177 YBL099W 4.8 2.7
10.2
 10.1
 12.4
 6.7
2.7
 6.7
 9.0
 -0.1
 -0.2
 1.8
 16.0
 9.5
 8.6
24 IDP1 isocitrate dehydrogenase (NADP(+)) IDP1 851493 YDL066W 4.8 2.1
 2.5
 4.9
2.3
 3.3
1.7
 4.6
1.4
 5.2
0.6
 5.4
0.5
 7.9
0.6
 -0.2
 0.6
 1.2
 4.0
1.3
 5.4
0.0
 4.1
1.8
25 ATP20 F1F0 ATP synthase subunit g 856131 YPR020W 4.6 2.8
 1.7











26 QCR7 ubiquinol--cytochrome-c reductase subunit 7 852142 YDR529C 4.5 2.7
 1.7
 0.9
 4.9
 6.8
 4.8
 3.7
 5.3
 2.1
-0.1
 1.9
0.5
 0.5
0.4
 4.7
 3.2
 2.9
27 DUG1 metallodipeptidase 850605 YFR044C 4.5 1.7
 2.6
 2.0
0.8
 -0.7
 2.1
-0.1
 1.1
-0.8
 0.1
-0.9
 0.0
-0.9
 -1.0
 0.1
 -0.7
 2.4
-0.1
 1.4
0.4
 2.4
0.3
28 YJL068C S-formylglutathione hydrolase 853377 YJL068C 4.4 2.2
 2.1
 4.3
 1.3
 6.5
 1.9
 2.5
 3.7
 -0.3
 0.3
 0.9
 -0.3
 2.5
 2.2
29 SDH1 succinate dehydrogenase flavoprotein subunit SDH1 853709 YKL148C 4.4 2.2
 2.1
 5.6
 8.4
 12.0
 5.7
 4.0
 5.7
 1.2
-0.4
 0.5
-0.5
 1.9
0.1
 7.8
2.3
 4.7
1.7
 6.8
30 LAT1 dihydrolipoyllysine-residue acetyltransferase 855653 YNL071W 4.4 1.5
 2.8
 6.9
 5.6
 5.1
 4.5
 4.3
 4.5
 -0.2
 -0.4
 1.6
 11.5
 2.2
 5.4
31 SDH3 succinate dehydrogenase cytochrome b subunit SDH3 853716 YKL141W 4.4 2.4
 1.9
 5.9
 6.7
 8.2
 3.8
 2.9
 4.5
 0.6
-0.3
 1.4
-0.2
 1.2
-0.0
 7.7
5.0
32 SDH2 succinate dehydrogenase iron-sulfur protein subunit SDH2 850685 YLL041C 4.4 2.9
 1.4
 7.0
 8.7
 11.6
 7.8
 4.7
 4.6
 -0.7
 -0.4
 0.9
 13.7
 3.2
 4.7
33 SDH4 succinate dehydrogenase membrane anchor subunit SDH4 851758 YDR178W 4.3 2.4
 1.8











34 CPR3 peptidylprolyl isomerase CPR3 854897 YML078W 4.3 1.8
 2.4
 3.2
2.4
 5.3
1.6
 6.1
0.6
 2.7
2.0
 4.2
1.9
 4.0
1.8
 0.0
0.0
 -0.2
-0.3
 0.8
-0.0
 2.0
1.6
 1.9
0.3
 2.8
0.5
35 PRC1 carboxypeptidase C PRC1 855343 YMR297W 4.3 1.8
 2.3
 -0.3
 -0.2
 2.3
 -0.4
 -0.8
-0.9
 -0.4
-2.1


1.1
1.1
 0.9
 0.4
36 PDB1 pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta 852522 YBR221C 4.3 1.5
 2.6
 6.7
 6.8
 7.3
 4.5
 4.0
 5.9
 -0.1
 -0.0
 1.2
 5.8
 5.2
 4.1
37 YMR31 mitochondrial 37S ribosomal protein YMR31 850610 YFR049W 4.2 2.4
 1.6











38 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 854919 YML120C 4.1 2.4
 1.6











39 COX6 cytochrome c oxidase subunit VI 856448 YHR051W 4.0 2.5
 1.4
 6.5
 6.0
 6.4
 8.0
 4.9
4.6
 6.2
5.6
 -0.5
 -0.2
 1.3
 4.6
 3.3
 3.8
40 ICL2 methylisocitrate lyase ICL2 856114 YPR006C 4.0 2.2
 1.7



1.2
 0.3


1.5

41 MDH3 malate dehydrogenase MDH3 851481 YDL078C 3.9 2.1
 1.8











42 IPP1 inorganic diphosphatase IPP1 852296 YBR011C 3.9 1.7
 2.1
 5.3
2.9
 5.5
5.4
 5.0
3.6
 2.8
 1.0
-0.7
 0.7
0.6
 0.1
 -0.5
 1.1
 2.4
 5.0
3.2
 2.8
1.9
43 COX9 cytochrome c oxidase subunit VIIa 851492 YDL067C 3.9 2.2












44 VMA2 H(+)-transporting V1 sector ATPase subunit B 852424 YBR127C 3.9 1.6
 2.2
 1.7
-0.1
 0.6
-0.2
 2.0
0.4
 0.1
 1.7
1.5
 2.6
0.7
 0.1
 0.2
 -0.0
 5.3
1.5
 2.0
0.2
 1.4
-0.2
45 MIC10 Mic10p 850300 YCL057C-A 3.9 1.6
 2.2
 3.3
 3.2
 3.3
 3.5
 2.9
 3.9
 1.1
0.7
 1.2
0.2
 1.7
0.9
 4.5
 1.1
 3.1
46 TUF1 translation elongation factor Tu 854359 YOR187W 3.9 2.0
 1.8
 4.5
 5.9
 8.8
2.7
 3.6
 -0.4
-0.6
 1.1
0.7
 2.4
2.1
 3.9
1.1
 3.0
 5.1
47 MIR1 Mir1p 853540 YJR077C 3.8 1.6
 2.1











48 THR1 homoserine kinase 856420 YHR025W 3.8 1.1
 2.5











49 ATP15 F1F0 ATP synthase subunit epsilon 855857 YPL271W 3.8 2.1
0.4
 3.1
 1.9
 3.6
 3.0
 4.0
 -0.3
-0.5
 0.7
0.2
 0.9
0.6
 2.7
 1.1
 1.2
50 LSC1 succinate--CoA ligase (GDP-forming) subunit alpha 854310 YOR142W 3.7 1.5
 2.1
 9.6
 9.9
 11.5
 3.4
 6.4
 8.5
 2.3
-0.2
 1.3
0.3
 1.3
0.9
 5.7
2.8
 4.4
 5.6
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