Orthologous genes in OrthoFinder**

Species Gene Description
 dre-u.3   rffl   ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 
 dre-r.3   rffl   ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 
 dre-u.3   rnf34a   ring finger protein 34a 
 dre-u.3   zgc:171740   zgc:171740 
 dre-u.3   rnf34b   ring finger protein 34b 
 hsa-u.4   RFFL   ring finger and FYVE like domain containing E3 ubiquitin protein ligase 
 hsa-u.4   RNF34   ring finger protein 34 
 mmu-u.4   Rffl   ring finger and FYVE like domain containing protein 
 mmu-u.4   Rnf34   ring finger protein 34 
 rno-u.3   Rffl   ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 
 rno-u.3   Rnf34   ring finger protein 34 
 gga-u.3   RNF34   ring finger protein 34 
 gga-u.3   RFFL   ring finger and FYVE like domain containing E3 ubiquitin protein ligase 
 mcc-u.3   RFFL   ring finger and FYVE like domain containing E3 ubiquitin protein ligase 
 mcc-u.3   RNF34   ring finger protein 34 
 cfa-u.3   RFFL   ring finger and FYVE like domain containing E3 ubiquitin protein ligase 
 cfa-u.3   RNF34   ring finger protein 34 
 dme-u.3   CG17019   uncharacterized protein 

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Top 50 coexpressed genes to rffl (dre-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 dre4120   Ubiquitin mediated proteolysis  3 156 2.18
 dre5168   Herpes simplex virus 1 infection  3 173 2.05
 dre5132   Salmonella infection  3 332 -
 dre4144   Endocytosis  3 341 -
 dre4010   MAPK signaling pathway  2 409 -

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dre:rffl (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

dre-u.3
for
rffl
dre-r.3
for
rffl
dre-u.3
for
rnf34a
dre-u.3
for
zgc:171740
dre-u.3
for
rnf34b
hsa-u.4
for
RFFL
hsa-u.4
for
RNF34
mmu-u.4
for
Rffl
mmu-u.4
for
Rnf34
rno-u.3
for
Rffl
rno-u.3
for
Rnf34
gga-u.3
for
RNF34
gga-u.3
for
RFFL
mcc-u.3
for
RFFL
mcc-u.3
for
RNF34
cfa-u.3
for
RFFL
cfa-u.3
for
RNF34
dme-u.3
for
CG17019
1 traf6 TNF receptor-associated factor 6 554561 7.2 3.8
 -0.3
 -1.1
 0.1
 2.1
 0.9
 2.2
 -0.0
 1.2
 -0.9
 1.6
 3.4
 3.3
 0.7
 -0.9
 0.0
 1.5
2 pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 571356 5.3 2.8
 0.7
-0.1
 -1.0
-1.1
 -1.1
-1.9
 0.5
0.4
 -0.9
-2.4
 1.7
1.2
 -0.5
-0.6
 1.5
-0.9
 1.1
-0.2
 -0.2
-0.4
 -0.4
-2.6
 2.8
0.4
 -0.0
-0.6
 0.5
-2.4
 1.0
0.6
 -0.5
3 tmem185 transmembrane protein 185 393409 5.2 2.7
 1.3
 -1.3
 -1.0
 0.4
 1.3
 1.1
0.9
 2.0
1.7
 0.5
-0.8
 1.9
0.4
 2.6
 1.0
 0.3
0.2
 0.2
0.2
 0.8
0.8
 2.1
1.0
 0.8
4 c1galt1b core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b 337131 4.8 2.5
 1.6
1.4
 -0.1
-0.7
 0.0
-0.5
 1.8
 -0.4
 0.7
 -1.6
 1.5
 -0.6
 0.4
 0.4
 0.2
 -0.9
 -0.3
 0.6
 2.1
-1.9
5 ap4b1 adaptor related protein complex 4 subunit beta 1 393309 4.6 2.4
 1.5
 -1.1
 -0.2
 -0.0
 3.3
 2.7
 2.4
 1.5
 3.4
 2.4
 1.8
 0.3
 1.8
 1.0
 1.4
6 trim45 tripartite motif containing 45 558117 4.5 2.4
 -0.1
 1.3
 -0.3
 -1.5
 0.7
 -0.3
 0.9
 1.2
 1.3
 -0.5
 -0.2
 0.0
 1.4
 1.8
 0.6
 -1.2
7 tmem259 transmembrane protein 259 571445 4.4 2.3
 0.6
 -0.2
 -1.0
 1.3
 -1.0
 0.2
 -1.8
 1.7
 -1.3
 2.7
 1.7
 0.4
 -1.0
 -0.2
 0.5
 -0.6
8 wacb WW domain containing adaptor with coiled-coil b 449798 4.4 2.3
 2.8
1.4
 -0.7
-3.6
 -1.5
-1.7
 2.1
 0.2
 1.8
 -0.0
 1.2
 0.6
 2.8
 1.6
 3.8
 1.9
 2.3
 1.7
 -0.3
9 rnf139 ring finger protein 139 100144552 4.3 2.3
 2.2
 -0.1
 1.8
 0.1
 -1.3
 2.9
 2.6
 2.1
 -0.0
 1.9
 2.3
 1.7
 -1.3
 0.4
 1.2
 2.3
10 zdhhc23b zinc finger DHHC-type palmitoyltransferase 23b 445301 4.2 2.2
 1.9
-1.1
 0.8
-1.0
 0.8
-1.3
 1.0
 0.4
 -0.2
 -0.3
 0.5
 -1.1
 0.6
 0.7
 0.7
 -1.1
 0.3
 0.3
 3.0
11 apaf1 apoptotic peptidase activating factor 1 58131 4.2 2.2
 1.8
 -1.4
 -1.9
 1.2
 2.2
 -0.4
 0.7
 0.2
 0.8
 0.6
 3.7
 -0.2
 1.8
 0.9
 2.4
12 rab27a RAB27A, member RAS oncogene family 570907 4.2 2.2
 -0.7
-1.7
 0.7
-0.1
 2.7
0.1
 0.9
0.8
 1.5
 0.6
-0.1
 1.3
-0.6
 0.3
 -0.3

0.9
 1.7
 0.9
0.1
 0.9
-0.9
 1.5
13 slc35a1 solute carrier family 35 member A1 100004536 4.1 2.2
 2.2
 -1.0
 0.4
 -1.6
 0.7
 -0.4
 0.8
 -0.9
 -0.4
 1.1
 0.3
 -1.1
 1.4
 1.3
 3.1
 0.1
14 tmem51b transmembrane protein 51b 327162 4.1 2.2















15 si:ch73-142c19.1 si:ch73-142c19.1 100142653 4.0 2.1
 1.1
 -0.2
 -0.8

0.3
0.3
 2.1
0.8
 -0.4
 0.4



0.9
 0.8
16 polm polymerase (DNA directed), mu 393218 4.0 2.1
 1.0
 0.1
 -0.7
 0.3
-0.3
 0.5
-0.2
 1.8
0.4
 0.0
-0.1
 0.6
0.5
 1.7
0.4
 -0.5
 0.4
 0.9
-0.8
 -0.6
-1.7
 1.6
0.8
 0.3
-1.3
17 si:dkeyp-104h9.5 si:dkeyp-104h9.5 568307 4.0 2.1
 1.2
 -1.8
 -0.7
 -0.9
 0.1
 1.2
 0.4
 -0.2
 0.4
 1.9
 2.6
 1.0
 -0.0
 -1.0
 -1.0
 0.5
18 dcaf12 DDB1 and CUL4 associated factor 12 570671 4.0 2.1
 2.5
 -0.0
 -0.4
 1.3
 1.9
 3.5
-0.4
 1.6
0.6
 1.8
-1.0
 0.3
-0.1
 1.2
 2.9
 -0.0
 1.2
 1.4
 2.1
 0.5
19 syngr2a synaptogyrin 2a 563028 4.0 2.1
 1.9
0.9
 1.6
1.0
 1.1
0.9
 0.7
0.2
 0.3
0.2
 1.2
0.2
 0.3
-0.0
 2.0
0.4
 0.9
-0.8
 1.0
0.9
 1.0
0.6
 1.3
-0.4
 1.0
0.1
 4.2
1.1
 0.6
0.2
 0.6
20 fbxo4 F-box protein 4 100319387 4.0 2.1
 1.5
 1.2
 -1.2
 -0.5
 0.4
 -0.7
 -0.4
 -0.5
 0.4
 0.9
 -0.3
 -0.1
 -0.2
 2.4
 1.6
21 tmem168a transmembrane protein 168a 100034546 4.0 2.1















22 zdhhc18a zinc finger DHHC-type palmitoyltransferase 18a 564062 4.0 2.1
 1.2
0.7
 0.3
-0.2
 1.0
0.4
 4.0
1.2
 0.9
-0.0
 1.0
0.7
 0.7
0.1
 1.8
0.5
 2.8
1.5
 1.8
1.1
 0.8
0.3
 5.5
2.0
 1.6
-0.1
 2.9
0.9
 1.8
0.8
 0.0
23 bnip2 BCL2 interacting protein 2 394197 3.9 2.1
 0.9
0.2
 1.7
1.2
 1.6
1.4
 -0.3
-1.5
 0.2
-0.2
 -1.0
-1.4
 1.0
-0.8
 -0.7
-0.8
 0.3
-0.7
 1.0
-0.7
 -0.6
-0.6
 2.0
-0.8
 0.5
-0.6
 1.2
0.4
 0.4
-0.4
 3.5
24 ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 406624 3.9 2.1
 0.5
0.5
 0.9
-0.1
 -0.1
-0.4
 -0.9
 -1.2
 0.6
 -0.2
 -1.1
 0.6
 -1.3
 -0.3
 -2.1
 -0.8
 0.6
 -1.7
 0.5
0.4
25 rela v-rel avian reticuloendotheliosis viral oncogene homolog A 415099 3.9 2.1
 0.4
-0.2
 -0.3
-1.1
 0.9
-0.7
 3.0
1.0
 -0.7
-2.6
 2.6
0.7
 -0.0
-0.4
 1.1
-0.5
 0.2
0.1
 2.1
0.6
 1.3
1.1
 2.1
-1.2
 1.0
-0.0
 1.3
-1.2
 0.2
-1.0
 1.8
0.7
26 cog1 component of oligomeric golgi complex 1 100334475 3.9 2.1
 3.7
 -1.0
 -0.8
 1.4
 0.9
 1.3
 0.2
 0.5
 0.1
 2.5
 0.9
 1.3
 0.7
 1.8
 0.8
 1.4
27 mief2 mitochondrial elongation factor 2 767710 3.9 2.1
 1.9
-0.8
 -0.8
-1.5
 0.6
-1.3
 1.8
 -0.4
 1.5
 0.8
 4.2
 1.0
 1.5
 0.6
 1.1
 2.3
 1.3
 -0.2
28 lgals3a lectin, galactoside binding soluble 3a 557373 3.9 2.1
 1.4
0.9
 1.6
-0.2
 1.1
-0.5
 0.5
0.5
 -0.1
-0.2
 2.3
2.0
 0.5
0.1
 1.8
1.1
 0.6
-0.1
 0.1
 1.8
 2.0
-0.4
 2.1
-0.9
 1.2
-0.2
 -0.0
-0.4
 2.4
2.1
29 rgp1 GP1 homolog, RAB6A GEF complex partner 1 436881 3.9 2.1
 3.3
 -2.4
 -0.8
 2.8
 0.8
 1.4
 -0.5
 0.7
 0.5
 1.5
 2.0
 0.5
 -1.1
 -0.8
 1.2
 1.4
30 ist1 IST1 factor associated with ESCRT-III 321460 3.9 2.1
 0.2
 -0.9
 -0.6
 1.6
 4.2
 2.5
 3.1
 0.0
 3.7
 2.9
 2.0
 1.0
 4.0
 -1.5
 2.2
 3.1
31 lrrc31 leucine rich repeat containing 31 556343 3.9 2.1
 1.6
 -0.1
 -0.2



-0.9
 -0.3
 0.8
 0.1
 -0.5
 -1.1


32 nudt19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 794545 3.8 2.0
 0.4
 -0.0
 1.5
 1.1
 -0.6
 -0.7
 1.1
 -1.3
 -0.1
 0.4
 -0.0
 -0.2
 -0.3
 -1.0
 0.3
 1.2
0.9
33 keap1a kelch-like ECH-associated protein 1a 321837 3.8 2.0















34 stx5al syntaxin 5A, like 323105 3.8 2.0
 3.1
1.7
 -1.4
-1.7
 0.2
-0.8
 2.0
 0.7
 1.0
 1.2
 0.6
 -0.0

-0.6
 0.7
 -0.4
 -0.5
 3.0
35 wdr62 WD repeat domain 62 570949 3.8 2.0
 0.3
0.3
 1.7
-0.7
 0.9
-1.5
 0.7
-0.3
 -0.4
-0.4
 0.3
0.1
 0.7
-0.6
 0.6
-0.4
 3.1
-1.2
 -0.2
 -0.8
 0.1
-0.4
 1.6
0.3
 2.9
0.5
 0.5
-1.0
 -0.9
36 mtg2 mitochondrial ribosome-associated GTPase 2 100001905 3.7 2.0
 2.6
 -0.3
 -0.1
 1.0
 3.1
 -1.1
 0.1
 0.2
 0.9
 0.7
 -1.3
 0.2
 1.3
 -0.2
 -0.4
 1.0
37 dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 570225 3.7 2.0
 0.5
 -0.4
 0.1
 0.7
 -0.9
 2.5
 0.6
 1.4
 2.3
 1.4
 1.6
 1.2
 -1.0
 0.9
 1.0
38 hps5 HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 100037388 3.7 2.0
 0.3
 -2.0
 -0.9
 -1.1
 1.1
 0.8
 0.7
 1.6
 1.4
 1.2
 1.6
 0.3
 0.5
 0.7
 2.0
 1.8
39 LOC571446 zinc transporter ZIP9-B-like 571446 3.7 2.0
 2.9
1.6
 -0.3
-0.5
 2.1
-0.2
 -1.2
 0.6
 0.2
 -1.3
 0.6
 -0.7
 2.4
 0.5
 0.3
 -0.2
 0.4
 0.6
 -0.6
40 hps1 HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 563067 3.7 1.9
 2.4
 0.4
 -0.4
 2.1
 -0.3
 0.8
 -0.3
 0.8
 -1.0
 0.8
 0.6
 0.2
 0.4
 1.2
 0.1
 1.5
41 vps37ba VPS37B subunit of ESCRT-I a 559483 3.7 1.9
 0.6
0.5
 1.6
-0.4
 0.2
-1.4
 2.0
 0.7
 3.5
0.5
 0.6
-0.0
 0.7
-0.0
 3.1
-0.4
 2.5
1.1
 1.1
0.6
 -0.6
 0.9
 1.1
0.8
 0.4
-0.4
 2.1
42 si:dkey-60a16.1 si:dkey-60a16.1 594863 3.7 1.9















43 slc25a51b solute carrier family 25 member 51b 556422 3.7 1.9
 2.7
-0.5
 0.5
-0.5
 2.1
-0.9

0.6
 -1.2
 0.1
 -0.4
 1.8
 -0.9
 1.3
1.0
 1.3
1.0
 -1.0
 0.8
 2.1
44 slc25a36b solute carrier family 25 member 36b 558307 3.6 1.9
 1.1
0.3
 0.2
-0.2
 1.5
-0.3
 -1.1
-2.4
 0.2
-2.4
 1.7
-0.2
 1.6
-0.3
 -0.7
-1.1
 2.1
0.2
 0.8
0.6
 1.3
0.9
 1.7
-0.1
 0.8
-1.5
 -0.1
-0.3
 0.7
-0.2
 1.5
45 plekhf2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 393214 3.6 1.9
 3.0
0.3
 -0.1
-0.5
 -0.2
-0.4
 1.0
0.1
 0.5
0.5
 3.0
-0.1
 2.0
1.3
 1.8
0.7
 0.3
-0.7
 2.2
1.0
 1.7
0.6
 2.5
2.4
 0.6
-0.5
 -0.5
 0.0
 3.8
46 aftpha aftiphilin a 556043 3.6 1.9
 2.2
0.5
 -0.5
-0.7
 -1.1
-1.7
 1.5
 0.7
 2.4
 2.5
 2.0
 1.8
 1.5
 1.4
 2.0
 2.3
 1.3
 0.9
 0.9
47 insig2 insulin induced gene 2 399645 3.6 1.9
 1.8
1.6
 -0.3
-1.1
 0.3
-1.0
 0.0
-0.9
 1.0
-1.2
 1.7
0.9
 1.6
-0.3
 1.1
0.1
 2.3
-0.7
 0.4
0.2
 2.5
1.2
 1.6
0.3
 -0.5
-1.8
 -0.9
 0.2
48 pyroxd1 pyridine nucleotide-disulphide oxidoreductase domain 1 393736 3.6 1.9
 0.9
 -1.7
 -0.8

0.5
 -0.9
 0.8
 -0.1
 0.7
 0.2
 -0.7
 0.1
 -1.8
 -1.2
 0.5
49 arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 101883993 3.6 1.9















50 tfdp2 transcription factor Dp-2 338204 3.6 1.9
 1.8
1.4
 -0.4
-0.6
 1.0
-0.5
 0.1
-0.8
 0.9
-1.1
 0.4
-0.2
 1.2
0.8
 2.4
0.7
 0.1
-0.1
 0.2
-0.4
 1.4
-0.6
 1.5
-0.1
 1.4
0.8
 0.2
-0.2
 1.4
0.5
 1.7
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