Orthologous genes in OrthoFinder**

Species Gene Description
 sce-m.4   HEM3   hydroxymethylbilane synthase 
 sce-u.3   HEM3   hydroxymethylbilane synthase 
 sce-r.3   HEM3   hydroxymethylbilane synthase 
 hsa-u.4   HMBS   hydroxymethylbilane synthase 
 mmu-u.4   Hmbs   hydroxymethylbilane synthase 
 rno-u.3   Hmbs   hydroxymethylbilane synthase 
 gga-u.3   HMBS   hydroxymethylbilane synthase 
 dre-u.3   hmbsb   hydroxymethylbilane synthase, b 
 dre-u.3   hmbsa   hydroxymethylbilane synthase a 
 dme-u.3   l(3)02640   lethal (3) 02640 
 mcc-u.3   HMBS   hydroxymethylbilane synthase 
 cfa-u.3   HMBS   hydroxymethylbilane synthase 

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Top 50 coexpressed genes to HEM3 (sce-m.4 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 sce260   Glycine, serine and threonine metabolism  2 30 -
 sce3015   mRNA surveillance pathway  3 48 -
 sce1200   Carbon metabolism  2 112 -
 sce1240   Biosynthesis of cofactors  2 131 -
 sce3010   Ribosome  2 187 -

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sce:HEM3 (hydroxymethylbilane synthase) External Links;


Show/Hide Columns:        
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

sce-m.4
for
HEM3
sce-u.3
for
HEM3
sce-r.3
for
HEM3
hsa-u.4
for
HMBS
mmu-u.4
for
Hmbs
rno-u.3
for
Hmbs
gga-u.3
for
HMBS
dre-u.3
for
hmbsb
dre-u.3
for
hmbsa
dme-u.3
for
l(3)02640
mcc-u.3
for
HMBS
cfa-u.3
for
HMBS
1 PUF3 mRNA-binding protein PUF3 850647 YLL013C 5.7 7.8
 1.7
 0.1
-1.3
 0.1
-0.5
 -0.3
-1.2
 0.9
-2.2
 -0.6
-0.7
 -1.0
-1.3
 -0.5
 -1.3
-2.0
 -1.4
-1.7
2 TDA10 putative ATP-dependent kinase 853119 YGR205W 4.2 6.3
 1.9








3 PSP2 Psp2p 854991 YML017W 4.1 6.3
 1.9








4 SRO9 Sro9p 850320 YCL037C 3.4 4.1
 0.5
 1.3
0.5
 -0.6
 -0.2
-0.8
 0.2
-0.3
 1.3
-0.5
 2.1
-0.2
 -0.1
 0.7
-0.4
 1.8
-0.1
5 CPD1 2',3'-cyclic-nucleotide 3'-phosphodiesterase 853162 YGR247W 3.0 3.8
 0.6








6 PSR1 phosphatase 850650 YLL010C 2.8 4.1
 1.2
 0.7
-0.7
 0.9
0.4
 2.1
0.9
 0.2
-1.7
 -1.1
-1.2
 1.3
0.1
 -3.1
 0.1
-0.5
 0.7
-0.5
7 HOS2 histone deacetylase HOS2 852681 YGL194C 2.7 3.6
 0.8
 1.5
0.3
 1.8
0.8
 1.0
0.2
 1.4
1.3
 1.7
0.1
 0.0
-1.3
 -2.0
 1.7
0.2
 1.5
0.1
8 NSE4 Smc5-Smc6 complex subunit NSE4 851453 YDL105W 2.2 2.0
 -0.2
 2.4
-0.9
 2.1
-0.9
 1.7
-1.0
 2.5
 2.1
 -0.1
 -1.8
 1.5
-1.0
 -0.9
-1.0
9 THP3 Thp3p 856158 YPR045C 2.1 3.4
 1.2
 -1.9
 -0.5
 -0.1
 0.4
 -0.7
 -0.3
 -1.5
 -0.9
 -0.9
10 CAB3 phosphopantothenoylcysteine decarboxylase complex subunit CAB3 853774 YKL088W 1.9 2.9
 0.9
 0.9
2.5
 1.5
 -0.0
 2.0
2.4
11 GPI8 GPI-anchor transamidase 851931 YDR331W 1.9 3.4
 1.5
 -0.2
 -0.2
 0.7
 0.4
 1.1
 0.5
 -0.8
 -0.6
 -0.2
12 YGR126W uncharacterized protein 853027 YGR126W 1.8 2.5
 0.6








13 AGP2 Agp2p 852429 YBR132C 1.8 1.7
 -0.1








14 NUF2 kinetochore-associated Ndc80 complex subunit NUF2 854085 YOL069W 1.8 1.8
 0.0
 0.1
 -0.2
 -0.1
 0.3
 -0.0
 0.3
1.0
 -0.6
15 ETP1 Etp1p 856376 YHL010C 1.8 2.8
 1.0
 -1.5
 -0.1
 -1.8
 1.6
 -0.2
 -0.2
 -0.1
 2.0
 -0.4
16 SAC1 phosphatidylinositol-3-phosphatase SAC1 853668 YKL212W 1.7 4.1
 2.2
 -0.1
 0.1
 -1.1
 1.6
 2.0
0.9
 0.7
0.3
 2.8
 -0.1
 -0.1
17 HEM1 5-aminolevulinate synthase 851818 YDR232W 1.7 3.4
 1.6
 3.2
0.3
 4.4
1.2
 1.8
1.4
 3.3
 5.5
-0.6
 2.5
0.4
 7.1
 1.8
1.4
 2.1
-0.8
18 ARE2 sterol acyltransferase 855753 YNR019W 1.6 1.2
 -0.4
 0.9
 0.1
 1.1
 0.7
 0.6
-0.2
 1.7
0.4
 0.5
 -0.1
 0.9
19 DHH1 DExD/H-box ATP-dependent RNA helicase DHH1 851394 YDL160C 1.6 2.6
 0.9
 0.4
 -1.0
 0.5
 0.9
 0.7
0.3
 1.1
0.1
 -0.9
 0.2
 0.5
20 PPH22 phosphoprotein phosphatase 2A catalytic subunit PPH22 851339 YDL188C 1.6 3.0
 1.3
 -0.3
-0.5
 2.5
0.2
 0.4
-0.0
 3.2
1.4
 1.4
1.4
 1.5
1.2
 0.7
-0.3
 0.8
0.4
 3.6
0.4
21 MRP4 mitochondrial 37S ribosomal protein MRP4 856384 YHL004W 1.6 2.8
 1.2
 2.2
 1.2
 0.9
 0.8
 0.4
 2.2
 2.7
 0.8
 1.8
22 PPT1 protein serine/threonine phosphatase 853023 YGR123C 1.6 2.4
 0.8
 0.6
 0.2
 -0.0
0.5
 3.0
 0.0
 -1.1
 1.7
23 IDP1 isocitrate dehydrogenase (NADP(+)) IDP1 851493 YDL066W 1.5 2.5
 0.9
 1.4
1.1
 2.0
1.5
 1.4
0.8
 2.2
0.4
 -0.9
-1.7
 0.4
-1.4
 2.7
 0.5
0.0
 0.7
0.2
24 TIF6 translation initiation factor 6 856126 YPR016C 1.5 2.0
 0.5
 1.1
 -0.2
 -1.1
 3.1
 -0.9
 1.4
 1.1
 0.4
 2.6
25 MSS116 ATP-dependent RNA helicase 851775 YDR194C 1.5 2.4
 0.9








26 AIM36 Aim36p 855189 YMR157C 1.5 1.8
 0.3








27 ADA2 chromatin-binding transcription regulator ADA2 852059 YDR448W 1.4 3.2
 1.7
 0.6
-0.1
 0.7
0.2
 0.8
-0.1
 0.2
-0.0
 -1.1
-2.3
 -0.8
-0.8
 -0.3
-0.3
 0.6
0.1
 1.5
1.2
28 CPS1 Gly-Xaa carboxypeptidase 853267 YJL172W 1.4 0.5
 -0.9
 -0.2
 -0.3
 0.9
 1.5
 -0.4
-0.6
 -0.3
-0.7
0.4
 -0.6
29 MCK1 serine/threonine/tyrosine protein kinase MCK1 855409 YNL307C 1.4 1.3
 -0.1








30 SUA7 transcription factor TFIIB 856201 YPR086W 1.4 2.7
 1.2
 -0.9
 -1.7
 0.4
 2.4
 -0.5
 -2.0
 -0.5
 -1.0
 0.0
31 SKY1 serine/threonine protein kinase SKY1 855256 YMR216C 1.4 2.8
 1.4
 1.5
-0.1
 0.5
-1.2
 -0.2
-0.5
 1.1
 1.3
0.4
 2.0
1.9
 -0.4
-0.8
 1.1
-0.9
 0.4
0.2
32 FEX1 fluoride transporter 854572 YOR390W 1.4 2.1
 0.7








33 CCC1 Ccc1p 850917 YLR220W 1.4 2.3
 0.9








34 LEM3 Lem3p 855393 YNL323W 1.4 2.1
 0.8
 -0.2
-1.6
 -0.5
-0.5
 0.7
-2.0
 0.6
-0.1
 0.2
0.1
 0.6
-0.4
 -0.0
 -0.3
-0.6
 -0.6
-1.7
35 VHS1 putative serine/threonine protein kinase VHS1 851834 YDR247W 1.4 2.3
 1.0








36 HAM1 nucleoside triphosphate pyrophosphohydrolase HAM1 853532 YJR069C 1.4 1.4
 0.0
 2.1
 2.6
 2.1
 1.7
 0.2
 0.8
 -0.4
 0.6
 3.7
37 SGN1 Sgn1p 854817 YIR001C 1.3 2.8
 1.4
-0.7
 -0.8
 0.3
 0.3
-0.8
 -0.4
-1.4
 -2.3
 -0.2
 1.2
38 RMD5 ubiquitin-protein ligase RMD5 851842 YDR255C 1.3 1.5
 0.2
 2.3
0.5
 1.7
0.2
 1.8
-0.2
 1.5
 -0.9
 0.5
 -0.2
 2.8
-0.3
 4.0
1.6
39 YNL035C uncharacterized protein 855695 YNL035C 1.3 2.5
 1.1
 0.6
 0.9
 0.6
 0.6
 1.1
 1.6
1.3
 -0.2
40 NAT5 peptide alpha-N-acetyltransferase subunit NAT5 854427 YOR253W 1.3 2.1
 0.8
 -0.3
 0.1
 -0.7
 -0.1
 1.2
 2.2
 -1.7
 0.0
 1.8
41 CDS1 phosphatidate cytidylyltransferase 852317 YBR029C 1.3 1.1
 -0.2
 -0.9
-1.8
 -0.9
-1.0
 -0.4
-0.9
 2.0
0.1
 1.9
0.5
 0.1
-0.3
 0.4
 -0.2
-0.5
 0.1
-0.9
42 MRPS28 mitochondrial 37S ribosomal protein MRPS28 851937 YDR337W 1.3 1.8
 0.5
 2.6
 1.8
 2.8
 2.1
 0.4
 2.9
 2.5
 2.2
 2.5
43 TEM1 Ras family GTPase TEM1 854938 YML064C 1.3 2.1
 0.8








44 YBR238C uncharacterized protein 852540 YBR238C 1.3 2.6
 1.3








45 TRI1 Tri1p 855273 YMR233W 1.3 2.6
 1.3





-1.2

46 HEK2 Hek2p 852248 YBL032W 1.3 1.8
 0.5








47 NOT3 CCR4-NOT core subunit NOT3 854773 YIL038C 1.3 2.2
 1.0
 -0.7
 0.1
 -0.5
-0.3
-0.7
 -0.0
-1.1
 -0.8
 -0.7
 -0.2
48 UBP8 ubiquitin-specific protease UBP8 855263 YMR223W 1.3 2.8
 1.5
 -0.9
-1.1
 -0.6
-2.5
 -0.8
-2.1
 -0.3
 -2.0
 -1.4
 -0.8
 0.2
-0.7
 0.1
-0.6
49 PPQ1 protein-serine/threonine phosphatase 855923 YPL179W 1.3 1.9
 0.6
 1.0
0.3
 4.5
1.3
 4.2
1.1
 2.8
1.6
 1.2
1.0
 0.7
0.1
 0.2
0.1
 1.2
-0.3
 3.0
0.8
50 MRP51 mitochondrial 37S ribosomal protein MRP51 855985 YPL118W 1.2 2.2
 0.9








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