Orthologous genes in OrthoFinder**

Species Gene Description
 cfa-u.3   LAG3   lymphocyte activating 3 
 cfa-r.3   LAG3   lymphocyte activating 3 
 cfa-m.4   LAG3   lymphocyte activating 3 
 hsa-u.4   LAG3   lymphocyte activating 3 
 mmu-u.4   Lag3   lymphocyte-activation gene 3 
 mcc-u.3   LAG3   lymphocyte activating 3 
 gga-u.3   LAG3   lymphocyte activating 3 

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Top 50 coexpressed genes to LAG3 (cfa-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 cfa4650   Natural killer cell mediated cytotoxicity  5 77 5.31
 cfa5142   Chagas disease  5 90 4.97
 cfa4660   T cell receptor signaling pathway  5 91 4.95
 cfa4060   Cytokine-cytokine receptor interaction  4 188 2.49
 cfa4014   Ras signaling pathway  4 196 2.43

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cfa:LAG3 (lymphocyte activating 3) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

cfa-u.3
for
LAG3
cfa-r.3
for
LAG3
cfa-m.4
for
LAG3
hsa-u.4
for
LAG3
mmu-u.4
for
Lag3
mcc-u.3
for
LAG3
gga-u.3
for
LAG3
1 GZMB granzyme B 490630 3.9 1.5
 2.7
 8.0
6.9
 3.2
1.9
 2.7
2.6
 1.6
2 CTSW cathepsin W 483725 3.5 1.1
 3.0
 5.0
 3.3
 2.9
3 APOC1 apolipoprotein C1 476437 3.5 1.5
 2.2
 0.6
 0.9
 0.6
4 PTMS parathymosin 611633 3.3 1.8
 1.8



5 GPR171 G protein-coupled receptor 171 485716 3.3 1.8
 1.8
 3.7
 1.8
 2.6
 2.7
6 CD27 CD27 molecule 611674 3.3 1.6
 2.0
 2.4
 2.7

7 NKG7 natural killer cell granule protein 7 100856108 3.3 1.8
7.8
 3.1
 5.2
8 C1QB complement C1q B chain 487381 3.3 1.3
 2.4
 2.6
 2.9
 3.7
 0.4
9 HCK HCK proto-oncogene, Src family tyrosine kinase 485828 3.2 1.5
 2.0
 3.9
1.1
 3.4
1.5
 2.8
2.4
 3.5
1.6
10 LOC607937 T cell receptor alpha variable 9-2 607937 3.1 1.3
 2.2

3.0
11 LAIR1 leukocyte associated immunoglobulin like receptor 1 484308 3.1 2.1
 1.0
 3.2
-0.4
 2.0
 0.4
12 LAT linker for activation of T cells 607947 3.0 0.7
 2.8
 3.0
 2.3
 2.1
13 EFEMP2 EGF containing fibulin extracellular matrix protein 2 476020 2.9 1.4
 1.8
 -0.0
-0.7
 0.2
-0.5
 0.5
-0.2
 0.2
14 C1QC complement C1q C chain 487382 2.9 1.1
 2.2
 2.5
 2.9
 3.3
 -0.3
15 PYCARD PYD and CARD domain containing 100856347 2.9 1.6
0.4
 2.3
 1.9
16 CD7 CD7 molecule 607675 2.9 1.2
 2.0
 4.8
 1.9
 1.1
17 SLA Src like adaptor 608259 2.9 0.9
 2.4
 0.9
 1.2
 0.3
 1.2
18 C27H12orf57 chromosome 27 C12orf57 homolog 119866431 2.9 1.6
0.9
 0.8
 -0.2
 0.6
19 GNA14 G protein subunit alpha 14 484156 2.9 0.9
 2.3
 0.9
0.8
 1.0
0.7
 0.8
0.4
 0.7
0.6
20 CCL5 C-C motif chemokine ligand 5 403522 2.9 1.0
 2.2
 3.8
3.4
 4.3
3.4
 2.8
1.6
 3.5
2.2
21 LOC119869117 immunoglobulin lambda variable 1-40-like 119869117 2.9 1.6


2.8
1.5
22 LOC484897 adhesion G protein-coupled receptor E2-like 484897 2.9 1.5
 1.5
 1.2
0.3
 -0.7
-1.1
 -0.2
-0.2
23 HSH2D hematopoietic SH2 domain containing 484852 2.8 0.8
 2.5
 1.6
 1.2
 -0.7
24 GNB3 G protein subunit beta 3 403511 2.8 0.8
 2.4
 2.9
0.2
 1.6
1.2
 1.6
0.1
 0.3
-0.3
25 TYROBP transmembrane immune signaling adaptor TYROBP 476477 2.8 1.6
 1.4
 0.9
 0.9
 0.2
26 PTGS1 prostaglandin-endoperoxide synthase 1 403544 2.8 1.0
 2.1
 -0.3
 -0.1
 2.0
 0.2
27 KEL Kell metallo-endopeptidase 100855519 2.8 1.5
0.4
0.9
 -0.4
28 TMEM91 transmembrane protein 91 100682781 2.8 1.5
0.8
 0.8
 -0.7
29 EBI3 Epstein-Barr virus induced 3 485043 2.8 1.2
 1.8
 2.4
 3.0
 1.2
30 CTLA4 cytotoxic T-lymphocyte associated protein 4 403696 2.8 1.4
 1.6
 4.3
 3.9
 3.2
 6.5
31 CXCL13 C-X-C motif chemokine ligand 13 608156 2.8 1.5
 1.5
 3.0
 1.4
4.6
2.0
32 LOC607055 angiopoietin-related protein 5-like 607055 2.7 1.0
 2.1



33 LOC478984 low affinity immunoglobulin gamma Fc region receptor III 478984 2.7 1.1
 2.0
 0.8
0.8
 2.1
1.1
 2.1
1.2
 0.6
0.3
34 CD8A CD8a molecule 403157 2.7 1.2
 1.8
 5.8
 3.6
 3.6
 1.9
35 CD3E CD3e molecule 442981 2.7 1.2
 1.7
 4.1
 2.5
 2.8
 2.7
36 ZAP70 zeta chain of T cell receptor associated protein kinase 70 100271860 2.7 1.5
3.3
-2.0
 5.1
0.4
 3.4
0.2
 4.0
1.0
37 LOC608641 uncharacterized LOC608641 608641 2.7 1.2
 1.7
1.6

38 WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 119873288 2.7 1.5

1.0
 -0.1
 -0.9
39 SIT1 signaling threshold regulating transmembrane adaptor 1 611919 2.7 1.2
 1.7
 4.4
 1.2
 3.3
40 GIMAP4 GTPase, IMAP family member 4 475533 2.6 0.8
 2.2
 2.1
 0.6
 2.1
41 KIT KIT proto-oncogene, receptor tyrosine kinase 403811 2.6 0.9
 2.1
 -2.1
 -0.0
 -1.4
 0.9
42 RASSF7 Ras association domain family member 7 100856695 2.6 1.4
1.2
 -0.4
 -0.2
43 FAIM2 Fas apoptotic inhibitory molecule 2 477613 2.6 1.2
 1.7
 1.4
0.8
 1.0
-0.3
 -0.2
-0.2
 0.2
-1.8
44 CST7 cystatin F 485563 2.6 1.5
 1.3
 4.8
 5.8
 4.6
 2.0
45 IGFLR1 IGF like family receptor 1 484576 2.6 1.3
 1.5
 2.8
 1.4
 1.9
46 TOX thymocyte selection associated high mobility group box 486964 2.6 1.4
 1.5
 1.6
1.4
 1.8
1.0
 2.4
0.8
 1.5
1.4
47 DIPK1B divergent protein kinase domain 1B 491248 2.6 1.2
 1.6
 -0.1
 1.6
-1.4
 0.3
-1.0
 -1.0
-1.4
48 AIF1 allograft inflammatory factor 1 474841 2.6 1.3
 1.5
 0.7
-0.8
 2.1
-0.5
 0.6
-0.9
 1.0
49 GLCCI1 glucocorticoid induced 1 612938 2.6 0.9
 2.1
 1.9
 0.9
 2.6
 1.3
50 LOC100688768 uncharacterized LOC100688768 100688768





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