Orthologous genes in OrthoFinder**

Species Gene Description
 dre-u.3   srebf2   sterol regulatory element binding transcription factor 2 
 dre-r.3   srebf2   sterol regulatory element binding transcription factor 2 
 dre-u.3   srebf1   sterol regulatory element binding transcription factor 1 
 hsa-u.4   SREBF1   sterol regulatory element binding transcription factor 1 
 hsa-u.4   SREBF2   sterol regulatory element binding transcription factor 2 
 mmu-u.4   Srebf1   sterol regulatory element binding transcription factor 1 
 mmu-u.4   Srebf2   sterol regulatory element binding factor 2 
 rno-u.3   Srebf1   sterol regulatory element binding transcription factor 1 
 rno-u.3   Srebf2   sterol regulatory element binding transcription factor 2 
 gga-u.3   SREBF1   sterol regulatory element binding transcription factor 1 
 gga-u.3   SREBF2   sterol regulatory element binding transcription factor 2 
 mcc-u.3   SREBF1   sterol regulatory element binding transcription factor 1 
 mcc-u.3   SREBF2   sterol regulatory element binding transcription factor 2 
 cfa-u.3   SREBF1   sterol regulatory element binding transcription factor 1 
 dme-u.3   SREBP   Sterol regulatory element binding protein 
 cel-u.3   sbp-1   BHLH domain-containing protein 
 sce-u.3   HMS1   Hms1p 
 sce-u.3   TYE7   Tye7p 
 spo-u.3   syj2   inositol-1,4,5-trisphosphate 5-phosphatase 2 

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Top 50 coexpressed genes to srebf2 (dre-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 dre100   Steroid biosynthesis  12 21 6.73
 dre900   Terpenoid backbone biosynthesis  7 21 6.73
 dre1212   Fatty acid metabolism  4 73 4.51
 dre3320   PPAR signaling pathway  4 84 4.27
 dre71   Fatty acid degradation  3 55 3.47

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dre:srebf2 (sterol regulatory element binding transcription factor 2) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

dre-u.3
for
srebf2
dre-r.3
for
srebf2
dre-u.3
for
srebf1
hsa-u.4
for
SREBF1
hsa-u.4
for
SREBF2
mmu-u.4
for
Srebf1
mmu-u.4
for
Srebf2
rno-u.3
for
Srebf1
rno-u.3
for
Srebf2
gga-u.3
for
SREBF1
gga-u.3
for
SREBF2
mcc-u.3
for
SREBF1
mcc-u.3
for
SREBF2
cfa-u.3
for
SREBF1
dme-u.3
for
SREBP
cel-u.3
for
sbp-1
sce-u.3
for
HMS1
sce-u.3
for
TYE7
spo-u.3
for
syj2
1 ldlrb low density lipoprotein receptor b 393460 12.9 6.7
 5.4
3.8
 6.8
2.4
 14.1
4.9
 6.7
0.9
 15.2
3.4
 4.4
-1.3
 7.4
1.0
 4.4
-0.5
 10.0
1.1
 4.2
1.6
 6.5
2.9
 3.3
3.1
 3.0
2.9
 0.4
-1.2


2 cyp51 cytochrome P450, family 51 414331 11.0 5.7
 2.4
 3.0
 7.8
 3.2
 15.6
 2.1
 11.4

1.3
 7.7
 1.7

1.2
 2.5
 1.4
3 lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 795400 10.6 5.5
 2.6
 6.4
 11.9
 5.4
 10.5
 3.8
 9.4
 4.0
 14.4
 2.6
 3.1
 2.5

0.7
 -0.0
 -1.8
4 sqlea squalene epoxidase a 799528 10.0 5.2
 1.8
 2.6
 13.7
 3.5
 16.0
 0.9
 12.4
 3.5
 15.1
 0.3
 8.1
 1.0

1.4
 2.2
5 msmo1 methylsterol monooxygenase 1 406662 9.4 4.9
 3.3
 2.6
 13.3
 3.5
 14.4
 2.1
 12.3
 4.2
 14.9
 2.1
 6.0
 0.8
0.2

1.7
 1.8
6 hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 394060 9.0 4.7
 2.5
 3.9
-0.7
 14.1
-0.8
 3.5
-0.7
 14.9
-1.3
 2.5
-0.9
 11.2
-1.3
 2.1
0.7
 8.9
-0.1
 1.2
-0.6
 8.2
0.3
 1.5
-0.3
 2.4
 -0.3
 -0.5
 0.2
7 aclya ATP citrate lyase a 436922 8.1 4.2
 2.6
-0.5
 4.0
 6.6
 7.8
 6.7
 6.3
 7.3
 2.4
 5.3
 1.5
 4.1
 2.6
 2.3
 2.2
0.6


8 insig1 insulin induced gene 1 334189 7.9 4.1
 6.4
3.3
 6.8
-0.6
 12.1
0.3
 6.6
-0.1
 10.5
-0.4
 4.4
-0.8
 7.2
-1.0
 4.4
-0.4
 11.1
0.8
 2.7
-0.4
 3.2
-0.5
 2.9




9 dhcr7 7-dehydrocholesterol reductase 378446 7.9 4.1
 3.0
2.0
 6.6
2.8
 13.7
4.5
 6.7
4.0
 10.5
7.4
 4.0
1.3
 7.7
6.1
 3.9
1.1
 12.1
2.6
 2.9
2.1
 5.1
0.4
 2.6
0.1
 -0.5
 -0.6
 0.2
-1.2
 -0.1
-1.6
10 fdft1 farnesyl-diphosphate farnesyltransferase 1 571911 7.8 4.1
 6.7
 2.9
 13.3
 4.1
 11.6
 3.2
 9.7
 3.6
 13.9
 0.9
 8.2
 1.2

0.6
 -0.5
11 ebp EBP cholestenol delta-isomerase 436600 7.7 4.0
 3.8
 3.1
 7.8
 1.6
 3.2
 0.9
 5.9
 7.1
 11.0
 0.4
 4.8
 1.0




12 scarb2a scavenger receptor class B, member 2a 192340 7.7 4.0
 3.5
1.6
 0.4
 0.6
 2.2
 -0.5
 0.7
 -0.7
 -0.9
 0.2
 1.8
 0.7
 -1.4
 1.4
1.3
 1.0
-0.4


13 tm7sf2 transmembrane 7 superfamily member 2 494054 7.5 3.9
 3.0
2.0
 6.6
2.8
 13.7
4.5
 6.7
4.0
 10.5
7.4
 4.0
1.3
 7.7
6.1
 3.9
1.1
 12.1
2.6
 2.9
2.1
 5.1
0.4
 2.6
0.1
 -0.5
 -0.6
 0.2
-1.2
 -0.1
-1.6
14 dhcr24 24-dehydrocholesterol reductase 494102 7.3 3.8
 3.2
 3.3
 12.0
 3.8
 12.5
 3.2
 10.0
 4.2
 14.4
 1.7
 6.8
 4.3
0.6
0.5


15 hmgcra 3-hydroxy-3-methylglutaryl-CoA reductase a 559054 7.2 3.8
 3.3
0.4
 3.1
 12.2
 3.9
 13.9
 1.6
 9.7
 4.0
 11.1
 1.4
 2.3
 1.3
 0.3
 -0.9
 -0.4
-1.0
 1.1
-0.8
 -0.5
16 fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 552997 7.2 3.8
 2.6
 4.1
 10.4
 3.9
 12.7
 3.3
 9.7
 4.0
 13.4
 1.6
 5.5
 1.1
 0.1
 -0.9
 0.9
 0.8
17 sc5d sterol-C5-desaturase 447891 7.0 3.6
 2.8
 1.7
 8.5
 5.0
 10.5
 1.7
 7.8
 6.9
 11.3
 1.0
 3.1
 2.0

-0.0
 1.3
18 hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 768185 6.8 3.6
 2.2
 2.8
 8.9
 2.1
 9.5
 1.1
 7.8
 4.2
 11.1
 0.5
 2.6
 1.6

-1.5
 -0.2
19 nsdhl NAD(P) dependent steroid dehydrogenase-like 550369 6.8 3.5
 2.0
 1.9
 8.3
 4.2
 11.2
 3.2
 7.0
 3.8
 14.1
 -0.1
 3.9
 1.9

0.2
 0.4
20 tmem97 transmembrane protein 97 569147 6.7 3.5
 2.6
 1.1
 7.1
 0.9
 5.5
 1.8
 5.8
 -0.3
 0.5
 0.4
 2.6
 0.2

0.8
 -0.2
21 mvda mevalonate (diphospho) decarboxylase a 492781 6.7 3.5
 1.7
 4.8
 11.2
 4.1
 11.8

5.0
 11.2
 2.5
 6.8
 1.4
 -1.5
 0.9
 0.3
 -0.1
 2.2
22 klc1b kinesin light chain 1b 335499 6.4 3.4
 1.4
1.4
 1.6
0.9
 1.4
0.7
 1.1
-0.9
 1.5
0.2
 1.5
1.4
 3.5
-1.6
 2.3
 1.5
 2.1
1.2
 0.9
0.4
 1.7
-0.3
 2.9
 0.3


23 acsbg2 acyl-CoA synthetase bubblegum family member 2 335159 6.0 3.1
 3.9
-0.6
 0.8
 0.1
 1.6
 -0.1
 0.6
0.4
 0.5
-1.6
 2.8
-0.7
 7.7
-0.9
 0.3
-0.0
 -0.4
-1.1
 0.8
 3.0
-0.4



24 acat2 acetyl-CoA acetyltransferase 2 30643 5.8 3.0
 3.6
 3.5
 11.1
 4.0
1.4
 8.5
0.4
 1.3
0.5
 9.7
0.7
 3.2
 6.9

1.2
 2.2



25 srebf1 sterol regulatory element binding transcription factor 1 793274 5.5 2.9
 5.5
 7.2
 7.2
 4.2
 4.2
 3.2
 3.2
 5.8
 5.8
 1.2
 1.2


1.3
 1.3
26 taldo1 transaldolase 1 324556 5.4 2.9
 2.2
 0.2
 -0.1
 1.8
 0.5
 0.4
 -0.0
 0.9
 0.1
 1.0
 2.0
 -0.2
 2.9
 0.9
 0.6
-1.4
 2.3
-0.9
 0.5
27 gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 322104 5.3 2.8
 0.6
0.6
 1.3
-0.6
 1.6
0.7
 2.4
0.8
 4.2
2.8
 1.9
0.2
 3.6
2.7
 0.7
0.5
 0.1
-0.8
 2.0
0.5
 3.3
3.1
 0.5
-0.4
 1.6
-0.1
 0.9
-0.4
 1.1
 1.1
28 heatr5b HEAT repeat containing 5B 571772 5.2 2.7
 2.4
1.9
 -0.4
-1.1
 0.1
-0.7
 1.8
0.9
 1.8
-0.6
 1.1
0.2
 0.2
-0.3
 0.2
0.1
 -0.1
-0.5
 0.8
-1.0
 0.6
-0.4
 -0.7
-1.3
 0.5
 -0.2
 0.1
 1.8
 -1.2
29 zswim6 zinc finger, SWIM-type containing 6 403057 5.1 2.7
 1.6
1.5
 2.2
-0.1
 2.7
0.1
 0.3
-0.3
 2.2
0.9
 -0.3
-1.3
 0.7
0.4
 1.4
0.7
 0.8
-0.2
 1.2
0.0
 0.6
0.6
 1.3
0.6




30 idi1 isopentenyl-diphosphate delta isomerase 1 553513 5.1 2.7
 2.6
 4.0
 10.3
 2.6
 12.9
 0.3
 10.0
 3.8
 14.2
 3.2
0.3
 4.9
0.7
 2.6
 0.5
 0.2
 0.3
 1.2
 -0.7
31 stard4 StAR-related lipid transfer (START) domain containing 4 550374 5.0 2.6
 3.8
0.9
 0.9
 0.1
 3.4
0.4
 12.1
-0.2
 2.0
1.0
 5.7
0.2
 3.5
2.8
 7.8
3.1
 1.2
0.2
 4.1
1.6
 1.2
-0.1
-1.6


32 ctnnb2 catenin, beta 2 324004 5.0 2.6
 2.2
0.5
 2.0
-0.2
 2.3
1.1
 0.8
0.7
 2.4
1.6
 2.1
1.3
 2.8
1.2
 1.0
-0.1
 2.1
-0.7
 1.9
1.6
 1.4
0.6
 1.3
-1.2
 -0.7
 -0.3

0.8
33 ccdc134 coiled-coil domain containing 134 571638 5.0 2.6
 0.4
-1.4
 1.3
 2.7
 1.1
 1.1
 -0.2
 1.8
 1.1
 6.0
 2.0
 0.7

1.0


34 txndc11 thioredoxin domain containing 11 100330433 5.0 2.6
 1.9
 1.3
 0.5
 1.2
 1.3
 2.1
 1.6
 -0.2
 0.7
 1.7
 1.6
 0.6
 2.0



35 tfg trafficking from ER to golgi regulator 336466 4.9 2.6
 1.1
 -0.3
 1.0
 0.5
 -0.6
 1.6
 2.5
 0.3
 2.4
 0.9
 0.3
 1.6
0.8
0.2


36 slc10a3 solute carrier family 10 member 3 406519 4.9 2.6
 0.8
 -0.6
 -0.9
 0.5
 -0.6
 -0.2
 0.4

0.6
 0.8
 0.6
 3.6
 -0.4


37 map4k4 mitogen-activated protein kinase kinase kinase kinase 4 103908625 4.8 2.5
 2.2
1.4
 3.6
-0.4
 2.6
0.9
 1.3
1.0
 2.7
0.7
 0.4
0.3
 3.3
0.1
 0.0
-0.9
 0.2
-0.3
 0.8
0.5
 3.9
1.2
 2.2
-0.6
 0.5
 2.0


38 rdh12 retinol dehydrogenase 12 436597 4.7 2.5
 1.9
1.5
 3.7
1.8
 5.0
0.7
 3.6
1.7
 6.5
1.9
 0.9
0.9
 3.4
0.8
 2.1
0.9
 6.1
1.5
 0.9
0.3
 0.7
0.6
 1.4
1.2
 1.5
0.5
 1.3
0.3
 -1.3
 0.0
39 myh9b myosin, heavy chain 9b, non-muscle 561431 4.7 2.5
 2.8
1.1
 0.9
0.8
 2.5
0.2
 1.5
1.4
 2.1
1.9
 2.1
0.9
 2.4
1.0
 1.4
1.3
 1.1
1.1
 1.6
1.4
 3.2
2.1
 2.7
1.7
 1.8
1.2
 1.8
1.3
 -0.2
-0.7
 1.9
-0.1
 2.1
0.4
40 prrc2b proline-rich coiled-coil 2B 561451 4.6 2.4
 2.1
1.7
 0.3
 5.0
 2.4
 2.4
 0.7
 2.9
 -0.8
 -0.4
 0.8
 3.6
 1.2
2.7


41 sik3 SIK family kinase 3 393513 4.6 2.4
 3.0

0.8
 0.8
 0.9
 -0.5
 1.9
 0.8
 1.1
 3.1
 1.6




42 mbd5 methyl-CpG binding domain protein 5 100009623 4.6 2.4
















43 wdr1 WD repeat domain 1 394014 4.5 2.4
 -0.0
 -1.2
 0.9
 -1.3
 2.3
 -0.2
 2.7
 -0.8
 1.3
 0.9
 3.7
 -0.7
 1.2
 1.3
-0.7
 -0.3
 -0.6
44 acsl3b acyl-CoA synthetase long chain family member 3b 559656 4.5 2.4
 4.0
2.2
 8.7
1.1
 6.6
3.0
 5.5
2.1
 7.3
3.0
 4.3
1.1
 4.9
2.4
 2.6
-0.0
 3.4
2.7
 5.2
2.3
 3.3
1.6
 2.7
0.9
 5.7
 1.2
-0.5
 1.5
1.2
 1.6
1.4
45 ubap2a ubiquitin associated protein 2a 563733 4.5 2.4
 0.3
0.0
 0.5
0.3
 2.5
1.8
 1.0
-0.9
 2.8
1.8
 0.6
-0.2
 1.4
0.1
 2.1
0.2
 1.3
0.8
 1.1
0.3
 3.2
3.0
 1.9
-0.2
 -0.4
 1.8


46 lrp6 low density lipoprotein receptor-related protein 6 100003877 4.4 2.3
 3.9
2.4
 1.5
0.7
 1.6
0.2
 0.4
0.3
 2.7
0.7
 2.5
0.1
 1.5
-0.5
 0.2
-0.6
 -0.4
-1.6
 1.4
0.6
 0.8
-0.5
 0.8
-0.1
 1.4


0.2
47 LOC110439853 zinc finger protein 883-like 110439853 4.4 2.3
















48 fads2 fatty acid desaturase 2 140615 4.4 2.3
 2.5
 6.6
4.9
 10.1
9.8
 5.5
5.0
 7.7
6.7
 5.7
4.3
 5.4
3.6
 2.5
1.4
 6.2
2.3
 2.6
1.7
 5.4
2.3
 3.4
1.0
1.3
0.9

0.8
49 ebpl EBP like 768138 4.3 2.3
 1.9
 0.5
 0.0
 2.3
 1.2
 1.6
 0.4

-1.6
 1.0
 0.1




50 mvk mevalonate kinase 492477 4.3 2.3
 1.3
 6.4
 10.4
 3.6
 10.7
 3.8
 8.4
 2.0
 7.0
 2.2
 3.3
 3.3
0.1
 0.0
 0.2
 2.4
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