Orthologous genes in OrthoFinder**

Species Gene Description
 rno-r.3   Hmgcs2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 rno-u.3   Hmgcs2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 rno-m.5   Hmgcs2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 rno-u.3   Hmgcs1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 mmu-u.4   Hmgcs2   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 
 mmu-u.4   Hmgcs1   3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 
 hsa-u.4   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 hsa-u.4   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 mcc-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 mcc-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 cfa-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 cfa-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 gga-u.3   HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 
 gga-u.3   HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 
 dre-u.3   hmgcs1   3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 
 dme-u.3   Hmgs   HMG Coenzyme A synthase 
 cel-u.3   hmgs-1   Hydroxymethylglutaryl-CoA synthase 
 sce-u.3   ERG13   hydroxymethylglutaryl-CoA synthase 

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Top 50 coexpressed genes to Hmgcs2 (rno-r.3 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 rno71   Fatty acid degradation  11 47 6.54
 rno1212   Fatty acid metabolism  7 57 6.11
 rno3320   PPAR signaling pathway  6 78 6.91
 rno4146   Peroxisome  9 85 6.69
 rno62   Fatty acid elongation  5 27 7.80

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rno:Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) External Links;


Show/Hide Columns:        
Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID LINK Target Reference

rno-r.3
for
Hmgcs2
rno-u.3
for
Hmgcs2
rno-m.5
for
Hmgcs2
rno-u.3
for
Hmgcs1
mmu-u.4
for
Hmgcs2
mmu-u.4
for
Hmgcs1
hsa-u.4
for
HMGCS2
hsa-u.4
for
HMGCS1
mcc-u.3
for
HMGCS1
mcc-u.3
for
HMGCS2
cfa-u.3
for
HMGCS2
cfa-u.3
for
HMGCS1
gga-u.3
for
HMGCS2
gga-u.3
for
HMGCS1
dre-u.3
for
hmgcs1
dme-u.3
for
Hmgs
cel-u.3
for
hmgs-1
sce-u.3
for
ERG13
1 Cpt1a carnitine palmitoyltransferase 1A 25757 4.3 8.5
 3.8
 -0.0
-1.1
 6.2
1.0
 -0.1
-0.5
 3.1
-1.3
 -1.3
-2.4
 0.3
-0.5
 2.6
-1.5
 0.9
-0.1
 -0.0
-1.5
 0.9
 1.5
 1.6
1.6
 0.4
 -2.1
2 Angptl4 angiopoietin-like 4 362850 3.8 7.0
 2.8
 -0.3
 7.3
 -0.7
 1.1
 -1.0
 -1.0
 1.1
 0.6
 -2.4
 1.1
 0.3
 1.6


3 Ech1 enoyl-CoA hydratase 1 64526 3.7 7.3
 3.2
 -0.9
 4.9
 0.7
 3.4
 1.4
 0.2
 0.6

1.6
 1.4
 0.3
 0.9
 0.8
0.1
4 Sult1a1 sulfotransferase family 1A member 1 83783 3.7 7.0
 3.0
 1.1
1.1
 5.7
1.8
 1.4
1.0
 4.6
3.1
 1.1
0.7
 1.2
0.4
 2.4
1.8
 2.6
2.4
 0.7
0.6
 3.4
1.1
 1.0
0.8
 2.0
1.1
 1.8
1.1
 0.1
5 Eci2 enoyl-CoA delta isomerase 2 291075 3.4 5.7
 2.0
 1.2
0.8
 6.0
-0.1
 0.6
-0.1
 1.7
 -0.1
 0.4
 -0.4
 0.6
 1.2
 0.8
 2.4
 1.9
 -0.6
 -0.1
-0.6
 1.1
-0.4
6 Eci1 enoyl-CoA delta isomerase 1 29740 3.3 5.4
 1.9
 0.1
 3.0
 -0.4
 1.3
 -0.4
 -0.7
 -0.9
 0.7
 1.2
 1.7
 0.6
 -0.6
 1.5
0.8

7 Acaa2 acetyl-CoA acyltransferase 2 170465 3.2 6.7
 3.1
 0.8
 6.3
 0.6
 2.3
 0.8
 0.4
 2.7
 2.8
 0.7
 1.5
 2.7
 1.1
 1.1
 0.5
8 Cpt2 carnitine palmitoyltransferase 2 25413 3.1 5.5
 2.1
 1.0
 3.8
 0.8
 2.1
 -0.2
 0.1
 1.3
 0.7
 2.2
 0.5
 1.4
 3.7
 1.5
 1.6
 -1.1
9 Crot carnitine O-octanoyltransferase 83842 3.0 5.3
 2.1
 1.0
 2.7
 1.9
 1.4
 -0.6
 1.4
 0.6
 0.0
 2.1
 1.0
 0.3
 1.0
 1.6
 -0.5
10 Acot1 acyl-CoA thioesterase 1 50559 3.0 6.2
 2.9
 1.7
1.0
 7.2
3.9
 0.8
0.6
 2.4
2.0
 2.3
0.9
 1.9
1.1
 2.2
1.9
 1.7
1.7
 1.5
1.3
 3.5
0.7
 1.5
0.1
 3.3
1.8
0.3
0.1
11 Aldh3a2 aldehyde dehydrogenase 3 family, member A2 65183 2.8 4.2
 1.2
 2.3
-0.2
 2.5
0.9
 0.5
0.5
 2.3
1.0
 0.8
0.3
 2.3
0.4
 1.4
0.8
 0.9
-0.3
 -1.0
-1.2
 1.9
0.6
 1.8
0.9
 0.2
0.1
 1.0
 1.3
-0.4
 4.4
12 Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase 171142 2.8 5.4
 2.4
 1.3
 3.9
 0.5
 2.0
 0.9
 2.4
 1.0
 1.3
 2.0
 2.1
 1.0
 0.4


13 Retsat retinol saturase 246298 2.7 4.4
 1.5
 -0.1
 4.6
 -0.6
 1.4
 1.0
 1.1
 0.3
 1.0
 2.1
 2.5
 0.4
 3.3
-0.1


14 Pex11a peroxisomal biogenesis factor 11 alpha 85249 2.7 4.8
 1.9
 0.1
0.0
 3.8
0.9
 -0.1
-1.3
 3.4
0.3
 0.2
-0.8
 0.7
0.6
 1.6
-0.4
 1.4
0.0
 0.9
-0.2
 2.8
1.3
 0.7
-0.7
 0.1
-0.8
 1.0
1.4
15 Decr1 2,4-dienoyl-CoA reductase 1 117543 2.7 5.5
 2.5
 0.6
 3.8
 0.8
 1.5
 0.8
 0.5
 0.9
 -0.9
 -0.0
 1.4
 1.2
 0.5
0.7
0.2
16 Acot2 acyl-CoA thioesterase 2 192272 2.7 5.3
 2.5
 1.7
1.0
 7.2
3.9
 0.8
0.6
 2.4
2.0
 2.3
0.9
 1.9
1.1
 2.2
1.9
 1.7
1.7
 1.5
1.3
 3.5
0.7
 1.5
0.1
 3.3
1.8
0.3
0.1
17 Pdk4 pyruvate dehydrogenase kinase 4 89813 2.6 4.8
 1.9
 1.5
-0.5
 4.7
0.2
 2.1
0.2
 2.6
0.8
 1.2
0.4
 0.1
-0.5
 1.0
0.7
 0.8
-0.1
 1.6
-0.3
 0.2
-0.5
 0.4
-0.9
 0.6
-0.2
 -0.2
 0.1
18 Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 79244 2.6 3.6
 0.9
 1.9
 3.6
 2.5
 1.2
 2.8
 3.2
 0.9
 1.9
 2.8
 2.1
 2.9
 1.8
 1.5
 1.3
-0.4
 -0.3
19 Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 313375 2.6 3.5
 0.8
 0.4
0.3
 3.5
1.9
 1.4
0.6
 3.1
 0.3
 0.5
 0.2
 1.5
 -0.5
 0.9
0.1
 0.9
0.1
 1.5
0.8
 1.1
0.6
 3.3
1.9
20 Adh1 alcohol dehydrogenase 1 (class I) 24172 2.6 4.7
 2.0
 1.9
0.9
 2.6
1.3
 1.4
0.6
 5.0
4.0
 1.4
1.0
 1.9
0.7
 2.4
2.1
 1.8
1.5
 2.0
1.8
 1.8
1.7
 0.8
-0.3
 -0.8
 0.2
 0.0
 0.6
21 Aox1 aldehyde oxidase 1 54349 2.5 4.0
 1.4
 0.7
0.4
 3.4
1.6
 -0.3
-0.4
 1.6
0.8
 -0.4
-1.0
 0.3
 1.6
1.4
 0.2
-1.0
 -0.6
-1.0
 0.7
-0.9
 0.9
-0.8
 0.4
0.3
 -1.7
 1.4
0.5
22 Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 289456 2.4 3.6
 1.0
 0.9
0.4
 4.1
3.7
 0.3
-0.5
 1.4
0.5
 0.4
0.2
 0.6
0.1
 2.2
2.2
 2.2
1.8
 1.3
0.8
 1.9
1.2
 1.2
0.7
 0.8
0.5
 1.5
1.2
 1.4
0.8
 0.1
-0.6
23 Acad11 acyl-CoA dehydrogenase family, member 11 315973 2.3 3.4
 0.9
 0.6
-0.1
 1.9
0.7
 0.4
-0.2
 1.3
 -0.8
 2.0
0.6
 0.7
-0.4
 0.9
0.6
 0.8
0.3
 0.8
-0.1
 1.7
-0.1
 1.4
0.5
24 Paqr7 progestin and adipoQ receptor family member 7 313615 2.3 4.2
1.4
0.3
 2.2
-0.1
 1.3
0.5
 0.6
-1.2
 -0.3
-0.3
 1.2
1.1
 -0.7
-1.3
 1.4
 -0.9
 0.9
-0.1
 1.1
-0.4
 0.6
0.3
0.6
25 Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 25146 2.3 3.8
 1.4
 0.8
 1.1
 0.7
 1.6
 0.8
 0.3
 0.6
 1.6
 -0.8
 1.0
 -0.2
 -0.8
-1.1


26 Colq collagen like tail subunit of asymmetric acetylcholinesterase 29755 2.3 3.9
 1.4
 -0.7

0.5
 -0.6
 0.4
 -1.0



0.4
-0.7


27 Ephx2 epoxide hydrolase 2 65030 2.3 4.5
 2.0
 0.5
 5.0
 0.1
 1.9
 0.0
 0.2
 0.7
 1.6
 0.2
 1.9
 1.0
 1.4


28 Acot3 acyl-CoA thioesterase 3 314304 2.3 4.1
1.7
1.0
 7.2
3.9
 0.8
0.6
 2.4
2.0
 2.3
0.9
 1.9
1.1
 2.2
1.9
 1.7
1.7
 1.5
1.3
 3.5
0.7
 1.5
0.1
 3.3
1.8
0.3
0.1
29 Hacl1 2-hydroxyacyl-CoA lyase 1 85255 2.3 2.9
 0.6
 2.8
 2.2
 3.3
 0.5
 0.0
 0.9
 0.6

1.2
 0.1
 0.5
 -0.8
 -1.6
 0.1
30 Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha 170670 2.3 4.9
 2.4
 -0.1
 3.9
 0.8
 2.1
 1.0
 0.6
 1.8
 2.1
 2.8
 1.3
 3.0
 3.4
2.1
 1.8
 1.5
-0.7
31 Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 50549 2.2 4.0
1.6
1.0
 5.5
4.6
 0.6
0.5
 4.5
2.2
 1.5
1.1
 0.7
0.5
 3.4
1.8
 3.9
3.4
 0.8
0.5
 2.1
1.9
 2.0
1.0
 0.4
-0.4
 1.9
1.8
 1.5
1.3
 -0.1
32 Abhd14b abhydrolase domain containing 14b 300983 2.2 2.5
 0.3
 -0.9
-2.2
 1.9
-0.5
 0.8
0.3
 0.6
0.4
 -0.7
-1.9
 1.1
 1.1
 0.5
-0.7
 0.1
-1.5
 0.7
0.5
 -0.6
-0.9
 1.5
0.6
2.2
33 Vnn1 vanin 1 29142 2.2 4.0
 1.6
 2.0
0.1
 4.5
1.7
 2.9
0.9
 0.5
0.1
 -0.0
-0.3
 0.5
0.4
 0.7
0.2
 1.5
1.0
 0.3
-0.4
 0.3
-0.1
 1.0
0.7
 -0.5
 0.2
0.0

34 Lcat lecithin cholesterol acyltransferase 24530 2.2 3.8
 1.5
 0.8
-0.8
 2.9
-0.5
 0.5
-0.9
 0.7
-0.0
 -0.1
-0.6
 -0.6
-0.8
 -0.5
-0.6
 0.1
-0.0
 0.0
-0.2
 2.5
-2.2
 -0.6
-1.4
 -0.5
-2.5
 -0.6
-1.2
 -0.4
35 Fbxo21 F-box protein 21 360818 2.2 3.6
 1.3
 0.5
 2.2
 1.2
 0.2
 0.5
 0.0
 -0.5
 1.0
 1.1
 0.5
 -1.0
 -0.7


36 Dhrs3 dehydrogenase/reductase 3 313689 2.2 3.5
 1.2
 0.3
 2.3
 0.6
 -0.1
 -1.7
 -2.7
 0.1
 0.6
 -1.7
 1.0
 0.6
 0.3
-0.5


37 Hsdl2 hydroxysteroid dehydrogenase like 2 313200 2.2 4.5
 2.2
 0.1
 4.9
 1.3
 2.7
 -0.3
 1.2
 1.2
 1.5
 2.5
 0.4
 0.4
 -0.3
 1.7
 2.0
-0.5
38 Acox1 acyl-CoA oxidase 1 50681 2.1 3.3
 1.1
 2.0
0.0
 2.9
2.1
 2.7
1.0
 2.4
1.3
 1.0
-0.2
 3.6
0.5
 0.8
0.3
 1.5
1.3
 1.8
0.5
 1.9
-0.3
 2.1
-0.2
 2.7
 1.6
1.6
 1.4
0.5
 -0.4
39 Fmo1 flavin containing dimethylaniline monoxygenase 1 25256 2.1 2.5
 0.4
 -0.1
-0.5
 5.0
2.9
 0.5
-0.4
 2.4
1.7
 0.8
0.5
 1.6
0.9
 2.0
0.3
 3.8
1.8
 1.6
1.5
 1.4
-0.2
 0.5
-0.5
 0.3
-0.6
 1.6
-0.6
 2.4
2.1
 -0.3
40 Agt angiotensinogen 24179 2.1 3.1
 1.0
 -0.2
 4.2
 0.2
 2.5
 0.3
 1.1
 0.8
 2.9
 2.5
 2.4
 1.6
 -0.7


41 Abhd1 abhydrolase domain containing 1 313917 2.1 3.8
 1.6
 1.3
1.1
 1.8
1.3
 0.7
0.2
 0.6
 1.1
 0.2
 -0.4
 0.2
-0.8
 0.6
-0.5
 2.5
-0.2
 3.6
0.1
 1.8
 0.5
 1.6
1.3
 2.1
0.5
42 Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 25086 2.1 3.3
 1.2
 2.0
1.4
 3.4
2.4
 1.8
1.2
 4.4
4.0
 0.9
0.6
 1.7
1.2
 3.0
2.7
 4.5
3.9
 1.2
0.8
 2.1
2.0
 1.3
0.9
 1.0
0.7
0.4
43 RGD1310587 similar to hypothetical protein FLJ14146 360894 2.1 2.2
 0.2
 0.7
 2.2
 1.0
 1.6
 1.1
 0.3
 -0.6

0.4
 0.1
 0.2


44 Selenop selenoprotein P 29360 2.1 2.8
 0.7
 0.4
 2.6
 0.6
 1.0
 0.4
 1.4
 0.5
 -0.1
 -0.7
 3.3
0.6
 1.5
0.3
 0.2
-0.4


45 Maob monoamine oxidase B 25750 2.0 2.7
 0.6
 2.3
1.0
 3.7
1.0
 2.0
1.1
 2.2
1.0
 0.4
-0.0
 0.4
0.3
 2.6
2.3
 2.7
-0.6
 1.0
-0.1
 0.3
-0.6
 0.3
0.1
 1.0
0.3
 -0.3
 1.1
46 Slc25a20 solute carrier family 25 member 20 117035 2.0 4.4
 2.2
 0.1
 5.3
 -0.3
 3.6
 -1.2
 0.9
 2.4
 1.2
 -0.6
 1.3
 1.0
 2.5
 3.7
1.3
 1.5
0.3
 1.8
-1.4
47 Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 171522 2.0 2.8
 0.7
 0.5
0.1
 4.4
3.2
 0.2
-0.1
 1.3
 0.5
 -0.2
-0.4
 1.1
0.1
 1.6
 0.6
 0.0
 -0.4

0.2
48 Gpd1 glycerol-3-phosphate dehydrogenase 1 60666 2.0 2.9
 0.9
 0.3
-0.5
 1.6
0.9
 1.1
0.4
 3.1
0.8
 1.0
0.5
 1.2
 0.9
 2.6
-0.8
 2.4
2.0
 2.2
0.1
 1.8
-0.5
 1.0
0.3
 0.7
-0.2
 0.4
-0.2
 1.2
-0.8
49 Cyp2t1 cytochrome P450, family 2, subfamily t, polypeptide 1 171380 2.0 3.3
 1.2
 0.7





0.1
 -1.2





50 Vwa8 von Willebrand factor A domain containing 8 290381

0.2
 3.4
 0.2
 0.5
 0.4
 0.3
 -0.5
 0.9
 2.0
 0.5
 1.5
 1.0
 2.5
 0.5
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