Orthologous genes in OrthoFinder**

Species Gene Description
 cfa-u.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 cfa-r.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 cfa-m.4   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 hsa-u.4   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 mmu-u.4   Hmgcr   3-hydroxy-3-methylglutaryl-Coenzyme A reductase 
 rno-u.3   Hmgcr   3-hydroxy-3-methylglutaryl-CoA reductase 
 mcc-u.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 gga-u.3   HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase 
 dre-u.3   hmgcra   3-hydroxy-3-methylglutaryl-CoA reductase a 
 dre-u.3   hmgcrb   3-hydroxy-3-methylglutaryl-CoA reductase b 
 dme-u.3   Hmgcr   HMG Coenzyme A reductase 
 cel-u.3   hmgr-1   3-hydroxy-3-methylglutaryl coenzyme A reductase 
 sce-u.3   HMG2   hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 
 sce-u.3   HMG1   hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 
 spo-u.3   isu1   Fe-sulfur cluster assembly protein Isu1 

close


Top 50 coexpressed genes to HMGCR (cfa-u.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 cfa100   Steroid biosynthesis  13 20 6.33
 cfa1212   Fatty acid metabolism  8 54 6.08
 cfa900   Terpenoid backbone biosynthesis  6 20 6.33
 cfa620   Pyruvate metabolism  5 39 6.80
 cfa3320   PPAR signaling pathway  5 69 5.54

close


cfa:HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) External Links;


Show/Hide Columns:        
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

cfa-u.3
for
HMGCR
cfa-r.3
for
HMGCR
cfa-m.4
for
HMGCR
hsa-u.4
for
HMGCR
mmu-u.4
for
Hmgcr
rno-u.3
for
Hmgcr
mcc-u.3
for
HMGCR
gga-u.3
for
HMGCR
dre-u.3
for
hmgcra
dre-u.3
for
hmgcrb
dme-u.3
for
Hmgcr
cel-u.3
for
hmgr-1
sce-u.3
for
HMG2
sce-u.3
for
HMG1
spo-u.3
for
isu1
1 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 479344 17.1 9.5
 8.1
 25.0
-0.0
 21.1
-1.1
 16.3
-1.5
 9.7
0.7
 15.0
0.3
 12.2
 1.7
 5.7
 4.1
 0.4
 7.4
2 SQLE squalene epoxidase 608021 14.2 7.2
 7.7
 20.0
 19.6
 18.6
 6.4
 16.2
 13.4
 -0.5

-0.3
 4.8
3 IDI1 isopentenyl-diphosphate delta isomerase 1 100687634 14.1 7.4
19.4
 16.9
 14.7
 4.1
2.4
 15.6
 7.1
 -0.2
 1.8
 1.3
 -0.8
 5.1
 -1.3
4 ACLY ATP citrate lyase 607852 13.6 8.1
 5.8
 10.0
 8.8
 8.4
 2.1
 7.0
 3.9
0.0
 2.0
-0.3
 1.3
 0.2
-0.1


5 FDFT1 farnesyl-diphosphate farnesyltransferase 1 477362 13.2 6.6
 7.2
 17.1
 16.1
 13.0
 2.5
 14.8
 7.9
 -0.8

0.1
 4.7
6 FDPS farnesyl diphosphate synthase 480129 13.2 7.1
 6.5
 12.8
 16.1
 12.7
 4.0
 12.4
 10.6
 0.1
 -0.9
 3.1
 -0.7
 4.1
7 CYP51A1 cytochrome P450 family 51 subfamily A member 1 475225 12.5 6.1
 6.9
 13.3
 22.4
 15.0
 5.5
15.6
 -0.7

0.8
 6.8
 -0.8
8 MSMO1 methylsterol monooxygenase 1 475491 11.9 5.3
 7.4
 20.3
 19.7
 16.6
 8.3
 19.1
 15.3
 -0.5

0.4
 5.5
9 ACAT2 acetyl-CoA acetyltransferase 2 484063 11.8 6.0
 6.3
 15.7
 11.7
1.0
 13.6
-0.2
6.8
 7.6
 0.9
 2.0



10 INSIG1 insulin induced gene 1 475554 11.5 6.3
 5.5
 15.6
1.2
 17.0
0.3
 12.4
-0.8
 2.1
0.4
 11.7
1.6
 8.9
0.3
 2.6
1.4




11 SC5D sterol-C5-desaturase 610411 11.1 6.4
 5.0
 12.8
 13.8
 10.5
 4.3
 8.2
 12.8
 -1.6

-0.4
 4.5
12 LDLR low density lipoprotein receptor 100683160 11.0 5.8
14.6
4.1
 17.7
5.1
 8.6
2.0
 3.1
1.8
 9.0
2.5
 6.3
5.6
 1.0
0.3
 1.0
0.3
 1.3
-0.2


13 NSDHL NAD(P) dependent steroid dehydrogenase-like 481079 10.7 5.6
 5.5
 14.6
 13.8
 10.4
 2.0
 14.4
 11.2
 0.3

0.0
 5.0
14 DHCR7 7-dehydrocholesterol reductase 483675 10.6 5.3
 5.7
 15.1
5.4
 11.1
9.8
 10.6
8.6
 4.7
2.9
 15.0
4.5
 10.5
8.9
 0.6
0.3
 -0.6
 -0.6
 2.0
-0.8
 5.7
1.1
15 LSS lanosterol synthase 491611 10.1 5.4
 5.1
 10.3
 13.8
 12.4
 2.9
 13.2
 15.8
 -0.9

-0.5
 5.0
 -1.0
16 EBP EBP cholestenol delta-isomerase 609430 9.9 4.6
 5.9
 10.6
 4.7
 6.7
 1.8
 11.9
 10.0
 2.1




17 MVD mevalonate diphosphate decarboxylase 489663 9.2 4.9
 4.7
 15.1
 14.3
2.9
 7.9
 9.2
 0.9
 2.4
 0.1
 -0.7
 5.0
 0.3
18 RDH11 retinol dehydrogenase 11 480366 8.6 4.6
 4.3
 8.6
0.7
 11.7
1.0
 4.1
1.2
 3.3
1.1
 6.8
0.8
 6.7
2.7
 2.4
1.6
 3.3
0.9
 3.9
2.5
 -1.2
 -0.2
19 DHCR24 24-dehydrocholesterol reductase 489573 8.5 4.8
 3.9
 13.0
 13.1
 10.6
 4.7
 13.1
 12.6
 -0.6
-0.4
-1.1


20 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 475939 8.1 4.4
 3.9
 6.1
 5.4
 2.3
 0.9
 6.6
 3.7
0.2
 1.0
0.6
 1.4
0.5
 2.2
0.2
 0.9
 1.2
 -0.1
-0.2
21 STARD4 StAR related lipid transfer domain containing 4 479141 7.8 4.7
 3.3
 0.4
 14.9
0.4
 10.0
0.5
 2.8
-1.0
 17.7
3.5
 3.5
1.4
 -0.2
-1.3
-0.1


22 FASN fatty acid synthase 483378 7.8 3.9
 4.4
 10.6
 7.8
 7.0
 1.7
 9.0
 4.8
 0.6
 0.9
0.6
 -0.1

-2.2
23 HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 609364 7.3 3.1
 4.7
 12.9
 13.8
 12.3
 2.0
 12.1
 10.3
 -1.4

0.2
 3.6
24 SCD stearoyl-CoA desaturase 486839 6.6 4.2
 2.4
 12.1
0.2
 7.1
5.1
 5.0
3.8
 2.6
-0.4
 6.5
0.4
 4.2
-0.3
 1.8
1.2
 2.1
2.0
 -0.4
-0.8
 3.1
 2.8
25 TM7SF2 transmembrane 7 superfamily member 2 476027 6.4 2.5
 4.4
 15.1
5.4
 11.1
9.8
 10.6
8.6
 4.7
2.9
 15.0
4.5
 10.5
8.9
 0.6
0.3
 -0.6
 -0.6
 2.0
-0.8
 5.7
1.1
26 ERG28 ergosterol biosynthesis 28 homolog 611962 6.3 3.4
 3.2
 11.0
 8.7
 7.3
 0.5
 6.6
 5.3
 -0.6

1.5
 5.4
27 MVK mevalonate kinase 486309 6.2 3.6
 2.8
 12.6
 10.3
 9.0
 1.6
 9.4
 6.7
 1.7
1.2
 -0.4
 4.7
 -1.0
28 AACS acetoacetyl-CoA synthetase 486240 6.1 3.0
 3.4
 5.6
 12.0
 11.1
 3.8
 14.3
 8.5
 -0.5
0.9


29 SLC25A1 solute carrier family 25 member 1 608348 5.9 3.2
 2.9
 6.5
 5.0
 5.1
 0.0
 1.6
 1.0
-0.1
 -0.2
-1.7
2.0
0.7
 -0.1
-2.1
 -0.4
-0.5
 -0.0
30 CYB5B cytochrome b5 type B (outer mitochondrial membrane) 610942 5.8 3.8
 2.1
 6.0
0.7
 6.5
1.0
 3.8
1.1
 0.5
-0.9
 2.3
2.0
 3.5
0.6
 1.2
-0.5
 0.1
-0.2
 -1.0
-1.5
 -0.8
 6.7
31 SELENOI selenoprotein I 100302747 5.8 3.1
6.2
 3.9
 2.4
 3.3
 6.0
-0.5
 2.0
 2.2
 0.5
0.3
 2.0
 2.5
0.2
 1.3
0.4
 -0.5
-1.0
32 FADS2 fatty acid desaturase 2 483792 5.8 2.9
 3.3
 8.8
8.0
 8.1
7.2
 5.5
4.2
 2.5
-0.2
 6.1
5.5
 10.9
 0.4
0.8
-0.1

-0.1
33 LOC102155379 uncharacterized LOC102155379 102155379 5.6 3.0












34 PCYT2 phosphate cytidylyltransferase 2, ethanolamine 607608 5.5 2.8
 3.0
 6.9
 8.0
 4.9
 0.6
 -0.6
 1.8
 3.5
 2.6
 1.2
-0.8
 1.4
 -1.3
 0.1
35 PLA2G3 phospholipase A2 group III 486361 5.2 3.1
 2.3
 4.6
0.4
 -0.1
 1.5
0.8
 2.6
0.2
 -0.4
-1.0
 2.5
0.1



36 TMEM41B transmembrane protein 41B 476845 5.2 2.9
 2.6
 5.0
 6.5
 2.9
 2.2
 2.4
 1.1
 2.8
 1.5
 1.7


37 DLAT dihydrolipoamide S-acetyltransferase 489406 5.1 3.1
 2.2
 2.8
 1.0
 1.9
 1.2
 0.5
 -0.4
 2.3
 1.8
 0.9
 1.7
 0.4
 -0.1
38 ACSL4 acyl-CoA synthetase long chain family member 4 481018 4.8 3.0
 1.9
 10.0
4.9
 8.5
7.6
 4.7
3.9
 5.0
4.3
 3.8
1.9
 2.0
1.2
 4.8
1.3
 1.0
 0.5
-1.1
 3.5
0.6
 1.8
1.6
39 ACACA acetyl-CoA carboxylase alpha 491130 4.8 2.5
 2.5
 9.5
-1.6
 5.5
-0.5
 5.7
0.3
 1.2
-1.4
 5.6
-1.9
 3.7
-1.1
 1.3
-0.9
 0.7
 0.7
 3.1
-1.0
 2.4
2.1
 -1.3
40 LOC102154725 methylsterol monooxygenase 1-like 102154725 4.7 2.5
20.3
 19.7
 16.6
 8.3
 19.1
 15.3
 -0.5

0.4
 5.5
41 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 489771 4.7 3.4
 1.3
 5.5
0.5
 4.9
0.9
 4.5
0.6
 1.3
0.6
 1.8
1.1
 1.0
0.5
 1.6
-1.1
 1.8
 1.7
 1.3
 0.7
 -0.5
42 SCARB1 scavenger receptor class B member 1 486241 4.5 2.3
 2.5
 2.7
 2.4
 2.2
 -0.5
 0.0
 0.2
 -0.1




43 WDR37 WD repeat domain 37 607652 4.5 1.8
 3.1
 2.3
 2.1
 2.4
 0.3
 1.7
 1.4
 1.2
 2.9
 2.8


44 ELOVL1 ELOVL fatty acid elongase 1 100855761 4.4 2.4
6.4
2.6
 4.0
3.5
 2.2
2.1
 1.4
1.4
 2.3
1.3
 5.8
3.1
 0.9
0.7
 1.4
1.2


-1.2
45 ENO1 enolase 1 479597 4.4 2.4
 2.2
 1.0
-0.7
 2.3
0.5
 1.7
-0.4
 0.5
-0.3
 1.8
0.1
 1.9
1.0
 1.1
0.2
 0.8
 2.7
 0.6
0.5
 1.0
0.3
46 PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial 480255 4.4 2.3
 2.4
 0.2
-0.4
 -0.4
-1.6
 0.1
-1.4
 -0.2
-0.7
 -0.7
 0.5
-0.2
 1.1
0.8
 -0.7
 1.6
0.1


47 LETM1 leucine zipper and EF-hand containing transmembrane protein 1 488807 4.4 2.6
 1.9
 1.1
 0.3
 1.8
 2.1
 -0.4
 -1.2
 1.4
 2.5
 6.0
 -0.1
-1.0
 1.0
-0.4
48 NARS1 asparaginyl-tRNA synthetase 1 607631 4.4 1.6
 3.2
 1.4
 1.0
 2.5
 3.4
 2.4
 0.9
 1.8
 -0.1
 0.8
 0.6
 0.2
 1.8
49 PDHB pyruvate dehydrogenase E1 subunit beta 476574 4.4 2.7
 1.7
 2.8
 0.5
 1.7
 0.2
 1.4
 0.0
 1.1
 2.2
 0.8
 1.4
 0.3
50 NIPA2 NIPA magnesium transporter 2 479002 4.3 2.0
 2.7
 2.1
 1.5
 0.5
 1.4
 1.2
-0.7
 1.1
-0.1
 3.9
-0.6
 0.2
 1.2

-0.6
The preparation time of this page was 0.6 [sec].