Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-u.4   TOPBP1   DNA topoisomerase II binding protein 1 
 hsa-r.6   TOPBP1   DNA topoisomerase II binding protein 1 
 hsa-m.7   TOPBP1   DNA topoisomerase II binding protein 1 
 hsa-m2.4   TOPBP1   DNA topoisomerase II binding protein 1 
 mcc-u.3   TOPBP1   DNA topoisomerase II binding protein 1 
 mmu-u.4   Topbp1   topoisomerase (DNA) II binding protein 1 
 rno-u.3   Topbp1   DNA topoisomerase II binding protein 1 
 cfa-u.3   TOPBP1   DNA topoisomerase II binding protein 1 
 gga-u.3   TOPBP1   topoisomerase (DNA) II binding protein 1 
 dre-u.3   topbp1   DNA topoisomerase II binding protein 1 
 dme-u.3   mus101   mutagen-sensitive 101 
 sce-u.3   DPB11   protein kinase activating protein DPB11 
 spo-u.3   SPAC3H1.14   putative Vid24 family vesicle protein 

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Top 50 coexpressed genes to TOPBP1 (hsa-u.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa3030   DNA replication  8 34 7.29
 hsa3430   Mismatch repair  6 21 6.38
 hsa3420   Nucleotide excision repair  5 43 6.76
 hsa4110   Cell cycle  5 120 4.53
 hsa3460   Fanconi anemia pathway  4 46 4.97

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hsa:TOPBP1 (DNA topoisomerase II binding protein 1) External Links;


Show/Hide Columns:          
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

hsa-u.4
for
TOPBP1
hsa-r.6
for
TOPBP1
hsa-m.7
for
TOPBP1
hsa-m2.4
for
TOPBP1
mcc-u.3
for
TOPBP1
mmu-u.4
for
Topbp1
rno-u.3
for
Topbp1
cfa-u.3
for
TOPBP1
gga-u.3
for
TOPBP1
dre-u.3
for
topbp1
dme-u.3
for
mus101
sce-u.3
for
DPB11
spo-u.3
for
SPAC3H1.14
1 ATAD2 ATPase family AAA domain containing 2 29028 0 9.2 9.6
 3.6
 6.6
 5.1
0.3
 11.0
1.1
 6.0
 5.8
1.4
 4.0
1.6
 0.9
0.1
2 SMC2 structural maintenance of chromosomes 2 10592 0 9.0 8.5
 3.5
 7.3
 5.5
 9.3
 6.8
 3.0
 1.3
 3.6
 2.2
 0.2
3 RFC4 replication factor C subunit 4 5984 5 8.7 8.3
 6.1
 7.0
 2.6
 7.0
 4.7
 2.6
 2.6
 3.5
 3.8
 1.4
4 KNTC1 kinetochore associated 1 9735 0 8.4 8.8
 4.0
 5.9
 3.8
 4.6
 4.0
 3.7
 3.2
 3.7
 5.2

5 RFC3 replication factor C subunit 3 5983 2 7.8 8.5
 2.6
 5.3
 1.0
 5.8
 4.8
 2.1
 2.6
 4.0
 2.3
 0.1
 -0.5
6 NUP155 nucleoporin 155 9631 0 7.8 8.3
 2.1
 5.4
 6.3
 6.9
 5.6
 3.2
 1.2
 3.4
 2.4
 0.5
-0.1
 -1.1
7 RBL1 RB transcriptional corepressor like 1 5933 1 7.8 8.3
 2.1
 5.4
 2.9
0.2
 6.3
0.9
 4.3
1.4
 2.6
1.0
 4.7
1.0
 4.3
-0.6
 5.6
5.1

8 CTDSPL2 CTD small phosphatase like 2 51496 0 7.6 8.8
 1.4
 4.5
 2.5
 3.6
 0.1
 3.1
 2.3
 1.4
-0.0


9 POLD3 DNA polymerase delta 3, accessory subunit 10714 0 7.6 7.9
 2.6
 5.4
 2.9
 4.9
 3.8
 2.9
 1.4
 2.1


10 POLA1 DNA polymerase alpha 1, catalytic subunit 5422 10 7.5 7.6
 2.9
 5.7
 4.4
 7.0
 4.9
 2.1
 5.0
 6.3
 4.0
 0.7
 -0.8
11 ATAD5 ATPase family AAA domain containing 5 79915 0 7.5 6.1
 1.7
 7.1
 2.7
 7.6
 7.5
 5.5
 3.4
 5.1
3.5
 4.6
 3.5
12 STAG1 stromal antigen 1 10274 0 7.3 7.5
 3.6
 5.3
 1.0
0.6
 1.6
1.3
 1.5
0.8
 6.0
3.8
 1.1
0.6
 3.6
1.4
 2.4
 0.6
13 CENPJ centromere protein J 55835 0 7.3 7.7
 2.6
 5.0
 0.1
 3.2
 3.7
 3.9
 3.6
 4.5
 5.6

14 CEP295 centrosomal protein 295 85459 0 7.2 6.8
 2.4
 5.8
 2.5
 6.0
 4.3
 4.1
 3.7
 4.4


15 FANCI FA complementation group I 55215 6 7.1 5.4
 3.1
 7.1
 3.2
 3.1
 6.0
 3.5
 3.4
 4.5
 2.5

16 CCDC14 coiled-coil domain containing 14 64770 0 7.1 7.1
 4.0
 5.3
 2.2
 2.4
 3.2
 0.2
 1.7
 2.7


17 U2SURP U2 snRNP associated SURP domain containing 23350 0 7.1 6.1
 2.9
 6.4
 3.6
 1.8
 4.2
 4.4
 2.4
 1.6
-0.4
 -2.0
0.5
18 SMC4 structural maintenance of chromosomes 4 10051 0 7.0 5.6
 3.9
 6.8
 5.1
 5.7
 6.5
 5.6
 1.9
 5.2
 2.8
 -0.1
19 FANCD2 FA complementation group D2 2177 14 6.8 6.7
 2.2
 5.3
 2.6
 4.2
 4.7
 3.2
 3.9
 6.3
 3.5
-0.2
20 MCM4 minichromosome maintenance complex component 4 4173 2 6.8 5.6
 2.0
 6.3
 4.0
 11.0
 7.0
 5.7
 5.1
 3.9
 4.9
 0.5
 -0.3
21 ZNF148 zinc finger protein 148 7707 0 6.7 7.0
 2.4
 4.8
 1.0
 0.6
 0.6
 1.1
 0.4
 -1.0


22 CCP110 centriolar coiled-coil protein 110 9738 0 6.7 7.1
 1.9
 4.7
 3.0
 3.5
 1.3
 3.3
 1.7
2.7

23 DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 23317 0 6.6 4.9
 2.0
 6.7
 5.0
 2.2
 1.2
 5.3
 0.6
0.6

24 MCM8 minichromosome maintenance 8 homologous recombination repair factor 84515 1 6.6 6.5
 2.8
 5.2
 3.2
 7.4
 5.2
 4.4
 1.7
 5.5
 2.9

25 RAD18 RAD18 E3 ubiquitin protein ligase 56852 5 6.6 7.2
 2.1
 4.5
 5.3
 5.3
 3.8
 2.0
 1.8
 4.3
1.3
 1.5
26 SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 11198 0 6.5 5.5
 1.0
 5.9
 4.2
 2.0
 2.7
 4.0
 1.7
 4.5
 3.4
 0.4
 -1.5
27 CIP2A cellular inhibitor of PP2A 57650 0 6.5 6.1
 1.8
 5.3
 3.0
 5.7
 3.6
 2.1
 2.2
 6.6


28 PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 30849 1 6.4 5.5
 3.2
 5.8
 1.8
 1.4
 2.7
 5.5
 1.1
 1.7
 0.4
 -1.3
29 MSH2 mutS homolog 2 4436 2 6.4 6.2
 2.4
 5.0
 3.4
 4.2
 5.2
 2.7
 2.4
 4.2
 5.1
 -0.0
 1.9
30 RIF1 replication timing regulatory factor 1 55183 0 6.4 6.4
 1.7
 4.8
 1.8
 3.7
 5.3
 7.2
 2.8
 3.1
 4.7
2.0
31 USP1 ubiquitin specific peptidase 1 7398 2 6.3 6.3
 2.8
 4.8
 3.8
 7.5
 6.1
 7.0
 2.2
 3.1


32 MSH6 mutS homolog 6 2956 0 6.3 5.1
 1.5
 6.0
 4.6
 8.2
 4.8
 3.4
 4.5
 5.4
 7.1
 0.6
 0.8
33 RFC5 replication factor C subunit 5 5985 1 6.3 6.2
 2.2
 4.8
 4.0
 5.6
 6.2
 2.4
 2.4
 2.4
 3.1
 -0.0
 0.4
34 MCM2 minichromosome maintenance complex component 2 4171 6 6.2 6.7
 3.3
 4.3
 1.5
 9.2
 4.9
 3.6
 2.6
 3.7
 4.3
 0.8
35 GMPS guanine monophosphate synthase 8833 0 6.2 5.7
 3.1
 5.3
 3.4
 1.5
 0.2
 1.9
 0.3
 0.6
 -0.2
 -0.4
 -2.1
36 USP37 ubiquitin specific peptidase 37 57695 0 6.1 7.1
 1.6
 3.7
 3.3
 2.4
 4.4
 2.6
 5.4
 2.5


37 MMS22L MMS22 like, DNA repair protein 253714 0 6.1 5.3
5.4
 3.2
 8.7
 4.9
 3.2
 3.4
 5.4


38 WDHD1 WD repeat and HMG-box DNA binding protein 1 11169 1 6.0 5.9
 2.0
 4.7
 5.3
 7.6
 5.3
 4.3
 3.9
 4.6
 7.1
 0.4
39 DDX46 DEAD-box helicase 46 9879 0 6.0 5.6
 3.4
 5.0
 4.1
 1.7
4.5
 0.7
 2.6
 1.8
 3.1
 -2.3
40 TMPO thymopoietin 7112 0 6.0 7.9
 1.5
 2.7
 3.1
 4.5
 3.5
 3.1
 1.1
 3.8
1.3


41 DSN1 DSN1 component of MIS12 kinetochore complex 79980 0 6.0 5.3
 2.8
 5.2
 2.4
 6.0
4.2
 1.1
 1.6


42 NCAPD3 non-SMC condensin II complex subunit D3 23310 0 6.0 6.8
 2.4
 3.8
 4.2
 8.4
 5.7
 5.3
 3.7
 4.6


43 RRM1 ribonucleotide reductase catalytic subunit M1 6240 0 6.0 5.1
 1.6
 5.4
 4.9
 7.3
 4.4
 5.4
 3.2
 5.3
 2.4
 0.4
-0.9
 1.0
44 OPA1 OPA1 mitochondrial dynamin like GTPase 4976 0 6.0 4.7
 2.2
 5.8
 3.1
 1.0
 -0.1
 6.1
 -0.4
 0.9
 -0.5

45 CEP192 centrosomal protein 192 55125 0 5.9 6.6
 2.4
 3.8
 3.2
 6.6
4.0
0.3
 3.9
 2.8
 6.0

46 ECT2 epithelial cell transforming 2 1894 4 5.9 6.5
 2.2
 3.9
 3.6
 4.1
 1.7
 2.5
 4.0
 2.6
 3.2

47 ZWILCH zwilch kinetochore protein 55055 0 5.9 5.0
 2.6
 5.3
 5.2
 9.1
 4.6
 3.5
 3.0
 2.5
 3.7

48 ATR ATR serine/threonine kinase 545 92 5.8 6.6
 3.1
 3.6
 3.1
 2.9
 3.7
 5.2
 3.3
 3.9
 6.4
 0.7
 1.5
49 POLE DNA polymerase epsilon, catalytic subunit 5426 0 5.8 5.1
 2.2
 5.1
 3.7
 10.1
 5.2
 4.6
 4.0
 5.1
 6.0
 1.0
 0.2
50 MIS18BP1 MIS18 binding protein 1 55320 0 5.8 6.1
 1.8
 4.1
 4.5
 3.4
 6.1
 3.4
 4.0
 2.8


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