Orthologous genes in OrthoFinder**

Species Gene Description
 dre-u.3  pde4cb  phosphodiesterase 4C, cAMP-specific b 
 dre-r.3  pde4cb  phosphodiesterase 4C, cAMP-specific b 
 dre-u.3  pde4a  phosphodiesterase 4A, cAMP-specific 
 dre-u.3  pde4d  phosphodiesterase 4D, cAMP-specific 
 dre-u.3  pde4ca  phosphodiesterase 4C, cAMP-specific a 
 hsa-u.4  PDE4A  phosphodiesterase 4A 
 mmu-u.4  Pde4c  phosphodiesterase 4C, cAMP specific 
 mmu-u.4  Pde4d  phosphodiesterase 4D, cAMP specific 
 mmu-u.4  Pde4a  phosphodiesterase 4A, cAMP specific 
 rno-u.3  Pde4d  phosphodiesterase 4D 
 rno-u.3  Pde4b  phosphodiesterase 4B 
 gga-u.3  PDE4C  phosphodiesterase 4C 
 gga-u.3  PDE4B  phosphodiesterase 4B 
 mcc-u.3  PDE4D  phosphodiesterase 4D 
 mcc-u.3  PDE4A  phosphodiesterase 4A 
 cfa-u.3  PDE4A  phosphodiesterase 4A 
 cfa-u.3  PDE4C  phosphodiesterase 4C 
 dme-u.3  dnc  dunce 
 sce-u.3  PDE2  3',5'-cyclic-nucleotide phosphodiesterase PDE2 
 spo-u.3  lkh1  dual-specificity 

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Top 50 coexpressed genes to pde4cb (dre-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 dre260   Glycine, serine and threonine metabolism  1 47 -
 dre561   Glycerolipid metabolism  1 72 -
 dre4310   Wnt signaling pathway  2 220 -
 dre4261   Adrenergic signaling in cardiomyocytes  2 244 -
 dre4010   MAPK signaling pathway  3 409 -

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dre:pde4cb (phosphodiesterase 4C, cAMP-specific b) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID
Other ID LINK Target Reference

dre-u.3
for
pde4cb


dre-r.3
for
pde4cb


dre-u.3
for
pde4a


dre-u.3
for
pde4d


dre-u.3
for
pde4ca


hsa-u.4
for
PDE4A


mmu-u.4
for
Pde4c


mmu-u.4
for
Pde4d


mmu-u.4
for
Pde4a


rno-u.3
for
Pde4d


rno-u.3
for
Pde4b


gga-u.3
for
PDE4C


gga-u.3
for
PDE4B


mcc-u.3
for
PDE4D


mcc-u.3
for
PDE4A


cfa-u.3
for
PDE4A


cfa-u.3
for
PDE4C


dme-u.3
for
dnc


sce-u.3
for
PDE2


spo-u.3
for
lkh1

1 mmd2a monocyte to macrophage differentiation-associated 2a 558749 4.3 2.3
1.2
0.5
2.3
2.3
2.0
1.3
0.7
0.7
-0.2
-0.7
-0.8
0.5
0.0
0.7
-0.9
1.7
0.6
1.6
0.0
1.3
0.4
1.1
0.5
-0.1
-1.0
0.9

0.5
2 rap1gap2a RAP1 GTPase activating protein 2a 561339 3.9 2.1
1.1
0.6
1.1
0.8
2.1
-0.3
1.1
0.9
0.9
2.0
0.8
0.1
2.0
1.9
2.8
1.9
1.8
2.0



3 dgke diacylglycerol kinase, epsilon 100150463 3.6 1.9
-0.2
3.0
1.9
0.2
-0.1
1.3
0.4
1.3
1.5
0.4
-0.9
0.9
0.4
2.1
0.2
0.7


4 qpct glutaminyl-peptide cyclotransferase 795685 3.6 1.9
0.8
-1.0
0.9
-1.1
1.7
0.1
1.5
0.3
-1.0
-1.1
-0.4
-1.3
0.4
-0.3
1.4
-0.9
1.2
0.6
-0.2
-1.1
1.0
-0.1
0.8
-0.8
1.1
-1.5
1.0
-0.1
0.1
-1.2
0.3
0.1
-1.4

5 rnf144aa ring finger protein 144aa 570968 3.6 1.9
-0.1
-1.6
2.4
1.5
0.4
0.4
-0.8
0.7
0.4
0.2
-0.3
-0.1
-0.7
1.4
0.7
2.1
1.4
0.3
-0.7
0.8
0.5
1.3
-0.7
-0.1
-0.2
1.0
-0.4
2.1
0.2
1.2


6 fam102ba family with sequence similarity 102 member Ba 724011 3.5 1.9
0.6
-0.3
2.1
2.0
4.9
1.7
3.7
-1.0
-0.2
-0.3
0.5
-0.6
-0.2
-1.3
-0.3
-0.8
1.4
-0.0
-0.1
-0.6
-1.3
-1.5
1.9
-0.7
1.9
-0.9
1.5
1.0
0.6
-0.7
0.5

0.7
7 itga3a integrin, alpha 3a 407685 3.5 1.8
-0.3
-0.8
1.1
-0.4
1.1
-0.3
-1.4
0.1
-0.1
1.2
-0.9
0.6
-1.1
-0.3
-0.6
0.5
-0.3
-1.3



8 ttc6 tetratricopeptide repeat domain 6 568208 3.4 1.8
-1.3
0.8
2.1






0.5
-0.7
0.5
0.2





9 grb14 growth factor receptor-bound protein 14 100334415 3.4 1.8
-0.5
1.4
0.5
-1.2
1.4
1.1
0.2
0.1
-0.2
0.5
-0.7
-1.2
-1.8
1.7
-1.4



10 rnf19b ring finger protein 19B 562396 3.4 1.8
0.8
4.3
3.0
0.1
-0.6
0.2
0.2
0.1
2.2
-0.5
2.9
0.8
1.7
-0.1
-0.5



11 apbb2b amyloid beta (A4) precursor protein-binding, family B, member 2b 564990 3.4 1.8
0.9
0.8
4.3
2.3
1.2
0.3
1.4
0.8
0.5
1.2
1.1
1.5
0.7
1.2
0.6
1.3
0.0
1.2
-0.0
1.7
1.4
2.5
0.8
0.7
-1.6
0.3
-1.2



12 LOC797750 BAH and coiled-coil domain-containing protein 1-like 797750 3.4 1.8
0.7
0.1
3.9
0.7
1.8
0.4
2.7
0.3
-0.1
1.6
-1.6
0.1
1.7
-0.2
-0.5
0.9
1.3
-0.9
2.6


13 creb5b cAMP responsive element binding protein 5b 565910 3.4 1.8
1.7
1.2
2.6
2.3
4.9
2.3
1.1
0.1
-1.0
0.4
0.2
0.3
0.3
3.9
0.9
1.3
0.6
0.7
0.4
0.5
-0.6
1.7
0.0
0.2
0.2
0.5
-0.8
1.7
-0.4
-0.0


14 sema3ab sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab 30267 3.4 1.8
2.1
1.7
3.8
2.7
1.6
1.4
0.6
0.4
3.7
1.5
0.8
0.6
0.0
0.0
2.7
1.9
0.9
0.8
3.3
3.2
3.0
1.2
0.9
0.5
0.9
0.7
0.9
0.9
2.4
0.7
0.6
-1.0

0.3
-0.8
15 arhgap46b Rho GTPase activating protein 46b 568268 3.4 1.8
0.8
-0.1
1.8
0.9
1.8
-0.0
-0.2
-0.1
-0.4
1.5
0.3
-0.6
1.3
-1.3
0.7
0.5
-1.3
-0.5
0.6
1.5
1.0


16 LOC799265 UNC93-like protein MFSD11 799265 3.3 1.8
0.7
0.6
3.9
1.7
0.7
-0.4
0.2
-0.8
-0.5
0.4
0.1
-1.0
0.3
-1.5
-0.5
-0.3
-0.7
-1.3
0.2

0.1
17 plekhg1 pleckstrin homology and RhoGEF domain containing G1 101886810 3.3 1.8
1.6
1.8
0.1

0.1
0.2
-1.7
1.8
1.5
-0.6
-0.7
-1.2
-1.2
-0.6
-0.0
0.5


18 bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 555655 3.3 1.8
1.6
-1.7
2.9
2.8
1.4
0.3
1.4
-0.8
1.2
0.4
2.0
1.7
-0.7
0.3
0.1
1.7
-0.7
-0.7
3.0


19 ism2a isthmin 2a 100535376 3.3 1.8
-2.0
3.1
0.6
0.7









0.3
-1.2



20 ank3b ankyrin 3b 100126016 3.3 1.8
1.1
0.9
0.2
-0.4
1.6
0.6
-1.3
1.0
3.2
-0.5
2.8
1.1
0.7
0.9
-0.6
0.7
0.8
-0.6



21 cerk ceramide kinase 558496 3.2 1.7
1.0
0.2
2.1
-0.4
0.5
-1.1
0.6
0.6
0.4
0.3
2.0
1.3
-0.2
0.2
-0.9
0.3
-0.3
0.4
0.1


22 mtss1la MTSS I-BAR domain containing 2a 560413 3.2 1.7
0.5
0.0
5.3
1.6
0.4
0.1
1.3
0.5
0.7
-0.6
0.8
0.7
0.9
-0.8
0.2
0.0
0.8
0.0
2.2
-0.7
1.0
0.6
1.8
0.9
1.7
1.6
-0.0
-0.9
1.5
-0.3
3.0


23 fam20cb FAM20C golgi associated secretory pathway kinase b 560397 3.2 1.7
0.8
0.0
0.7
0.3
1.4
0.6

0.8
-0.3
-0.3
-0.4
0.5
1.2
-0.6
1.2
-0.6
0.0
1.3
2.2
-0.3
3.8

0.9
24 arhgef3 Rho guanine nucleotide exchange factor (GEF) 3 570228 3.2 1.7
0.5
0.3
0.1
-0.1
1.5
0.5
0.1
-1.5
1.2
1.0
0.3
-0.0
0.0
-0.9
0.9
0.5
0.4
-1.3
-0.7
-1.5
0.3
-0.5
2.1
-1.0
2.2
-0.4
-2.0
-2.3
0.5
0.4

1.8
-1.2

25 rxraa retinoid X receptor, alpha a 555578 3.2 1.7
1.2
1.0
1.2
0.1
0.2
-0.4
2.2
-0.4
1.0
0.5
-0.1
-0.3
1.4
0.8
1.7
-0.6
0.5
-0.1
-0.2
0.2
1.9
1.0
2.2
1.3
0.2
0.1
1.6
-0.1
0.2


26 abcd1 ATP-binding cassette, sub-family D (ALD), member 1 566367 3.2 1.7
-0.8
-1.6
2.1
1.3
2.7
-0.1
1.7
-0.5
0.2
-0.3
1.1
-0.0
2.0
0.4
1.0
-0.8
0.3
-0.2
-0.1
1.1
0.8
-1.4
1.0
-2.0
0.8
0.8
1.1
0.4

27 rflna refilin A 368489 3.2 1.7
-0.3
1.7
0.1

-0.8
-1.5
-1.0
-0.1
-1.2
-0.9
-0.8


-0.1
0.6



28 arhgap27 Rho GTPase activating protein 27 564211 3.1 1.7
1.1
0.7
0.6
0.5
1.0
0.9
0.7
-0.5
0.6
-0.0
0.6
-0.1
0.3
0.3
0.7
0.4
0.6
0.5
2.0
-0.3
0.1
-0.4
1.4
1.2
1.0
0.6
0.8
0.7
1.9
1.5
4.1
0.1
0.1
-0.1
29 b3galt1a UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1a 559521 3.1 1.7
2.5
1.1
2.3
0.6
1.4
1.3
0.4
0.1
-0.0
-0.4
1.9
0.2
-0.1
-0.4
0.6
0.4
1.0
1.0
0.7
0.6
0.2
-1.8
1.8
1.5
1.2
-0.1
-0.9
-1.2
1.2
-0.6
0.5
0.5


30 chdh choline dehydrogenase 100331020 3.1 1.7
1.1
-0.5
-0.0
1.2
1.4
0.7
-0.4
0.7
-0.3
0.1
-0.6
-1.7
-0.5
0.9
2.0
1.1
1.0

0.6
31 mctp1b multiple C2 domains, transmembrane 1b 100334264 3.1 1.7
1.3
0.3
1.3
1.0
1.2
1.0
1.5
0.3
0.4
-0.7
0.6
0.3
-0.6
-1.4
-0.6
-0.4
-0.1
-0.4
0.8
-0.7
0.4
0.3
0.5
-0.8
-0.8
-0.8
0.8
0.4
2.1

1.7
1.4
32 si:dkey-16j16.4 si:dkey-16j16.4 492696 3.1 1.7
-1.2
1.3
1.3






-0.4
-0.1







33 fam117bb family with sequence similarity 117 member Bb 100003476 3.1 1.7


















34 tet1 tet methylcytosine dioxygenase 1 101883702 3.1 1.7
1.3
5.5
1.2
0.6
-1.3
1.5
-0.1
0.1
0.2
0.1
-0.7
0.9
-0.1
-1.1
-0.6



35 ptger2a prostaglandin E receptor 2a (subtype EP2) 393608 3.1 1.6
-0.6
0.8
1.2
2.6
0.8
0.4
-1.1


2.3
0.6
1.6
-0.1
1.6
-1.6



36 wnt9b wingless-type MMTV integration site family, member 9B 565677 3.0 1.6
-0.3
0.6
0.3




-0.2
1.6
-0.3
-0.5







37 LOC101882866 tyrosine-protein kinase SgK223-like 101882866 3.0 1.6


















38 klhl25 kelch like family member 25 556885 3.0 1.6
1.2
-0.1
1.2
1.1
0.5
0.2
0.4
-0.3
-0.3
-1.3
1.2
-0.8
0.1
-0.1
1.3
0.1
1.2
-0.5
1.4
0.3
1.3
0.6
1.3
0.2
0.5
-0.5
-0.7
-1.3
0.6
-0.0



39 mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 568573 3.0 1.6
-1.4
2.1
-0.0
2.3
0.1
0.4
-0.4
0.2
-1.1
-0.8
-0.1
-1.7
2.7
-0.5
0.3



40 gltpd2b glycolipid transfer protein domain containing 2b 565337 3.0 1.6
-0.1
-0.3
0.7
0.4
0.3
0.3
-0.3
-1.0
-0.7
0.7
0.0
-0.9
-0.5
-1.7
-0.2
1.1
0.6
-0.1
-0.7

-0.7
-1.4
41 psd2 pleckstrin and Sec7 domain containing 2 557199 3.0 1.6
2.3
1.4
1.8
1.4
1.5
1.5
1.2
1.1
0.6
0.2
0.1
-0.1
1.8
0.2
0.3
0.0
0.2
-0.7
1.7
1.4
1.2
0.5
0.7
-0.1
1.6
0.5
-0.1
-1.1
1.0
0.6
1.3


42 cacnb3a calcium channel, voltage-dependent, beta 3a 565158 3.0 1.6
1.7
1.2
3.7
2.1
0.7
0.5
4.1
1.7
0.7
0.5
2.2
0.6
3.9
1.1
1.3
0.7
1.8
0.6
2.0
0.7
2.6
1.8
0.8
0.4
2.5
1.6
1.4
-0.3
2.6
0.9
2.3


43 LOC101884669 interleukin-6 receptor subunit beta-like 101884669 3.0 1.6


















44 ccdc80l1 coiled-coil domain containing 80 like 1 569128 2.9 1.6


















45 mtmr11 myotubularin related protein 11 101882209 2.9 1.6
-0.6
1.1
-0.5
0.5
0.7
0.3
0.5
-1.4
-0.8
1.6
-0.4
-0.6
-1.3
1.7
0.4



46 rapgefl1 Rap guanine nucleotide exchange factor (GEF)-like 1 100149497 2.9 1.6
1.3
1.5
2.1
1.4
0.3
-0.3
0.8
-0.4
-0.9
1.6
0.6
-1.0
1.0
-0.5
1.2



47 cited4a Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a 562291 2.9 1.6
-1.7
-2.0
1.7
-1.8
2.1
-2.1
-1.4
-0.2
0.3
0.3
0.3
-0.4
-0.8
0.1
-0.5
-0.4
0.4
0.4


-0.5
48 btbd11b BTB (POZ) domain containing 11b 100034519 2.9 1.6
1.1
0.5
1.1
1.1
1.6
0.5
0.2
-1.1
1.5
-1.9
1.5
-0.2
-0.4
-1.9
0.5
-0.3
1.5
0.2
1.1
1.0
3.2
0.6
2.7
-1.4
0.8
0.1
0.5
-0.1
-0.6
-0.8
-0.7

0.9
49 nfatc3a nuclear factor of activated T cells 3a 561772 2.9 1.5
-1.3
1.7
0.1
0.6
-0.7
0.1
-0.9
1.1
-0.1
-0.7
-0.9
-0.2
1.7
0.4
0.4



50 epha2b eph receptor A2 b 568718 2.9 1.5
2.4
1.7
5.9
2.9
1.7
1.7
0.5
0.5
1.2
1.1
1.3
1.3
1.1
1.0
2.7
2.0
0.7
0.6
1.1
0.9
2.6
1.4
1.0
1.0
1.3
1.1
0.8
0.5
0.3
0.2
-0.4


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