Orthologous genes in OrthoFinder**

Species Gene Description
 hsa-r.6   DPYD   dihydropyrimidine dehydrogenase 
 hsa-u.4   DPYD   dihydropyrimidine dehydrogenase 
 hsa-m.7   DPYD   dihydropyrimidine dehydrogenase 
 hsa-m2.4   DPYD   dihydropyrimidine dehydrogenase 
 mcc-u.3   DPYD   dihydropyrimidine dehydrogenase 
 mmu-u.4   Dpyd   dihydropyrimidine dehydrogenase 
 rno-u.3   Dpyd   dihydropyrimidine dehydrogenase 
 cfa-u.3   DPYD   dihydropyrimidine dehydrogenase 
 gga-u.3   DPYD   dihydropyrimidine dehydrogenase 
 dre-u.3   dpyda.1   dihydropyrimidine dehydrogenase a, tandem duplicate 1 
 dre-u.3   dpydb   dihydropyrimidine dehydrogenase b 
 dme-u.3   su(r)   suppressor of rudimentary 
 cel-u.3   dpyd-1   Dihydropyrimidine dehydrogenase [NADP(+)] 

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Top 50 coexpressed genes to DPYD (hsa-r.6 coexpression data)

 KEGG ID   Pathway name   #genes in coex list   #genes in genome   -log10(p)   Link to the KEGG* map 
(Multiple genes)
 hsa4722   Neurotrophin signaling pathway  4 112 3.45
 hsa4936   Alcoholic liver disease  4 118 3.37
 hsa4010   MAPK signaling pathway  4 263 2.10
 hsa4020   Calcium signaling pathway  3 240 -
 hsa4151   PI3K-Akt signaling pathway  4 354 -

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hsa:DPYD (dihydropyrimidine dehydrogenase) External Links;


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Show Coexpressed Genes
UMAP
Gene Function KEGG Entrez
Gene
ID		 Other ID CoexPub LINK Target Reference

hsa-r.6
for
DPYD
hsa-u.4
for
DPYD
hsa-m.7
for
DPYD
hsa-m2.4
for
DPYD
mcc-u.3
for
DPYD
mmu-u.4
for
Dpyd
rno-u.3
for
Dpyd
cfa-u.3
for
DPYD
gga-u.3
for
DPYD
dre-u.3
for
dpyda.1
dre-u.3
for
dpydb
dme-u.3
for
su(r)
cel-u.3
for
dpyd-1
1 CLIP4 CAP-Gly domain containing linker protein family member 4 79745 0 4.9 4.7
 1.8
 3.4
 -0.6
-1.4
 1.4
0.4
 0.8
-0.1
 -0.4
-0.6
 0.0
 1.5
0.5
 0.9
0.0

2 ANKRD44 ankyrin repeat domain 44 91526 0 4.6 4.0
 1.8
 2.5
 0.1
-0.7
 0.1
-0.4
 0.8
-1.0
 -0.1
-1.5
 1.5
0.1
 0.9
0.0
 2.0
1.0

3 C5 complement C5 727 0 4.5 3.8
 1.0
 2.1
 0.6
 1.7
 1.8
1.1
 -0.1
 3.5

4 SLC9A9 solute carrier family 9 member A9 285195 0 4.5 4.2
 1.1
 2.9
 0.7
0.0
 0.9
0.1
 1.5
-0.2
 0.6
0.0
 1.4
0.3
 0.6
0.5
 0.2
0.2
 -0.2
 -0.9
5 UTRN utrophin 7402 0 4.4 4.2
 1.7
 3.0
 0.6
0.3
 -1.1
 1.2
 1.3
 2.1
-0.1
 1.6
-1.5
 1.8
-0.1
 -1.5
6 RCBTB2 RCC1 and BTB domain containing protein 2 1102 0 4.4 3.8
 1.8
 2.3
 0.9
 1.5
 1.3
 1.3
 -1.0
 1.0
 0.9

7 PTPRC protein tyrosine phosphatase receptor type C 5788 0 4.3 3.5
 1.2
 1.9
 -0.1
 1.4
 0.9
 2.0
 0.3
 -1.0
 0.3
 -0.8
 -1.3
8 MAP3K5 mitogen-activated protein kinase kinase kinase 5 4217 0 4.3 4.6
 1.3
 3.8
 1.6
0.5
 1.1
-0.2
 0.4
0.2
 1.6
1.3
 0.6
0.5
 1.0
-0.0
 0.1
-0.1
 -0.4
 1.5
9 DOCK2 dedicator of cytokinesis 2 1794 0 4.2 4.3
 1.1
 3.3
 3.9
0.6
 1.4
0.6
 1.9
1.6
 1.8
1.0
 1.9
1.7
 2.3
2.1
 1.8
1.6
 0.4
-0.5
 -0.5
10 SBF2 SET binding factor 2 81846 0 4.1 4.3
 1.8
 3.5
 3.2
0.7
 1.1
-0.0
 2.0
-1.0
 2.1
-0.4
 1.8
-0.6
 0.7
-0.1
 0.2
0.1
 -2.0
 1.5
11 NR3C1 nuclear receptor subfamily 3 group C member 1 2908 0 4.1 4.4
 1.1
 3.6
 -1.1
 1.0
 1.3
 0.8
 0.2
 0.1
 -0.7

12 TMEM71 transmembrane protein 71 137835 0 4.0 3.5
 1.9
 2.1
 -0.9
 0.0
 0.8
 -0.3
 -0.7
 0.1
 -1.9

13 CFH complement factor H 3075 0 3.9 3.4
 1.7
 2.0
 1.5
0.4
 3.0
2.7
 2.9
1.9
 1.4
-0.1
 1.2
 -0.7
-1.0
 3.4
2.4

14 MCTP1 multiple C2 and transmembrane domain containing 1 79772 0 3.9 3.5
 1.8
 2.3
 2.9
0.5
 1.0
-0.1
 0.5
 1.0
-0.4
 0.9
-0.2
 1.3
1.2
 0.7
0.0
 -0.3
15 ALCAM activated leukocyte cell adhesion molecule 214 0 3.9 3.5
 0.9
 2.2
 0.9
 0.4
 1.7
 1.0
 0.6
 -0.2
-1.7
 0.4
-0.9

16 NEK7 NIMA related kinase 7 140609 0 3.7 3.7
 1.7
 2.7
 0.3
-0.5
 -0.2
-0.3
 -0.1
-0.2
 1.1
0.8
 1.5
0.5
 0.9
0.7
 0.4
0.2
2.6
17 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 5562 0 3.7 3.1
 1.5
 1.7
 -0.0
 1.6
-0.2
 1.8
-0.1
 1.6
-0.2
 0.7
-1.2
 1.8
-0.5
 1.0
0.1
 1.5
 1.8
-0.5
18 DOCK10 dedicator of cytokinesis 10 55619 0 3.7 3.8
 1.0
 2.9
 1.8
0.8
 1.7
0.8
 1.6
1.2
 2.8
0.3
 0.7
0.3
 2.7
0.1
 0.7
0.3
 -0.6
 -0.6
19 HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 51170 0 3.7 2.9
 1.6
 1.4
 2.1
1.7
 2.8
0.9
 1.9
0.8
 4.2
1.5
 1.9
1.5
 1.6
1.1
 1.8
1.1
 2.3
1.1
 1.8
1.1
20 PTGFR prostaglandin F receptor 5737 0 3.6 3.6
 1.0
 2.8
 0.3
 1.5
 0.8
 0.7
 1.0
 -0.2
 0.3
 1.4
21 MAPK14 mitogen-activated protein kinase 14 1432 0 3.6 3.5
 0.9
 2.6
 1.3
0.3
 -0.3
-0.8
 0.4
-0.3
 2.2
1.1
 1.6
1.2
 1.3
0.5
 0.4
0.4
 -0.1
-0.7
 0.3
-0.9
22 ITGA4 integrin subunit alpha 4 3676 0 3.6 3.4
 1.0
 2.4
 1.3
 0.8
 1.4
 0.4
 0.3
 0.6
 0.7

23 SLC16A7 solute carrier family 16 member 7 9194 0 3.5 4.2
 1.4
 3.8
 2.8
0.5
 2.0
1.8
 3.5
1.2
 3.9
1.4
 1.4
1.4
 0.9
0.7
 3.0
2.2
 4.1
3.8
 3.9
3.4
24 CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 8418 0 3.5 2.8
 1.2
 1.3








25 PRKCA protein kinase C alpha 5578 0 3.5 3.1
 2.0
 1.9
 2.3
1.0
 1.4
0.7
 0.9
0.7
 1.1
1.1
 3.9
2.0
 2.6
1.9
 1.8
1.1
 0.3
-0.1
 0.7
0.6
26 SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 25939 0 3.5 3.2
 1.2
 2.1
 1.8
 0.2
 0.2
 0.3
 0.5
 -1.0
 0.2
 -0.6
 0.7
27 GBP3 guanylate binding protein 3 2635 0 3.4 3.9
 1.6
 3.4
 1.1
1.1
 0.9
0.9
 0.4
0.1
 1.2
1.0
 0.2
-0.2
 0.7
-0.2
 0.7
-0.5
-0.5
28 MAP3K3 mitogen-activated protein kinase kinase kinase 3 4215 0 3.4 3.1
 1.1
 2.1
 1.1
-0.5
 0.4
-1.1
 0.1
-0.4
 0.5
0.2
 1.0
0.8
 1.1
0.8
 0.7
-0.8

29 SLC8A1 solute carrier family 8 member A1 6546 0 3.4 4.0
 2.5
 3.6
 4.3
-0.5
 1.0
-0.6
 0.1
0.1
 0.4
-0.4
 0.9
-0.1
 1.4
1.4
 1.4
0.8
 0.2
 2.9
1.6
30 USP4 ubiquitin specific peptidase 4 7375 0 3.4 3.1
 0.5
 2.0
 0.2
-2.1
 0.8
-0.6
 0.9
0.6
 1.4
-1.3
 1.2
-2.0
 0.1
-0.1
 0.8
0.2
-0.3
31 CRYBG1 crystallin beta-gamma domain containing 1 202 0 3.4 3.8
 0.9
 3.3
 1.6
 0.5
 0.1
 3.1
 1.0
 -0.6
 -0.0

32 RBL2 RB transcriptional corepressor like 2 5934 0 3.3 2.8
 1.2
 1.6
 1.9
-0.9
 2.1
-0.1
 1.4
0.4
 1.6
0.1
 -0.3
-0.5
 -0.1
-0.2
 -0.9
-1.2
 0.2
-1.1
 -0.7
33 INSYN2B inhibitory synaptic factor family member 2B 100131897 0 3.3 3.3


0.2
 0.2
 1.1
 -1.4
 1.3
 0.0

34 HP1BP3 heterochromatin protein 1 binding protein 3 50809 0 3.3 2.8
 0.9
 1.5
 1.5
 0.6
 0.9
 -0.8
 1.3
 -1.1
 -0.2

35 TBC1D5 TBC1 domain family member 5 9779 0 3.3 3.0
 0.8
 2.0
 1.2
 1.2
 -0.0
 2.4
 1.3
 -0.6
 -0.0
 -0.7
 -0.2
36 USP33 ubiquitin specific peptidase 33 23032 0 3.3 3.3
 1.2
 2.5
 1.2
0.9
 0.5
-0.5
 0.9
0.2
 1.5
-0.7
 1.0
-0.8
 0.0
-1.4
 0.1
-0.6
 -0.7
37 SNX29 sorting nexin 29 92017 0 3.3 2.6
 1.0
 1.3
 0.4
 0.2
 1.3
 -0.3
 0.6

-1.1
38 FAM172A family with sequence similarity 172 member A 83989 0 3.2 2.7
 1.0
 1.5
 1.7
 1.7
 2.0
 2.5
 1.5
-0.2
 1.6
 0.1
 -0.6
 -0.4
39 BACE1 beta-secretase 1 23621 0 3.2 3.1
 1.4
 2.2
 1.2
 0.5
 -0.8
 0.7
 0.5
 -1.3
 -0.4

40 CD44 CD44 molecule (Indian blood group) 960 0 3.2 2.9
 1.1
 2.0
 -1.1
 -0.1
 -0.9
 0.8
0.4
-0.5
 -1.0
-1.1

41 BTN3A1 butyrophilin subfamily 3 member A1 11119 0 3.2 2.7
 1.0
 1.6
 1.5
1.1
 1.1
-0.1
 -1.2
 0.5
0.4
 -0.9



42 RALGAPA2 Ral GTPase activating protein catalytic subunit alpha 2 57186 0 3.2 2.7
 0.1
 1.5
 1.4
1.1
 1.6
-0.1
 0.9
0.3
 1.4
-0.7
 2.1
0.6
 2.5
1.2
 2.0
0.1
 -0.9
 0.2
43 LOC112268267 uncharacterized LOC112268267 112268267 0 3.2 3.2










44 BCAS3 BCAS3 microtubule associated cell migration factor 54828 0 3.2 2.8
 0.6
 1.7
 1.0
 0.7
 0.9
 0.5
 1.6
 2.9
 1.5
 0.7
 -0.5
45 KIDINS220 kinase D interacting substrate 220 57498 0 3.2 3.2
 0.6
 2.4
 1.2
 0.4
 2.0
 1.8
 0.5
 0.9
-0.8
 -0.6
-1.0
 0.1
 0.6
46 POLA1 DNA polymerase alpha 1, catalytic subunit 5422 0 3.2 3.1
 0.9
 2.3
 0.1
 1.4
 2.2
 -1.0
 1.9
 -0.7
 0.5
 0.7
 1.2
47 CIITA class II major histocompatibility complex transactivator 4261 0 3.1 2.7
 0.5
 1.7
 0.2
 0.4
 0.1
 -0.2
 0.2
 -0.0
 -1.5

48 QKI QKI, KH domain containing RNA binding 9444 0 3.1 2.3
 1.2
 1.0
 0.0
 -0.2
 -0.8
 0.5
 0.9
 1.4
1.2
 -0.6
-1.1
 -0.2
 0.6
0.4
49 STX10 syntaxin 10 8677 0 3.1 2.2
 1.2
 0.8
 0.4
-1.1
 -0.5
 -0.2
 -0.2
-1.6
 0.2
 0.1
-1.3
 -0.6
-1.4
 0.1
 -0.5
50 TMTC2 transmembrane O-mannosyltransferase targeting cadherins 2 160335 0 3.1 3.0
 0.9
 2.1
 -0.2
 1.9
 2.1
1.1
 0.9
-0.1
 1.0
0.2
 0.6
0.5
 0.1
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