Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-u.4  PCSK2  proprotein convertase subtilisin/kexin type 2 
 hsa-r.6  PCSK2  proprotein convertase subtilisin/kexin type 2 
 hsa-m.7  PCSK2  proprotein convertase subtilisin/kexin type 2 
 hsa-m2.4  PCSK2  proprotein convertase subtilisin/kexin type 2 
 hsa-u.4  PCSK4  proprotein convertase subtilisin/kexin type 4 
 hsa-u.4  PCSK5  proprotein convertase subtilisin/kexin type 5 
 hsa-u.4  PCSK7  proprotein convertase subtilisin/kexin type 7 
 mcc-u.3  PCSK1  proprotein convertase subtilisin/kexin type 1 
 mcc-u.3  PCSK5  proprotein convertase subtilisin/kexin type 5 
 mmu-u.4  Pcsk7  proprotein convertase subtilisin/kexin type 7 
 mmu-u.4  Furin  furin (paired basic amino acid cleaving enzyme) 
 rno-u.3  Pcsk4  proprotein convertase subtilisin/kexin type 4 
 rno-u.3  Pcsk7  proprotein convertase subtilisin/kexin type 7 
 cfa-u.3  PCSK2  proprotein convertase subtilisin/kexin type 2 
 cfa-u.3  PCSK6  proprotein convertase subtilisin/kexin type 6 
 gga-u.3  PCSK4  proprotein convertase subtilisin/kexin type 4 
 gga-u.3  PCSK1  proprotein convertase subtilisin/kexin type 1 
 gga-u.3  PCSK6  proprotein convertase subtilisin/kexin type 6 
 dre-u.3  pcsk6  proprotein convertase subtilisin/kexin type 6 
 dre-u.3  pcsk7  proprotein convertase subtilisin/kexin type 7 
 dre-u.3  pcsk5a  proprotein convertase subtilisin/kexin type 5a 
 dme-u.3  Fur1  Furin 1 
 dme-u.3  Fur2  Furin 2 
 dme-u.3  amon  amontillado 
 cel-u.3  bli-4  Endoprotease bli-4 
 cel-u.3  kpc-1  Furin-like protease kpc-1 
 cel-u.3  egl-3  Neuroendocrine convertase 2 
 sce-u.3  KEX2  kexin KEX2 
 spo-u.3  rpl39  60S ribosomal protein L39 

close


Top 50 coexpressed genes to PCSK2 (hsa-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa2010   ABC transporters  1 45 -
 hsa4724   Glutamatergic synapse  2 114 -
 hsa4514   Cell adhesion molecules  2 149 -
 hsa4024   cAMP signaling pathway  1 221 -
 hsa4080   Neuroactive ligand-receptor interaction  2 353 -

close


hsa:PCSK2 (proprotein convertase subtilisin/kexin type 2) External Links;


Show/Hide Columns:          
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID
Other ID CoexPub LINK Target Reference

hsa-u.4
for
PCSK2


hsa-r.6
for
PCSK2


hsa-m.7
for
PCSK2


hsa-m2.4
for
PCSK2


hsa-u.4
for
PCSK4


hsa-u.4
for
PCSK5


hsa-u.4
for
PCSK7


mcc-u.3
for
PCSK1


mcc-u.3
for
PCSK5


mmu-u.4
for
Pcsk7


mmu-u.4
for
Furin


rno-u.3
for
Pcsk4


rno-u.3
for
Pcsk7


cfa-u.3
for
PCSK2


cfa-u.3
for
PCSK6


gga-u.3
for
PCSK4


gga-u.3
for
PCSK1


gga-u.3
for
PCSK6


dre-u.3
for
pcsk6


dre-u.3
for
pcsk7


dre-u.3
for
pcsk5a


dme-u.3
for
Fur1


dme-u.3
for
Fur2


dme-u.3
for
amon


cel-u.3
for
bli-4


cel-u.3
for
kpc-1


cel-u.3
for
egl-3


sce-u.3
for
KEX2


spo-u.3
for
rpl39

1 XKR4 XK related 4 114786 0 6.9 7.5
4.8
4.6
1.1
-0.6
0.1
-1.0
0.2
-0.4
1.8
1.1
-0.2
-0.3


2.2
1.0
0.3
-1.5
0.8
0.3
1.1
-0.6
0.9
0.7
-0.3
-0.6
0.8
0.1
-0.4
-0.7
1.5
1.1
0.7
1.4
-1.3
0.8
1.0
-0.1

3.3
2.9
2 SORCS1 sortilin related VPS10 domain containing receptor 1 114815 0 6.6 6.2
3.7
5.4
-0.2
0.6
-0.9
-0.5
-0.2
-0.2
-1.5
-1.2
-0.1
1.7
0.8
-0.9
1.9
1.1
0.7
-0.1
-0.0








3 SEZ6L seizure related 6 homolog like 23544 0 6.0 4.7
3.6
5.8
0.1
0.5
-0.1
1.5
0.2
-0.5
0.2
1.4
-1.1
1.5
-0.7
0.4
-0.6
-0.4
2.6
1.2
-0.4








4 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2899 0 6.0 6.3
3.0
4.2
0.1
-0.5
0.0
-1.1
-0.4
-0.5
1.8
0.6
1.2
0.3
0.3
0.1
0.6
-0.5
1.2
1.0
0.8
-0.1


0.5
-0.1
1.6
-0.3
0.5
-0.0
1.9
0.1
0.6
0.4
1.5
0.7
0.2
-0.2
0.6
-0.2
4.2
1.7
0.8
-0.6
0.6
-0.1
3.2
1.3


5 SYT4 synaptotagmin 4 6860 1 5.8 4.8
3.5
5.4
3.9
2.8
0.4
0.4
0.5
0.4
3.0
2.0
1.3
1.3
0.7
0.2
0.8
0.8
2.9
2.5
1.3
1.1
4.2
3.7
0.5
0.2
1.0
0.3
3.1
2.2
1.1
0.8
1.6
1.6
1.4
0.5
1.8
1.3
0.6
0.6
1.6
0.7
9.0
8.7
0.6
0.3
2.3
1.8
11.3
5.1

2.3
0.9
6 ZNF536 zinc finger protein 536 9745 0 5.5 5.6
1.7
4.2
-0.5
0.5
-0.3
1.6
0.9
0.6
-0.1
1.1
1.0


0.3
0.7
-1.5
-0.3
0.7
0.5








7 LRRTM1 leucine rich repeat transmembrane neuronal 1 347730 0 5.4 4.7
1.8
4.8
0.8
0.1
-0.7
1.7
0.0
-0.2
-0.4
0.0
-1.4


0.2
-0.3
-0.5
-0.9
-0.3
0.5








8 PMP2 peripheral myelin protein 2 5375 0 5.3 5.6
2.7
3.7
-0.4
-0.8
0.3
0.2
0.4
-0.3
0.3
-0.3
1.1
0.3
0.5
-0.1
0.4
0.2
1.9
1.8
0.7
0.4
0.3
-0.7
1.0
-0.0
1.0
-0.1
0.3
0.1
0.6
0.1
-0.8
-1.0
1.5
-0.4
-0.0
-0.2



-0.4
-0.5
0.4
-0.3
-0.5
-0.8

2.0
9 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 51046 0 5.2 5.6
3.3
3.6
-1.1
-0.8
-0.5
3.2
-0.3
-0.3
-0.6
-0.0
-1.6


0.2
-0.3
1.6
0.4
0.2
-0.0
-0.5
-0.1
-0.2








10 SLC17A6 solute carrier family 17 member 6 57084 0 5.2 4.6
3.6
4.6
1.6
0.1
0.5
0.3
0.3
-0.0
3.3
2.6
0.8
0.2
2.4
1.3
1.9
0.2
3.5
0.2
1.1
0.3
1.5
0.1
0.3
-0.6
-0.4
-0.8
0.8
-0.6
1.0
0.4
1.2
0.5
3.1
1.3
0.8
0.6
1.7
1.4
2.2
1.0
2.5
2.1
4.4
3.2
3.9
2.5
4.1
2.6


11 CADM3 cell adhesion molecule 3 57863 0 5.1 4.9
1.2
4.1
-0.2
-0.8
0.6
0.1
0.8
-0.2
1.0
0.5
1.3
-0.8
-0.2
-0.2
-0.1
-0.8
0.9
0.6
1.0
-0.1
1.9
1.4
0.4
0.2
-0.2
-0.4
2.4
1.6
1.1
-2.3
1.7
0.7
0.9
0.3
0.7
-0.2








12 OPCML opioid binding protein/cell adhesion molecule like 4978 0 5.1 5.1
3.2
3.9
3.4
0.5
1.2
1.0
0.4
0.1
2.8
1.6
2.5
1.2
-0.3
-0.4
0.7
0.2
0.6
0.5
-0.0
-0.5
1.6
1.0
0.9
-0.7
0.7
0.1
2.0
1.8
2.0
0.4
2.8
2.7
1.8
0.4
1.4
1.4
3.1
2.7
0.7
0.4
4.1
4.0
0.4
-0.9
0.4
0.1
-0.1
-0.2


13 STMN2 stathmin 2 11075 0 5.1 3.5
2.8
5.3
0.9
0.7
-0.1
-0.2
0.1
-0.0
1.9
0.4
1.5
0.6
0.0
-0.2
-0.5
-1.0
0.5
-0.1
0.2
-0.7
2.0
1.4
1.1
-0.3
0.3
0.2
0.8
0.6
0.5
-0.1
2.1
0.2
-0.4
-0.4
0.5
0.4
-0.0
1.9
1.2




-0.5
-0.6
14 FAM135B family with sequence similarity 135 member B 51059 0 5.0 4.1
1.1
4.6
0.2
-0.8
1.9
0.0
0.2
-1.2
3.9
0.2
0.7
0.5
1.0
-0.9
0.4
-0.1
0.7
0.5
-0.1
-0.1
-0.8
0.8
0.7
-0.6
1.5
-0.1
0.4
-0.3
0.1
-0.5
1.0
-0.4
0.7
-0.5
1.5
-0.3
0.7
2.4
-0.3
-0.6


15 SLC35F1 solute carrier family 35 member F1 222553 0 5.0 4.1
2.2
4.6
-0.6
-0.8
1.0
0.7
0.7
-0.1
2.1
-0.7
0.9
0.4
0.3
-0.1
-0.0
-0.2
-0.0
-1.2
-0.5
-0.6
1.8
0.8
0.2
-1.2
0.2
-0.9
1.9
-0.2
-0.6
-1.4
0.7
-0.7
0.4
-0.7
0.1
-1.4



1.5
-0.4
-1.0


16 ELAVL4 ELAV like RNA binding protein 4 1996 0 4.9 3.7
4.2
4.9
0.6
0.6
0.6
0.0
0.0
-0.8
5.2
2.9
0.9
0.8
-0.6
-0.9
0.9
-0.0
0.9
0.6
1.0
-0.1
3.1
1.2
0.5
-0.3
1.3
-0.4
0.1
-0.3
-0.2
-0.5
-0.3
-0.3
1.6
0.3
0.1
0.1
1.7
-0.1
-0.1
-1.1
2.7
2.0
0.1
1.6
1.6

-1.0
-1.8
17 DCX doublecortin 1641 0 4.9 4.8
3.3
3.8
-1.7
-0.4
-0.6
4.2
0.7
0.2
-0.6
-0.6
-0.1


0.4
0.4
1.3
-1.0
0.2
-0.4








18 RIMBP2 RIMS binding protein 2 23504 0 4.9 2.8
3.2
5.9
0.3
0.1
-0.1
1.8
0.8
-0.6
-0.4
1.5
-2.1
0.2
0.6
0.9
-0.1
0.1
0.7
0.6
0.5
-0.2
1.9
0.0
1.6
0.7
3.9
-0.6
1.9
1.8

-0.7
19 CLVS2 clavesin 2 134829 0 4.9 4.1
1.9
4.5
-0.6
-0.8
0.8
-1.2
-0.5
-1.2
1.9
1.2
0.1
-0.9
-0.8
-0.7
0.1
-1.0
0.7
-0.7
1.3
-0.1
0.2
-0.5
-0.2
-0.2
-0.3
-2.2
-0.1
-1.4
0.7
0.5
0.4
1.7
1.3
0.2
-0.2





20 CADM2 cell adhesion molecule 2 253559 0 4.9 4.2
3.4
4.4
-0.2
-0.8
0.6
0.1
0.8
-0.2
1.0
0.5
1.3
-0.8
-0.2
-0.2
-0.1
-0.8
0.9
0.6
1.0
-0.1
1.9
1.4
0.4
0.2
-0.2
-0.4
2.4
1.6
1.1
-2.3
1.7
0.7
0.9
0.3
0.7
-0.2








21 PLP1 proteolipid protein 1 5354 0 4.9 4.7
2.3
3.9
-0.0
-0.2
0.1
0.1
-0.4
-0.5
2.5
1.9
2.2
1.7
-0.2
-0.6
-1.2
-1.7
0.8
-0.4
-0.3
-0.4
1.3
0.2
0.9
-0.5
0.2
-0.5
1.7
0.3
0.8
-0.1
1.8
0.1
1.7
0.6
0.3
0.1
1.5
-0.4
-0.9
0.1
-1.0
-1.5


22 SST somatostatin 6750 0 4.9 4.8
2.7
3.7
0.8
0.5
-0.8
3.3
-1.1
-0.4
0.2
1.0
-1.4
1.8
-0.3
1.3
-0.8
-0.1
-0.2
1.4
-0.4








23 SLC7A14 solute carrier family 7 member 14 57709 0 4.8 4.9
3.2
3.6
1.3
1.0
1.1
0.3
0.5
0.1
4.6
1.5
1.7
1.4
0.8
0.2
2.4
0.4
1.7
1.1
-0.2
-0.7
1.7
1.5
0.7
0.5
0.8
0.8
2.1
1.3
2.1
1.5
2.4
2.4
1.3
1.3
1.6
1.4
1.6
0.5
1.4
0.6
8.7
3.2
3.0
1.7
0.4
0.4
2.3
1.9


24 ABCC8 ATP binding cassette subfamily C member 8 6833 0 4.7 4.7
1.2
3.5
0.7
-0.2
-1.0
0.9
1.3
0.3
0.3
1.7
0.5


-0.4
-0.1
0.6
0.8
0.7
-0.0
-0.2
0.9
-0.4








25 SVOP SV2 related protein 55530 0 4.7 4.3
2.2
3.9
-0.6
-1.6
-0.6
1.8
0.7
0.3
-0.4
2.0
-1.2
1.9
-0.2
0.6
-1.5
0.8
-0.6
-0.2
0.3
0.6
0.7
-1.3
0.6
1.4
2.1

-0.6
26 SRRM4 serine/arginine repetitive matrix 4 84530 0 4.6 4.3
3.3
3.7
-0.1
-1.0
-0.6
1.4
-0.7
-0.8
0.5
0.8
-0.2


-0.2
1.3
-1.0
0.5
-1.4
-0.6








27 CRTAC1 cartilage acidic protein 1 55118 0 4.5 4.4
3.8
3.5
0.4
-0.1
-1.3
0.3
1.2
-0.4
-0.7
1.8
-1.1
1.0
2.2
0.1
-0.3
0.9
1.5
-1.6
0.8








28 SHISA6 shisa family member 6 388336 0 4.5 4.8
2.7
3.2
-0.3
0.4
-1.1
-0.6
2.2
-0.9
0.6
-0.4
0.2


-0.7
1.5
0.2
0.8
-0.4
2.1
-1.2
0.9
0.7







-0.2
29 CELF3 CUGBP Elav-like family member 3 11189 0 4.5 3.2
1.9
4.7
3.9
2.2
-0.1
-0.7
-0.6
-0.7
1.5
0.8
0.2
-0.4
0.6
0.0
-0.8
-0.8
1.1
0.7
-0.3
-0.6
0.7
-0.5
1.5
0.0
1.0
0.6
0.2
0.2
0.1
0.0
1.3
0.8
0.7
0.0
0.8
-2.0
2.2
0.2
1.8
2.5


30 NELL1 neural EGFL like 1 4745 0 4.5 3.7
2.4
4.2
0.1
-0.2
3.9
0.1
0.1
-1.4
3.5
1.4
2.6
1.3
0.1
-0.9
0.1
0.1
0.6
-0.1
-1.1
-1.2
0.8
0.3
1.0
-0.2
0.3
0.2
1.6
1.6
1.3
0.2
1.1
-1.0
1.6
-0.6
0.6
-0.1
0.1
1.7
0.1





31 CNTNAP5 contactin associated protein family member 5 129684 0 4.5 3.7
1.7
4.2
0.7
0.2
2.2
-0.2
1.2
-0.2
2.8
1.0
0.9
0.4
0.3
-0.5
0.1
-0.1
1.4
0.7
0.4
0.1
1.8
1.3
-0.1
-0.2
1.1
0.3
0.1
-0.1
1.8
0.7
1.1
0.8
0.5
0.4
1.2
0.8
2.2
-0.1
-0.8
-0.8
1.6
-0.0
0.8
0.6
2.6
2.0
1.9
0.2


32 ASTN1 astrotactin 1 460 0 4.5 3.7
1.8
4.1
0.2
1.3
-0.2
0.6
1.7
-0.1
-0.6
-1.1
-0.4
1.6
0.1
-0.1
-1.0
-0.1
3.1
0.8
0.7








33 ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 56899 0 4.4 3.4
2.9
4.4
1.0
-0.1
0.5
-0.9
1.3
-1.5
2.5
-0.8
0.1
-0.3
2.0
0.2
1.4
-0.0
-0.5
-0.5
1.8
-0.4
1.3
1.4
0.9
0.1
0.2
-0.2
0.9
-0.2
2.2
1.6
4.9
3.5
0.2
-0.5
2.2
0.3
-0.6





34 ACTL6B actin like 6B 51412 0 4.4 4.6
2.9
3.2
0.7
-0.5
-0.3
-1.9
-0.3
-0.8
2.5
-1.5
-0.6
-1.1
1.0
0.3
-0.5
-1.5
1.9
-1.8
2.7
0.5
0.2
-0.2
-0.9
-0.9
-1.1
0.5
-0.3
0.3
-1.8
0.4
-0.3
-0.8
-0.5
-0.3
0.8
0.4
0.6
0.1
-1.0
35 SPHKAP SPHK1 interactor, AKAP domain containing 80309 0 4.4 4.1
2.7
3.7
-1.4
-0.9
-0.6
0.8
0.3
-1.1
-0.0
0.6
-1.1
1.6
-0.7
-0.5
-0.2
-1.2
1.1
-0.3
-0.1








36 LOC107986780 small integral membrane protein 14 pseudogene 107986780 0 4.3 4.4



























37 GFRA3 GDNF family receptor alpha 3 2676 0 4.3 3.2
2.0
4.4
0.5
0.2
-1.8
-1.6
0.4
0.0
-0.3
-0.7
0.7
1.7
0.1
0.2
-0.6
2.7
1.1
0.4
0.5
-0.6
0.8
0.7



-0.7
1.3
1.2


38 SLITRK1 SLIT and NTRK like family member 1 114798 0 4.3 3.8
2.3
3.7
-1.0
-1.6
-0.1


-0.2
-0.3
1.7
-1.1


0.8
-0.5
-0.8
-1.2
-0.1
0.8








39 NSG2 neuronal vesicle trafficking associated 2 51617 0 4.3 3.6
3.1
3.9
0.0
-1.5
-0.9
0.2
-0.4
0.6
-0.9
-0.6
-0.9
3.0
0.3
0.0
1.3
-0.8
-1.2
-0.3
0.0








40 CHGA chromogranin A 1113 0 4.2 3.5
3.7
3.9
0.2
0.6
-0.7
2.8
0.4
-0.2
-0.4
0.5
-0.9
0.7
0.7
0.5
1.3
-1.0
-0.4
-0.5
0.8








41 KIF1A kinesin family member 1A 547 0 4.2 3.1
1.5
4.3
0.7
-1.0
0.3
0.1
2.0
-0.9
-0.4
-0.5
-0.0
-0.5
1.6
1.2
2.0
0.4
0.3
-0.4
1.2
-0.8
1.9
-0.9
1.0
0.7
1.0
0.3
1.3
0.1
1.0
0.8
1.8
1.5
-0.4
-0.8
0.6
-0.2
-0.6
0.6
4.3
0.5
2.4
4.2


42 LRRC4C leucine rich repeat containing 4C 57689 0 4.2 3.0
1.7
4.4
3.1
-0.6
1.0
0.2
-0.4
-0.6
0.5
0.1
0.4
0.2
0.2
-0.0
0.7
0.4
1.0
0.2
-0.3
-0.7
1.5
-0.3
-0.3
-0.6
0.2
-0.8
-0.6
0.2
0.2
0.3
0.1
1.2
1.0








43 SCG3 secretogranin III 29106 0 4.2 3.3
2.8
4.0
-1.0
-0.0
0.2
1.7
0.8
-0.6
-1.0
0.1
-1.0
0.6
-0.5
-0.9
2.1
-1.7
1.1
0.7
0.1








44 AMER3 APC membrane recruitment protein 3 205147 0 4.1 5.9
2.3
1.4
0.4
-0.8
0.1
2.2
-0.5
0.3
0.6
1.8
-0.8


0.6
-0.3
-0.0
-0.6
-1.3
0.2








45 SLITRK2 SLIT and NTRK like family member 2 84631 0 4.1 4.8
1.6
2.4
0.8
0.5
0.2
-0.1
-0.3
-0.5
2.4
0.5
0.1
-0.1
0.2
-0.5
0.8
-0.4
-0.8
-1.3
1.6
0.9
0.2
-1.1
-0.2
-1.1
-0.2
-0.5
1.3
0.1
0.5
0.1
0.4
-0.0
0.4
0.4
0.7
0.5
0.3





46 CDH7 cadherin 7 1005 0 4.1 3.0
1.1
4.2
-0.3
-0.3
-1.0




-0.8
-0.6





0.3
0.1
-0.1








47 RAB3C RAB3C, member RAS oncogene family 115827 0 4.1 3.5
3.5
3.7
1.6
0.7
-0.2
-0.2
-0.0
-0.1
2.6
1.5
0.0
-0.3
1.4
-0.1
0.6
-0.5
1.7
0.1
0.6
-1.5
1.0
1.0
1.2
0.7
0.8
-0.7
2.6
2.5
0.7
-0.4
3.1
1.0
0.7
0.2
1.9
1.0
0.2
-0.0
10.6
-1.4
-0.0
3.1

-1.0
-1.6
48 HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 348980 0 4.1 3.8
1.9
3.3
-0.1
-0.5
-1.2
-0.4
0.1
-0.2
0.5
1.7
-0.3


0.4
2.3
0.2
1.3
-0.8
-0.1








49 GJD2 gap junction protein delta 2 57369 0 4.0 4.2
-0.2
3.0
0.0
-0.6
-0.3
1.0
-1.3
-0.4
0.2
0.1
-0.4


0.7
0.3
-0.1
2.0
-0.1
1.0
-0.6
0.6
0.4








50 ELAVL3 ELAV like RNA binding protein 3 1995 0 4.0 2.4
2.6
4.7
0.6
0.6
0.6
0.0
0.0
-0.8
5.2
2.9
0.9
0.8
-0.6
-0.9
0.9
-0.0
0.9
0.6
1.0
-0.1
3.1
1.2
0.5
-0.3
1.3
-0.4
0.1
-0.3
-0.2
-0.5
-0.3
-0.3
1.6
0.3
0.1
0.1
1.7
-0.1
-0.1
-1.1
2.7
2.0
0.1
1.6
1.6

-1.0
-1.8
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