Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-u.4   SRD5A1   steroid 5 alpha-reductase 1 
 hsa-r.6   SRD5A1   steroid 5 alpha-reductase 1 
 hsa-m.7   SRD5A1   steroid 5 alpha-reductase 1 
 hsa-m2.4   SRD5A1   steroid 5 alpha-reductase 1 
 hsa-u.4   SRD5A2   steroid 5 alpha-reductase 2 
 mcc-u.3   SRD5A1   steroid 5 alpha-reductase 1 
 mmu-u.4   Srd5a2   steroid 5 alpha-reductase 2 
 mmu-u.4   Srd5a1   steroid 5 alpha-reductase 1 
 rno-u.3   Srd5a1   steroid 5 alpha-reductase 1 
 cfa-u.3   SRD5A1   steroid 5 alpha-reductase 1 
 gga-u.3   SRD5A1   steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 
 gga-u.3   SRD5A2   steroid 5 alpha-reductase 2 
 dre-u.3   srd5a2a   steroid-5-alpha-reductase, alpha polypeptide 2a 
 cel-u.3   ZK1251.3   3-oxo-5-alpha-steroid 4-dehydrogenase 
 cel-u.3   F42F12.3   3-oxo-5-alpha-steroid 4-dehydrogenase 
 cel-u.3   F19H6.4   3-oxo-5-alpha-steroid 4-dehydrogenase 
 spo-u.3   SPCC126.08c   putative lectin family glycoprotein receptor 

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Top 50 coexpressed genes to SRD5A1 (hsa-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa1240   Biosynthesis of cofactors  3 132 2.14
 hsa3018   RNA degradation  2 79 -
 hsa4146   Peroxisome  2 82 -
 hsa4360   Axon guidance  3 182 -
 hsa5022   Pathways of neurodegeneration - multiple diseases  3 476 -

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hsa:SRD5A1 (steroid 5 alpha-reductase 1) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

hsa-u.4
for
SRD5A1
hsa-r.6
for
SRD5A1
hsa-m.7
for
SRD5A1
hsa-m2.4
for
SRD5A1
hsa-u.4
for
SRD5A2
mcc-u.3
for
SRD5A1
mmu-u.4
for
Srd5a2
mmu-u.4
for
Srd5a1
rno-u.3
for
Srd5a1
cfa-u.3
for
SRD5A1
gga-u.3
for
SRD5A1
gga-u.3
for
SRD5A2
dre-u.3
for
srd5a2a
cel-u.3
for
ZK1251.3
cel-u.3
for
F42F12.3
cel-u.3
for
F19H6.4
spo-u.3
for
SPCC126.08c
1 TENT4A terminal nucleotidyltransferase 4A 11044 0 5.3 4.7
 2.5
 4.6
 0.5
0.1
 1.2
0.7
 0.2
-0.4
 2.1
-0.4
 1.9
0.2
 2.3
-0.0
 1.6
0.4
 -1.2
-1.5
 0.9
0.1
 -0.2
 -0.4
 1.4
 -0.7
-1.1
2 C5orf22 chromosome 5 open reading frame 22 55322 0 4.6 4.0
 2.4
 4.1
 0.2
 -0.4
 -0.3
 0.8
 -1.3
 -0.5
 1.6
 1.6
 -0.5



3 PGRMC1 progesterone receptor membrane component 1 10857 0 4.3 4.0
 0.9
 3.6
 1.6
-0.8
 1.6
1.4
 -0.4
-0.5
 1.9
0.9
 0.9
0.5
 2.0
1.4
 1.6
1.6
 -0.1
-1.9
 2.7
0.1
 -0.6
 4.4
 1.3
 -0.3
4 FASTKD3 FAST kinase domains 3 79072 0 3.9 3.4
 1.4
 3.4
 0.3
 0.7
 -0.3
 1.0
 0.0
 0.0
 0.6
 0.9
 -0.2



5 GOLPH3 golgi phosphoprotein 3 64083 0 3.8 3.5
 1.5
 3.3
 1.1
0.6
 0.8
0.7
 0.2
-0.0
 -0.5
-0.9
 0.1
-0.2
 1.5
1.3
 0.6
0.2
 1.2
0.6
 0.1
-0.2
 -0.8
 0.1
 -0.2
6 ATPSCKMT ATP synthase c subunit lysine N-methyltransferase 134145 0 3.8 4.3
 1.4
 2.4
 0.5
 1.4
 1.1
 0.8
 -1.0
 0.3
 1.3
 -1.1
 -0.1
 0.4
 0.2
 -0.6
7 OTULIN OTU deubiquitinase with linear linkage specificity 90268 0 3.8 3.3
 2.1
 3.4
 -0.1
 -1.3
 -0.6
 0.4
 1.3
 1.6
 0.3
 0.6
 -0.5



8 ICE1 interactor of little elongation complex ELL subunit 1 23379 0 3.7 2.4
 1.4
 4.1
 0.5
 -1.4
 -0.9
 -1.3
 0.2
 0.6
 -0.8
 -0.6
 -1.0



9 SMIM13 small integral membrane protein 13 221710 0 3.7 3.7
 1.5
-0.1
 0.9
 -0.7
 1.4
 -1.1
 0.8
 1.8
 -1.0
 -0.4



10 MBLAC2 metallo-beta-lactamase domain containing 2 153364 0 3.6 3.4
 0.8
 3.0
 0.1
 1.3
 -0.1
 2.1
 -0.3
 1.4
 1.0
 1.1
 0.4



11 BPHL biphenyl hydrolase like 670 0 3.6 4.1
 2.0
 2.3
 0.7
 0.5
 0.1
 0.5
 1.2
 0.8
 0.1
 -0.3
 -0.8
 0.0
 0.1
 0.4
12 NLN neurolysin 57486 0 3.6 4.0
 0.9
 2.4
 -0.1
-0.2
 0.7
0.2
 0.9
-0.3
 1.4
1.2
 0.1
-0.4
 0.8
-0.4
 1.4
-2.3
 0.4
0.2
 -0.5
-0.8
 -0.2
 -0.6
 -0.6
13 PDXP pyridoxal phosphatase 57026 0 3.5 2.6
3.6
 0.8
-1.5
 -1.6
 -0.8
-1.4
 1.3
1.1
 1.7
0.3
 1.8
0.9
 2.6
1.7
 1.2
0.4
 1.8
1.1
 -0.3
-0.4
 1.0
-0.9
 0.4
0.1
14 PANK1 pantothenate kinase 1 53354 0 3.5 3.9
 2.2
 2.3
 0.9
-0.2
 1.2
1.2
 0.8
0.7
 1.9
1.2
 3.0
1.1
 0.9
0.6
 3.0
0.1
 -0.5
-0.9
 0.9
-0.8



15 RUSC1 RUN and SH3 domain containing 1 23623 0 3.5 3.2
 1.8
 3.0
 -1.2
 -0.6
 -1.1
 0.6
 -0.6
 1.0
 0.7
 1.0
 0.4



16 PEX26 peroxisomal biogenesis factor 26 55670 0 3.5 2.4
 0.4
 3.7
 -0.4
 0.5
 0.1
 2.7
 0.6
 0.9
 2.6
 1.9
 -1.3



17 ASB13 ankyrin repeat and SOCS box containing 13 79754 0 3.5 2.9
 1.0
 3.2
 0.2
0.3
 1.3
 -0.2
 0.5
 1.5
 -0.7
 0.5



18 SIGMAR1 sigma non-opioid intracellular receptor 1 10280 0 3.4 2.1
 0.7
 3.9
 0.1
 3.1
 1.5
 3.2
 2.5
 0.8
 0.8
 -0.9
 0.2


-0.2
19 F12 coagulation factor XII 2161 0 3.4 2.4
 1.5
 3.6
 1.4
 0.6
 0.9
 0.5
 1.0
 0.4






20 DPYSL2 dihydropyrimidinase like 2 1808 0 3.4 4.1
 1.8
 1.9
 5.1
-0.1
 0.8
0.3
 2.1
0.1
 1.1
1.0
 2.3
1.4
 1.5
1.0
 1.1
0.4
 0.8
0.2
 2.1
1.4
 -0.2
-0.9
 1.0
-0.3
 0.4
0.1
 2.4
1.3
21 PI4K2B phosphatidylinositol 4-kinase type 2 beta 55300 0 3.3 3.8
 0.2
 2.0
 1.0
 2.0
-1.6
 0.1
-0.7
 1.1
1.0
 0.4
0.2
 1.6
0.3
 2.4
2.3
 0.7
-0.9
 -0.4
-2.1
 0.3
-1.1
 0.3
-0.2
 1.7
0.0
 0.5
22 CDK5 cyclin dependent kinase 5 1020 0 3.3 3.9
 1.3
 2.0
 -0.2
 1.3
 -0.3
 1.8
 -0.4
 -0.4
 -0.3
 -1.8
 -0.4
 -0.4
 0.5
 -0.3
 0.0
23 TPMT thiopurine S-methyltransferase 7172 0 3.3 4.0
 1.3
 1.8
 1.3
 0.4
 1.6
 3.8
 0.7
 -0.9
 -0.7
 0.1
 -0.3



24 DESI1 desumoylating isopeptidase 1 27351 0 3.3 3.4
 1.2
 2.4
 0.1
 1.7
 -1.4
 2.0
 2.6
 0.1
 2.8
 -2.5
 1.3
-0.3



25 NSUN2 NOP2/Sun RNA methyltransferase 2 54888 0 3.3 4.1
 2.5
 1.7
 0.2
 1.3
 0.0
 2.5
 2.1
 2.5
 3.1
 0.5
 -0.5
 0.9
 0.5
 -0.4
 -1.9
26 VDAC1 voltage dependent anion channel 1 7416 0 3.3 2.9
 0.8
 3.0
 0.6
0.2
 -0.5
-0.7
 0.7
0.6
 -0.6
-1.0
 0.3
-0.4
 2.0
1.2
 0.9
-0.3
 -0.0
-0.7
 0.7
0.3
 -0.0
 -0.2
 1.7
27 EI24 EI24 autophagy associated transmembrane protein 9538 0 3.3 2.9
 1.5
 2.9
 0.4
 1.9
 -0.1
 1.2
 1.9
 1.1
 1.2
 -0.4
 -0.1
 0.4
 0.7
 -1.0
28 ICMT isoprenylcysteine carboxyl methyltransferase 23463 0 3.3 2.5
 0.9
 3.4
 0.9
 2.1
 -0.8
 1.1
 0.9
 3.2
 0.1
 -2.1
 0.2
 3.3
0.9
 1.2
0.9
 -0.3
-0.5
 -0.3
29 VMA21 vacuolar ATPase assembly factor VMA21 203547 0 3.3 2.5
 0.2
 3.3
 0.3
 2.2
 0.5
 1.6
 0.6
0.2
 0.2
 -0.0
 0.0
 1.1
 -0.7
30 DROSHA drosha ribonuclease III 29102 0 3.3 2.4
 1.7
 3.4
 0.1
 0.5
 0.0
 -0.7
 -0.5
 -0.3
 -0.4
 -0.8
 -1.5
 -0.1
 -1.5
 -0.2
 0.3
31 FAM220A family with sequence similarity 220 member A 84792 0 3.3 2.8
 1.6
 3.0
 -0.4
-0.6
 -0.5
 -1.7






0.6
0.1
32 RAD1 RAD1 checkpoint DNA exonuclease 5810 0 3.3 2.9
 1.3
 2.9
 0.3
 0.4
 -0.7
 0.9
 -0.4
 0.2
 -0.3
 0.6
 -0.3
 -0.5
 0.6
 0.1
33 CCDC6 coiled-coil domain containing 6 8030 0 3.3 3.0
 1.9
 2.8
 0.3
 -0.4
 0.7
 -0.3
 -0.0
 0.8
 -0.0
 -1.3
 -0.7
-1.3



34 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 1979 0 3.3 3.2
 1.3
 2.6
 0.1
0.0
 -0.6
-0.9
 0.6
0.2
 1.5
0.2
 0.5
-1.5
 1.4
0.6
 0.1
-0.4
 0.7
-0.4
 0.5
0.1



35 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 5910 0 3.3 3.7
 1.3
 2.0
 0.6
 1.7
 -0.4
 1.7
 1.4
 -0.7
 0.6
-0.7
 0.9
-0.5
 1.1
0.3



36 ARMC10 armadillo repeat containing 10 83787 0 3.3 2.6
 1.5
 3.1
 0.5
0.1
 1.3
0.3
 -0.3
-0.3
 -0.4
-0.7
 -0.3
-0.4
 0.2
0.1
 1.4
 -0.4
 -0.6
 0.3
 0.1
 -0.4
37 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 7532 0 3.3 3.6
 0.9
 2.1
 0.4
0.1
 1.7
1.3
 0.2
-0.0
 0.9
0.8
 1.0
0.3
 0.9
0.8
 1.2
1.0
 0.7
0.1
 0.9
0.8
 1.0
0.7
 0.6
0.2
 1.9
1.8
 -0.5
38 PXMP2 peroxisomal membrane protein 2 5827 0 3.2 2.9
 1.0
 2.8
 0.6
 0.5
 0.6
 2.0
 1.7


1.2



39 CREG1 cellular repressor of E1A stimulated genes 1 8804 0 3.2 2.2
 0.9
 3.4
 -0.2
 -0.2
 -0.7
 -0.8
 0.2
 -1.3
 0.5
 -0.4
 -1.0



40 RAC3 Rac family small GTPase 3 5881 0 3.2 2.1
 0.5
 3.6
 0.0
-0.1
 1.8
0.3
 0.4
0.3
 1.7
-0.1
 0.4
0.3
 1.3
0.1
 -0.2
-0.4
 0.4
0.3
 0.7
0.2
 0.1
-0.1
 2.7
1.2
 0.5
-0.1
 -0.1
-0.1
41 RAP2A RAP2A, member of RAS oncogene family 5911 0 3.2 3.2
 0.7
 2.4
 -0.2
-0.6
 0.6
0.1
 -0.0
-0.9
 2.4
0.3
 0.2
-0.2
 0.6
0.3
 2.0
1.3
 -0.4
-1.2
 -0.3
-0.3
 -0.5
 -0.2
 -0.4
42 PAQR4 progestin and adipoQ receptor family member 4 124222 0 3.2 2.3
 0.7
 3.2
 -0.5
 0.6
 -1.2
 1.2
 2.4
 1.3

-0.5


-0.9
43 RAB10 RAB10, member RAS oncogene family 10890 0 3.2 4.2
 1.1
 1.4
 0.3
0.3
 0.7
0.2
 0.5
0.3
 1.2
0.7
 1.4
0.9
 1.1
0.1
 -0.4
-1.4
 0.4
-0.4
 -0.4
-0.5
 0.0
-1.0
 1.7
-0.6
 1.6
-1.5
44 ABCB10 ATP binding cassette subfamily B member 10 23456 0 3.2 2.9
 0.8
 2.7
 0.4
 -0.6
 0.4
 2.7
 0.3
 0.1
 -1.4
 -0.3
 0.1
 -0.1
 -0.7
 -0.6
45 PEPD peptidase D 5184 0 3.2 2.9
 1.1
 2.6
 0.7
 1.4
 0.2
 0.9
 1.3
 1.2
 -0.6
 0.2
 0.6
 -0.6
 1.5
 -0.3
46 PGAM1 phosphoglycerate mutase 1 5223 0 3.1 2.6
 0.9
 2.9
 -0.3
-0.6
 0.7
0.4
 0.3
0.3
 1.0
0.4
 1.1
0.9
 0.4
-0.4
 2.4
0.4
 0.8
0.6
 1.6
-0.4



47 EXOSC6 exosome component 6 118460 0 3.1 1.6
 0.4
 3.9
 0.1
 1.1

-0.4
 -1.0
 -0.2
 -0.4
 0.6



48 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 154807 0 3.1 3.6
 0.6
 1.9
 -0.1
-0.3
 1.7
1.3
 -0.2
-1.2
 2.5
2.1
 1.6
0.6
 2.6
1.2
 2.0
 -0.6
 0.7
-0.9



49 STMP1 short transmembrane mitochondrial protein 1 647087 0 3.1 3.1
 1.7
-0.9
 0.5
0.4
 -0.1
 0.9
 0.8
 -0.6
 1.0
 0.1
 -1.3



50 NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 26012 0 3.1 2.2
 0.4
 3.2
 -0.8
 0.5
 -0.0
 1.7
 0.2
 1.4
 -1.3
 0.2
 0.1



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