Orthologous genes in OrthoFinder**

Species Gene Description
 dre-u.3   pole2   polymerase (DNA directed), epsilon 2 
 dre-r.3   pole2   polymerase (DNA directed), epsilon 2 
 dre-m.5   pole2   polymerase (DNA directed), epsilon 2 
 hsa-u.4   POLE2   DNA polymerase epsilon 2, accessory subunit 
 mmu-u.4   Pole2   polymerase (DNA directed), epsilon 2 (p59 subunit) 
 rno-u.3   Pole2   DNA polymerase epsilon 2, accessory subunit 
 gga-u.3   POLE2   DNA polymerase epsilon 2, accessory subunit 
 mcc-u.3   POLE2   DNA polymerase epsilon 2, accessory subunit 
 cfa-u.3   POLE2   DNA polymerase epsilon 2, accessory subunit 
 dme-u.3   DNApol-epsilon58   DNA polymerase epsilon 58kD subunit 
 cel-u.3   pole-2   putative DNA polymerase epsilon subunit 2 
 sce-u.3   DPB2   DNA polymerase epsilon noncatalytic subunit 
 spo-u.3   rpm2   ATP-dependent RNA helicase Rpm2 

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Top 50 coexpressed genes to pole2 (dre-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 dre3030   DNA replication  10 37 7.52
 dre4110   Cell cycle  7 153 7.04
 dre3430   Mismatch repair  5 22 6.64
 dre3420   Nucleotide excision repair  5 43 7.18
 dre3410   Base excision repair  4 36 5.75

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dre:pole2 (polymerase (DNA directed), epsilon 2) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

dre-u.3
for
pole2
dre-r.3
for
pole2
dre-m.5
for
pole2
hsa-u.4
for
POLE2
mmu-u.4
for
Pole2
rno-u.3
for
Pole2
gga-u.3
for
POLE2
mcc-u.3
for
POLE2
cfa-u.3
for
POLE2
dme-u.3
for
DNApol-epsilon58
cel-u.3
for
pole-2
sce-u.3
for
DPB2
spo-u.3
for
rpm2
1 mms22l MMS22-like, DNA repair protein 563411 9.8 5.0
 4.0
 5.9
 7.9
 8.6
 1.5
 3.5
 2.0



2 pclaf PCNA clamp associated factor 100333229 9.5 5.0
5.3
 4.1
 6.3
 1.4
 2.8
 0.8



3 tyms thymidylate synthetase 81540 9.3 5.4
 3.1
 4.9
 5.2
 2.9
 3.0
 4.0
 3.8
 12.1
 0.6
 4.2
4 rfc4 replication factor C (activator 1) 4 406435 9.2 5.3
 3.1
 6.5
 5.5
 3.5
 4.8
 4.6
 4.6
 5.6
 4.7
 0.7
5 mcm7 minichromosome maintenance complex component 7 192333 8.8 4.7
 3.3
 4.0
 6.3
 4.4
 1.3
 3.8
 1.8
 8.2
 2.9
 2.1
 1.5
6 recql4 RecQ helicase-like 4 567383 8.8 4.6
2.8
 3.2
 5.6
 1.2
 3.5
 2.0
 10.3


7 dnmt1 DNA (cytosine-5-)-methyltransferase 1 30430 8.7 4.6
 3.4
 3.1
 5.0
 3.8
 1.4
 0.1
 2.0


0.5
8 zgc:85936 zgc:85936 406563 8.7 4.5
1.0
 3.1
 3.6
 1.2
 1.3
 2.7
 -1.6
 0.7
0.8
9 rnaseh2a ribonuclease H2, subunit A 393195 8.6 5.5
 2.3
 3.5
 1.9
 1.2
3.9
 -0.3
 7.9
 7.8
 2.5
10 rfc3 replication factor C (activator 1) 3 259256 8.4 4.9
 2.7
 6.1
 4.8
 3.9
 2.7
 2.0
 2.5
 4.1
 1.3
 3.3
 0.4
11 fanci FA complementation group I 324185 8.2 4.3
6.0
 5.7
 6.0
 0.4
 4.2
 2.0
 1.0
 2.9

12 pola1 polymerase (DNA directed), alpha 1 317740 8.0 4.0
 3.3
 4.1
 5.4
 3.8
 1.2
 4.5
 -0.5
 10.7
 0.6
 6.7
 -0.7
13 orc4 origin recognition complex, subunit 4 406462 7.9 3.6
 3.6
 -0.6
 1.2
 -1.0
 6.0
 0.9
 2.4
 5.9
2.0
 1.1
14 smc4 structural maintenance of chromosomes 4 192332 7.9 4.3
 2.9
 1.9
 3.1
 3.6
 0.3
 3.9
 2.5
 0.9
 1.6
-1.2
 0.3
15 nsd2 nuclear receptor binding SET domain protein 2 100000709 7.9 4.6
 2.6
 -0.8
 1.7
0.3
 1.8
-0.2
 0.3
0.2
 3.2
-0.1
 1.4
-1.6
 3.1


16 nasp nuclear autoantigenic sperm protein (histone-binding) 799570 7.8 4.6
 2.6
 3.2
 4.0
 3.4
 1.6
 3.7
 2.2
 0.8
 1.2
0.9

17 cdca7a cell division cycle associated 7a 550236 7.8 4.2
 2.9
 5.0
 4.5
 6.5
 5.4
 4.4
 2.1



18 dsn1 DSN1 homolog, MIS12 kinetochore complex component 100002916 7.7 4.0
6.6
 3.9
1.6
 2.9
 1.7



19 wdhd1 WD repeat and HMG-box DNA binding protein 1 436999 7.7 4.3
 2.8
 11.1
 7.4
 6.7
 1.7
 4.3
 3.8
 12.2
 2.7
 4.1
20 haus4 HAUS augmin-like complex, subunit 4 436698 7.7 4.4
 2.7
 2.7
 2.9
 3.6
 2.5
 1.8




21 unga uracil DNA glycosylase a 393949 7.7 4.9
 2.2
 3.7
 4.8
 3.2
 2.0
 3.1
 2.9
0.4
 2.7
 0.7
22 clspn claspin 564151 7.7 4.0
5.9
 5.8
 5.5
 -0.3
 1.7
 1.1
 8.7
 0.8

23 rad54l RAD54 like 394119 7.6 4.2
 2.7
 4.5
 6.8
 6.7
 3.4
 3.4
 2.5
 0.3
 0.4
 3.1
 0.8
24 pold1 polymerase (DNA directed), delta 1, catalytic subunit 556456 7.6 3.6
 3.3
 3.6
 5.2
 6.0
 1.8
 0.2
 3.1
 4.8
 3.4
 3.6
 -0.4
25 haus5 HAUS augmin-like complex, subunit 5 492797 7.4 3.9
 2.9
 2.7
 5.1
 1.7
2.4
 2.8



26 msh6 mutS homolog 6 (E. coli) 260437 7.4 3.8
 3.0
 4.2
 3.8
 1.2
 1.5
 2.1
 3.4
 3.2
 0.7
 6.3
 1.5
27 chaf1a chromatin assembly factor 1, subunit A (p150) 563212 7.4 3.9
4.0
 4.3
 6.6
 1.8
 4.3
 2.1
 4.8
 3.2

28 cdk2 cyclin-dependent kinase 2 406715 7.4 4.1
 2.6
 4.5
4.2
 4.8
3.9
 6.0
5.2
 3.2
3.0
 6.1
2.8
 2.4
1.3
 5.2
3.7
 5.1
1.5
 2.7
1.2
29 fancc FA complementation group C 692127 7.2 3.7
4.5
 2.1
 3.1
 1.3
 2.1
 1.4



30 ncapd2 non-SMC condensin I complex, subunit D2 552978 7.1 3.7
-0.9
 3.2
 4.3
 3.0
 3.8
 1.7
 3.0
 0.7
 3.3
 1.5
31 orc2 origin recognition complex, subunit 2 768161 7.1 3.9
 2.6
 1.2
 2.0
 1.1
 3.1
 3.5
 2.1
 11.9
 5.9
 3.4
 0.9
32 chek1 checkpoint kinase 1 393162 7.1 4.1
 2.4
 6.7
 7.6
 4.3
 2.7
 3.1
 2.7
 0.7
 2.3
-0.0
 1.4
-0.9
33 mcm4 minichromosome maintenance complex component 4 337598 7.0 3.4
 3.1
 6.4
 7.1
 4.6
 4.5
 3.3
 3.3
 8.2
 1.2
 2.1
 0.5
34 pola2 polymerase (DNA directed), alpha 2 322059 7.0 4.2
 2.2
 4.4
 6.7
 3.5
 3.0
 4.4
 1.5
 9.6
 4.1
 7.8
35 pold2 polymerase (DNA directed), delta 2, regulatory subunit 796456 7.0 3.8
 2.6
 0.2
 2.0
 2.8
 2.0
 1.5
 1.6
 5.4
 6.6
 3.1
 -0.2
36 rrm1 ribonucleotide reductase M1 polypeptide 30740 6.9 4.1
 2.3
 4.3
 4.1
 4.1
 2.5
 3.8
 1.6
 6.9
 1.1
 4.9
-0.0
 0.3
37 ncapg2 non-SMC condensin II complex, subunit G2 100037337 6.9 3.6
3.6
 4.3
 4.9
 2.2
 4.4
 2.0
4.7

38 kif22 kinesin family member 22 561788 6.8 3.6
1.4
 2.5
 4.6
3.7
 2.0



39 cdc6 cell division cycle 6 homolog (S. cerevisiae) 402825 6.8 4.1
 2.1
 6.5
 8.5
 6.1
 2.0
 3.6
 2.4
 4.8
 5.7
 2.0
 -0.3
40 gins2 GINS complex subunit 2 554146 6.7 4.0
 2.2
 9.0
 6.4
 4.2
 3.9
 4.5
 4.0
 2.3
 0.8
 -0.3
41 fancd2 FA complementation group D2 394241 6.7 3.5
4.2
 3.2
 5.9
 1.4
 3.3
 2.6
 2.9
 0.8
1.4
42 pole polymerase (DNA directed), epsilon 553405 6.7 3.5
3.6
 5.0
 6.0
 2.3
 4.4
 2.4
 8.0
 0.7
 4.1
 -0.9
43 tonsl tonsoku-like, DNA repair protein 492655 6.7 3.2
 3.0
 3.1
 4.2
 3.8
4.0
 1.3
 1.8


44 krcp kelch repeat-containing protein 323406 6.6 3.5
 2.6









45 eed embryonic ectoderm development 550463 6.6 3.4
2.4
 2.0
 0.7
 1.6
 1.9
 0.1
 7.7
0.6
 4.5

46 dctd dCMP deaminase 550332 6.6 3.4
-0.6
 3.1
 3.5
 3.1
 -0.4
 -1.6
 0.6
 3.7

47 chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 554366 6.6 3.2
 2.8
 1.7
 3.6
 4.9
 1.8
 0.8
 1.3
 7.9
 5.1
 5.9
48 asf1ba anti-silencing function 1Ba histone chaperone 386897 6.6 3.4
4.3
0.2
 5.0
2.5
 7.1
0.6
 3.4
1.6
 0.8
0.6
 2.1
1.7
 4.7
 2.5
1.3
 4.7
 1.7
49 ncapd3 non-SMC condensin II complex, subunit D3 556493 6.6 3.6
 2.5
 3.0
 5.1
 4.8
 1.1
 3.6
 1.8
0.5

50 chaf1b chromatin assembly factor 1, subunit B 406285











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